检索结果-南通市图书馆

Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease

引用

Neural Regeneration Research 2018年第4期13卷 709-716页

作者： Ya-Ru Wen jun-hua yang Xiao Wang Zhi-Bin Yao Department of Anatomy and Neurobiology Zhongshan School of MedicineSun Yat-sen University Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen University

Impaired amyloid-β clearance from the brain is a core pathological event in Alzheimer＇s *** therapeutic effect of current pharmacotherapies is unsatisfactory,and some treatments cause severe side *** meningeal lymphatic vessels might be a new route for amyloid-β *** study investigated whether promoting dural lymphangiogenesis facilitated the clearance of amyloid-β from the ***,human lymphatic endothelial cells were treated with 100 ng/m L recombinant human vascular endothelial growth factor-C（rh VEGF-C） *** microscopy verified that rh VEGF-C,a specific ligand for vascular endothelial growth factor receptor-3（VEGFR-3）,significantly promoted tube formation of human lymphatic endothelial cells in *** an in vivo study,200 μg/m L rh VEGF-C was injected into the cisterna magna of APP/PS1 transgenic mice,once every 2 days,four times in *** staining demonstrated high levels of dural lymphangiogenesis in Alzheimer＇s disease *** week after rh VEGF-C administration,enzyme-linked immunosorbent assay results showed that levels of soluble amyloid-β were decreased in cerebrospinal fluid and *** Morris water maze test demonstrated that spatial cognition was *** results indicate that the upregulation of dural lymphangiogenesis facilities amyloid-β clearance from the brain of APP/PS1 mice,suggesting the potential of the VEGF-C/VEGFR-3 signaling pathway as a therapeutic target for Alzheimer＇s disease.

关键词： nerve regeneration dura mater lymphangiogenesis amyloid-β Alzheimer's disease recombinant haman vascular endothelial growth factor-C lymphatic endothelial cells lymphatic clearance neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mitigation of black carbon emissions could immediately reduce 6.3% of glacier melting in the Qilian Mountains

引用

Advances in Climate Change Research 2024年第4期15卷 725-736页

作者： Ji-Zu CHEN Wen-Tao DU Shi-Chang KANG Xiang QIN Wei-jun SUN Li-Hui LUO yang LI jun-hua yang You-Yan JIANG Qilian Shan Station of Glaciology and Eco-environment Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Geography and Environment Shandong Normal UniversityJinan 250014China Zhangye Meteorological Bureau Zhangye 734000China Lanzhou Regional Climate Center Lanzhou 730020China Institute of International Rivers and Eco-security Yunnan UniversityKunming 650500China Gansu Provincial Industry Technology Center of Inteligent Equipment and Big Data for Disaster Prevention Northwest Institute of Eco-Environment and ResourcesChinese Academy of ScienceLanzhou 730000China

Global warming in tandem with surface albedo reduction caused by black carbon(BC)deposition on glaciers accelerated glacier melting;however,their respective contributions remain *** in the Qilian Mountains are crucial for the development of oases in the Hexi Corridor;however,their area has decreased by more than 20%over the past ***,this study developed a dynamic deposition model for light-absorbing particles(LAPs),coupled with a surface energy and mass balance *** comprehensively assessed the effects of BC and warming on the melting of a typical glacier in the Qilian Mountains based on the coupled *** on the glacier surface caused 13.1%of annual glacier-wide melting,of which directly deposited atmospheric BC reduced the surface albedo by 0.02 and accounted for 9.1%of glacier *** air temperature during 2000-2010 has increased by 1.5℃ relative to that during the 1950s,accounting for 51.9%of current glacier ***,BC emission have increased by 4.6 times compared to those of the early Industrial Revolution recorded in an ice core,accounting conservatively for 6.3%of current glacier *** BC emissions has a limited influence on current glacier melting;however,in the long-term,mitigation should exert a noteworthy impact on glacier melting through the self-purification of glaciers.

关键词： Glacier Melting Black carbon Simulation Qilian Mountains

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pancreatic neuroendocrine tumor detected by technetium-99m methoxy-2-isobutylisonitrile single photon emission computed tomography/computed tomography:A case report

引用

World Journal of Clinical Cases 2023年第12期11卷 2825-2831页

作者： Chang-Jiang Liu hua-jun yang Yan-Chun Peng De-Yu huang Department of Nuclear Medicine Xingyi People’s HospitalXingyi 562400Guizhou ProvinceChina Department of Pulmonary and Critical Care Medicine Xingyi People’s HospitalXingyi 562400Guizhou ProvinceChina Department of Hepatobiliary Pancreatic and Splenic SurgeryXingyi People’s HospitalXingyi 562400Guizhou ProvinceChina Department of Pathology Xingyi People’s HospitalXingyi 562400Guizhou ProvinceChina

BACKGROUND Pancreatic neuroendocrine tumors(NETs)account for about 1%–2%of pancreatic tumors and about 8%of all *** tomography(CT),magnetic resonance imaging,and endoscopic ultrasound are common imaging modalities for the diagnosis of pancreatic ***,somatostatin receptor imaging is of great value for diagnosing pancreatic ***,we report the efficacy of technetium-99m methoxy-2-isobutylisonitrile(99mTc-MIBI)single photon emission CT(SPECT)/CT for detecting pancreatic *** SUMMARY A 57-year-old woman presented to our hospital with a 1-d history of persistent upper abdominal distending *** distending pain in the upper abdomen was aggravated after eating,with nausea and *** blood test results showed a high neutrophil percentage,low leukomonocyte and monocyte percentages,and low leukomonocyte and eosinophil ***,liver and kidney function,and tumor markers alpha-fetoprotein,carcinoembryonic antigen,and cancer antigen(CA)125,CA72-4,CA19-9,and CA153 were *** CT showed a mass,with multiple calcifications between the pancreas and the *** boundary between the mass and the pancreas and spleen was poorly ***-enhanced CT revealed that the upper abdominal mass was unevenly and gradually enhanced.99mTc-MIBI SPECT/CT revealed that a focal radioactive concentration,with mild radioactive concentration extending into the upper abdominal mass,was present at the pancreatic body and *** 99mTc-MIBI SPECT/CT manifestations were consistent with the final pathological diagnosis of pancreatic *** 99mTc-MIBI SPECT/CT appears to be a valuable tool for detecting pancreatic NETs.

关键词： Neuroendocrine tumors Pancreas Tc-99m-Methoxy-2-isobutylisonitrile Single photon emission computed tomography X-ray computed tomography Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of regional bulbar redness using an imagebased objective method

引用

International Journal of Ophthalmology(English edition) 2014年第1期7卷 71-76页

作者： Wen-Juan Zhao Fang Duan Zhong-Ting Li hua-jun yang Qiang huang Kai-Li Wu Zhongshan Ophthalmic Center State Key Laboratory of OphthalmologySun Yat-sen University

AIM: To develop an image-based objective method to precisely evaluate regional ocular bulbar injection. · METHODS: Six healthy adult volunteers were photographed in four orientations(superior,inferior,nasal and temporal sides) with and without stimulating eye drops. Six line segments(covering 30°) were drawn 4mm away from the limbus on each image using ImageJ software. The graph peaks,which were derived from the areas under the line segments and corresponded to the cross-sectional grey-level of the vessels,were analyzed to obtain peak area,peak height/width(PH/PW),and peak numbers. Different-sized areas were selected to calculate the pixels based on the edge-detection algorithm. Also,conjunctival and superficial scleral vessels were analyzed separately. ·RESULTS: This method had a smaller coefficient of variation,especially for PH/PW,in all four orientations. Hyperaemia parameters changed the least after challenging in the superior region. Moreover,95% of the PH/PW ratios were greater than 0.87 in conjunctival vessels and less than 1.00 in superficial scleral vessels. PH/PW significantly increased in conjunctival vessels and changed less in superficial scleral vessels. ·CONCLUSION: A new method of objectively assessing bulbar injection based on ocular surface images was developed. This method can be used to quantify ocular regional injection and to distinguish the superficial scleral and conjunctival vessels.

关键词： ocular surface hyperaemia image analysis ImageJ

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis

引用

Oncology research 2025年第1期33卷 185-198页

作者： Zhouyang Cheng Yuchen hua yang Cao jun Qin Department of General Surgery Affiliated Hospital of Nantong University Nantong 226001 China. Department of Surgery Affiliated Hospital of Nantong University Medical School of Nantong University Nantong 226001 China. Department of Operation Affiliated Hospital of Nantong University Nantong 226001 China.

Objective:Gastric cancer (GC) is a globally common cancer characterized by high incidence and mortality worldwide. Advances in the molecular understanding of GC provide promising targets for GC diagnosis and therapy. Long non-coding RNAs (lncRNAs) and their downstream regulators are regarded to be implicated in the progression of multiple types of malignancies. Studies have shown that the lncRNA small nucleolar RNA host gene 4 (SNHG4) serves as a tumor promoter in various malignancies, while its function in GC has yet to be characterized. Therefore, our study aimed to explore the role and underlying mechanism of SNHG4 in GC.Methods:We used qRT-PCR to analyze SNHG4 expression in GC tissues and cells. Kaplan-Meier analysis was used to assess the correlation between SNHG4 expression and the survival rate of GC patients. Cellular function experiments such as CCK-8, BrdU, colony formation, flow cytometry analysis, and transwell were performed to explore the effects of SNHG4 on GC cell proliferation, apoptosis, cell cycle, migration, and invasion. We also established xenograft mouse models to explore the effect of SNHG4 on GC tumor growth. Mechanically, dual luciferase reporter assay was used to verify the interaction between SNHG4 and miR-409-3p and between miR-409-3p and cAMP responsive element binding protein 1 (CREB1).Results:The results indicated that SNHG4 was overexpressed in GC tissues and cell lines, and was linked with poor survival rate of GC patients. SNHG4 promoted GC cell proliferation, migration, and invasion while inhibiting cell apoptosis and cell cycle arrest . The experiment indicated that SNHG4 facilitated GC tumor growth. Furthermore, SNHG4 was demonstrated to bind to miR-409-3p. Moreover, CREB1 was directly targeted by miR-409-3p. Rescue assays demonstrated that miR-409-3p deficiency reversed the suppressive impact of SNHG4 knockdown on GC cell malignancy. Additionally, miR-409-3p was also revealed to inhibit GC cell proliferation, migration, and

关键词： Gastric cancer MicroRNA-409-3p (miR-409-3p) Small nucleolar RNA host gene 4 (SNHG4) cAMP responsive element binding protein 1 (CREB1)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applications of Self-Collimated Properties of Photonic Crystal in 3D Imaging Lidar System

引用

Journal of Electronic Science and Technology 2011年第1期9卷 78-80页

作者： Ying Zhu hua-jun yang the School of Physical Electronics University of Electronic Science and Technology of China Chengdu 610054 China

Photonic crystals （PCs） are increasingly attracting attention due to their ability to control light *** this paper,the dispersion properties of a two-dimensional （2D） square lattice PCs with plane- wave expansion （PWE） method are presented,the equi-frequency contours and the band structure are analyzed,and the alignment transmission characteristics are simulated by using the finite difference time domain （FDTD） *** addition,for the wavelength of 1.55 m,a kind of application structure with the lattice constant a=405 nm and the radius of air holes R=135 nm which can restrict the transmission of beams in photonic crystal without defect is proposed and *** structure which can collimate the output beam and compress its divergence angle is easy to *** has wide application prospects in optical communication and three-dimensional （3D） imaging lidar systems.

关键词： Lidar photonic crystals plane-wave expansion self-collimation.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oral administration of geranylgeranylacetone plus local somatothermal stimulation: A simple, effective, safe and operable preconditioning combination for conferring tolerance against ischemia-reperfusion injury in rat livers

引用

World Journal of Gastroenterology 2005年第36期11卷 5725-5731页

作者： Ning Fan Guang-Shun yang jun-hua Lu Ning yang Hai-Bin Zhang Department of Laparoscopy Affiliated Eastern Hospital of Hepatobiliary Surgery Second Military Medical University Shanghai 200438 China

AIM： To explore a simple, effective, safe and operable pretreatment for conferring tolerance against ischemia- reperfusion （I-R） injury in rat livers. METHODS： Forty-five rats were divided into five groups （each group n = 9）. Group C： control group; group G： geranylgeranylacetone （GGA） was administered without heat stress; group S： local heat stress alone; group WG： GGA plus whole-body heat stress; group SG： GGA administration plus local heat stress. After completion of the I-R procedure, the ischemic-reperfused liver lobes in five groups were resected and tested for heat shock protein （HSP70） by RT-PCR, Western blotting analysis and immunohistochemical staining. The blood samples were collected for ALT and AST measurement at the end of occlusion of blood supply, 30 min after reperfusion, 24, 48, 72 h after surgery from the inferior vena cava. Survival was monitored for 1 wk. RESULTS： The production of HSP70 after I-R injury increased, the liver enzyme levels after reperfusion decreased rapidly, and the survival rates increased in groups C-SG. CONCLUSION： The combination of GGA plus local somatothermal stimulation is a simple, effective, safe and operable pretreatment to induce HSP70 in patients with liver tumor and cirrhosis before hepatectomy and in donors before harvesting graft for liver transplantation.2005 The WJG Press and Elsevier Inc. All rights reserved.

关键词： Ischemia-reperfusion injury Heat shock protein Geranylgeranylacetone, Local somatothermal stimulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optical Antenna System Design for 3D Imaging Lidar

引用

Journal of Electronic Science and Technology 2011年第1期9卷 67-70页

作者： hua-jun yang Xiao-Ping huang the School of Physical Electronics University of Electronic Science and Technology of China Chengdu 610054 China

A new aspheric surface pre-collimation lenses system for the optical antenna of three-dimensional （3D） imaging of lidar has been optimally designed and simulated by optical design software *** kinds of aspheric surfaces spherical lenses including the sections of spherical,elliptical,hyperbola,and parabola have been *** optical system,including the elliptical cylinder lenses collimation and the optical antenna,can be realized less than 5 rad collimation angle for dot source semiconductor laser beam.

关键词： Aspheric surface pre-collimation lenses system optical antenna three-dimensional imaging lidar.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

单通道混合信号的深度联合分离译码算法

引用

系统工程与电子技术 2018年第6期40卷 1378-1384页

作者：付君彭华杨勇解放军信息工程大学信息系统工程学院河南郑州450002

针对采用低密度奇偶校验(low density parity check,LDPC)码编码的单通道同频混合信号,提出一种深度联合分离译码算法。采用了Gibbs分离过程中的逐符号分离步骤和译码过程中的逐符号译码步骤之间交替更改变量节点似然软信息的方式,在初... 详细信息

针对采用低密度奇偶校验(low density parity check,LDPC)码编码的单通道同频混合信号,提出一种深度联合分离译码算法。采用了Gibbs分离过程中的逐符号分离步骤和译码过程中的逐符号译码步骤之间交替更改变量节点似然软信息的方式,在初期译码步骤输出的软信息模值较小,便于分离步骤对译码步骤的结果及时进行纠正,降低整体误比特率,软信息达到译码门限后开始发挥译码作用并最终和分离步骤达到一致收敛。仿真结果表明,本文提出的深度联合算法能够有效避免传统迭代分离译码算法由于分离过程的误比特率超出软输入软输出(soft input soft output,SISO)译码器纠错能力范围导致算法无法收敛的现象,降低联合分离译码算法的门限并提升整体性能,对于8PSK调制的混合信号在误比特率为10-3时有1dB的性能改善。

关键词：深度联合单通道盲分离和积译码 Gibbs采样软信息

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Minilaparotomy to rectal cancer has higher overall survival rate and earlier short-term recovery

引用

World Journal of Gastroenterology 2012年第37期18卷 5289-5294页

作者： Xiao-Dong Wang Ming-jun huang Chuan-hua yang Ka Li Li Li Gastrointestinal Surgery Center West China Hospital in Sichuan University Chengdu 610041 Sichuan Province China

AIM： To report our experience using mini-laparotomy for the resection of rectal cancer using the total meso- rectal excision （TME） technique, METHODS： Consecutive patients with rectal cancer who underwent anal-colorectal surgery at the authors＇ hospital between March 2001 and june 2009 were included, In total, 1415 patients were included in the study, The cases were divided into two surgical proce- dure groups （traditional open laparotomy or mini-lap- arotomy）, The mini-laparotomy group was defined as having an incision length ≤ 12 cm. Every patient un- derwent the TME technique with a standard operation performed by the same clinical team. The multimodal preoperative evaluation system and postoperative fast track were used. To assess the short-term outcomes, data on the postoperative complications and recovery functions of these cases were collected and analysed. The study included a plan for patient follow-up, to ob- tain the long-term outcomes related to 5-year survival and local recurrence. RESULTS： The mini-laparotomy group had 410 pati- ents, and 1015 cases underwent traditional laparoto- my. There were no differences in baseline characteris- tics between the two surgical procedure groups. The overall 5-year survival rate was not different between the rnini-laparotorny and traditional laparotorny groups （80.6% vs 79.4%, P = 0.333）, nor was the 5-year local recurrence （1.4% vs 1.5%, P = 0.544）. However, 1-year mortality was decreased in the rnini-laparotorny group compared with the traditional laparotorny group （0% vs 4.2%, P 〈 0.0001）. Overall 1-year survival rates were 100% for Stage Ⅰ, 98.4% for Stage Ⅱ, 97.1% for Stage Ⅲ, and 86.6% for Stage Ⅳ. Local recurrence did not differ between the surgical groups at 1 or 5 years. Local recurrence at 1 year was 0.5% （2 cases） for mini-laparotorny and 0.5% （5 cases） for traditional laparotorny （P = 0.670）. Local recurrence at 5 years was 1.5% （6 cases） for mini-laparotorny and 1.4% （14 cases） for traditional laparotorn

关键词： Rectal neoplasm Mini-laparotomy Survival Total mesorectal excision

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：