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Effect of morphine and M-cholinoceptor blocking drugs on human sphincter of Oddi during choledochofiberscopy manometry

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hepatobiliary & Pancreatic Diseases International 2003年第1期2卷 121-125页

作者： Shuo-Dong Wu jing Kong Wei Wang Qiang Zhang jun-zhe jin the department of hepatobiliary, second affiliated hospital, china.medical university, shenyang 110004, china department of hepatobiliary Second Affiliated Hospital China Medical University Shenyang 110004 China.

OBJECTIVE: To evaluate the effects of morphine on the human sphincter of Oddi pressure and the antagonism of anticholinergic agents against morphine. METHODS: The action of these drugs on the sphincter of Oddi (SO) was evaluated by means of choledochofiberscopy manometry in 40 operated patients with T-tube. The patients were divided randomly into 4 groups: anisodamine, atropine, buscopan, and control. The following data were recorded: duodenal pressure (DP), basal pressure of the sphincter of Oddi (BPSO), contractive amplitude of the sphincter of Oddi (CASO), contractive frequency of the sphincter of Oddi (CFSO), contractive duration of the sphincter of Oddi (CDSO), and pressure of the common bile duct (PCBD). Both morphine and anticholinergic agents were given intramuscularly. RESULTS: After injection of 10 mg morphine, BPSO, CASO, CFSO, and PCBD increased significantly. After injection of 15 mg anisodamine or 0.75 mg atropine, CASO, BPSO declined obviously, and after injection of 20 mg buscopan, CASO, BPSO, CFSO declined obviously, but in anisodamine, atropine and buscopan groups, they differed insignificantly. CONCLUSIONS: The results illustrate that SO manometry via choledochofiberscopy is a new method for SO dynamic study. Morphine can increase DP, BPSO, CASO, PCBD, but anisodamine atropine and buscopan can antagonize the effect of morphine.

关键词： biliary manometry via choledochofiberscopy morphine anisodamine atropine buscopan contractive amplitude basal pressure sphincter of Oddi

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KLF4 Inhibits the Activation of Human Hepatic Stellate Cell In Vitro

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Current medical Science 2024年第3期44卷 512-518页

作者： Xing-yu YANG zhe CHEN jun TAN Yin-kai XUE Hai zheNG department of Emergency Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China department of Thoracic Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective Hepatic stellate cells(HSCs)play a crucial role in liver ***-stage liver fibrosis is reversible and intimately associated with the state of ***-like factor 4(KLF4)plays a pivotal role in a wide array of physiological and pathological *** study aimed to investigate the effect of KLF4 on the proliferation,apoptosis and phenotype of quiescent HSCs Methods We designed a KLF4 lentiviral vector and a KLF4 siRNA lentiviral vector,to upregulate and silence KLF4 expression in human HSC LX-2 cells via *** proliferation was assessed using the CCK-8 *** cytometry was used to detect the cell cycle distribution and apoptosis *** blotting was used to determine the levels of some quiescence and activation markers of HSCs Results Overexpression of KLF4 significantly increased the levels of E-cadherin and ZO-1,which are quiescent HSC markers,while significantly decreased the levels of N-cadherin and a-SMA,known activated HSC *** contrast,cell proliferation and apoptosis rates were elevated in LX-2 cells in which KLF4 expression was silenced Conclusion KLF4 inhibits the proliferation and activation of human LX-2 *** might be a key regulatory protein in the maintenance of HSC quiescence and may serve as a target for the inhibition of hepatic fibrosis.

关键词： Kruppel-like factor 4 hepatic stellate cells LX-2 cells liver fibrosis

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Effects of somatostatin analogues on human sphincter of Oddi pressure

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hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 302-305页

作者： Shuo-Dong Wu, zhen-Hai Zhang, jing Kong, Yan-jun Li, jun-zhe jin, Wei Wang, Dong-Yan Li and Min-Fei Wang shenyang, china No.2 department of General Surgery, second Affilia- ted hospital, china.medical university, shenyang 110004, china department of General Surgery Second Affiliated Hospital China Medical University Shenyang 110004 China. wushuodong@***

BACKGROUND: Somatostatin, a neuropeptide and hor- mone , exists in the biliary tract of several species. The effects of somatostatin and its analogues on the sphincter of Oddi motility have been controversial. The aim of this study was to observe the action of stilamin and sandostatin on the sphincter of Oddi via choledochofiberscope manometry. METHODS: Twenty patients who had had'T' duct after cholecystectomy and choledochotomy were divided into 2 groups randomly: stilamin and sandostatin. They were subjected to manometry via a choledochofiberscope through the'T' duct tract. The following data recorded in- cluded duodenal pressure (DP), sphincter of Oddi basal pressure (SOBP), sphincter of Oddi contractive amplitude (SOCA), frequency of the sphincter of Oddi (SOF), dura- tion of the sphincter of Oddi, and the common bile duct pressure (CBDP). RESULTS: After intravenous administration of stilamin at a dose of 250 μg/h, the mean SOCA increased from 89.18 (26.50) to 128.57(54.21) mmHg (P <0.05). After the ad- ministration of stilamin at a dose of 500 μg/h the mean SO- CA declined to 92.18(42.81) mmHg (P<0.05), and mean SOBP declined from 17.63(13.36) to 8.16(4.01) mmHg (P<0.05). Although SOF had declined from 9.25(2.45) to 7.46(1.52) n/min, it was not significantly influenced. After intravenous administration of sandostatin at a dose of 100 μg, the mean CBDP increased obviously. CONCLUSIONS: Intravenous administration of stilamin at a dose of 250 μg/h stimulates the motility of the sphincter of Oddi whereas the injection of stilamin at a dose of 500 μg/h inhibits its motility. Intravenous injection of sandosta- tin of 100 μg has no effect on the sphincter of Oddi.

关键词： biliary manometry via choledochofiberoscopy sphincter of Oddi somatostatin stilamin sandostatin

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Association between heat and upper urinary tract stones morbidity and medical costs: A study in the subtropical humid climate zone

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Advances in Climate Change Research 2024年第4期15卷 717-724页

作者： Chen-Lu YANG jun-zhe BAO Peng BI Ya-Dong ZHANG Chao-Ming TAN Kai CHEN College of Public Health Zhengzhou UniversityZhengzhou 450001China School of Public Health The University of AdelaideAdelaide 5000Australia department of Andrology The First Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Nanjing Social Insurance Management Center Nanjing 210008China department of Environmental Health Sciences Yale UniversityNew Haven 06520USA Yale Center on Climate Change and Health Yale UniversityNew Haven 06520USA

Urolithiasis is a heat-specific *** heat-related urolithiasis susceptibility subtypes,economic burden,and modifying factors could assist governments in targeting interventions to reduce the heat-related health risks of urolithiasis *** collected data on 23,492 patients with upper urinary tract stones(main subtypes of urolithiasis)from 2013 to 2017 in Nanjing,*** adopted generalized additive quasi-Poisson models to examine the associations between daily mean temperatures and morbidity of upper urinary tract stones,while generalized additive Gaussian models were used to explore the relationships between temperatures and log-transformed medical *** examined the modification effects of disease subtypes(kidney and ureteral calculus),sex,and age through stratified analyses and the modif-cation effects of other meteorological factors by introducing interaction terms in the *** found that short-term summer heat exposure has a statistically significant effect on ureteral calculus morbidity but not on kidney calculus *** ureter calculus,a 1℃ temperature increase was associated with a 4.36%(95%confidence interval[CI]:1.94%,6.83%)increase in daily hospitalization and a 5.44%(95%CI:2.71%,8.25%)increase in daily medical *** attributable fraction associated with heat(greater than the median value of daily mean temperature,26.8℃)was 7.85%(95%empirical confidence interval[eCI]:3.64%,11.44%)for hospitalization and 9.36%(95%eCI:4.91%,13.14%)for medical *** effects of heat on ureter calculus morbidity were significantly higher among the males and those with high sunshine duration than females and those with low sunshine ***-term summer heat exposure was associated with increased morbidity and medical costs of ureteral *** government organizations should take effective intervention measures,including community health education,to reduce the health hazards and economic losses caused by heat.

关键词： Heat Upper urinary tract stones Economic burden Modification effects

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Classification of breast microcalcifications: radiological-pathological correlation

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中华医学杂志(英文版) 2005年第17期000卷 23-29页

作者： SUN zhe,LIANG Hong-wei and XU Hui-miandepartment of Oncological Surgery, First affiliated hospital of china.medical university, shenyang 110001, china department of Oncological Surgery First Affiliated Hospital of China Medical University Shenyang 110001 China

Background Microcalcifications play a very important role in detection of breast cancer, especially early stagebreast ***, ambiguity still exists in understanding the relationship between radiological andpathological characteristics of *** definitive indication of a biopsy has not been *** purpose of this study is to evaluate the relationship of classification of breast microcalcifications using full-field digital mammography to the pathological *** For all the women an open biopsy had been *** hundred and three mammographsshowing clustered microcalcifications from 98 consecutive patients were reviewed along with their *** investigate the value of each criterion for the detection of cancer, univariate and multivariate analyseswere performed on the entire sample and then on morphological *** Pathological examination showed 67 malignant lesions (65.05%) and 36 benign lesions (34.95%).In the univariate analysis, four radiological variables were significant: morphological type (P=0.001),complicated by a mass (P=0.002), number of microcalcifications per cluster (P=0.02) and linear ortriangular distribution of clusters (P=0.009).In the multivariate analysis, two criteria remained significant:morphological type (P<0.001) and complicated by a mass (P=0.001).The percentage of malignancy was37.0%, 60.0%, 78.8%, and 88.9%, respectively, for type 2 (regularly punctiform), type 3 (dusty), type4 ( irregularly punctiform) and type 5 ( vermicular) microcalcifications ( Le Gal’s classification).Themalignancy was78.6% for microcalcifications complicated by a mass and 48.9% without a *** differencewas significant (P<0.05).The relationship between morphological types of microcalcifications and thepathological characteristics was also *** subgroups, type 3 (dusty) microcalcifications complicated by amass (P=0.001) or with the number of microcalcifications more than 10 (P

关键词： calcinosis · breast neoplasms · mammography

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A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients

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The Innovation 2024年第3期5卷 77-87页

作者： zhe Zhang Wenjing Yang zhengshan Chen Haoang Chi Shipo Wu Wanru zheng Ruochun jin Busen Wang Yudong Wang Nan Huo jinlong Zhang Xiaohong Song Liyang Xu jun Zhang Lihua Hou Wei Chen Institute of Biotechnology Academy of Military Medical SciencesBeijing 100071China department of Intelligent Data Science College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China Intelligent Game and Decision Lab Academy of Military ScienceBeijing 100091China

The vaccine-induced innate immune response is essential for the generation of an antibody *** date,how Ad5-vectored vaccines are influenced by preexisting anti-Ad5 antibodies during activation of the early immune response remains ***,we investigated the specific alterations in GP1,2-specific IgG-related elements of the early immune response at the genetic,molecular,and cellular levels on days 0,1,3,and 7 after Ad5-EBOV *** a causal multiomics analysis,distinct early immune responses associated with GP1,2-specific IgG were observed in Ad5-EBOV recipients with a low level of preexisting anti-Ad5 *** study revealed the correlates of the Ad5-EBOV-induced IgG response and provided mechanistic evidence for overcoming preexisting Ad5 immunity during the administration of Ad5-vectored vaccines.

关键词： vaccine immunity alterations

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Prevention of grafted liver from reperfusive injury

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World Journal of Gastroenterology 2001年第4期7卷 572-574页

作者： Kai Ma Yang Yu Xian-Min Bu Yan-jun Li Xian-Wei Dai Liang Wang Yang Dai Hai-Ying Zhao Xiang-Hong Yang department of General Surgery,second Clinical College,china.medical university,shenyang 110003,Liaoning Province,chinaDepartrnent of Physiology,shenyang Physical Education College,shenyang,Liaoning Province,chinadepartment of Pathology,china.medical university,shenyang,Liaoning Province,china department of General Surgery Second Clinical College China Medical University Shenyang 110003 Liaoning Province China.

INTRODUCTIONThe incidence of primary non-function(PNF)of grafted liver in the early postoperative stage is 2%-23%[1-4],its main cause is the ischemic-rechemic injure[5,6].In this experiment,anisodamine was added into the preserving fluid and the grafted liver was rewarmed at different temperatures to protect the cell membranc and prevent ischemic-reperfusive injury.

关键词： Liver Transplantation Animals Body Temperature Drugs, Chinese Herbal Free Radical Scavengers Hepatocytes Lipid Peroxidation Liver Male Microscopy, Electron Rats Rats, Wistar Reactive Oxygen Species Reperfusion Injury control Research Support, Non-U.S. Gov't Solanaceous Alkaloids Superoxide Dismutase

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Chinese herbal medicine Ginkgo biloba *** for ischemic stroke:An overview of systematic reviews and meta-analyses

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Journal of Integrative Medicine 2024年第2期22卷 163-179页

作者： Tian-tian Meng Ya-ping You Min Li Jian-bo Guo Xin-bin Song jing-yi Ding Xiao-long Xie An-qi Li Shang-jin Li Xiang-jun Yin Peng Wang zhe Wang Bao-liang Wang Qing-yong He department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100032China department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing 100071China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Chinese Medicine the University of Hong KongHong KongChina Graduate School Henan University of Chinese MedicineZhengzhou 450008Henan ProvinceChina department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100010China department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesZhengzhou 450008Henan ProvinceChina School of Integrated Traditional Chinese and Western Medicine Southwest Medical UniversityHangzhou 310053Zhejiang ProvinceChina School of Basic medical Sciences Zhejiang Chinese Medical UniversityHangzhu 310053Zhejang ProvinceChina department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450003Henan ProvinceChina

Background:Ginkgo biloba ***(GBLPs)are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke(IS).Recently,several systematic reviews(SRs)and meta-analyses(MAs)of GBLPs for IS have been ***:This overview aims to assess the quality of related SRs and *** strategy:Pub Med,Embase,Cochrane Library,Web of Science,Chinese Biological Medicine,china National Knowledge Infrastructure,Wanfang,and Chinese Science and Technology Journals databases were searched from their inception to December 31,*** criteria:SRs and MAs of randomized controlled trials(RCTs)that explored the efficacy of GBLPs for patients with IS were *** extraction and analysis:Two independent reviewers extracted data and assessed the methodological quality,risk of bias(ROB),reporting quality,and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),Risk of Bias in Systematic Reviews(ROBIS),the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),***,descriptive analysis and data synthesis were ***:Twenty-nine SRs/MAs involving 119 outcomes were included in this *** overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2,and 28 had a high ROB based on the *** to the PRISMA statement,the reporting items of the included SRs/MAs are relatively *** results based on GRADE showed that of the 119 outcomes,8 were rated as moderate quality,24 as low quality,and 87 as very low *** on the data synthesis,GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function ***:GBLPs can be considered a beneficial supplemental therapy for ***,because of the low quality of the existing eviden

关键词： statement synthesis alone

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Integrated Chinese and Western Medicine in Treatment of Bronchopleural Fistula with Mycobacterium abscessus:A Case Report

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Chinese Journal of Integrative Medicine 2024年第8期30卷 742-746页

作者： WANG Qian-yun CHENG Miao BAN Cheng-jun ZHANG Li-shan WANG Hong-wu YANG Bing ZOU Heng WANG Ming-zhe The First Clinical medical College of Beijing university of Chinese Medicine Beijing100700China department of Respiratory Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China

Bronchopleural fistula(BPF)is defined as a pathological connection between the trachea or bronchus and the pleural *** may occur as a serious complication after lung surgery.^((1))It has a low incidence of 1%-3%^((2.3... 详细信息

关键词： pleural lung surgery

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Prognostic Factors for Patients after Curative Resection for Proximal Gastric Cancer

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Journal of Huazhong university of Science and Technology(medical Sciences) 2010年第4期30卷 530-535页

作者：赵东晖徐惠绵李凯孙哲 department of Surgical Oncology Research Unit of General Surgery Department of Gastrointestinal Oncosurgery First Affiliated Hospital of China Medical University

The factors influencing the long-term survival of patients with proximal gastric cancer (PGC) after curative resection were investigated. Data from 171 patients who underwent curative resection for PGC were retrospectively analyzed. The patients were grouped according to the clinicopathological factors and operative procedures. The tumor depth (T stage) and lymph node metastasis (pN stage) were graded according to the fifth edition of TNM Staging System published by UICC in 1997. The metastatic lymph node ratio (MLR) was divided into four levels: 0%, 30%. The data of survival rate were analyzed by Kaplan-Meier method (log-rank test) and Cox regression model. The 5-year overall survival rate of 171 patients was 37.32%. The univariate analysis demonstrated that the survival time of the postoperative patients with PGC was related to tumor size (χ2=4.57, P=0.0325), gross type (χ2=21.38, P30% (χ2=13.34, P=0.0003), TNM Ⅲ (χ2=14.05, P=0.0002) or TNM Ⅳ stage (χ2=4.37, P=0.0366); and combining splenectomy was beneficial to the cases of T3 (χ2=5.68, P=0.0171) or MLR >30% (χ2=6.11, P=0.0134). It was concluded that MLR, pN stage, TNM stage, T stage, and gross type had advantages in providing a precise prognostic evaluation for patients undergoing curative resection for PGC, in which MLR was the most valuable index. TG and combining splenectomy were useful to improve the prognosis to patients with PGC of TNM Ⅲ/Ⅲ stage, serosa invasion, or extensive regional lymph node metastasis.

关键词： stomach neoplasms proximal gastric cancer curative resection prognosis.

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