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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng jun-hong wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Improving slurryability, rheology,and stability of slurry fuel from blending petroleum coke with lignite

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Petroleum Science 2015年第1期12卷 157-169页

作者： jun-hong wu Jian-Zhong Liu Yu-Jie Yu Rui-Kun Wang jun-Hu Zhou Ke-Fa Cen State Key Laboratory of Clean Energy Utilization Zhejiang University

Petroleum coke and lignite are two important fossil fuels that have not been widely used in China. Petroleum coke-lignite slurry （PCLS）, a mixture of petro- leum coke, lignite, water, and additives, efficiently utilizes the two materials. In this study, we investigate the effects of the proportion （7） of petroleum coke on slurryability, rheo- logical behavior, stability, and increasing temperature characteristics of PCLSs. The results show that the fixed- viscosity solid concentration （COo） increases with increasing 7. The ~Oo of lignite-water slurry （LWS, ~ = 0） is 46.7 %, compared to 71.3 % for the petroleum coke-water slurry （PCWS, c~ --- i00 %）, while that of PCLS is in between the two values. The rheological behavior of PCLS perfectly fits the power-law model. The PCWS acts as a dilatant fluid. As decreases, the slurry behaves first as an approximate Newtonian fluid, and then turns into a pseudo-plastic fluid that exhibits shear-thinning behavior. With increasing ct, the rigid sedimentation and water separation ratio （WSR） increase, indicating a decrease in the stability of PCLS. When α is 60-70 %, the result is a high-quality slurry fuel for industrial applications, which has high slurryability （ω0 = 57-60 %）, good stability （WSR 〈 2 %）, and superior pseudo-plastic behavior （n = 0.9）.

关键词： Petroleum coke Lignite Coal-water slurry Rheological characteristics Slurry stability

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Effects of antiseizure medications on alternative psychosis and strategies for their application

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World Journal of Psychiatry 2022年第4期12卷 580-587页

作者： Yin Yan jun-hong wu Xiao-Yan Peng Xue-Feng Wang Department of Neurology the First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqing 400016China

Forced normalization(FN)is a unique phenomenon that is often seen in the treatment of *** is characterized by abnormal mental behavior and disordered emotions in epilepsy patients despite a significantly improved electroencephalogram and successful seizure control;the occurrence of FN seriously affects patients’quality of *** causes of FN include antiseizure medications(ASMs),epilepsy surgery and vagus nerve stimulation,with ASMs being the most common ***,with the timely reduction or discontinuation of ASMs and the use of antipsychotic drugs,the overall prognosis is ***,we perform an extensive review of the literature pertaining to FN,including its epidemiology,possible mechanisms,clinical features,treatment and prognosis.

关键词： Forced normalization Antiseizure medications Neurotransmitter Antipsychotic drugs Electroshock

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Pharmacokinetic studies of multi-bioactive components in rat plasma after oral administration of Xintiantai Ⅰ extract and effects of guide drug borneol on pharmacokinetics

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Chinese Herbal Medicines 2020年第1期12卷 79-87页

作者： Shao-yu Liang Yong-chang Zeng Qian-qian Jiang jun-hong wu Zheng-zhi wu The First Affiliated Hospital of Shenzhen University Shenzhen 518035China Shenzhen Institute of Geriatrics Shenzhen 518020China

Objective:To investigate the in vivo pharmacokinetic characteristics of 17 bioactive components including ginsenoside Rg1,Rb1,Rd,berberine,epiberberine,jatrorrhizine,palmatine,columbamine,coptisine,evodiamine,dehydroevodiamine,rutaecarpine,limonin,hyperin,curcumin,demethoxycurcumin and bisdemethoxycurcumin in rat plasma after oral administration of Xintiantai I extract powder(XI)and Xintiantai I without guide drug borneol extract powder(XI without borneol),and study the compatibility effects of guide drug borneol on the ***:A UHPLC-MS/MS method was established and fully validated for the comparative pharmacokinetics of 17 bioactive *** pharmacokinetics parameters of 17 bioactive components after oral administration of XI and XI without borneol were calculated by the software of DAS 3.0 and ***:The specificity,linearity,lower limit of quantification(LLOQ),precision,accuracy,extraction recovery rates,matrix effects,and stability of the UHPLC-MS/MS assay were good within the acceptance criteria from FDA *** drug borneol can significantly increase AUC of G-Rd,palmatine,hyperin,curcumin,demethoxycurcumin,bisdemethoxycurcumin and Cmaxof 16 bioactive components except for dehydroevodiamine(P<0.05),decrease Tmaxof G-Rd,berberine,columbamin,coptisine,limonin and MRT of 17 bioactive components in XI group(P<0.05).Conclusion:Guide drug borneol enhanced the absorption of G-Rd,palmatine,hyperin,curcumin,demethoxycurcumin and bisdemethoxycurcumin.

关键词： borneol comparative pharmacokinetics multi-bioactive components UHPLC-MS/M XintiantaiⅠ

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Aceclidine and pilocarpine interact differently with muscarinic receptor in isolated rabbit iris muscle

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中国药理通讯 2005年第4期22卷 20-22页

作者： Liang Zhu Yong - Yao Cui Ju - Mei Feng Xing - jun wu hong -Zhuan Chen Institute of Drug Research Shanghai Second Medical University 280 South Chongqing Road Shanghai 200025

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Retrospective analysis of pathological types and imaging features in pancreatic cancer: A comprehensive study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 121-129页

作者： Yang-Gang Luo Mei wu hong-Guang Chen Pathology Department Xuanhan County People’s HospitalDazhou 636150Sichuan ProvinceChina

BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late *** the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment *** To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging *** We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our *** types were determined by histopathological examination of the surgical spe-cimens or biopsy *** imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic *** analyses were performed to identify significant associations between pathological types and specific imaging *** There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare *** imaging features were identified in each pathological *** ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural *** tumors often appear as hypervascular lesions in contrast-enhanced *** analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging *** findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.

关键词： Pancreatic cancer Pathological types Imaging features Retrospective analysis Diagnostic accuracy

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Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： Xian-Rong wu Xiao-hong He Yong-Fang Xie School of Life Health Information Science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps Gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

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湍流模型对梯形翼高升力构型的影响

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空气动力学学报 2013年第1期31卷 52-55页

作者：王运涛洪俊武孟德虹中国空气动力研究与发展中心空气动力学国家重点实验室四川绵阳621000

采用"亚跨超CFD软件平台"(TRIP)数值模拟了梯形翼全展长高升力构型,主要目的是考察湍流模型对高升力构型气动特性的影响。相应的风洞试验是1998年在NASA Ames 12英尺增压风洞中完成的。本文采用一方程和两方程湍流模型,数值模拟了全展... 详细信息

采用"亚跨超CFD软件平台"(TRIP)数值模拟了梯形翼全展长高升力构型,主要目的是考察湍流模型对高升力构型气动特性的影响。相应的风洞试验是1998年在NASA Ames 12英尺增压风洞中完成的。本文采用一方程和两方程湍流模型,数值模拟了全展长高升力构型的气动特性并给出了典型站位的压力分布。研究表明,与修正后的试验数据相比较,在定常可收敛的迎角范围内,两种湍流模型得到的气动力系数和压力分布与试验结果吻合较好,SA一方程湍流模型的计算结果更接近试验值;迎角大于19.19°后,襟翼后缘的较大范围分离是导致采用SST模型不能得到收敛的气动特性的主要原因。

关键词： TRIP 梯形翼湍流模型气动特性压力分布

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