检索结果-南通市图书馆

Investigating Ion Transport through Artificial Transmembrane Channels Containing Introverted Groups

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第11期40卷 1293-1297页

作者： Ya-Wei li Yong-Hong Fu jun-li hou Department of Chemistry Fudan University220 Handan RoadShanghai 200433China

The investigation on the relationship between structure and transport activity of artificial transmembrane channels has still re-mained a challenge because of lacking strategy to precisely arrange the functional group in the channel ***,we report a general strategy to monitor ion transport through the artificial channels by using unimolecular tubular molecules containing intro-verted *** found that the ion transport rate decreased with elongation of the introverted sidechains and the channel with propyl group as the introverted sidechain exhibited the longest opening duration ***,we have revealed that,comparing to the ion transport rate,the opening duration is a more important factor for determining the transport activity of the artificial channels.

关键词： Supramolecular chemistry Self-assembly Nanostructures Artificial transmembrane channels Pillararene

Deformylated Gramicidin A and Its Derivatives Showing High Antimicrobial Activity and Low Hemolytic Toxicity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2019年第1期37卷 25-29页

作者： Wei-Wei Haoyang Min Zhang jun-li hou Department of Chemistry Fudan University220 Handan RoadShanghai 200433China

Summary of main observation and conclusion Gramicidin A is a natural peptide,which shows high antimicrobial activity to Gram-positive bacteria. However,the hemolytic toxicity prevents its therapeutic *** demonstrated that by simply removing the formyl group at the N terminus,the hemolytic toxicity of the peptide could be obviously *** deformylated gramicidin A (1)could efficiently insert into the lipid bilayer to form transmembrane *** peptide can also selectively insert into the membrane of Gram-positive bacteria but not that of erythrocytes,leading to its high antimicrobial activity and very low hemolytic *** derivation of 1 could be achieved by decoration at the terminal NH2 group,which also produced peptides showing high activity and low hemolytic *** derivation method provided us with an efficient strategy to build a library for future activity and cytotoxicity screening in vitro and in vivo.

关键词： peptide build group

Unimolecular artificial transmembrane channel with terminal dihydrogen phosphate groups showing transport selectivity for ammonium

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2020年第1期31卷 77-80页

作者： Jian-Yu Chen Qi Xiao Harekrushna Behera jun-li hou Department of Chemistry Fudan University

A new artificial transmembrane channel molecule bearing dihydrogen phosphate groups has been *** terminal dihydrogen phosphate groups enable the channel to be highly negatively charged at both ends of the channel *** artificial channel could incorporate into the lipid bilayer efficiently under low *** channel displays high NH4+/K+selectivity due to the electrostatic interaction and hydrogen bonding between NH4+and the terminal dihydrogen phosphate groups.

关键词： Artificial transmembrane channel Ammonium transport Dihydrogen phosphate Pillararene Transmembrane transport Transport selectivity

Vesicle fusion induced by zwitterionic amphiphilic channels

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第1期35卷 264-266页

作者： Qingyu Huan Tao lin Yong-Hong Fu jun-li hou Department of Chemistry Fudan UniversityShanghai 200433China

A new strategy to induce vesicle fusion has been developed by employing pillar[5]arene derivatives that were channel-like and were prepared by appending side chains onto pillar[5]arenes *** channels feature with hydrophilic negatively and positively charged groups at both ends and hydrophobic Trp residues at the outer surface,which endows the channels with *** zwitterionic amphiphilic channels could spontaneously incorporate into the bilayer membranes of lipid vesicles to induce vesicle fusion driven by the electrostatic interactions between negatively charged and positively charged groups.

关键词： Vesicle fusion Pillararene Electrostatic interaction lipid bilayers

Flexible Organic Framework-Modified Membranes for Osmotic Energy Harvesting

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2023年第14期41卷 1713-1719页

作者： Tao lin Lei Zhang Chao li Yong-Hong Fu Longcheng Gao jun-li hou Department of Chemistry Fudan University220 Handan RoadShanghai200433 China Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing100191 China

Bioinspired membranes are advantageous in capturing the osmotic ***,the conventional hybrid membranes possess low harvesting power density due to their low interfacial ionic transport efficiency and high internal ***,a new kind of hybrid membranes consisting of porous polymer and flexible organic frameworks was *** 3D porous framework enables ions to flux with high efficiency at the polymer-framework interface,resulting in high osmotic energy harvesting *** systematically screening the pore size of the frameworks,the output power density as high as 5.7 W/m^(2) was achieved under 50-fold KCl salinity gradient.

关键词： Osmotic energy harvesting Hybrid membrane Nanochannel Flexible organic frameworks Power density

Artificial Water Channel that Couples with Cell Protrusion Formation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2023年第8期5卷 1745-1752页

作者： Qi Xiao Ting Fan Yinglan Wang Zhan-Ting li jun-li hou Yunfeng Wang Department of Chemistry Fudan UniversityShanghai 200433 ENT Institute and Otorhinolaryngology Department of Eye&ENT Hospital Fudan UniversityShanghai 200031

In natural systems,water transport across the cellular plasma membranes is mainly mediated by naturally occurring channel protein aquaporins(AQPs),which lead to a series of important physiological functions including cell *** construction of artificial analogs of the natural AQPs would generate a new strategy for treating AQP-related *** this report,an artificial water channel has been developed from a unimolecular tubular molecule,which featured structural encapsulation of a single-file water wire composed of oppositely orientated dipolar water *** AQP-like structure endowed the artificial channel in living cells with AQP-like water permeability and ***,the artificial channel coupled with cell protrusion formation by mediating water transmembrane transport,leading to cell shape change and migration *** artificial channel-facilitated cell migration showed application in enhancing in vivo healing of traumatic injury.

关键词： artificial water channel aquaporin cell protrusion cell migration injury healing

Ruthenium(Ⅱ)-cored supramolecular organic framework-mediated recyclable visible light photoreduction of azides to amines and cascade formation of lactams

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2019年第7期30卷 1383-1386页

作者： Yi-Peng Wu Meng Yan Zhong-Zheng Gao jun-li hou Hui Wang Dan-Wei Zhang junliang Zhang Zhan-Ting li Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsCollaborative Innovation Centre of Chemistry for Energy Materials(iChEM) Fudan University

Ru(bpy)3]2+-cored supramolecular organic framework SMOF-1, assembled from a [Ru(bpy)3]2+-derived hexaarmed molecule and cucurbit[8]uril, has been demonstrated to heterogeneously catalyze visible light-induced reduction of phenyl, benzyl, 2-phenylethyl and 3-phenylpropyl azides in acetonitrile to produce the corresponding amines in good to high yields. For the last two kinds of azides that bear a CO2Me group at the para-position of the benzene ring, cascade reactions take place to generate the corresponding lactams in high yields. Compared with homogeneous control [Ru(bpy)3]Cl2, SMOF-1 exhibits remarkably increased photocatalysis activity as a result of synergistic effect of the [Ru(bpy)3]2+ units that form cubic cages to host the azide molecules and related intermediates. Moreover, SMOF-1 displays high recyclability and considerable photocatalysis activity after 3 to 12 runs.

关键词： Supramolecular organic framework Visible light photocatalysis Recyclability Azide reduction Amine Lactam

Artificial Water Channel Promoting Depolymerization of Actin Filaments to Trigger Cancer Cell Apoptosis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第12期42卷 1335-1340页

作者： Lei Zhang Yin-Gui Cao Ting Fan Jjiatong Zhao Yong-Hong Fu Qi Xiao Zhan-Ting li Yunfeng Wang Bo Xiao jun-li hou Department of Chemistry Fudan University220 Handan RoadShanghai 200433China State Key Laboratory of Silkworm Genome Biology Cllege of SericultureTextileand Biomass Sciences InstitutionSouthwest UniversityChongqing400715China ENT Institute and Otorhinolaryngology Department of Eye&ENT Hospital Fudan UniversityShanghai 200031 Fudan International School 325 Guoquan RoadShanghai 200433China

Actin filaments play important physiological functions,which have become potential targets of antitumor *** chemicals to intervene their polymerization-depolymerization dynamics would generate new strategies for designing antitumor *** this report,an artificial water channel appending acetazolamide moiety,a ligand that can selectively bind to carbonic anhydrase IX,has been prepared.

关键词： Artificial water channel Actin depolymerization Cell apoptosis Nanostructures Molecular recognition Supramolecular chemistry

钢筋增强超高韧性水泥基复合材料梁的剪切性能试验研究（英文）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2015年第4期16卷 251-264页

作者： li-jun hou Zhi-yong LUAN Da CHEN Shi-lang XU Key Laboratory of Coastal Disaster and Defence of Ministry of Education Hohai University College of Civil Engineering and Architecture Zhejiang University

目的:揭示不同剪跨比和配箍率的钢筋增强超高韧性水泥基复合材料(RUHTCC)梁的抗剪性能,为超高韧性水泥基复合材料(UHTCC)用于结构关键抗剪部位提供参考。方法:基于抗剪试验结果,阐明剪跨比和配箍率对RUHTCC梁抗剪性能的影响,明确UHTCC... 详细信息

目的:揭示不同剪跨比和配箍率的钢筋增强超高韧性水泥基复合材料(RUHTCC)梁的抗剪性能,为超高韧性水泥基复合材料(UHTCC)用于结构关键抗剪部位提供参考。方法:基于抗剪试验结果,阐明剪跨比和配箍率对RUHTCC梁抗剪性能的影响,明确UHTCC与箍筋之间的复合抗剪效应,揭示RUHTCC梁的抗剪机理。方法:以剪跨比和配箍率为变量参数,通过RUHTCC梁在跨中集中荷载作用下的弯曲试验,研究RUHTCC梁的剪切裂缝形态、荷载-挠度行为、破坏模式、开裂剪切强度和极限剪切强度等抗剪性能,并结合试验结果,分析RUHTCC梁的剪力传递机理。结论:***梁呈现出优良的剪切抗力以及稳态的斜裂缝扩展过程和多缝剪切开裂行为。2.配置少量的箍筋可将典型的剪切破坏转变为较为延性的弯剪破坏甚至弯曲破坏。然而,箍筋的配置并未显著提高RUHTCC梁的抗剪能力,同时耦合UHTCC与箍筋也没有表现出协同抗剪效应。3.拉杆-拱模型和桁架-拱模型可用以描述RUHTCC短梁和细长梁的抗剪机理。

关键词： UHTCC 剪跨比箍筋剪切性能抗剪机理