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Failure mechanisms of AlGaN/GaN HEMTs irradiated by high-energy heavy ions with and without bias

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Nuclear Science and Techniques 2025年第1期36卷 49-58页

作者： Pei-Pei Hu Li-jun Xu sheng-Xia Zhang Peng-Fei Zhai Ling Lv Xiao-Yu Yan Zong-Zhen Li Yan-Rong Cao Xue-Feng Zheng Jian zeng Yuan He Jie Liu Institute of Modern Physics Chinese Academy of Sciences(CAS)Lanzhou 730000China Key Laboratory of Wide Band‑gap Semiconductor Materials Ministry of EducationXidian UniversityXi’an 710071China University of Chinese Academy of Sciences(UCAS) Beijing 100049China

Gallium nitride(GaN)-based devices have significant potential for space ***,the mechanisms of radiation damage to the device,particularly from strong ionizing radiation,remains *** study investigates the effects of radiation on p-gate AlGaN/GaN high-electron-mobility transistors(HEMTs).Under a high voltage,the HEMT leakage current increased sharply and was accompanied by a rapid increase in power density that caused"thermal burnout"of the *** addition,a burnout signature appeared on the surface of the burned devices,proving that a single-event burnout effect ***,degradation,including an increase in the on-resistance and a decrease in the breakdown voltage,was observed in devices irradiated with high-energy heavy ions and without *** latent tracks induced by heavy ions penetrated the heterojunction interface and extended into the GaN ***,a new type of N_(2)bubble defect was discovered inside the tracks using Fresnel *** accumulation of N_(2)bubbles in the heterojunction and buffer layers is more likely to cause leakage and *** study indicates that electrical stress accelerates the failure rate and that improving heat dissipation is an effective reinforcement method for GaN-based devices.

关键词： GaN HEMTs Heavy ions Single-event burnout Latent tracks Degradation

Penile metastasis from colon cancer with BRAF_(V600E)mutation treated with BRAF/MEK-targeted therapy plus cetuximab:A case report

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 402-409页

作者： jun-Chen Wu Hua-Xi Cheng Qiu-sheng Lan He-Yang Xu Yu-Jie zeng Wei Lai Zhong-Hua Chu Department of Gastrointestinal Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120Guangdong ProvinceChina

BACKGROUND The incidence of colon cancer has been progressively increasing over time,whereas penile metastasis of colon cancer has remained exceedingly *** the prognosis for colon cancer with BRAF_(V600E)mutation is relatively unfavorable,further exploration and investigation are still required to develop treatment strategies for such rare *** SUMMARY About one year after surgery and chemotherapy,a 50-year-old patient with sigmoid colon cancer developed a mass at the base of the patient's penis,accompanied by severe tenderness and pain during *** disease progression,multiple metastatic nodules also emerged in other regions of the penis,including the coronal *** nodules located in the coronal sulcus were excised for histopathological *** histopathological findings revealed that the nodules were metastases originating from the sigmoid colon cancer,with a BRAF V600E mutation *** prompted a modification of the therapy regimen of cetuximab,dabrafenib and trametinib,which effectively held back the progression of penile metastasis in the *** Combining the BRAF/MEK-targeted therapy with cetuximab demonstrates a favorable therapeutic response in BRAF_(V600E)-mutated colon cancer with penile metastasis.

关键词： Colon cancer Penile metastasis BRAF_(V600E)mutation Targeted therapy Case report

A supramolecular formulation of icariin@sulfonatoazocalixarene for hypoxia-targeted osteoarthritis therapy

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Chinese Chemical Letters 2025年第1期36卷 267-271页

作者： Chao Zhang Ai-Feng Liu Shihui Li Fang-Yuan Chen jun-Tao Zhang Fang-Xing zeng Hui-Chuan Feng Ping Wang Wen-Chao Geng Chuan-Rui Ma Dong-sheng Guo Orthopedics department First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300380China Orthopedics department National Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin 300380China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China

Osteoarthritis(OA)is the most prevalent joint disease and icariin is a promising drug for its ***,the clinical use of icariin is hindered by poor water solubility,low bioavailability,and nonspecific release and biological ***,sulfonated azocalix[4]arene(SAC4A)with enhanced water solubility,recognition capacity,and designed responsiveness was used to improve the efficiency of icariin for OA ***4A,a macrocycle with well-defined molecular weight and structure,could encapsulate and enhance water solubility of various *** addition,SAC4A enables hypoxia-responsive release of loaded *** with icariin treatment,supramolecular complex icariin@SAC4A significantly relieved OA symptoms of rats,including more regular bone morphology and structure,and lower degree of cartilage ***,the supramolecular formulation demonstrated various advantages,including easy preparation,hypoxia-triggered release,and small size that conducive to drug penetration.

关键词： Biomaterial Supramolecular chemistry Calixarene Icariin Osteoarthritis

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利益关联、评级资格管制与基金评级公正性

管理科学学报 2017年第9期20卷 101-112页

作者：张俊生曾亚敏中山大学管理学院广州510275 暨南大学管理学院广州510632

具有基金评级资格的证券公司与证券投资基金之间存在着紧密而有趣的经济关系,一方面,具有基金评级资格的证券公司可以对基金进行评级,另一方面,基金与证券公司之间可能存在利益关联,具体体现在:1)基金要通过证券公司的交易席位进行交易... 详细信息

具有基金评级资格的证券公司与证券投资基金之间存在着紧密而有趣的经济关系,一方面,具有基金评级资格的证券公司可以对基金进行评级,另一方面,基金与证券公司之间可能存在利益关联,具体体现在:1)基金要通过证券公司的交易席位进行交易并相应地给予证券公司交易佣金;2)证券公司可能是投资基金的大股东.那么这两种利益关联会损害证券公司作为基金评级机构的公正性吗?研究发现:1)如果证券公司与投资基金之间存在交易佣金关系或股权关系,那么证券公司会显著提高基金的评级等级;2)通过利益关联获得的基金评级对基金未来业绩解释力明显较低;3)2010年实施基金评价资格管制之后,上述两种现象更为明显.综合研究结果表明,利益关联会损害证券公司作为基金评级机构的公正性,且基金评级资格管制可能进一步加剧了利益关联对评级公正性的损害.

关键词：基金评级交易佣金评级机构股权附属评级管制

Quantum-enhanced interferometry with unbalanced entangled coherent states

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Chinese Physics B 2025年第2期34卷 54-62页

作者： jun Tang Zi-Hang Du Wei Zhong Lan Zhou Yu-Bo sheng Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China School of Science Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210003China

We propose a quantum-enhanced metrological scheme utilizing unbalanced entangled coherent states(ECSs) generated by passing a coherent state and a coherent state superposition through an unbalanced beam splitter(BS). We identify the optimal phase sensitivity of this scheme by maximizing the quantum Fisher information(QFI) with respect to the BS transmission ratio. Our scheme outperforms the conventional scheme with a balanced BS, particularly in the presence of single-mode photon loss. Notably, our scheme retains quantum advantage in phase sensitivity in the limit of high photon intensity, where the balanced scheme offers no advantage over the classical strategy.

关键词： quantum-enhanced interferometry entangled coherent state quantum Fisher information

Flow behavior and dynamic softening mechanism of Pt−10Ir precious alloy

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 225-242页

作者： Xin-pei ZHANG jun-jie HE Lin PI Quan FU Wen-yan ZHOU jun CHENG sheng-wen BAI Xuan ZHOU Yi LIU Yong MAO Materials Genome Institute School of Materials and EnergyYunnan UniversityKunming 650091China Kunming Precious Materials&Technology Co. Ltd.Yunnan Precious Metals Laboratory Co.Ltd.Sino-Platinum Metals Co.Ltd.Kunming 650106China Kunming Institute of Precious Metals Kunming 650106China State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals Sino-Platinum Metals Co.Ltd.Kunming 650106China Shaanxi Key Laboratory of Biomedical Metal Materials Northwest Institute for Non-ferrous Metal ResearchXi’an 710016China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The hot deformation behavior of Pt−10Ir alloy was studied under a wide range of deformation *** a low deformation temperature(950−1150℃),the softening mechanism is primarily dynamic *** addition,dynamic recrystallization by progressive lattice rotation near grain boundaries(DRX by LRGBs)and microshear bands assisted dynamic recrystallization(MSBs assisted DRX)coordinate the ***,it is difficult for the dynamic softening to offset the stain hardening due to a limited amount of DRXed *** a high deformation temperature(1250−1350℃),three main DRX mechanisms associated with strain rates occur:DRX by LRGBs,DRX by a homogeneous increase in misorientation(HIM)and geometric DRX(GDRX).With increasing strain,DRX by LRGBs is enhanced gradually under high strain rates;the“pinch-off”effect is enhanced at low strain rates,which was conducive to the formation of a uniform and fine microstructure.

关键词： platinum alloy hot deformation microstructure evolution dynamic recovery dynamic recrystallization

No-touch recipient hepatectomy in liver transplantation for liver malignancies: A state-of-the-art review

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 39-44页

作者： sheng-jun Xu Qiang Wei Xin Hu Chang-Biao Li Zhe Yang Shu-Sen Zheng Xiao Xu NHC Key Laboratory of Combined Multi-organ Transplantation Institute of Organ TransplantationZhejiang UniversityHangzhou 310003China School of Clinical Medicine Hangzhou Medical CollegeHangzhou 310059China General Surgery Cancer CenterDepartment of Gastrointestinal and Pancreatic SurgeryZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014China Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Institute of Translational Medicine Zhejiang UniversityHangzhou 310000China

Tumor recurrence, the Gordian knot of liver transplantation for malignancies, may be attributed to many parameters. The technique of the “classical” recipient hepatectomy is believed to be one of the potential reasons to cause tumor evasion because of the possible increase of circulating tumor cells, thus leading to an increased recurrent rate. On this background, the no-touch oncological recipient hepatectomy technique has been developed. A comprehensive review of the development and the key surgical steps of the no-touch recipient hepatectomy is presented. This technique might improve clinical outcomes, especially for those recipients who are at a high risk for tumor recurrence. Multicenter prospective studies should be set up to further validate the prognostic role of this technique in patients with liver cancer treated with liver transplantation.

关键词： Liver transplantation Hepatocellular cancer Tumor recurrence Surgical technique No-touch recipient hepatectomy Vena cave sparing hepatectomy

An integrated photocatalytic redox architecture for simultaneous overall conversion of CO_(2)and H_(2)O toward CH_(4)and H_(2)O_(2)

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Science Bulletin 2025年第3期70卷 373-382页

作者： Muhammad Salman Nasir Bowen sheng Ying Zhao Haotian Ye jun Song Jinglin Li Ping Wang Tao Wang Xinqiang Wang Zhen Huang Baowen Zhou Key Laboratory for Power Machinery and Engineering of Ministry of Education Research Center for Renewable Synthetic FuelSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Artificial Microstructure and Mesoscopic Physics School of PhysicsNano-Optoelectronics Frontier Center of Ministry of Education(NFC-MOE)Peking UniversityBeijing 100871China Department of Mining and Materials Engineering McGill UniversityMontrealH3A 0G4Canada Electron Microscopy Laboratory School of PhysicsPeking UniversityBeijing 100871China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China Collaborative Innovation Center of Quantum Matter School of PhysicsPeking UniversityBeijing 100871China

Solar-driven overall conversion of CO_(2)and H_(2)O into fuels and chemicals shows an ultimate strategy for carbon neutrality yet remains a huge ***,an integrated photocatalytic redox architecture of Zn NPs/GaN Nanowires(NWs)/Si is explored for light-driven overall conversion of CO_(2)and H_(2)O into CH_(4)and H_(2)O_(2)simultaneously without any external sacrificial agents and *** as-designed architecture affords a benchmark CH_(4)activity of 189 mmol gcat^(-1)h^(-1)with a high selectivity of 93.6%,in the synchronized formation of H_(2)O_(2)at a considerable rate of 25 m g^(-1)h^(-1).Moreover,a considerable turnover number of 27,280 mol CH_(4)per mol Zn was achieved over a long-term operation of 80 *** operando spectroscopic characterizations,isotope experiments,and density functional theory calculations,it is unraveled that Zn sites are synergetic with GaN to drive CO_(2)-to-CH_(4)conversion with a lowered energy barrier of 0.27 eV while inhibiting hydrogen evolution reaction with a relatively high energy barrier of 0.93 ***,owing to the unique surface properties of GaN,water is split into*OH and*H,followed by the formation of H_(2)O_(2)because of the alleviated adsorption strength of*OH by Zn ***,the hierarchical architecture enables the achievement of high activity and high selectivity of CH_(4)from CO_(2)reduction in distilled water along with the generation of H_(2)O_(2).This work provides an integrated photocatalytic redox architecture for the synchronized production of CH_(4)and H_(2)O_(2)with the only inputs of CO_(2),distilled water,and light.

关键词： Zn nanoparticles GaN nanowires/Si Integrated redox architecture Artificial photosynthesis CH_(4)and H_(2)0_(2)

Development and validation of a nomogram prediction model for overall survival in patients with rectal cancer

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 93-104页

作者： Ling Liang Xiao-sheng Li Ze-jun Huang Zu-Hai Hu Qian-Jie Xu Yu-Liang Yuan Wei Zhang Hai-Ke Lei Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multiomics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Rectal cancer is prevalent and associated with substantial morbidity and *** To develop a nomogram prediction model for overall survival(OS)in patients with rectal cancer by leveraging a comprehensive analysis of demographic,clinicopathological,haematological,and follow-up data to identify independent prognostic *** We conducted a prospective cohort study in China involving rectal cancer patients and applied Cox regression and least absolute shrinkage and selection operator regression to assess the significance of various variables as independent prognostic factors for *** identified factors were integrated into a nomogram model,which was evaluated for predictive accuracy via the C-index,area under the curve(AUC),calibration curve,and decision curve analysis(DCA).RESULTS Multivariate analysis revealed independent predictors of OS,including the Karnofsky performance status,age,sex,TNM stage,chemotherapy,surgery,targeted therapy,β2-microglobulin,lactate dehydrogenase,and the neutrophil-to-lymphocyte *** nomogram demonstrated a C-index of 0.80 for the training and validation cohorts,with AUC values indicating high predictive accuracy for 1-year,3-year,and 5-year *** calibration curves confirmed the model's excellent agreement with the observed survival rates,and DCA revealed the superior clinical utility of the nomogram over the TNM staging *** In this study,a novel prognostic model that accurately predicts the OS of rectal cancer patients was *** model exhibited excellent discriminatory and calibration capabilities,thus offering a reliable tool for health care professionals to estimate patient survival.

关键词： Rectal cancer Overall survival Nomogram Prognosis