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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 164-170页

作者： WU min cao Kailei XIAO Weirong YU Zetai cao Jierong DING Qingjun LI Jinhui China Railway Construction Corporation Harbour and Channel Engineering Bureau Group Co. LTDZhuhai 519000China Con-struction Headquarters of Zhoushan Liuheng Bridge Phase II Project Zhoushan 316000China China Railway Construction Bridge En-gineering Bureau Group Co. LTDTianjin 300000China State Key Laboratory of Silicate Material for Architecture(Wuhan University of Technology) Wuhan 430070China College of Materials Science and Engineering Wuhan Textile UniversityWuhan 430200China

The paper presents experimental investigation results of crack pattern change in cement pastes caused by external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an X-ray computed tomography(X-ray CT)was used,i e,the tomography system of Zeiss Xradia 510 *** results indicate that X-CT can monitor the development process and distribution characteristics of the internal cracks of cement pastes under ESA with attack *** addition,the C3A content in the cement significantly affects the damage mode of cement paste specimens during sulfate *** damage of ordinary Portland cement(OPC)pastes subjected to sulfate attack with high C3A content are severe,while the damage of sulfate resistant Portland cement(SRPC)pastes is much smaller than that of OPC ***,a quadratic function describes the correlation between the crack volume fraction and development depth for two cement pastes immermed in sulfate solution.

关键词： concrete external sulfate attack damage evolution situ X-ray computed tomography

Epidemiology and microbiology of nosocomial bloodstream infections: analysis of 482 cases from a retrospective surveillance study

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第1期16卷 70-77页

作者： Jian-nong WU Tie-er GAN Yue-xian ZHU jun-min cao Cong-hua JI Yi-hua WU Bin LV Department of Hospital Infection Control the First Affiliated Hospital of Zhejiang Chinese Medical University Microbiology Laboratory the First Affiliated Hospital of Zhejiang Chinese Medical University Clinical Evaluation and Analysis Center the First Affiliated Hospital of Zhejiang Chinese Medical University Department of Epidemiology and Health Statistics School of Public Health Zhejiang University Department of Gastroenterology the First Affiliated Hospital of Zhejiang Chinese Medical University

In many traditional Chinese medicine （TCM） hospitals, most patients are elderly with chronic diseases. Nosocomial bloodstream infections （nBSIs） are an important cause of morbidity and mortality. A retrospective sur- veillance study was performed to examine the epidemiology and microbiology of nBSIs in a TCM hospital from 2009 to 2011. A total of 482 patients with nBSIs were included in the study period. The incidence rate was 5.7/1000 admissions Escherichia coli （25.5%） was the most common Gram-negative and coagulase-negative staphylococcus （CONS）（14.1%） was the most common Gram-positive organism isolated. One-third of the E. coli and Klebsie/la pneumoniae isolated from the nBSIs were the third-generation cephalosporin-resistant. Half of the Acinetobacter species isolates were resistant to imipenem. Of all the CoNS isolates, 90.7% were resistant to methicillin. Carbapenems and glyco- peptide were the most frequently used for nBSI therapy. Only about one-third of patients （157/482） received appro- priate empirical therapy. Septic shock, hemodialysis, Pitt bacteremia score 〉4, urinary tract infection, and appropriate empirical therapy were most strongly associated with 28-d mortality. The incidence of nBSIs was low in the TCM hospital but the proportion of nBSIs due to antibiotic-resistant organisms was high. A high Pitt bacteremia score was one of the most important risk factors for mortality in nBSIs. Therefore, the implementation of appropriate empirical therapy is crucial to improve the clinical outcome of nBSIs.

关键词： Nosocomial bloodstream infection Traditional Chinese medicine hospital Epidemiology Microbiology

The Mechanism of Heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： GAO Qian LI jun WANG Xianhui cao Laifu GONG Jian LI Bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

Anti-inflammation of Tripterygium wilfordii Polycoride on Macrophages and Its Regulation to Inflammation via TLR4/NF-κB

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Chinese Herbal Medicines 2015年第2期7卷 155-161页

作者： Dan-ping Qin Yi-jun Zhou Shao-zhu Zhang jun-min cao Li-yu Xu Guo-dong Fang Jia Wang First Clinical Medical College of Zhejiang Chinese Medical University First Affiliated Hospital of Zhejiang Chinese Medical University

Objective To investigate the inhibitory effect of Tripterygium wilfordii polycoride（TWP） towards the pro-inflammatory factors（TNF-α and IL-1β） on the inflammatory reaction in macrophages induced by LPS and its regulatory effect and influence on the inflammation via TLR4/NF-k B. Methods The MTT method was adopted to test the effect of drugs, TWP, dexamethasone（DXM） and azathioprine（AZA） on cell growth and to select the appropriate concentration. LPS was used to induce the inflammatory reaction in RAW264.7 cell line of mice. Elisa kit was adopted to test the levels of TNF-α and IL-1β. Western blotting was adopted to test the protein expression of TNF-α and IL-1β. RT-PCR was adopted to test the expression of TLR4 and NF-κB. Results The inhibiting effect of TWP on the release of TNF-α and IL-1β in a dose dependent manner. The inhibitory effect of three different TWP dose groups is weaker than that in DXM group. However, TWP in high dose is better than AZA on TNF-α and is as strong as AZA on IL-1β. The dose dependent manner also exits in the effect on the expression of TLR4 and NF-κB, the effect is not weaker, but even stronger than that of DXM and AZA. Conclusion The research shows that down regulation of TLR4 and NF-k B p65 may be one of the mechanisms about the TWP inhibitory effect on TNF-α and IL-1β.

关键词： mechanism of anti-inflammation NF-κB Tripterygium wilfordii polycoride TLR4

lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis

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Oncology research 2025年第1期33卷 185-198页

作者： Zhouyang Cheng Yuchen Hua Yang cao jun Qin Department of General Surgery Affiliated Hospital of Nantong University Nantong 226001 China. Department of Surgery Affiliated Hospital of Nantong University Medical School of Nantong University Nantong 226001 China. Department of Operation Affiliated Hospital of Nantong University Nantong 226001 China.

Objective:Gastric cancer (GC) is a globally common cancer characterized by high incidence and mortality worldwide. Advances in the molecular understanding of GC provide promising targets for GC diagnosis and therapy. Long non-coding RNAs (lncRNAs) and their downstream regulators are regarded to be implicated in the progression of multiple types of malignancies. Studies have shown that the lncRNA small nucleolar RNA host gene 4 (SNHG4) serves as a tumor promoter in various malignancies, while its function in GC has yet to be characterized. Therefore, our study aimed to explore the role and underlying mechanism of SNHG4 in GC.Methods:We used qRT-PCR to analyze SNHG4 expression in GC tissues and cells. Kaplan-Meier analysis was used to assess the correlation between SNHG4 expression and the survival rate of GC patients. Cellular function experiments such as CCK-8, BrdU, colony formation, flow cytometry analysis, and transwell were performed to explore the effects of SNHG4 on GC cell proliferation, apoptosis, cell cycle, migration, and invasion. We also established xenograft mouse models to explore the effect of SNHG4 on GC tumor growth. Mechanically, dual luciferase reporter assay was used to verify the interaction between SNHG4 and miR-409-3p and between miR-409-3p and cAMP responsive element binding protein 1 (CREB1).Results:The results indicated that SNHG4 was overexpressed in GC tissues and cell lines, and was linked with poor survival rate of GC patients. SNHG4 promoted GC cell proliferation, migration, and invasion while inhibiting cell apoptosis and cell cycle arrest . The experiment indicated that SNHG4 facilitated GC tumor growth. Furthermore, SNHG4 was demonstrated to bind to miR-409-3p. Moreover, CREB1 was directly targeted by miR-409-3p. Rescue assays demonstrated that miR-409-3p deficiency reversed the suppressive impact of SNHG4 knockdown on GC cell malignancy. Additionally, miR-409-3p was also revealed to inhibit GC cell proliferation, migration, and

关键词： Gastric cancer MicroRNA-409-3p (miR-409-3p) Small nucleolar RNA host gene 4 (SNHG4) cAMP responsive element binding protein 1 (CREB1)

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing cao Chenglin Cai Guangming Wang min Zhou Luying Peng Yantao Fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

Systematic Acupuncture Explains Acupuncture at Baihui(GV20) and Fengchi(GB20) Targeting the Inflammatory Response to Regulate Migraine

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Journal of Traditional Chinese Medicine 2025年

作者： min Yu ZHENG Meifeng SUN Ju PENG Zetong cao Zhixian HUANG Xiaohua Medical College of Acu-Moxi and Rehabilitation， Guangzhou University of Chinese Medicine Department of Rehabilitation Medicine， the Affiliated Panyu Central Hospital of Guangzhou Medical University

Objective: To take Baihui (GV20) and Fengchi (GB20) targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating ***: The target information of Baihui (GV20) and Fengchi (GB20) was retrieved， and after intersection with migraine， Kyoto Encyclopedia of Genes and Genomes (KEGG)， Reactome， and UniProt Keywords were used for functional enrichment. After selecting the main pathway， rats were selected and nitroglycerin was used for modeling， and the behavioral scores， inflammatory factors， heme oxygenase 1 (HMOX1)， protein kinase B (AKT1)， signal transducer and activator of transcription 3 (STAT3)， phosphorylated extracellular signal-regulated kinase 1/2 (P-ERK1/ERK2) and other states of the rats in the acupuncture， twisting， and electroacupuncture groups were ***: A total of 135 Baihui (GV20) targets and 27 Fengchi (GB20) targets were collected. A total of 73 target information were obtained after the intersection of these targets in migraine. These 73 targets have three main pathways: hypoxia-inducible factor 1 (HIF-1) signaling pathway， signaling by interleukins and inflammatory response. The main targets in the pathway were verified and found that interleukin-1 beta (IL-1β)， interleukin-6 (IL-6)， tumor necrosis factor-alpha (TNF-α) and HMOX1， AKT1， STAT3， P-ERK1/ERK2 can be regulated by Baihui (GV20) and Fengchi (GB20).Conclusion: Baihui (GV20) and Fengchi (GB20) can regulate migraine by regulating inflammatory factors and HMOX1， AKT1， STAT3， P-ERK1/ERK2 and other changes in HIF-1 signaling pathway， Signaling by Interleukins and Inflammatory response pathways. Based on systems biology and network pharmacology， and with the model of "acupoint-target-disease"， explore the research methods of systematic acupuncture and moxibustion. We believe this is a usable research direction for exploring the mechanism of acupuncture stimulation.

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Impact of CYP2D6*10 alleles on risperidone pharmacokinetics in Chinese healthy volunteers

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Impact of CYP2D6*10 alleles on risperidone pharmacokinetics ...

第十三次全国临床药理学学术大会

作者： Wen-Juan He,Xin-Xia Liu,Yin-Song Zhu,min-jun cao,Hui Chen Institute of Clinical Pharmacology,Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030

Objective To evaluate the impact of the CYP2D6 genotype on the pharmacokinetics of risperidone in Chinese healthy subjects. Methods A single oral dose of 2 mg risperidone pharmacokinetic study was performed in 30 healthy Chinese *** concentrations of risperidone were measured by high-performance liquid chromatography with tandem mass spectroscopy detection(LC-MS/MS) *** pharmacokinetic parameters were analyzed by a noncompartmental linear PK *** CYP2D6 genotypes were identified by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) *** Subjects were grouped as CYP2D6*1/*1(n=6),CYP2D6*1/*10(n=8) and CYP2D6*10/*10(n=16) according to their *** differences were observed in the C,t,AUC and CL/F of risperidone between CYP2D6*1/*1 and CYP2D6*10/*10(P0.05).The T values of CYP2D6* 1 /* 1,CYP2D6* 1 /* 10 and CYP2D6* 10/* 10 were 1.13±0.28,0.78±0.15 and 1.13±0.63 h,respectively. Conclusion Compared with the CYP2D6*1/*1 allele,the CYP2D6*10/*10 allele had apparent influence on the pharmacokinetics of risperidone with a decreased enzyme activity of CYP2D6;while the CYP2D6*1/*10 allele didn’t exhibit significantly influence on the pharmacokinetics of *** results suggest that genotyping of CYP2D6 might be helpful in predicting the pharmacokinetics of risperidone and guide clinical reasonable administration.

关键词： CYP2D6 genotype risperidone pharmacokinetics

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湿陷性黄土地区管道敷设对策研讨

天然气与石油 2000年第4期18卷 46-49页

作者：向波闵军曹润苍四川石油勘察设计研究院四川成都610017

我国已建成的“陕—京输气管道”、正建设的“涩—兰输气管道”,拟建设的’西气东输管道”等长输管道都大段在湿陷性黄土地区敷设 ,在此地区虽已建成和运行了一些油、气管道工程 ,但水害却严重影响了管道的安全运行 ,故湿陷性黄土地区... 详细信息

我国已建成的“陕—京输气管道”、正建设的“涩—兰输气管道”,拟建设的’西气东输管道”等长输管道都大段在湿陷性黄土地区敷设 ,在此地区虽已建成和运行了一些油、气管道工程 ,但水害却严重影响了管道的安全运行 ,故湿陷性黄土地区管道敷设还需深入开展对策研究。本文通过对陕甘宁气田—北京输气管道工程途径吕梁山黄土沟壑梁峁山区段所进行的管道设计 ,提出了“七个环节”的全过程保证体系的思路 ;针对四种不同地形情况 ,相应地采取十种管道水工保护措施 ,确保管道安全运行。

关键词：湿陷性黄土地区管道敷设安全运行输气管道

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西双版纳山黄麻林鸟类群落结构及功能分析

生物多样性 2003年第3期11卷 216-222页

作者：王直军曹敏李国锋中国科学院西双版纳热带植物园昆明650223

山黄麻 (Tremaorientalis)林是西双版纳热带森林次生演替的初级阶段 ,鸟类与山黄麻林的相互关系对森林更新和生物多样性保护有重要意义。我们采用样带观测法 ,在山黄麻林内设 10条观测带 (各带 10 0m长 ,10m宽 ,合计面积 1hm2 )观测记... 详细信息

山黄麻 (Tremaorientalis)林是西双版纳热带森林次生演替的初级阶段 ,鸟类与山黄麻林的相互关系对森林更新和生物多样性保护有重要意义。我们采用样带观测法 ,在山黄麻林内设 10条观测带 (各带 10 0m长 ,10m宽 ,合计面积 1hm2 )观测记录鸟类 ,网捕鸟类了解摄食情况。观测到的鸟类隶属 7个营养生态位集团 ,涉及 11科、2 4属、4 5种 ;这些鸟类除 5种主要以虫为食 ,4种主要吃草籽外 ,绝大多数都摄食山黄麻果实 ,因而山黄麻果实大量成熟期鸟类较多。山黄麻林鸟类群落的季节动态与山黄麻物候关系密切 ,随山黄麻林的花果量而变动 ,鸟类集中在果熟的山黄麻树上摄食 ,在山黄麻果熟的高峰期 ,鸟类群落呈现出种群数量丰富 ,多样性高而均匀度低的分布格局。 36种食果鸟类的种群数量直接与山黄麻果实丰盛度有关 ,食虫、食草籽的鸟类与山黄麻林结构和食用山黄麻花果的昆虫数量均相关 ,山黄麻林维持了相应的鸟类群落 ,同时鸟类也控制了林内害虫 ,帮助山黄麻传授花粉、散播种子。在植被演替的过程中 ,山黄麻林与鸟类群落相互作用 ,协同发展。

关键词：西双版纳山黄麻林鸟类群落结构热带森林物候关系植被演替