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Assessment of Prognostic Factors of Racial Disparities in Testicular Germ Cell Tumor Survival in the United States(1992–2015)

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Biomedical and Environmental Sciences 2021年第2期34卷 152-162页

作者： WU Jing JI Yi Bing TANG Bi Wei BROWN Matthew WANG Bao hua DU Chen Lei DU Jian Shu WANG Xue Mei CAI Li jun WU Guo Yi ZHOU Yan National Center for Chronic and Non-communicable Diseases Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China Inner Mongolia Medical University Hohhot 010110Inner MongoliaChina National Cancer Insitiute National Institutes of HealthBethesda 20892MarylandUnited States Shanghai Topgen Biopharm Technology Co. LtdShanghai 201203China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghai 200433China Shanghai-MOST Key Laboratory of Health and Disease Genomics Chinese National Human Genome Center at ShanghaiShanghai 200000China

Objective Testicular germ cell tumors(TGCT) are the most common cancer among men aged 15 to 39 years. Previous studies have considered factors related to TGCT survival rate and race/ethnicity, but histological type of the diagnosed cancer has not yet been thoroughly assessed.Methods The data came from 42,854 eligible patients from 1992 to 2015 in the Surveillance Epidemiology and End Results 18. Frequencies and column percent by seminoma and nonseminoma subtypes were determined for each covariates. We used Cox proportional hazard regression to assess the impact of multiple factors on post-diagnostic mortality of TGCT.Results Black males were diagnosed at a later stage, more commonly with local or distant metastases.The incidence of TGCT in black non-seminoma tumors increased most significantly. The difference in survival rates between different ethnic and histological subtypes, overall survival(OS) in patients with non-seminoma was significantly worse than in patients with seminoma. The most important quantitative predictor of death was the stage at the time of diagnosis, and older diagnostic age is also important factor affecting mortality.Conclusion Histological type of testicular germ cell tumor is an important factor in determining the prognosis of testicular cancer in males of different ethnic groups.

关键词： Testicular cancer Germ cell tumor Race Survival rate Survival analysis

融合YOLO v5n与通道剪枝算法的轻量化奶牛发情行为识别

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农业工程学报 2022年第23期38卷 130-140页

作者：王政许兴时华志新尚钰莹段援朝宋怀波西北农林科技大学机械与电子工程学院杨凌712100 农业农村部农业物联网重点实验室杨凌712100 陕西省农业信息感知与智能服务重点实验室杨凌712100

及时、准确地监测奶牛发情行为是现代化奶牛养殖的必然要求。针对人工监测奶牛发情不及时、效率低等问题,该研究提出了一种融合YOLO v5n与通道剪枝算法的轻量化奶牛发情行为识别方法。在保证模型检测精度的基础上,基于通道剪枝算法,对包... 详细信息

及时、准确地监测奶牛发情行为是现代化奶牛养殖的必然要求。针对人工监测奶牛发情不及时、效率低等问题,该研究提出了一种融合YOLO v5n与通道剪枝算法的轻量化奶牛发情行为识别方法。在保证模型检测精度的基础上,基于通道剪枝算法,对包括CSPDarknet53主干特征提取网络等在内的模块进行了修剪,以期压缩模型结构与参数量并提高检测速度。为了验证算法的有效性,在2239幅奶牛爬跨行为数据集上进行测试,并与Faster R-CNN、SSD、YOLOX-Nano和YOLOv5-Nano模型进行了对比。试验结果表明,剪枝后模型均值平均精度(mean Average Precision,mAP)为97.70%,参数量(Params)为0.72 M,浮点计算量(Floating Point operations,FLOPs)为0.68 G,检测速度为50.26帧/s,与原始模型YOLOv5-Nano相比,剪枝后模型mAP不变的情况下,参数量和计算量分别减少了59.32%和49.63%,检测速度提高了33.71%,表明该剪枝操作可有效提升模型性能。与Faster R-CNN、SSD、YOLOX-Nano模型相比,该研究模型的mAP在与之相近的基础上,参数量分别减少了135.97、22.89和0.18 M,FLOPs分别减少了153.69、86.73和0.14 G,检测速度分别提高了36.04、13.22和23.02帧/s。此外,对模型在不同光照、不同遮挡、多尺度目标等复杂环境以及新环境下的检测结果表明,夜间环境下mAP为99.50%,轻度、中度、重度3种遮挡情况下平均mAP为93.53%,中等尺寸目标和小目标情况下平均mAP为98.77%,泛化性试验中奶牛爬跨行为检出率为84.62%,误检率为7.69%。综上,该模型具有轻量化、高精度、实时性、鲁棒性强、泛化性高等优点,可为复杂养殖环境、全天候条件下奶牛发情行为的准确、实时监测提供借鉴。

关键词：图像识别行为模型发情检测通道剪枝 YOLO v5n 奶牛爬跨行为复杂环境

生成式人工智能时代高职院校的教学变革:挑战、框架与路径

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大学教育科学 2023年第6期 112-120页

作者：吴庆华郭丽君长沙学院湖南农业大学教育学院长沙410128

生成式人工智能正以迅雷不及掩耳之势快速登入职业教育教学领域,通过智能评估、教学辅助“侵入”传统教学实训,推动职业院校教学主体、内容与组织的调整和变革。但是,这种由外部技术强制驱动教学变革的进程会忽视职业技能教学的互动性... 详细信息

生成式人工智能正以迅雷不及掩耳之势快速登入职业教育教学领域,通过智能评估、教学辅助“侵入”传统教学实训,推动职业院校教学主体、内容与组织的调整和变革。但是,这种由外部技术强制驱动教学变革的进程会忽视职业技能教学的互动性、职业性、开放性与实践性特征,导致职业教育过程中的主体权利边界模糊、教学评价理念滞后以及伦理隐私风险。面对从计算智能、感知智能再到认知智能的进阶发展,高职院校应该构建起集变革目标、算力平台、协作系统与评价保障为一体的教学变革要素框架,并从AI赋权与赋能两条路径提升教学体系的自我治理能力,拓宽治理边界,整体性建构智能时代高职院校教学生态系统,推动行业企业、政府、社会与职业院校的教学共同体建设。

关键词：生成式人工智能高职院校教学变革 ChatGPT 教学生态系统

New tirucallane-type triterpenoids from the resin of Boswellia carterii and their NO inhibitory activities

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Chinese Journal of Natural Medicines 2021年第9期19卷 686-692页

作者： LIU Fang-Shen ZHANG Ting-Ting XU jun JING Qin-Xue GONG Chi DONG Bang-Jian LI Da-Hong LIU Xiao-Qiu LI Zhan-Lin YUAN Zhong hua Hui-Ming Key Laboratory of Structure-Based Drug Design&Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China State Key Laboratory of Medicinal Chemical Biology College of Pharmacyand Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300071China

Six new tirucallane-type triterpenoids(1-6),along with ten known triterpenoids,were isolated from methylene chloride extract of the resin of Boswellia carterii Birdw.By the application of the comprehensive spectroscopic data,the structures of the compounds were clarified.The experimental electronic circular dichroism spectra were compared with those calculated,which allowed to assign the absolute configurations.Compounds 5 and 6 possesed a 2,3-seco tirucallane-type triterpenoid skeleton,which were first reported.Their inhibitory activity against NO formation in LPS-activated BV-2 cells were evaluated.Compound 9 showed appreciable inhibitory effect,with an IC_(50)value of 7.58±0.87μmol·L^(-1).

关键词： Boswellia carterii Birdw seco-Tirucallane triterpenoids NO inhibition

抗米勒管激素、血管内皮生长因子水平对子宫内膜异位症患者腹腔镜手术后妊娠结局的影响

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中国现代医学杂志 2022年第9期32卷 19-24页

作者：邵雨萍吴方周春张俊段丽君武汉市江夏区第一人民医院(华中科技大学协和江南医院)妇科湖北武汉430200

目的探讨抗米勒管激素(AMH)、血管内皮生长因子(VEGF)水平对子宫内膜异位症患者腹腔镜手术后妊娠结局的预测价值。方法选取2017年4月—2019年7月在武汉市江夏区第一人民医院(华中科技大学协和江南医院)行腹腔镜子宫内膜异位症治疗的137... 详细信息

目的探讨抗米勒管激素(AMH)、血管内皮生长因子(VEGF)水平对子宫内膜异位症患者腹腔镜手术后妊娠结局的预测价值。方法选取2017年4月—2019年7月在武汉市江夏区第一人民医院(华中科技大学协和江南医院)行腹腔镜子宫内膜异位症治疗的137例患者为研究对象。术后随访2年。根据患者术后2年的自然妊娠结局分组,将自然妊娠患者记为自然妊娠成功组,否则记为自然妊娠失败组。比较两组患者的美国生育协会修正分期法(r-AFS)分期,囊肿直径,血清抗精子蛋白17抗体(sp17Ab)、抗顶体蛋白酶抗体(AcrAb)、糖类抗原125、AMH、VEGF水平,以及术后促性腺激素释放激素激动剂治疗情况。采用多因素逐步Logistic回归分析模型分析影响子宫内膜异位症患者腹腔镜手术后妊娠结局的因素。绘制ROC曲线,分析子宫内膜异位症患者腹腔镜手术前AMH、VEGF水平对术后妊娠结局的预测价值。结果137例患者失访14例。123例患者中自然妊娠成功患者55例,剩余68例自然妊娠失败。多因素逐步Logistic回归分析结果显示,AMH水平[O^R=4.059(95%CI:1.670,9.865)]、VEGF水平[O^R=3.688(95%CI:1.517,8.962)]、sp17Ab水平[O^R=3.662(95%CI:1.507,8.900)]是子宫内膜异位症患者腹腔镜手术后妊娠结局的影响因素(P<0.05)。ROC曲线显示,AMH、VEGF及两者联合预测子宫内膜异位症患者腹腔镜手术后妊娠的AUC分别为0.750(95%CI:0.652,0.849)、0.763(95%CI:0.665,0.861)、0.889(95%CI:0.826,0.952),敏感性分别为72.73%(95%CI:0.588,0.835)、78.18%(95%CI:0.646,0.878)、72.73%(95%CI:0.588,0.835),特异性分别为70.59%(95%CI:0.581,0.807)、80.88%(95%CI:0.692,0.890)、89.71%(95%CI:0.794,0.954)。结论子宫内膜异位症患者术前血清AMH、VEGF水平对术后妊娠结局有预测价值,两者联合预测子宫内膜异位症患者腹腔镜手术后妊娠结局效能良好。

关键词：子宫内膜异位症腹腔镜手术抗米勒管激素血管内皮生长因子妊娠结局

Dynamic Characteristic Analysis of HIV Mother to Child Transmission in China

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Biomedical and Environmental Sciences 2010年第5期23卷 402-408页

作者： jun-JIE WANG KATHLEEN HEATHER REILLY hua HAN ZHI-HANG PENG NING WANG National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China Tulane University Health Sciences Center School of Public Health and Tropical MedicineNew OrleansLAUSA National ASIC Design Engineering Center Institute of AutomationChinese Academy of SciencesBeijing 100190China Department of Epidemiology and Biostatistics Nanjing Medical UniversityNanjing 210029China

Objective to explore dynamic characteristics of the HIV mother to child transmission （MTCT） epidemic in China.Methods A deterministic dynamic transmission model was used to determine the effect of key parameters on the likely long-term trends of the HIV MTCT epidemic in China.Matlab 7.0 was used to develop the model.Results The number of the susceptibles （S）,the transmission rate （β）,and the screening proportion （α） of HIV positive pregnant women have the greatest impact on the HIV MTCT epidemic in China.The growth of the MTCT epidemic in China could not be controlled only by decreasing the MTCT transmission rate.The prevalence of HIV positive women should be reduced and more pregnant women should be tested for HIV.Conclusion Prevention of MTCT （PMTCT） should focus not only on the reduction of HIV transmission rates and incidences of HIV among women but also on the increase of HIV testing for pregnant women.The most cost-effective PMTCT means for China should be investigated in future studies.

关键词： mother to child transmission dynamic model HIV China

Treatment of polycystic liver disease with resection-fenestration and a new classification

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World Journal of Gastroenterology 2008年第32期14卷 5066-5072页

作者： Tuan-Jie Li Hai-Bin Zhang jun-hua Lu jun Zhao Ning Yang Guang-Shun Yang Eastern Hepatobiliary Hospital Second Military Medical University Shanghai 200438 China

AIM: To evaluate outcomes in patients with autosomal dominant polycyst liver disease (APLD) treated by combined hepatic resection and fenestration. A new classification was recommended to presume postoperative complications and long outcome of patients. METHODS: Twenty-one patients with APLD were treated by a combined hepatic resection and fenestration technique. All patients were reviewed retrospectively, and clinical symptoms, performance status and morbidity were recorded. A new classifi cation of APLD is recommended here. RESULTS: All patients were discharged when free of symptoms. The mean follow-up time was 55.7 mo and three patients had a recurrence of symptoms at 81, 68 and 43 mo after operation, respectively. The overall morbidity rate was 76.2%. Two patients with Type B-Ⅱ and Type B-Ⅰ developed biliary leakage. Four patients had severe ascites, including three with Type B-Ⅲ and one with Type B-Ⅱ, Nine patients had pleural effusion, including one with Type A-Ⅰ; one with Type B-Ⅰ; fi ve with Type B-Ⅱ; one with Type A-Ⅲ and one with Type B-Ⅲ. Three patients with Type B had recurrence of symptoms, while none with Type A had severe complications. CONCLUSION: Combined hepatic resection and fenestration is an acceptable procedure for treatment of APLD. According to our classifi cation, postoperative complications and long outcome can be predicted before surgery.

关键词：肝病肾病开窗术治疗方法

基于超图卷积神经网络的多行为感知服务推荐方法

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浙江大学学报:工学版 2023年第10期57卷 1977-1986页

作者：陆佳炜李端倪王策策徐俊肖刚浙江工业大学计算机科学与技术学院浙江杭州310023 中国计量大学机电工程学院浙江杭州310018 中国计量大学信息工程学院浙江杭州310018

针对现有服务推荐方法中高阶服务特征提取不够充分的问题,提出基于超图卷积神经网络的多行为感知服务推荐方法(MBSRHGNN).该方法根据服务交互类型和服务组合信息构建多重超图,基于谱分解理论和多重超图的功能结构特性以设计双通道超图... 详细信息

针对现有服务推荐方法中高阶服务特征提取不够充分的问题,提出基于超图卷积神经网络的多行为感知服务推荐方法(MBSRHGNN).该方法根据服务交互类型和服务组合信息构建多重超图,基于谱分解理论和多重超图的功能结构特性以设计双通道超图卷积网络.利用切比雪夫多项式近似超图卷积核来降低计算复杂度;在超图卷积过程中,结合多行为推荐方法和自注意力机制度量多行为交互之间的重要性差异,提出HG-DiffPool超图池化方法来降低特征维度;通过融合服务嵌入向量和超图信号,学习不同服务的推荐概率分布;爬取真实服务数据,构造不同稀疏度的数据集进行实验.实验结果表明,所提的MBSRHGNN服务推荐方法能够适应数据高度稀疏的推荐场景,并且在推荐精确度和相关性上的表现优于现有基线方法.

关键词：服务推荐图神经网络超图学习多行为推荐注意力机制

川芎嗪通过PINK1/Parkin通路调控自噬对新生大鼠缺氧缺血性脑病的影响

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中国当代儿科杂志 2023年第7期25卷 751-758页

作者：杨丹王刚杨丽君段壬泽陈显兵湖北民族大学附属民大医院病理科湖北恩施445000 湖北民族大学医学部湖北恩施445000

目的研究川芎嗪注射液对缺氧缺血性脑病新生大鼠自噬的影响及其分子机制。方法将7日龄Sprague-Dawley新生大鼠随机分为假手术组(n=8)、模型组(n=12)、川芎嗪组(n=12)。模型组和川芎嗪组行左侧颈总动脉结扎后再缺氧处理,制备新生大鼠缺... 详细信息

目的研究川芎嗪注射液对缺氧缺血性脑病新生大鼠自噬的影响及其分子机制。方法将7日龄Sprague-Dawley新生大鼠随机分为假手术组(n=8)、模型组(n=12)、川芎嗪组(n=12)。模型组和川芎嗪组行左侧颈总动脉结扎后再缺氧处理,制备新生大鼠缺氧缺血性脑病模型。假手术组只暴露血管不做其他处理。川芎嗪组在缺氧缺血后每日腹腔注射川芎嗪注射液20 mg/kg,假手术组与模型组每日腹腔注射等体积的0.9%氯化钠溶液。在治疗7 d后取材,采用苏木精-伊红染色及尼氏染色观察脑组织神经元病理变化情况。采用免疫组织化学染色观察各组新生大鼠大脑海马及皮质区域PTEN诱导假定激酶1(PTEN-induced putative kinase 1,PINK1)、Parkin表达。采用TUNEL染色检测神经元凋亡情况。通过免疫印迹法检测PINK1、Parkin、自噬特异性基因Beclin1、微管相关蛋白1轻链3(microtubule-associated protein 1 light chain 3,LC3)和泛素结合蛋白(Protein 62,P62)的表达。结果与假手术组相比,模型组新生大鼠神经元数量减少,细胞间隙增大,排列疏松,胞质空泡化,尼氏小体减少;PINK1、Parkin阳性表达增加,神经元凋亡率升高(均P<0.05);PINK1、Parkin、Beclin1、LC3蛋白表达增加,P62蛋白表达减少(均P<0.05)。与模型组相比,川芎嗪组新生大鼠神经元数量增多,细胞排列整齐,尼氏小体增加;PINK1、Parkin阳性表达减少,神经元凋亡率降低(均P<0.05);PINK1、Parkin、Beclin1、LC3蛋白表达减少,P62蛋白表达增加(均P<0.05)。结论川芎嗪在一定程度上缓解了新生大鼠缺氧缺血性脑损伤,抑制神经元凋亡,其机制可能与抑制PINK1/Parkin介导的自噬相关。

关键词：川芎嗪 PINK1/Parkin 缺氧缺血性脑病自噬新生大鼠