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Clinical features and treatment outcomes of intraocular lymphoma:a single-center experience in China

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 574-581页

作者： Yu Di Hai-Yan Xu jun-jie ye Meng-Da Li Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Ophthalmology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

AIM:To investigate the clinical manifestations,diagnostic approaches,treatments,and outcomes of intraocular ***:In this retrospective study,16 patients(28 eyes)with intraocular lymphoma were recruited in the Department of Ophthalmology,Peking Union Medical College Hospital,from 2004 to *** patients underwent comprehensive ophthalmic *** specimens of 13 patients were sent for cytopathology examination and other adjunctive diagnostic *** patients were diagnosed with intraocular lymphoma according to analysis of the histopathological results of systemic lymphoma by one ***-three eyes were treated with intravitreal administration of methotrexate,4 eyes could not receive ocular treatment due to life-threatening lymphoma,and 1 eye did not require ocular treatment because the fundus lesions regressed after systematic ***:In 28 eyes,25 eyes were diagnosed with vitreoretinal lymphoma,and 3 eyes were diagnosed with ciliary body lymphoma,all of which were non-Hodgkin diffuse large B cell *** final visual acuity improved in 15 eyes(54%),remained unchanged in 5 eyes(18%),and decreased in 8 eyes(29%).Anterior segment inflammation disappeared or reduced in 8 and 5 eyes,respectively;and 15 eyes had no anterior segment *** eyes had mild vitreous opacity,1 eye had mild vitritis,and 7 eyes had pars plana vitrectomy combinedwith silicone oil *** lesions disappeared in 9 eyes and were relieved in 5 eyes;4 eyes showed no changes,and the remaining 10 eyes’fundus were ***:The clinical manifestations of intraocular lymphoma are diverse,and the misdiagnosis rate is *** analysis of vitreous is one of the gold standards for the ***,gene rearrangement and flow cytometric immunophenotypic analysis can improve the diagnostic *** chemotherapy or radiotherapy regimens may preserve visual acuity,and a multidisciplinary te

关键词： intraocular lymphoma diagnostic vitrectomy pathological examination immunohistochemistry gene rearrangement flow cytometric immunophenotype

Fundus manifestations and HIV viral loads of AIDS patients before and after HAART

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1438-1443页

作者： Yu Di Xin-Yu Zhao jun-jie ye Bing Li Nan Ma Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM: To investigate the fundus manifestations and human immunodeficiency virus(HIV) viral loads of acquired immune deficiency syndrome(AIDS) patients before and after highly active antiretroviral therapy(HAART).METHODS: This retrospective study included 21 AIDS patients(42 eyes) who presented to the Department of Ophthalmology, Peking Union Medical College Hospital, from 2007 to 2011. Among the patients, 16 showed a good response to HAART, 3 presented drug resistance and 2 were pre-HAART. All patients underwent comprehensive ophthalmic examinations. The HIV viral loads and the CD4+ T-cell counts were also ***: The best-corrected visual acuity(BCVA) of 38 eyes(19 patients) was improved, and cytomegalovirus retinitis(CMVR) in 5 eyes(3 patients) regressed after HAART. Furthermore, 16 patients treated with effective HAART had decreased plasma HIV viral loads(<78 copies/mL)and increased CD4+ T-cell counts(343±161 cells/μL, P<0.005), but the HIV viral load in tears was still detected at 2404 copies/mL. The CD4+ T-cell count was lower in the CMVR group than in the non-CMVR group(P=0.022), but the HIV viral load in the tears was not significantly different between the two groups(P=0.439).CONCLUSION: Most patients with AIDS show a good viral response with a decreased HIV viral load and an increased CD4+ T-cell count in plasma after HAART. However, the HIV viral load remain quite high in the tear samples. Based on our results, we suggest that AIDS patients undergo long-term HAART that should not be interrupted.

关键词： acquired immune deficiency syndrome cytomegalovirus retinitis highly active antiretroviral therapy human immunodeficiency virus viral loads tears

Microbial spectrum and risk factors of endogenous endophthalmitis in a tertiary center of Northern China

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1676-1682页

作者： Lin-Yang Gan jun-jie ye Hui-Ying Zhou Han-Yi Min Lin Zheng Department of Ophthalmology Peking Union MedicalCollege HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Ophthalmology Beijing Tian Tan HospitalCapital Medical UniversityBeijing 100730China

AIM: To study the clinical features, microbial spectrum, associated factors and prognosis of endogenous endophthalmitis(EE) in a group of Chinese ***: The medical records from 32 eyes of 29 patients diagnosed with EE in Peking Union Medical College Hospital from January 2009 to October 2019 were reviewed. RESULTS: The initial visual acuity(VA) of 30 eyes in this study was worse than 20/400. Twenty-three eyes were diagnosed with fungal endophthalmitis and nine with bacterial endophthalmitis. The most common fungal and bacterial isolates were Candida and Klebsiella pneumoniae, respectively. Several rare fungi and bacteria species were also isolated from our patients, including Cryptococcus, Paecilomyces, Brucella, and Bacillus licheniformis. The leading risk factor for EE was diabetes. The most common extraocular infection locus was genitourinary tract. Vitrectomy was performed on twenty-nine eyes. Eight eyes achieved final VA of 20/400 or better. EE caused by Candida had a better ***: The visual outcome of EE is based on pathogens and prompt intervention. Early vitrectomy and antimicrobial treatment are beneficial for EE.

关键词： endogenous endophthalmitis risk factors vitrectomy

An unusual case report of Burkholderia cepacia endophthalmitis

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International Journal of Ophthalmology(English edition) 2021年第5期14卷 787-790页

作者： Huan Chen Jing-Jia Zhang Ying-Chun Xu jun-jie ye Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Clinical Laboratory Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Dear Editor,I am Huan Chen from the Department of Ophthalmology,Peking Union Medical College Hospital in Beijing,China.I am writing this letter to present an unusual case of Burkholderia cepacia *** cepacia[Burkholderia cepacian complex(Bcc)]is a group of genetically unique Gram-negative bacilli with similar phenotypes,belonging to the genus pseudomonas,which is widely found in water,soil and plants.

关键词： unusual letter College

Advances in selective conversion of carbohydrates into 5-hydroxymethylfurfural

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Green Energy & Environment 2024年第9期9卷 1384-1406页

作者： jie Liang Jianchun Jiang Tingting Cai Chao Liu jun ye Xianhai Zeng Kui Wang Institute of Chemical Industry of Forest Products Chinese Academy of Forestry National Engineering Lab.for Biomass Chemical Utilization Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University College of Energy State Key Laboratory of Physical Chemistry of Solid Surfaces Xiamen University

Converting carbohydrates into 5-hydroxymethylfurfural(5-HMF) is an attractive and promising route for value-added utilization of agricultural and forestry biomass resource. As an important platform compound, 5-HMF possesses high active furan structure with hydroxymethyl and aldehyde group for production of various bio-chemicals and materials, meanwhile, which suffer from low stability and poor yield during the industrial biorefinery process. Hence, selective production of 5-HMF with high-yield and low-cost has attracted extensive attention from scientific and industrial researchers. This review sorted and described the latest advanced research on solvent and catalyst system, as well as energy field effect for production of 5-HMF with different feedstock in detail, emphatically discussing the solvent effect and its synergistic effect with other aspects. Besides, the future prospects and challenges for production of 5-HMF from carbohydrates were also presented, which provide a profound insight into industrial 5-HMF process with economic and environmental feature.

关键词： 5-Hydroxymethylfurfural Biorefinery Solvent Selectivity Carbohydrate

Systemic diffuse large B-cell lymphoma with bilateral ciliary body involvement

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Chinese Medical Journal 2020年第1期133卷 109-110页

作者： Yu Di jun-jie ye Bi-Lei Zhang Department of Ophthalmology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

To the Editor:Primary intraocular lymphoma(PIOL)is rare with an approximate incidence of 4.8/million and about 300 new cases annually in the United States.[1]Compared with PIOL,the prevalence of secondary intraocular lymphoma(SIOL)is significantly *** to the eye from a distant site via the circulation,SIOLs occur within the uvea,with most cases confined to the *** body involvement is rare in SIOL,while secondary diffuse large B-cell lymphoma with bilateral ciliary body involvement has,to our knowledge,been reported rarely.

关键词： involvement lymphoma annually

Distributed Optimal Formation Control for Unmanned Surface Vessels by a Regularized Game-Based Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 276-278页

作者： jun Shi Maojiao ye the School of Automation Nanjing University of Science and TechnologyNanjing 210094China IEEE

Dear Editor,This letter explores optimal formation control for a network of unmanned surface vessels(USVs).By designing an individual objective function for each USV,the optimal formation problem is transformed into a noncooperative *** this game theoretic framework,the optimal formation is achieved by seeking the Nash equilibrium of the regularized game.A modular structure consisting of a distributed Nash equilibrium seeker and a regulator is proposed.

关键词： Regular seeking optimal

Phonon-blockade-based multiple-photon bundle emission in a quadratically coupled optomechanical system

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Frontiers of physics 2024年第3期19卷 207-215页

作者： ye-jun Xu Hong Xie Interdisciplinary Research Center of Quantum and Photoelectric Information Chizhou UniversityChizhou 247000China Department of Mathematics and Physics Fujian Jiangxia UniversityFuzhou 350108China

We propose a scheme to realize antibunched multiple-photon bundles based on phonon blockade in a quadratically coupled optomechanical *** adjusting the detunings to match the conditions of phonon blockade in the photon sidebands,we establish super-Rabi oscillation between zero-photon state and multiple-photon states with adjustable super-Rabi frequencies under appropriate single-phonon resonant *** the system dissipation into account,we numerically calculate the standard and generalized second-order functions of the cavity mode as well as the quantum trajectories of the state populations with Monte Carlo simulation to confirm that the emitted photons form antibunched multiple-photon ***,the desirable n-photon states are reconstructed after a direct phonon emission based on phonon blockade,and thus the single-phonon emission heralds the cascade emission of n-photon *** proposal shows that the optomechanical system can simultaneously behave as antibunched multiple-photon emitter and single-phonon *** a nonclassical source could have potential applications in quantum information science.

关键词： multiple-photon bundle emission phonon blockade optomechanical system

Network meta-analysis of combination strategies in metastatic hormone-sensitive prostate cancer

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Asian Journal of Andrology 2024年第4期26卷 402-408页

作者： Shan-Shan Wang Xiao-jie Bian jun-Long Wu Bei-He Wang Sheng Zhang Ding-Wei ye Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China.

This study compared different doublet and triplet therapies for efficacy and safety in metastatic hormone-sensitive prostate cancer(mHSPC).PubMed,EMBASE,and the Cochrane Library were comprehensively searched for eligible randomized controlled trials(RCTs)published from inception to October *** included abiraterone,apalutamide,enzalutamide,docetaxel,darolutamide,and androgen deprivation therapy(ADT),either as doublet or triplet *** outcomes examined were overall survival(OS),progression-free survival(PFS),castration-resistant prostate cancer(CRPC)-free survival,time to symptomatic skeletal event(SSE),and *** surface under the cumulative ranking curve(SUCRA)was determined to identify the preferred *** RCTs were *** combination of darolutamide,docetaxel,and ADT had the highest SUCRA of 84.3 for OS,followed by combined abiraterone,docetaxel,and ADT(SUCRA=71.6).The highest SUCRAs for PFS were observed for triplet therapies(abiraterone,docetaxel,and ADT[SUCRA=74.9],followed by enzalutamide,docetaxel,and ADT[SUCRA=74.3])and other androgen receptor axis-targeted therapy-based doublet therapies(SUCRAs:26.5–59.3).Darolutamide,docetaxel,and ADT had the highest SUCRAs,i.e.,80.8 and 84.0 regarding CRPC-free survival and time to SSE,*** Grade>3 adverse events(AEs),the SUCRAs of triplet therapies(SUCRAs:14.8–31.5)were similar to that of docetaxel and ADT(SUCRA=39.5).Three studies had a low risk of bias in all categories;the remaining studies had at least an unclear risk of bias in at least one *** therapy demonstrated potentially enhanced effectiveness than doublet therapy in mHSPC,with acceptable safety *** might be the optimal option for triplet therapy in combination with docetaxel and ADT.

关键词： androgen antagonist androgen receptor antagonist docetaxel meta-analysis prostatic neoplasm