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Cotton GhPOX1 encoding plant class Ⅲ peroxidase may be responsible for the high level of reactive oxygen species production that is related to cotton fiber elongation

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Journal of Genetics and Genomics 2009年第3期36卷 141-150页

作者： Wenqian Mei Yongmei Qin Wenqiang song jun li Yuxian Zhu National Laboratory of Protein Engineering and Plant Genetic Engineering Department of Biochemistry and Molecular Biology College of Life Sciences Peking University Beijing 100871 China

The accumulation of reactive oxygen species （ROS） is involved in plant cell development. In plant, class III peroxidases are heme-containing enzymes encoded by a large multi-gene family participated in the release or consumption of ROS. The specific function of each member of the family is still elusive. Here, we showed that ROS was significantly generated during cotton fiber initiation and elongation, whereas, application of NADPH oxidase inhibitor diphenyleneiodonium （DPI） and peroxidase inhibitor salicylhydroxamic acid （SHAM） to the wild-type cotton ovule culture significantly suppressed fiber growth, respectively. Their inhibitory effects were caused by the reduction of superoxide radical （O2^-）. Ten GhPOX genes （cDNAs） encoding cotton class III peroxidases were isolated, among them eight GhPOX genes were reported for the first time. Microarray analyses indicated that GhPOX1 was the mostly predominantly expressed in fast-elongating cotton fiber cells. Real-time quantitative PCR analysis revealed the transcript level of GhPOX1 was over 400-fold higher in growing fiber cells than in ovules, flowers, roots, stems and leaves. To reveal the role of GhPOX1 in plant development, its Arabidopsis orthologue atpox13 mutant was demonstrated to be defective in branch root development. Taken together, the data suggest that GhPOX1 plays an important role during fiber cell elongation possibly by mediating production of reactive oxygen species.

关键词： Class III peroxidase GhPOX1 reactive oxygen species (ROS) cotton (Gossypium hirsutum)

Research on the floating performance of a novel large caliber machine gun based on the floating principle with complicated boundary conditions

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Defence Technology（防务技术） 2019年第4期15卷 607-614页

作者： Ye Lu Ke-dong Zhou Lei He jun-song li Xue-ying Huang School of Mechanical Engineering Nanjing University of Science and Technology Nanjing 210094 Jiangsu China No.208 Research Institute of China Ordnance Industries Beijing 102202 China 63856 Unit of PLA Baicheng 137001 Jilin China

In this paper,a novel large caliber machine gun was taken as the research object to analyze the floating technique based on the principle of fixed-point constraint and secondary counter-recoil.A rigid-flexible coupling multi-body dynamic model of the large caliber machine gun with muzzle brake based on floating principle was established,in which the influence of soil and human body was taken into *** dynamic simulation was conducted and then the results were compared with the corresponding experimental data The dynamic characteristics of the machine gun with or without floating technique were analyzed to indicate the influence of floating technique upon the performance of the ***,the rigid-flexible coupling dynamic models with five different firing angles was constructed to study the influence caused by the *** results indicated that the floating mechanism could reduce the recoil effectively and improve the operational performance of this novel large caliber machine gun.

关键词： Large caliber machine gun Floating performance Dynamic analysis Firing elevation

Syntheses,Crystal Structures and Bioactivities of Two Novel Isatin Derivatives

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Chemical Research in Chinese Universities 2011年第4期27卷 595-598页

作者： SHANG Jian-li li Hui-dong SHANG jun song Hai-bin li Zheng-ming WANG Jian-guo State Key Laboratory of Elemento-Organic Chemistry Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071 P. R. China

Two novel compounds 1-（4-fluorobenzyl）-4-chloro-（Z）-3-benzoylhydrazono-2-indolinone（1） and 1-（4-methoxybenzyl）-（Z）-3-benzoylhydrazono-2-indolinone（2） were synthesized and their crystal structures were determined by single-crystal X-ray *** 1（C22H15ClFN3O2） crystallized in the triclinic system,space group P1·with a=0.94198（19） nm,b=1.4339（3） nm,c=1.5018（3） nm,α=101.58（3）°,β=102.96（3）°,γ=102.73°,V=1.8602（6） nm3,Mr=407.82,Dc=1.456 g/cm3,μ=0.240 mm-1,F（000）=840,Z=4,R1=0.0442 and wR2=*** 2（C23H19N3O3） crystallized in the triclinic system,space group P1·with a=1.0022（2） nm,b=1.0192（2） nm,c=1.0461（2） nm,α=99.86（3）°,β=117.30（3）°,γ=94.13（3）°,V=0.9215（3） nm3,Mr=385.41,Dc=1.389 g/cm3,μ=0.094 mm-1,F（000）=404,Z=2,R1=0.0403 and wR2=*** preliminary herbicidal activities of the two compounds were also evaluated.

关键词： Acetohydroxy acid synthase(AHAS) Crystal structure Isatin derivative Herbicidal activity

Improved Multicast Traffic Scheduling Scheme in the Packet-Switching Systems

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The Journal of China Universities of Posts and Telecommunications 2004年第Z1期11卷 1-7页

作者： song Mei-na song jun-de li Hong-wen Beijing University of Posts and Telecommunications Beijing 100876 P.R.China Beijing University of Posts and Telecommunications Beijing 100876 P.R.China Beijing University of Posts and Telecommunications Beijing 100876 P.R.China

This paper proposes a new switching scheme of switch fabric, which is named Multicast-enabled Protocol Agnostic Forwarding Engine (M-PAFE). M-PAFE is a central scheduling crossbar-based switch fabric with embedded Combined Input and Output Queue from the queuing view. An extra switching path is dedicated for multicast cell processing in M-PAFE. And the simulation results are provided to evaluate the performance of M-PAFE in comparison with ESliP, which is a well-known algorithm implemented in Cisco 12000 routers.

关键词： combined input and output queue multicast central scheduling ESliP

Two-stent strategy for renal artery stenosis with bifurcation lesion

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第8期11卷 561-567页

作者： Hong-bing YAN Bin ZHENG Zheng WU Jian WANG Han-jun ZHAO li song Yun-peng CHI Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Renal artery stenosis(RAS) with a bifurcation lesion is a challenge for interventional *** aim of this study is to summarize our experience in RAS with a bifurcation *** patients with RAS involving bifurcation lesion are *** cases 1 to 3,a single-stent strategy was first ***,these three patients were converted to a two-stent strategy for bailout stent implantation in the side *** cases 4 and 5,a simultaneous kissing stent technique was *** showed that the reference vascular diameter of the main branch was much larger than those of the side *** obvious residual stenosis existed in cases 1 to 3 after stent implantation,no obvious residual stenosis was seen in cases 4 and *** artery duplex sonography was performed in cases 1 through 5 at 6,7,7,8,and 6 months,respectively,after the *** evidence of restenosis or occlusion was *** conclusion,stent implantation with the simultaneous kissing stent technique may result in more simple and more satisfactory immediate angiographic results.

关键词： Peripheral atherosclerotic artery disease Angioplasty Stents Renal artery stenosis

Low Correspondence of EGFR Mutations in Tumor Tissue And Paired Serum of Non-Small-Cell Lung Cancer Patients

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Chinese Journal of Cancer Research 2010年第1期22卷 27-31页

作者： Guo-hong song,jun Ren,li-jian Zhang,li-jun Di, Yan-hua Yuan,Jing Yu,jun Jia Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Medical Oncology,Peking University School of Oncology,Beijing Cancer Hospital & Institute,Beijing 100142,China Key laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Medical Oncology Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing China

Objective： Epidermal growth factor receptor （EGFR） mutations are strong determinants of tumor response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer （NSCLC） patients. The aim of this study was to evaluate the correspondence between EGFR mutations in non-small-cell lung cancer tissues and in circulating DNA. Methods： The research was conducted in 50 non-small-cell lung cancer patients who had undergone curative surgery, and in whom both serum and neoplastic tissues were available. Meanwhile sera of 33 cases of advanced NSCLC patients were also analyzed. DNA were extracted from each sample. Mutations of EGFR in exonl8-21 were examined by PCR amplification method and direct sequencing. Results： EGFR mutations were detected in 15 （30%） of 50 neoplastic tissue samples, 6 cases were in-frame deletion del E746-A750 in exonl9, 9 cases were substitution in exon 21 （all were L858R except one was L861Q）, but no mutated DNA resulted in paired serum circulating DNA samples of 50 resectable patients. As the 33 advanced NSCLC patients, EGFR mutations were detected in only 2 serum circulating DNA samples, all were L858R mutation in exon 21. Conclusion： These data indicated that it was difficult to identify EGFR mutations in circulating DNA of NSCLC patients. The use of EGFR mutation in serum as a clinical method for decision making of TKI therapy is unsatisfactory.

关键词： Circulating DNA Epidermal growth factor receptor (EGFR) Mutation Non-small-cell lung cancer (NSCLC)

STRUCTURE OF liQUID Al-Si ALLOYS

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Acta Metallurgica Sinica(English Letters) 1994年第1期7卷 49-53页

作者： GUI Manchang, JIA jun, song Guangchun, li Peiyong, li QingchunHarbin Institute of Technology, Harbin, China

In the light of DSC, electronic microprobe and X-ray diffration analyses of the melt-spinning ribbons and the structures of liquid hypoeutectic Al-7%Si, euteclic Al-12.7%Si and hypereutectic A1-18%Si alloys have been investigated. The results show that the Al-Si clusters in liquid hypoeutectic Al-Si alloy, the Si-Si clusters in liquid eutectic and hypereutectic Al-Si alloys exist at low temperatures, however, the size of clusters decreases gradurally with increasing temperature. This process in which inhomogeneous liquid turns into homogeneous one happens in a range of temperatures.

关键词： Al-Si alloy liquid alloy cluster

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期7卷 152-160页

作者： Zhi-jun Xie Jia-lin li ling Gong Xiang-li Zhong Hong-Jia song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

关键词： Arc ion plating Multilayer structure sp3 bond Ta-C coating Wear resistance

Challenges and strategies in progress of drug delivery system for traditional Chinese medicine Salviae Miltiorrhizae Radix et Rhizoma(Danshen)

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Chinese Herbal Medicines 2021年第1期13卷 78-89页

作者： Ruo-ning Wang Hua-cong Zhao Jian-yu Huang Hong-lan Wang jun-song li Yin Lu liu-qing Di School of Pharmacy Nanjing University of Chinese MedicineNanjing 210046China Jiangsu Engineering Research Center for Efficient Delivery System of TCM Nanjing 210046China Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing 210046China

Traditional Chinese medicines(TCMs), with a history of thousands of years, are widely used clinically with effective treatment. However, the drug delivery systems(DDSs) for TCMs remains major challenges due to the characteristics of multi-components including alkaloids, flavones, anthraquinones, glycosides,proteins, volatile oils and other types. Therefore, the novel preparations and technology of modern pharmaceutics is introduced to improve TCM therapeutic effects due to instability and low bioavailability of active ingredients. Salviae Miltiorrhizae Radix et Rhizoma, the radix and rhizomes of Salvia miltiorrhiza Bunge(Danshen in Chinese), is a well known Chinese herbal medicine for protecting the cardiovascular system, with active ingredients mainly including lipophilic tanshinones and hydrophilic salvianolic *** this review, this drug is taken as an example to present challenges and strategies in progress of DDSs for TCMs. This review would also summary the characteristics of active ingredients in it including physicochemical properties and pharmacological effects. The purpose of this review is to provide inspirations and ideas for the DDSs designed from TCMs by summarizing the advances on DDSs for both singleand multi-component from Danshen.

关键词： active ingredients challenges and strategies drug delivery systems Salvia miltiorrhiza Bunge Salviae Miltiorrhizae Radix et Rhizoma traditional Chinese medicines