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Epigenetic regulation of the inflammatory response in stroke

Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi Liang Fei yang Zixiao Li Qian Li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

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Compositional evolution of lava plains in the Syria-Thaumasia Block,Mars

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Science China(Physics,Mechanics & Astronomy) 2014年第5期57卷 994-1000页

作者： HUANG jun XIAO long Planetary Science Institute China University of Geosciences Mars Space Flight Facility Arizona State University

Tharsis is the most prominent volcanic province on Mars,yet the compositions of lava flows and how composition relates to the development of Tharsis are poorly *** of Tharsis is covered with air-fall dust,which inhibits spectroscopic determination of lava *** Syria-Thaumasia Block(STB)is a complex tectono-volcanic province closely related to the Tharsis *** lava plains of STB have different emplacement ages,which provide an opportunity to examine whether magma composition changed with the evolution of *** this study,we assessed the lava plains using Thermal Emission Spectrometer(TES)*** derived physical properties,we targeted dust-free regions from four different-aged geological units'surfaces and determined the mineralogical composition by modeling the average TES surface spectrum from each of the four *** units have similar mineralogy but the younger two units have elevated abundance of *** spatial distribution of wrinkle ridges indicates lava plains of unit HNr(older ridged plains material)and Hr(younger ridged plains material)were emplaced before the rise of Tharsis,whereas Hsl(flows of lower member)and Hsu(upper member)were emplaced after Tharsis uplift was *** show that the magma composition differed in the lava plains of STB after the uplift of *** study further characterizes early martian magma composition and evolution.

关键词： Syria-Thaumasia Block lava plains volcanism Tharsis Mars

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piR-7472影响电压调控钾离子通道促进小鼠成骨细胞分化的机制

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中国组织工程研究 2025年第14期29卷 2868-2874页

作者：隆宇斌王湘斌樊基耿杨厚志杨洋李勇邵阳市中心医院脊柱外科湖南省邵阳市422000 天津医科大学研究生院天津市300070 邵阳市中心医院肿瘤内科湖南省邵阳市422000

背景:现有研究在PIWI相互作用RNA(piRNA)抗骨质疏松方面取得了重大进展,但piRNA发挥功能的具体靶点和相关机制仍有待探索。目的:探讨piR-7472对小鼠成骨细胞(MC3T3-E1细胞)分化的影响及下游机制。方法:①12只C57/BL6J小鼠随机分为假手... 详细信息

背景:现有研究在PIWI相互作用RNA(piRNA)抗骨质疏松方面取得了重大进展,但piRNA发挥功能的具体靶点和相关机制仍有待探索。目的:探讨piR-7472对小鼠成骨细胞(MC3T3-E1细胞)分化的影响及下游机制。方法:①12只C57/BL6J小鼠随机分为假手术组和卵巢切除组,每组6只,术后8周通过Micro-CT检测小鼠的骨量,RT-qPCR检测piR-7472的表达;②将MC3T3-E1细胞分为NC mimics组、piR-7472 mimics组、NC inhibitor组与piR-7472 inhibitor组,转染后成骨诱导7 d采用RT-qPCR检测piR-7472、骨桥蛋白、胶原蛋白Ⅰ、Runt相关转录因子2、钾电压门控通道调节因子亚家族F成员1 mRNA的表达;成骨诱导7 d采用Western blot检测骨桥蛋白、Runt相关转录因子2、骨形态发生蛋白2、钾电压门控通道调节因子亚家族F成员1(KCNF1)蛋白表达;成骨诱导14 d通过碱性磷酸酶染色检测碱性磷酸酶的表达;成骨诱导21 d通过茜素红染色检测矿化结节数量;③双荧光素酶报告基因实验观察piR-7472是否能与钾电压门控通道调节因子亚家族F成员1相结合。结果与结论:①与假手术组相比,卵巢切除组小鼠骨密度、骨体积分数、骨小梁厚度、骨小梁数量明显下降,骨小梁分离度明显升高,并且骨组织中piR-7472 mRNA表达明显下调;②与NC组相比,piR-7472 mimics组骨桥蛋白、胶原蛋白Ⅰ、Runt相关转录因子2的mRNA表达明显升高,骨桥蛋白、Runt相关转录因子2、骨形态发生蛋白2的蛋白表达明显升高,矿化沉积与碱性磷酸酶表达增多;与NC inhibitor组相比,piR-7472 inhibitor组骨桥蛋白、胶原蛋白Ⅰ、Runt相关转录因子2的mRNA表达明显降低,骨桥蛋白、Runt相关转录因子2、骨形态发生蛋白2的蛋白表达明显降低,矿化沉积与碱性磷酸酶表达降低;③通过miRanda数据库预测发现piR-7472能与KCNF1相互作用;双荧光素酶报告基因实验发现piR-7472 mimcis能与钾电压门控通道调节因子亚家族F成员1结合并促进其表达。结果表明:piR-7472能够促进成骨前体细胞MC3T3-E1成骨分化,其发挥作用的机制可能是通过促进KCNF1表达实现的。

关键词：成骨细胞MC3T3-E1 PIWI相互作用RNA 成骨分化骨质疏松症电压调控的钾离子通道 KCNF1

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Opportunities and challenges of strain engineering for advanced electrocatalyst design

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Nano Research 2023年第7期16卷 8655-8669页

作者： Qing-Man Liang Xinchang Wang Xin-Wang Wan long-Xing Lin Bi-jun Geng Zhong-Qun Tian yang yang Department of Physics Pen-Tung Sah Institute of Micro-Nano Science and TechnologyState Key Laboratory of Physical Chemistry of Solid SurfacesXiamen UniversityXiamen 361005China

Electrocatalysis is becoming more and more important in energy conversion and storage due to rising energy demands,increasing carbon dioxide emissions,and impending climate *** design and synthesis of high-performance electrocatalysts are the spotlights of *** many design methodologies reported,strain engineering has gained growing attention because it can change the atomic arrangement and lattice structure of ***,strain engineering remains to be problematic in regulating the properties of *** review discusses the strain effect tactics to regulate metal and non-metal electrocatalysts,including three sections focusing on strain categorization,strain regulation mechanism,and applications in electrocatalysis,***,the current challenges and an outlook of strain engineering are discussed.

关键词： electrocatalysis electrocatalyst design strain engineering categorization and mechanism applications in electrocatalysis

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Fabrication of segregated poly(arylene sulfide sulfone)/graphene nanoplate composites reinforced by polymer fibers for electromagnetic interference shielding

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Nano Materials Science 2022年第3期4卷 285-293页

作者： Cheng-gong Chang Jia-cao yang Gang Zhang Sheng-ru long Xiao-jun Wang Jie yang College of Polymer Science and Engineering Sichuan UniversityChengdu610065China Analytical and Testing Center Sichuan UniversityChengdu610064China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu610065China Jiangsu JITRI Advanced Polymer Materials Research Institute Co. LtdChina

Poly(arylene sulfide sulfone)/graphene nanoplate(PASS/GNP) composites with segregated structure based on continuous polymer fiber skeletons were fabricated by coating a thin conductive layer on the PASS fibers and then performing compression molding. The formation of a unique segregated conductive network endowed the PASS/GNP composites with high electrical conductivity and excellent electromagnetic interference(EMI) shielding effectiveness(SE), reaching 17.8 S/m and 30.1 d B, respectively, when the content of the GNPs in the conductive layer was 20 wt%. The PASS/GNP composites also exhibited outstanding mechanical properties, which was attributed to the continuous PASS fiber skeletons that could withstand large loads and the strong interfacial interaction between the conductive layers and the PASS fibers that could provide good stress transfer. This approach is suitable for most soluble polymers.

关键词： Segregated structure EMI shielding Interfacial interaction Mechanical properties

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin yang Yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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Enhancing stationary entanglement between two optomechanical oscillators by Coulomb interaction with Kerr medium

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Chinese Physics B 2021年第12期30卷 406-412页

作者： Tian-Le yang Chen-long Zhu Sheng Liu Ye-jun Xu International Research Center of Quantum Information and Photoelectric Information School of Mechanical and Electronic EngineeringChizhou UniversityChizhou 247000China

We theoretically study the stationary entanglement of two charged nanomechanical oscillators coupling via Coulomb interaction in an optomechanical system with an additional Kerr *** show that the degree of entanglement between two nanomechanical oscillators is suppressed by Kerr interaction due to photon blockade and enhanced by Coulomb coupling *** also show other parameters for adjusting and obtaining entanglement,such as the driving power and the frequencies of the two oscillators,and the entanglement is robust against *** study proves a way for adjusting stationary entanglement between two optomechanical oscillators by Coulomb interaction and Kerr medium.

关键词： entanglement Kerr interaction Coulomb interaction optomechanics

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Structure and magnetic properties of melt-spun Sm-Fe-Nb ribbons and their nitrides

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Rare Metals 2018年第3期37卷 232-236页

作者： Wen-long Yan yang Luo Dun-Bo Yu Gui-Yong Wu Ning-Tao Quan Yuan-Fei yang Hai-jun Peng Zi-long Wang National Engineering Research Center for Rare Earth Materials General Research Institute for Nonferrous MetalsGrirem Advanced Materials Co. Ltd.

SmFe（10-x）Nbx（x = 0, 0.1, 0.2, 0.3） ribbons and their nitrides were prepared by melt-spinning, followed by annealing and subsequent nitriding. The structure and magnetic properties were investigated by means of X-ray diffraction（XRD） using the Rietveld method, vibrating sample magnetometer（VSM）, transmission electron microscope（TEM） and Mossbauer spectroscopy. XRD analysis shows that the addition of Nb can impede the precipitation of Sm2 Fe（17） and a-Fe phases and the Nb atoms occupy 2 e site in the alloys. At 300 K, the mean hyperfine fields of 2 e site are 29.58 T with Nb doping at x = 0.1 and the corresponding Curie temperature is 552 K. The optimal properties of remanence of Br = 0.9 T, intrinsic coercivity of H（cj）= 741.5 kA·m^-1, and maximum magnetic energy product of（BH）（max）= 124.2 kJ·m-（-3） are gained at x = 0.10 in the nitrides.

关键词： Melt-spinning SmFe10-xNbx powders Magnetic properties XRD Rietveld Mssbauer spectroscopy

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The Security of Using Large Language Models:A Survey With Emphasis on ChatGPT

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 1-26页

作者： Wei Zhou Xiaogang Zhu Qing-long Han Lin Li Xiao Chen Sheng Wen yang Xiang the School of Science Computing and Engineering Technologies Swinburne University of Technology IEEE the School of Computer and Mathematical Sciences the University of Adelaide Adelaide the Faculty of Science and Engineering Southern Cross University the School of Information and Physical Sciences the University of Newcastle

ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential security risks that need to be carefully evaluated and addressed. In this survey, we provide an overview of the current state of research on security of using ChatGPT, with aspects of bias, disinformation, ethics, misuse,attacks and privacy. We review and discuss the literature on these topics and highlight open research questions and future *** this survey, we aim to contribute to the academic discourse on AI security, enriching the understanding of potential risks and mitigations. We anticipate that this survey will be valuable for various stakeholders involved in AI development and usage, including AI researchers, developers, policy makers, and end-users.

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Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun Zhang Shengtao Gao Xingzhao Zhang Dacheng Ma Chuanlei Zhu jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

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