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Sharp bilinear decomposition for products of both anisotropic Hardy spaces and their dual spaces with its applications to endpoint boundedness of commutators

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Science China Mathematics 2024年第9期67卷 2091-2152页

作者： jun liu Dachun yang Mingdong Zhang School of Mathematics China University of Mining and TechnologyXuzhou 221116China Laboratory of Mathematics and Complex Systems(Ministry of Education of China) School of Mathematical SciencesBeijing Normal UniversityBeijing 100875China

Let a:=(a_(1),...,a_(n))2[1,∞)^(n),p∈(0,1),andα:=1/*** any x∈R^(n)and t∈[0,∞),letΦ_(p)(x,t):={t/1+(t[x]_(a)^(ν))^(1-p)if να■N,t/1+(t[x]_(a)^(ν))^(1-p)[log(e+|x|a)]^(p)if να∈N,let where [·]a:=1+|·|a,|·|a denotes the anisotropic quasi-homogeneous norm with respect to a,and ν:=a_(1)+…+a_(n).Let H_(a)^(p)(R^(n)),L_(a)^(a)(R^(n)),and H_(a)^(Φ_(p))(R^(n))be,respectively,the anisotropic Hardy space,the anisotropic Campanato space,and the anisotropic Musielak-Orlicz Hardy space associated with Φ_(p) on R^(n).In this article,via first establishing the wavelet characterization of anisotropic Campanato spaces,we prove that for any f∈H_(a)^(p)(R^(n))and g∈L_(a)^(a)(R^(n)),the product of f and g can be decomposed into S(f,g)+T(f,g) in the sense of tempered distributions,where S is a bilinear operator bounded from H_(a)^(p)(R^(n))*L_(a)^(a)(R^(Φ_(p))) to L^(1)(R^(n)) and T is a bilinear operator bounded from H_(a)^(p)(R^(n))*L_(a)^(a)(R^(n)) to H_(a)^(Φ_(p))(R^(n)) .Moreover,this bilinear decomposition is sharp in the dual sense that any y■H_(a)^(Φ_(p))(R^(n)) that fits into the above bilinear decomposition should satisfy(L^(1)(R^(n))+y)*=(L^(1)(R^(n)+H_(a)^(Φ_(p))(R^(n))*.As applications,for any non-constant b∈L_(a)^(a)(R^(n)) and any sublinear operator T satisfying some mild bounded assumptions,we find the largest subspace of H_(a)^(p)(R^(n)),denoted by H_(a,b)^(p)(R^(n)),such that the commutator [b,T] is bounded from H_(a,b)^(p)(R^(n))to L^(1)(R^(n)).In addition,when T is an anisotropic CalderónZygmund operator,the boundedness of [b,T] from H_(a,b)^(p)(R^(n))to L^(1)(R^(n))(or to H_(a)^(1)(R^(n)) is also *** key of their proofs is the wavelet characterization of function spaces under consideration.

关键词： anisotropic Euclidean space bilinear decomposition Hardy space Campanato space Musielak-Orlicz Hardy space commutator wavelet

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Quantum-enhanced microscopic imaging technology [Invited]

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Chinese Optics Letters 2024年第6期22卷 68-76页

作者： jun liu Xiaolong Su State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Microscopes are indispensable tools in modern biology and medicine. With the development of microscopy, the signal-tonoise ratio of microscopes is now limited by the shot noise. Recently, quantum-enhanced microscopic imaging provides a feasible approach for improving the signal-to-noise ratio since it can beat the shot-noise limit by using quantum light. In this review, we first briefly introduce quantum states applied in quantum-enhanced microscopic imaging, and then we provide an overview of the principle and progress of quantum-enhanced stimulated Raman scattering microscopy, entangled twophoton microscopy,and quantum-enhanced differential interference contrast microscopy.

关键词： squeezed state entangled state imaging microscopy

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Effects of retained dry material on the impact,overflow and landing dynamics

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3629-3640页

作者： jun Fang Yifei Cui Haiming liu State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijingChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina

During long-term operation,the performance of obstacles would be changed due to the material accumulating upslope the ***,the effects of retained material on impact,overflow and landing dynamics of granular flow have not yet been *** address this gap,physical flume tests and discrete element simulations are conducted considering a range of normalized deposition height h0/H from 0 to 1,where h0 and H represent the deposition height and obstacle height,*** analytical model is modified to evaluate the flow velocity and flow depth after interacting with the retained materials,which further serve to calculate the peak impact force on the ***,the computed impact forces successfully predict the experimental results when a≥25°.In addition,the results indicate that a higher h0/H leads to a lower dynamic impact force,a greater landing distance L,and a larger landing coefficient Cr,where Cr is the ratio of slope-parallel component of landing velocity to flow velocity just before *** to the existing overflow model,the measured landing distance L is underestimated by up to 30%,and therefore it is insufficient for obstacle design when there is retained ***,the recommended Cr in current design practice is found to be nonconservative for estimating the landing velocity of geophysical *** study provides insightful scientific basis for designing obstacles with deposition.

关键词： Granular flow Obstacle deposition Impact Overflow Landing

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Designing ultrastrong and thermally stable FeCrAl alloys with the fine-grained structure

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Journal of Materials Science & Technology 2024年第4期171卷 198-208页

作者： Shuaiyang liu Jinyu Zhang Hui Wang Gang liu Xiangdong Ding jun Sun State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China Science and Technology on Reactor Fuel and Materials Laboratory Nuclear Power Institute of ChinaChengdu 610041China

Designing microstructurally stable FeCrAl alloys with excellent strength-ductility synergy is highly desir-able for their engineering ***,due to the preference nucleation of precipitates at grain boundaries(GBs),the improved precipitation strengthening of these alloys is usually accompanied by in-tergranular ***,we propose a novel thermomechanical processing route coupled with the Si alloying strategy via precipitation of coherent deformable Laves precipitates inside equiaxed fine-grains to achieve FeCrAl alloys with ultrahigh yield strength over∼992 MPa,excellent uniform elongation of∼7.6%at room temperature,and superior thermal stability at temperature∼1200℃.The Si alloying not only decreases the stacking fault energy of Laves precipitates favorable for their stacking-fault-mediated deformation but also hinders grain coarsening at 1200℃due to the Si-enrichment favorable for GB pin-ning *** results prove the possibility of achieving the collaborative enhancement of mutually exclusive properties in alloys,such as strength-ductility-thermal stability via nanoprecipitation engineer-ing,and offer a promising route to prepare dispersion-strengthened materials.

关键词： FeCrAl alloys Si alloying Mechanical properties Thermal stability Laves phase

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Quick and automatic detection of co-seismic landslides with multifeature deep learning model

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Science China Earth Sciences 2024年第7期67卷 2311-2325页

作者： Wenchao HUANGFU Haijun QIU Peng CUI Dongdong yaNG ya liu Bingzhe TANG Zijing liu Mohib ULLAH College of Urban and Environmental Sciences Northwest UniversityXi'an 710127China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity Northwest UniversityXi'an 710127China Institute of Earth Surface System and Hazards Northwest UniversityXi'an 710127China

Co-seismic landslide detection is essential for post-disaster rescue and risk assessment after an earthquake ***,a variety of ground objects,including roads and bare land,have spectral characteristics similar to those of co-seismic landslides,making it difficult to gather information and assess their impact rapidly and ***,an automatic detection method based on a deep learning model,named ENVINet5,with multiple features(ENVINet5_MF)was proposed to solve this problem and improve the detection accuracy of co-seismic *** ENVINet5_MF method is advantageous for co-seismic landslide detection because it features a landslide gain index(LGI)that effectively eliminates the spectral interference of bare land and *** conducted two experiments using multi-temporal PlanetScope images acquired in Hokkaido,Japan,and Mainling,*** accuracy evaluation and rationality analysis show that ENVINet5_MF performed better than comparative methods and that the co-seismic landslide areas detected by ENVINet5_MF were the most consistent with ground reference *** findings of this study suggest that ENVINet5_MF can provide an efficient and accurate method for coseismic landslide detection to ensure a rapid response to co-seismic landslide disasters.

关键词： Co-seismic landslide Automatic detection Deep learning Landslide gain index PlanetScope images

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NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1421-1436页

作者： Yu-Jie Xu ya-Chang Huo Qi-Tai Zhao Jin-yan liu Yi-jun Tian Lei-Lei yang Yi Zhang Biotherapy Center and Cancer Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Oncology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina

BACKGROUND Metabolic reprogramming plays a key role in cancer progression and clinical outcomes;however,the patterns and primary regulators of metabolic reprogramming in colorectal cancer(CRC)are not well *** To explore the role of nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)in promoting progression of *** We evaluated the expression and function of dysregulated and survival-related metabolic genes using Gene Ontology and Kyoto Encyclopedia of Genes and *** clustering was used to cluster CRC based on dysregulated metabolic genes.A prediction model was constructed based on survival-related metabolic *** formation,migration,invasion,proliferation,apoptosis and clone formation was used to evaluate the biological function of NOX4 in *** sequencing was utilized to explore the alterations of gene expression NOX4 over-expression tumor *** vivo subcutaneous and lung metastasis mouse tumor model was used to explore the effect of NOX4 on tumor *** We comprehensively analyzed 3341 metabolic genes in CRC and identified three clusters based on dysregulated metabolic *** these genes,NOX4 was highly expressed in tumor tissues and correlated with worse *** vitro,NOX4 overexpression induced clone formation,migration,invasion,and stemness in CRC ***,RNA-sequencing analysis revealed that NOX4 overexpression activated the mitogen-activated protein kinase-MEK1/2-ERK1/2 signaling ***,a MEK1/2 inhibitor,abolished the NOX4-mediated tumor *** vivo,NOX4 overexpression promoted subcutaneous tumor growth and lung metastasis,whereas trametinib treatment can reversed the *** Our study comprehensively analyzed metabolic gene expression and highlighted the importance of NOX4 in promoting CRC metastasis,suggesting that trametinib could be a potential therapeutic drugs of CRC clinical therapy targeting NOX4.

关键词： Colorectal cancer Metabolic reprogramming Metastasis Nicotinamide adenine dinucleotide phosphate oxidase 4 Mitogen-activated protein kinase signaling

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Acupuncture for obesity and related diseases:Insight for regulating neural circuit

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Journal of Integrative Medicine 2024年第2期22卷 93-101页

作者： Lin-yan Jiang jun Tian ya-nan yang Shao-hui Jia Qing Shu Department of Rehabilitation Medicine Zhongnan HospitalWuhan UniversityWuhan 430071Hubei ProvinceChina School of Sports Medicine Wuhan Sports UniversityWuhan 430079Hubei ProvinceChina Department of Traditional Chinese Medicine China Resources&Wu Gang General HospitalWuhan 430080Hubei ProvinceChina

Obesity is defined as abnormal or excessive fat accumulation that may impair *** is associated with numerous pathological changes including insulin resistance,fatty liver,hyperlipidemias,and other obesity-related *** comorbidities comprise a significant public health *** anti-obesity drugs have been limited by side effects that include depression,suicidal thoughts,cardiovascular complications and *** treatment has been shown to be effective for treating obesity and obesity-related conditions,while avoiding side ***,the mechanisms of acupuncture in treating obesity-related diseases,especially its effect on neural circuits,are not well understood.A growing body of research has studied acupuncture’s effects on the endocrine system and other mechanisms related to the regulation of neural *** this article,recent research that was relevant to the use of acupuncture to treat obesity and obesity-related diseases through the neuroendocrine system,as well as some neural circuits involved,was *** on this,acupuncture’s potential ability to regulate neural circuits and its mechanisms of action in the endocrine system were reviewed,leading to a deeper mechanistic understanding of acupuncture’s effects and providing insight and direction for future research about obesity.

关键词： Obesity Acupuncture Neural circuit Appetite Energy metabolism

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Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： liu Xiao-rong LI Shuo-fu MEI Wen-ya liu Xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(P<0.05).Isorhamnetin downregulated the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1βin RA-FLS(P<0.05).The overexpression of either MMP2 or MMP9 reversed isorhamnetin-inhibited RA-FLS migration and invasion,as well as the levels of TNF-α,IL-6,and IL-1β(P<0.05).Furthermore,isorhamnetin bound to SRC and reduced the phosphorylation of SRC,ERK,and CREB(P<0.05).SRC overexpression reversed the inhibitory effect of isorhamnetin on RA-FLS viability,migration and invasion,as well as the negative regulation of MMP2 and MMP9(P<0.05).In in vivo studies,isorhamnetin decreased arthritis index scores(P<0.05)and alleviated synovial *** reduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

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Development and validation of a novel non-invasive test for diagnosing nonalcoholic fatty liver disease in Chinese children

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World Journal of Pediatrics 2024年第4期20卷 413-421页

作者： Zhe-Wen Qin Qian-Nan Ren Hong-Xi Zhang ya-Ru liu Ke Huang Wei Wu Guan-Ping Dong yan Ni jun-Fen Fu Division of Endocrinology National Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalDepartment of EndocrinologyNational Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalZhejiang University School of MedicineHangzhou310052China

With the exploding prevalence of obesity,many children are at risk of developing nonalcoholic fatty liver *** anthropometric and laboratory parameters,our study aimed to develop a model to quantitatively evaluate liver fat content(LFC)in children with *** A well-characterized cohort of 181 children between 5 and 16 years of age were recruited to the study in the Endocrinology Department as the derivation *** external validation cohort comprised 77 *** assessment of liver fat content was performed using proton magnetic resonance *** and laboratory metrics were measured in all subjects.B-ultrasound examination was carried out in the external validation *** Kruskal-Wallis test,Spearman bivariate correlation analyses,univariable linear regressions and multivariable linear regression were used to build the optimal predictive *** The model was based on indicators including alanine aminotransferase,homeostasis model assessment of insulin resistance,triglycerides,waist circumference and Tanner *** adjusted R^(2)of the model was 0.589,which presented high sensitivity and specificity both in internal[sensitivity of 0.824,specificity of 0.900,area under curve(AUC)of 0.900 with a 95%confidence interval:0.783–1.000]and external validation(sensitivity of 0.918 and specificity of 0.821,AUC of 0.901 with a 95%confidence interval:0.818–0.984).Conclusions Our model based on five clinical indicators was simple,non-invasive,and inexpensive;it had high sensitivity and specificity in predicting LFC in ***,it may be useful for identifying children with obesity who are at risk for developing nonalcoholic fatty liver disease.

关键词： Biochemical markers Children Magnetic resonance spectroscopy Nonalcoholic fatty liver disease Pediatric obesity

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Remarkable Wear Resistance in a Complex Concentrated Alloy with Nanohierarchical Architecture and Composition Undulation

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Research 2024年第1期2023卷 403-416页

作者： Yushan Geng Wenyuan Chen Hui Tan jun Cheng Shengyu Zhu jun yang Weimin liu State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049PR China Shandong Laboratory of yantai Advanced Materials and Green Manufacturing Yantai 264000PR China

Sustained wear damages on the sliding surfaces of alloys are generally the culprit responsible for the failure of various mechanical *** by high-entropy effects,here we deliberately deploy nanohierarchical architecture with composition undulation in a Ni50(AlNbTiV)_(50) complex concentrated alloy,which yields ultralow wear rate within the order of 10^(−7) to 10^(−6) mm^(3)/Nm between room temperature and 800℃.Such remarkable wear resistance heretofore represents one of the highest wear resistance reported for the bulk alloys or composites,and originates from the multi-type adaptive friction interface protection governed by intrinsically nano-coupled grains and *** cooperative heterostructure releases gradient frictional stress in stages upon wear at room temperature through the coexistence of multiple deformation pathways while activating a dense nanocrystalline glaze layer upon wear at 800℃ to minimize adhesive and oxidative *** work uncovers a practical avenue for tailoring wear properties with multicomponent heterostructures over a wide temperature range.

关键词： wear alloys friction

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