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Correlation between mitochondrial TRAP-1 expression and lymph node metastasis in colorectal cancer

World Journal of Gastroenterology 2012年第41期18卷 5965-5971页

作者： Jing-Yan Gao Bao-Rong Song jun-jie peng Yuan-Ming Lu Department of Colorectal Cancer Fudan University ShanghaiCancer Center Shanghai Medical College Fudan UniversityShanghai 200032 China Department of Human Anatomy and Histo-Em-bryology Shanghai Medical College Fudan University Shanghai200032 China Department of Oncology Shanghai MedicalCollege Fudan University Shanghai 200032 China

AIM： To evaluate the effect of mitochondrial tumor ne- crosis factor receptor-associated protein-1 （TRAP-l） on the lymph node metastasis （LNM） in Chinese colorectal cancer （CRC） patients, and develop potential LNM- associated biomarkers for CRC using quantitative real- time polymerase chain reaction （RT-PCR） analysis. METHODS： Differences in mitochondrial TRAP-1 gene expression between primary CRC with LNM （LNM CRC） and without LNM （non-LNM CRC） were assessed in 96 Chinese colorectal carcinoma samples using quantita- tive RT-PCR analysis, Western blotting, and confirmed with immunohistochemical assay. The relationship between clinicopathological parameters and potential diaclnostic biomarkers was also ***： TRAP-1 was significantly upregulated in LNM CRC compared with non-LNM CRC, which was confirmed by RT-PCR, Western blotting and immuno- histochemical assay. The expression of TRAP-1 in two different metastatic potential human colorectal cancer cell lines, LoVo and HT29, was analyzed with Western blotting. The expression level of TRAP-1 was dramati- cally higher in LoVo than in HT29. Overexpression of TRAP-1 was significantly associated with LNM （90.2% in LNM group vs 22% in non-LNM group, P 〈 0.001）, the advanced tumor node metastasis stage （89.1% in LNM group vs 26.9% in non-LNM group, P 〈 0.001）, the increased 5-year recurrence rate （82.7% in LNM group vs 22.6% in non-LNM group, P 〈 0.001） and the decreased 5-year overall survival rate （48.4% in LNM vs 83.2% in non-LNM group, P 〈 0.001）. Univariate and multivariate analyses indicated that TRAP-1 expression was an independent prognostic factor for recurrence and survival of CRC patients （Hazard ratio of 2.445 in recurrence, P = 0.017; 2.867 in survival, P = 0.028）. CONCLUSION： Mitochondria TRAP-1 affects the lymph node metastasis in CRC, and may be a potential bio- marker for LNM and a prognostic factor in CRC. Over- expression of TRAP-1 is a predictive factor for the poor outcome of colorectal cancer

关键词： Colorectal cancer Lymph node metastasis Prognosis Quantitative real-time polymerase chain reaction analysis Hsp90 family Mitochondria tumor necrosis factor receptor-associated protein-1

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Predicting prognosis of rectal cancer patients with total mesorectal excision using molecular markers

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World Journal of Gastroenterology 2007年第21期13卷 3009-3015页

作者： jun-jie peng San-jun Cai Hong-Feng Lu Guo-Xiang Cai peng Lian Zu-Qing Guan Ming-He Wang Ye Xu Department of Oncology Shanghai Medical Coliege Fudan University Shanghai 2000321 China Department of Pathology Cancer Hospital Fudan University Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China

AIM:To explore the prognostic variables in rectal cancer patients undergoing curative total mesorectal excision and the effect of postoperative chemotherapy in advanced rectal cancer. METHODS:A total of 259 consecutive rectal cancer patients treated with curative total mesorectal excision between 1999 and 2004 were collected. p53,p21,PCNA,and CD44v6 were examined using immunohistochemistry (IHC). The correlation between clinicopathological or molecular variables and clinical outcomes,including local recurrence,metastasis,disease-free survival and overall survival,was analyzed. RESULTS:The median follow-up was 44 mo. Five-year survival rates and 5-year disease free survival rates were 75.43% and 70.32%,respectively. Multi-analysis revealed TNM staging,preoperative CEA,and CD44v6 level were independent risk factors predicting overall survival or disease free survival. The hazard ratio of peroperative CEA was 2.65 (95% CI 1.4-5) and 3.10 (95% CI 1.37-6.54) for disease free survival and overall survival,respectively. The hazard ratio of CD44v6 was 1.93 (95% CI 1.04-3.61) and 2.21 (95% CI 1.01-4.88) for disease free survival and overall survival,respectively. TNM staging was the only risk factor predicting local recurrence. Postoperative chemotherapy without radiotherapy did not improve patients' outcome. CONCLUSION:TNM staging,preoperative CEA and CD44v6 were independent prognostic factors for rectal cancer patients with total mesorectal excision. Postoperative chemotherapy may be only used together with radiotherapy for rectal cancer patients.

关键词： Rectal cancer Total mesorectal excision Immunohistochemistry Disease free survival p53 p21 PCNA CD44v6 CEA Prognosis

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Lymphangiogenic and angiogenic microvessel density in human primary sporadic colorectal carcinoma

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World Journal of Gastroenterology 2008年第1期14卷 101-107页

作者： Ge Yan, Xiao-Yan Zhou, San-jun Cai, Gui-Hong Zhang, jun-jie peng, Xiang Du, Department of Pathology, Cancer Hospital of Fudan University Department of Oncology, Shanghai Medical College, Fudan University Colorectal Cancer Center, Fudan University, 270 Dong’an Road, Shanghai 200032, China Department of Pathology Cancer Hospital of Fudan University Shanghai 200032 China.

AIM： To investigate the distribution pattern of lymphatic vessels and microvessels in sporadic colorectal carcinoma （SCRC） and their relationship to metastasis and prognosis. METHODS： The lymphatic vessel density （LVD） and microvessel density （MVD） in tumor tissue obtained from 132 patients with primary SCRC, including 74 with metastases and 58 without metastases, were evaluated by immunohistochemistry using antibodies directed against D2-40 and yon Willebrand factor （vWF）. RESULTS：（1） The lymphatic vessels and microvessels at central portions of SCRC often had a reticular architecture with numerous tiny and ill-defined lumina, while those at tumor borders had large and open lumina. The LVD and MVD were both obviously higher in colorectal cancer patients with metastases than in those without （P 〈 0.001）. （2） For each one lymphatic vessel increased, there was a 1.45-fold increase in the risk of metastasis in SCRC. The specificity and sensitivity of LVD in predicting metastasis or non-metastasis in SCRC were 71.62% and 56.90%, respectively, and the corresponding LVD was 5. For each one microvessel increased, there was a 1.11-fold increase in the risk of metastasis in SCRC. The specificity and sensitivity of MVD were 66.22% and 51.72%, respectively. （3） Double labeling immunohistochemistry showed D2-40 immunoreactivity to be specific for lymphatic vessels. （4） Univariate analysis indicated that high LVD, high MVD, as well as co-accounting of high LVD and high MVD were associated with patient＇s poor disease-free survival （Puni 〈 0.05）; multivariate analysis indicated that co-accounting of LVD and MVD was an independent prognostic factor of colorectal cancer, CONCLUSION： D2-40 is a new specific antibody for lymphatic endothelial cells. Lymphogenesis and angiogenesis are commonly seen in SCRC, especially at tumor borders. The detection of LVD and MVD at tumor borders may be useful in predicting metastasis and prognosis in patients with SCRC, and, in particular, coaccount

关键词： Lymphangiogenesis Angiogenesis Lymphaticvessel density Microvessel density Sporadic colorectalcarcinoma Metastasis

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Prevalence and genotypes of Blastocystis and Cryptosporidium in Chinese Tan sheep in Ningxia Hui Autonomous Region,northwestern China

Prevalence and genotypes of Blastocystis and Cryptosporidium...

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2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Di Li jun-jie peng Yun-peng Bai Xu-Dong Guo Dong-Hui Zhou College of Animal Sciences (College of Bee Science) Fujian Agriculture and Forestry University Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences

Blastocystis and Cryptosporidium are both common zoonotic parasites which are considered to be opportunistic pathogens of humans and *** protozoa widely exists in the intestines of humans and many other animals,and will cause gastrointestinal diseases such as vomiting,abdominal pain and diarrhea after ***,which is found in many vertebrates,usually causes watery diarrhea in its host,but can lead to death in those with compromised or weakened immune systems if left *** present,there has been no investigation on the infection and genotyping of these two intestinal protozoa in Tan Sheep which is a breed endemic to Ningxia Region of *** study was conducted to investigate the prevalence and genotyping of two intestinal protozoa in Tan sheep in Ningxia.A total of 1014 fecal specimens of Tan sheep from six farms in the Ningxia Hui Autonomous Region were examined by PCR and nested PCR amplification based on the small subunit rRNA(SSU rRNA)gene fragment for Blastocystis and Cryptosporidium,*** overall prevalence of Blastocystis was 25.5%(259/1014).Six different genotypes were identified including ST1,ST4,ST5,ST10,ST12 and ST14;among which ST10 had the largest number and may have *** overall prevalence rate of Cryptosporidium was 1.2%(12/1014),two Cryptosporidium species(*** and ***) were identified through sequence *** this study,the prevalence of Blastocystis and Cryptosporidium in Tan sheep was reported for the first *** distribution of Blastocystis and Cryptosporidium genotypes in Tan sheep was *** results not only provided a scientific basis for the prevention and control of these intestinal protozoites in Tan sheep,but also provided data support and reference for public health.

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Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng jie Shen Jinxing Lu Chuqiang Huang Zhuoyuan Chen Feng peng Yunpeng Liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

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Global trend of review articles focused on cardiopulmonary bypass:Perspectives from bibliometrics

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World Journal of Methodology 2025年第2期15卷 166-173页

作者： Lei Deng Rui Zhou Xian-jie Zhang Yan-Hua peng Department of Gastroenterology Deyang People’s HospitalDeyang 618000Sichuan ProvinceChina Department of Anesthesiology and Perioperative Medicine Shanghai Fourth People's HospitalSchool of MedicineTongji UniversityShanghai 200434China Department of Anesthesiology Deyang People’s HospitalDeyang 618000Sichuan ProvinceChina

BACKGROUND Cardiopulmonary bypass(CPB)is a life-support technology widely used in *** articles reflect research advances in a certain topic or field within a certain period of *** To perform a bibliometric analysis of the review articles that focused on CPB for cardiovascular *** This study was based on a bibliometric *** were acquired from the Web of Science and basic bibliometric parameters were analyzed and visualized using VOSviewer and *** We identified 141 review articles on ***,the number of publications increased,and most of them were published in the 2010s(n=57,40.4%)and the 2020s(n=45,31.9%).There were 113(80.1%)narrative review articles,21(14.9%)meta-analysis studies and 7(5.0%)systematic review *** United States(n=25,17.7%)and China(n=21,14.9%)were the leading countries in terms of publication *** articles were published in 98 different *** Journal of Cardiothoracic and Vascular Anesthesia(n=14,10.0%)and Perfusion-United Kingdom(n=11,7.8%)were preferred by the *** high-frequency keywords included inflammatory response,children,acute kidney injury,meta-analysis and off-pump,except for CPB and cardiac *** response had the closest relationship with CPB during cardiac *** complications of CPB,including inflammatory response,kidney injury and ischemia,caught lots of *** The rapid increase of review papers shows that the research on CPB in cardiac surgery is increasingly being emphasized by scholars and clinical staff ***-analysis has been widely conducted to analyze clinical controversies and further guide clinical *** to improving the outcomes of patients undergoing cardiac surgery with CPB are the hot spots in this field.

关键词： Cardiopulmonary bypass Review article Bibliometric analysis Cardiac surgery Hot spots

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Symptom Clusters and Their Effect on the Depression of Chinese Cancer Survivors

Symptom Clusters and Their Effect on the Depression of Chine...

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第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Hou Liang Wang jie-jun peng peng Zheng Yin Department of Medical Oncology, Second Military Medical University Affiliated Changzheng Hospital, Shanghai 200070, China Department of Cancer Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China

＜正＞Objective: A cross-sectional study was conducted to determine the effect of the symptom cluster of pain, fatigue, anorexia and insomnia on the development of depression of Chinese cancer survivors based community. Methods: We investigated 200 Chinese cancer survivors living in pengpu Community of Shanghai based on hanghai Cancer Patient Database. Following questionnaires were adopted to investigate: Zung Self-Rating Depression Scale （ZSDS） and Brief Symptom Inventory. Results: The ZSDS score and the development of depression were associated with symptom severity of insomnia and fatigue. There was no significant association between depression severity and symptom cluster. A multiple Linear regression model explained 16.5% of the variance in ZSDS score. Anorexia severity explained 9.7% of the change, insomnia severity explained 4.9% of the change, and pain severity explained 1.9% of the change. A logistic regression model suggested that there was evidence for increase risks for having depression for each additional severity of insomnia （4.76 times） and pain （1389 times）. Cancer survivors with anorexia （0.269 times） and insomnia （37. 722 times） were more likely to development depression than the others. Conclusion: The symptom cluster of pain, fatigue, anorexia and insomnia associated with cancer survivors depression, could be named depression-related symptom cluster. Knowing this symptom cluster may help healthcare professionals understand plausible mechanisms for the aggregation of symptoms and the effect on the depression. It is necessary to be aware of the presence of symptom cluster and their possible adverse effect on cancer survivors.

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Relationship of Relatives’ Depression to Chinese Cancer Survivors’ symptoms,Quality of Life and Depression

Relationship of Relatives’ Depression to Chinese Cancer Sur...

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第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

＜正＞Objective: A cross-sectional study was conducted to determine the relationship of the relatives’ depression with cancer survivors’ depression, quality of life （QOL） and symptom in a Shanghai community. Methods: We investigated 200 cancer survivors and their relatives living in pengpu Community based on "Shanghai Cancer Patient Database". Questionnaires were adopted to investigate: Zung Self-Rating Depression Scale （ZSDS）, Chinese version of Functional Assessment of Cancer Therapy-General （FACT-G） scale and Brief Self-Rating Symptom Inventory. Results: The incidence of relatives’ depression was 16%. Correlation analysis showed that the relatives’ ZSDS score and the development of depression are associated with cancer survivors’ZSDS score, depression and FACT-G score. The relatives’depression grades were associated with cancer survivors’ disease stage, depression, nausea and FACT-G score. A multiple Linear regression model explained 31.5% of the variance in relatives’ ZSDS score. Cancer survivors’ ZSDS score explained 28.3% of the change, FACT-G score explained 1.5% of the change, and score of PHYSICAL WELL-BEING explained 1.7% of the change. A logistic regression model suggested that there was evidence for a increased risk for relatives having depression for each additional severity of nausea （40.7%）, and when cancer survivors’ ZSDS /FACT-G score increased one scale the risk for relatives’ depression increased 9.4%/-11.3%. Conclus-ion: Relatives’ depression was associated with cancer survivors’ depression, quality of life （QOL） and symptom in the Shanghai community. It is necessary to enhance the intervention to the depression of relatives.

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分层填料错流超重力装置传质性能

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过程工程学报 2017年第1期17卷 47-51页

作者：高亚洁袁志国刘有智刘慧军杜杰梁鹏飞中北大学超重力化工过程山西省重点实验室山西省超重力化工工程技术研究中心山西太原030051

采用气膜控制体系—NaOH溶液吸收气体中SO_2,研究了超重力因子β、空床气速u、喷淋密度q等操作条件对装置的气相体积传质系数kyae的影响和强化效果,验证了分层填料错流超重力装置对气相传质的强化效果,优化了结构,以提高传质效率.结果表... 详细信息

采用气膜控制体系—NaOH溶液吸收气体中SO_2,研究了超重力因子β、空床气速u、喷淋密度q等操作条件对装置的气相体积传质系数kyae的影响和强化效果,验证了分层填料错流超重力装置对气相传质的强化效果,优化了结构,以提高传质效率.结果表明,kyae随β,u和q增加而增加.在β=55,u=1.53 m/s,q=3 m3/(m2·h)时,kyae可达28 s-1以上,是喷淋塔的10~75倍,单层错流旋转床的1.4~2.2倍,比分裂填料旋转床操作条件温和、设备结构简单、能耗更低.本超重力装置能有效强化气膜控制传质过程.

关键词：错流超重力装置分层填料传质气相传质系数二氧化硫

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基于七段SVPWM的直线电机改进滑模控制研究

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计算机仿真 2017年第6期34卷 227-231页

作者：罗志伟谷爱昱洪俊杰彭峰广东工业大学自动化学院广东广州510006

针对传统矢量控制不能满足负载扰动时变的高精度永磁直线同步电机伺服系统与变指数趋近律滑模控制固有不足,采用基于七段插补空间矢量脉宽调制的改进积分滑模控制策略,解决微分滑模噪声放大与变指数滑模增益为零的问题,以及抑制滑模抖振... 详细信息

针对传统矢量控制不能满足负载扰动时变的高精度永磁直线同步电机伺服系统与变指数趋近律滑模控制固有不足,采用基于七段插补空间矢量脉宽调制的改进积分滑模控制策略,解决微分滑模噪声放大与变指数滑模增益为零的问题,以及抑制滑模抖振,提高控制系统精度。分析并搭建直线电机伺服控制系统的数学模型,对永磁直线电机的运行特性进行仿真研究,结果验证所提控制策略的正确性及有效性,为进行下一步实验平台的搭建与测试提供理论依据。

关键词：永磁直线同步电机七段插补改进积分滑模控制滑模抖振

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