检索结果-南通市图书馆

Characteristics and origin of low-organicmatter carbonate source rocks in the Middle-Upper Ordovician, Tarim Basin, northwestern China

引用

Journal of Palaeogeography 2024年第3期13卷 594-619页

作者： jun-Qing Chen Fu-Jie Jiang Xiong-Qi Pang Hai-jun Yang Kan-Yuan Shi bo Pang Hong Pang Jian-Fa Chen Zhuo-Heng Chen Xin-Gang Zhang Song Wu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China Basic Research Center for Energy Interdisciplinary College of ScienceChina University of Petroleum(Beijing)Beijing 102249China Beijing Key Laboratory of Optical Detection Technology for Oil and Gas China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Research Institute of Petroleum Exploration and Development PetroChina Tarim Oilfield CompanyKorla 841000Xinjiang Uygur Autonomous RegionChina Geological Survey of Canada Natural Resources CanadaCalgary T2L 2A7Canada

The continually-discovered large volumes of marine hydrocarbons indicate a huge exploration potential within the carbonate rocks of Ordovician in the Tarim Basin,northwestern *** Middle-Upper Ordovician(O2+3)carbonate source rocks are at a highly mature *** rocks presently contain a low amount of total organic carbon(TOC_(pd)≤0.5%)(TOC_(pd) means the present-day TOC).A mass balance approach is used to identify the source rocks that have expelled *** characteristics and origin of hydrocarbon expulsion from low-TOC_(pd) source rocks are studied,which are significant for oil exploration in the *** results showed that a low-TOC_(pd) O2+3 source rock having expelled hydrocarbons was type I and had a very narrow oil *** a high rock maturity and a high original TOC(TOCo)value exceeding 1%,nearly 80%of the generated hydrocarbons were *** content of gammacerane and C28 steranes in the oil and source rock extracts were relatively lean,with a V-shaped distribution of regular steranes,suggesting a possible genetic relation between the low-TOC_(pd) source rocks and the marine oil in the Tabei *** planktonic algae or acritarchs were the main hydrocarbon parent materials,distributed in the subsiding platform-slope *** matter was preserved under reducing conditions,and source rocks were formed with a favorable kerogen type and a moderate hydrocarbon generation *** study illustrates the hydrocarbon expulsion of low TOC_(pd) source rocks in northern Tarim Basin,which is greatly significant for analyzing the genesis of marine crude oil in Tarim Basin,and evaluating the distribution of marine source *** research method is theoretically significant for oil and gas exploration in the same type of highlymature carbonate paleobasins.

关键词： Carbonate source rock Mass balance approach Present-day TOC Genesis mechanism Tarim Basin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Elevated peripheral levels of receptor-interacting protein kinase 1(RIPK1)and IL-8 as biomarkers of human amyotrophic lateral sclerosis

引用

Signal Transduction and Targeted Therapy 2024年第1期9卷 271-278页

作者： jun Wei Min Li Zhi Ye Xinqian Hu Xiaoyan He Jia Wang Gaofeng Chen Chengyu zou Daichao Xu Hongbing Zhang junying Yuan Yunhong Zha Institute of Neural Regeneration and Repair and Department of Neurology The First College of Clinical Medical ScienceYichang Central HospitalCollege of Basic Medical ScienceChina Three Gorges UniversityHubei Province Clinical Medical Research Center for Rare Diseases of Nervous SystemYichang 443000China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai Key Laboratory of Aging StudiesShanghai 201210China State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemDepartment of PhysiologyInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Amyotrophic lateral sclerosis(ALS)is a devastating fatal neurodegenerative disease with no ***-interacting protein kinase 1(RIPK1)has been proposed to mediate pathogenesis of *** has been identified as an old drug that can also inhibit RIPK1 *** conducted a drug-repurposing biomarker study of primidone as a RIPK1 inhibitor using SOD1G93A mice and ALS ***1G93A mice treated with primidone showed significant delay of symptomatic onset and improved motor ***-hundred-sixty-two ALS participants dosed daily with primidone(62.5 mg)completed 24-week follow-up.A significant reduction was showed in serum levels of RIPK1 and IL-8,which were significantly higher in ALS patients than that of healthy controls(P<0.0001).Serum RIPK1 levels were correlated positively with the severity of bulbar symptoms(P<0.05).Our study suggests that serum levels of RIPK1 and IL-8 in peripheral can be used as clinical biomarkers for the activation of RIPK1 in central nervous system in human ALS *** primidone may provide a promising therapeutic strategy for *** effect of primidone for the treatment of other inflammatory diseases may also be considered,since the activation of RIPK1 has been implicated in mediating a variety of inflammatory diseases including COVID-19-associated cytokine release syndrome(CRS).(ChiCTR2200060149).

关键词： RIPK1 diseases Serum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Variations in the Prevalence of Anemia of Varying Severity Among Urban Non-Pregnant Women—China,2021

引用

China CDC weekly 2024年第10期6卷 175-180页

作者： Xiaoxi Liu bo Wang Sailimai Man Heling Bao Yuanyuan Huang Canqing Yu jun Lyu Linhong Wang Liming Li Hui Liu Institute of Medical Information Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Peking University Health Science Center Meinian Public Health Institute BeijingChina Meinian Institute of Health BeijingChina Peking University Center for Public Health and Epidemic Preparedness&Response BeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijingChina National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Anemia is a significant public health issue affecting women *** studies in China predominantly concentrated on anemia in pregnant or reproductiveage women,leaving a gap i... 详细信息

关键词： Anemia anemia China.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Retinal vascular morphological characteristics in diabetic retinopathy: an artificial intelligence study using a transfer learning system to analyze ultra-wide field images

引用

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1001-1006页

作者： Xin-Yi Deng Hui Liu Zheng-Xi Zhang Han-Xiao Li jun Wang Yi-Qi Chen Jian-bo Mao Ming-Zhai Sun Li-jun Shen Center for Rehabilitation Medicine Department of OphthalmologyZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina Department of Precision Machinery and Instrumentation University of Science and Technology of ChinaHefei 230026Anhui ProvinceChina Department of Retina Eye Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To investigate the morphological characteristics of retinal vessels in patients with different severity of diabetic retinopathy(DR)and in patients with or without diabetic macular edema(DME).METHODS:The 239 eyes of DR patients and 100 eyes of healthy individuals were recruited for the *** severity of DR patients was graded as mild,moderate and severe non-proliferative diabetic retinopathy(NPDR)according to the international clinical diabetic retinopathy(ICDR)disease severity scale classification,and retinal vascular morphology was quantitatively analyzed in ultra-wide field images using RU-net and transfer learning *** presence of DME was determined by optical coherence tomography(OCT),and differences in vascular morphological characteristics were compared between patients with and without ***:Retinal vessel segmentation using RU-net and transfer learning system had an accuracy of 99%and a Dice metric of *** with the healthy group,the DR group had smaller vessel angles(33.68±3.01 vs 37.78±1.60),smaller fractal dimension(Df)values(1.33±0.05 vs 1.41±0.03),less vessel density(1.12±0.44 vs 2.09±0.36)and fewer vascular branches(206.1±88.8 vs 396.5±91.3),all P<*** the severity of DR increased,Df values decreased,P=*** significant difference between the DME and non-DME groups were observed in vascular morphological ***:In this study,an artificial intelligence retinal vessel segmentation system is used with 99%accuracy,thus providing with relatively satisfactory performance in the evaluation of quantitative vascular *** patients have a tendency of vascular occlusion and *** presence of DME does not compromise the integral retinal vascular pattern.

关键词： diabetic retinopathy vascular morphology deep learning ultra-wide field imaging diabetic macular edema

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of exercise training on glucose metabolism indicators and inflammatory markers in obese children and adolescents:A metaanalysis

引用

World Journal of Diabetes 2024年第6期15卷 1353-1366页

作者： Le-Yang Li Song-Mei Li bo-Xian Pang jun-Ping Wei Qiu-Hong Wang Department of Endocrinology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Graduate School Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Obesity in children and adolescents is a serious problem,and the efficacy of exercise therapy for these patients is *** To assess the efficacy of exercise training on overweight and obese children based on glucose metabolism indicators and inflammatory *** The PubMed,Web of Science,and Embase databases were searched for randomized controlled trials related to exercise training and obese children until October *** meta-analysis was conducted using RevMan 5.3 software to evaluate the efficacy of exercise therapy on glucose metabolism indicators and inflammatory markers in obese *** In total,1010 patients from 28 studies were *** therapy reduced the levels of fasting blood glucose(FBG)[standardized mean difference(SMD):-0.78;95%confidence interval(CI):-1.24 to-0.32,P=0.0008],fasting insulin(FINS)(SMD:-1.55;95%CI:-2.12 to-0.98,Pbolism by reducing levels of FBG,FINS,HOMA-IR,as well as improves inflammatory status by reducing levels of IL-6,CRP,leptin,and increasing levels of adiponectin in overweight and obese *** was no statistically significant effect between exercise training and levels of TNF-α.Additional long-term trials should be conducted to explore this therapeutic perspective and confirm these results.

关键词： Exercise training Obesity Children and adolescents Glucose metabolism Inflammatory markers Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Production and characterization of monoclonal antibodies against grass carp CD4-1 and CD4-2

引用

Aquaculture and Fisheries 2024年第2期9卷 154-163页

作者： Bangjie Wang Yuting Qin Zhaosheng Sun Xiaozhen Zhu Zhao Jia Kangyong Chen Danjie Liu junya Wang jun zou Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationShanghai Ocean UniversityShanghai201306China International Research Center for Marine Biosciences at Shanghai Ocean University Ministry of Science and TechnologyShanghai201306China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai201306China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266071China

CD4 T helper cells are an important group of cells in the immune system of vertebrates and express CD4 receptor on the cell *** mammals,the CD4 receptor is encoded by a single copy gene,whilst in fish,two copies of cd4 genes,namely cd4-1 and cd4-2,are *** this study,the ectodomains of grass carp(Ctenopharyngodon idella,Ci)CD4-1 and CD4-2 were expressed in the *** cells and used to generate monoclonal antibodies in *** blotting,confocal microscopy and flow cytometry were performed to characterize the monoclonal *** has been shown that the CiCD4-1 and CiCD4-2 monoclonal antibodies had good specificity to react with the recombinant ectodomains of CiCD4-1 and CiCD4-2 expressed in the CHO-S cells and the native CD4 molecules of grass *** CiCD4-1 monoclonal antibody did not recognize CiCD4-2 and verse *** addition,the CD4-1 and CD4-2 monoclonal antibodies specifically recognized the CD4-1 and CD4-2 receptors expressed in the HEK293 cells and native molecules of fish ***,the percentages of lymphocytes in immune tissues of healthy fish were analyzed by flow *** was found that 17.6%of lymphocytes were CD4-1^(+)cells and 22.5%were CD4-2^(+)in the head *** the spleen,13.1%of lymphocytes were CD4-1^(+)and 18.6%were CD4-2^(+)while 7.3%of blood lymphocytes were CD4-1^(+)cells and 8.8%were CD4-2^(+)*** availability of the CD4-1 and CD4-2 monoclonal antibodies provides antibody-based tools for further elucidation of the functions of CD4 T cells in grass carp.

关键词： Grass carp CD4 Monoclonal antibodies Flow cytometry Confocal microscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

RNA-seq analysis of a zebrafish caudal fin cell line in response to infection with spring viraemia of carp virus

引用

Aquaculture and Fisheries 2024年第2期9卷 181-192页

作者： Wenji Huang Ning Ji Xin Zhao Jiahong Guo Jianhua Feng Kangyong Chen Yaxin Wu junya Wang jun zou Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationShanghai Ocean UniversityShanghai201306China International Research Center for Marine Biosciences Ministry of Science and TechnologyShanghai Ocean UniversityShanghai201306China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai201306China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266071China

A cell line,termed ZFIN,was established from the caudal fin of zebrafish and was shown to be susceptible to spring viremia of carp virus(SVCV).The ZFIN cells are epithelial like cells and have a moderate plasmid transfection efficiency of 13.9%.Using an RNA-seq approach,differentially expressed genes(DEGs)regulated by SVCV were *** of SVCV gave rise to 3931 DEGs and up-regulated DEGs were mostly enriched into the biological regulation and cellular processes,among which pathways for the type I interferon signaling and the response to exogenous dsRNA were the top two GO *** KEGG signaling pathways including TLR signaling pathway,RLR receptor signaling pathway,cytosolic DNA-sensing pathway,NLR signaling pathway,cytokine-cytokine receptor interaction and ferroptosis were significantly *** genes including ifnφ1,isg15 and mx were significantly *** addition,key DEGs involved in autophagy were *** results indicate that the ZFIN cell line provides a useful in vitro tool for study on the gene functions and cellular responses to viral infection in fish.

关键词： Caudal fin cells SVCV RNA-seq DEGs Innate antiviral response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computed tomography radiogenomics:A potential tool for prediction of molecular subtypes in gastric stromal tumor

引用

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1296-1308页

作者： Xiao-Nan Yin Zi-Hao Wang Li zou Cai-Wei Yang Chao-Yong Shen Bai-Ke Liu Yuan Yin Xi-Jiao Liu bo Zhang Gastric Cancer Research Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Paediatric Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastrointestinal Surgery Sichuan University West China HospitalChengdu 610041Sichuan ProvinceChina

BACKGROUND Preoperative knowledge of mutational status of gastrointestinal stromal tumors(GISTs)is essential to guide the individualized precision *** To develop a combined model that integrates clinical and contrast-enhanced computed tomography(CE-CT)features to predict gastric GISTs with specific genetic mutations,namely KIT exon 11 mutations or KIT exon 11 codons 557-558 *** A total of 231 GIST patients with definitive genetic phenotypes were divided into a training dataset and a validation dataset in a 7:3 *** models were constructed using selected clinical features,conventional CT features,and radiomics features extracted from abdominal CE-CT *** models were developed:ModelCT sign,modelCT sign+rad,and model CTsign+rad+*** diagnostic performance of these models was evaluated using receiver operating characteristic(ROC)curve analysis and the Delong *** The ROC analyses revealed that in the training cohort,the area under the curve(AUC)values for model_(CT sign),model_(CT sign+rad),and modelCT_(sign+rad+clinic)for predicting KIT exon 11 mutation were 0.743,0.818,and 0.915,*** the validation cohort,the AUC values for the same models were 0.670,0.781,and 0.811,*** predicting KIT exon 11 codons 557-558 deletions,the AUC values in the training cohort were 0.667,0.842,and 0.720 for model_(CT sign),model_(CT sign+rad),and modelCT_(sign+rad+clinic),*** the validation cohort,the AUC values for the same models were 0.610,0.782,and 0.795,*** on the decision curve analysis,it was determined that the model_(CT sign+rad+clinic)had clinical significance and *** Our findings demonstrate that the combined modelCT_(sign+rad+clinic)effectively distinguishes GISTs with KIT exon 11 mutation and KIT exon 11 codons 557-558 *** combined model has the potential to be valuable in assessing the genotype of GISTs.

关键词： Gastrointestinal stromal tumor Radiomics Gene mutation Computed tomography Model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simulation study on cuttings transport of the backreaming operation for long horizontal section wells

引用

Petroleum Science 2024年第2期21卷 1149-1170页

作者： Yu-Fei Chen Hui Zhang Wen-Xin Wu jun Li Yong Ouyang Zong-Yu Lu De-Xin Ma Yong-Chuan Wu jun-bo Liu Ke-Rou Liu Zhuo-Xin Dong China University of Petroleum(Beijing) Beijing102249China Beijing Normal University at Zhuhai Experimental and Practical Education Innovation CenterZhuhai519087GuangdongChina Oil&Gas Technology Research Institute of PetroChina Changqing Oilfield Company Xi'an710016ShaanxiChina PetroChina Xinjiang Oilfield Company Karamay834002XinjiangChina China Oilfield Services Ltd. Tianjin300459China

The backreaming operation plays a significant role in safe drilling for horizontal wellbores, while it may cause severe stuck pipe accidents. To lower the risk of the stuck pipe in backreaming operations, the mechanism of cuttings transport needs to be carefully investigated. In this research, a transient cuttings transport with multiple flow patterns model is developed to predict the evolution of cuttings transported in the annulus while backreaming. The established model can provide predictions of the distribution of cuttings bed along the wellbore considering the bulldozer effect caused by large-size drilling tools(LSDTs). The sensitivity analyses of the size of LSDTs, and backreaming operating parameters are conducted in Section 4. And a new theory is proposed to explain the mechanism of cuttings transport in the backreaming operation, in which both the bit and LSDTs have the “cleaning effect” and “plugging effect”.The results demonstrate that the cuttings bed in annuli is in a state of dynamic equilibrium, but the overall trend and the distribution pattern are obvious. First, larger diameters and longer drilling tools could lead to a higher risk of the stuck pipe. Second, we find that it is not the case that the higher flow rate is always better for hole cleaning, so three flow-rate intervals are discussed separately under the given conditions. When the “dangerous flow rate”(borehole near the step surface and causes a stuck pipe directly. If the flow rate increases to the “low flow rate” interval(33-35 L/s in Case 4), a smaller flow rate instead facilitates borehole cleaning. If the flow rate is large enough to be in the “high flow rate” interval(>35 L/s in Case 4),the higher the flow rate, the better the cleaning effect of cuttings beds. Third, an interval of tripping velocity called “dangerous velocity” is proposed, in which the cuttings bed accumulation near the LSDTs is more serious than

关键词： Backreaming Stuck pipe Hole cleaning Transient solid transport Multiple flow patterns

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of the gut microbiome on atherosclerosis

引用

mLife 2024年第2期3卷 167-175页

作者： Yuqin Mao Chao Kong Tongtong Zang Lingsen You Li-Shun Wang Li Shen jun-bo Ge Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghaiChina National Clinical Research Center for Interventional Medicine ShanghaiChina Center for Traditional Chinese Medicine and Gut Microbiota Minhang HospitalFudan UniversityShanghaiChina

Atherosclerosis is a chronic inflammatory metabolic disease with a complex ***,the exact details of its pathogenesis are still unclear,which limits effective clinical treatment of ***,multiple studies have demonstrated that the gut microbiota plays a pivotal role in the onset and progression of *** review discusses possible treatments for atherosclerosis using the gut microbiome as an intervention target and summarizes the role of the gut microbiome and its metabolites in the development of *** strategies for the treatment of atherosclerosis are *** review provides clues for further research on the mechanisms of the relationship between the gut microbiota and atherosclerosis.

关键词： atherosclerosis coronary heart disease gut microbiome metabolites treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：