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Intranasal iron administration induces iron deposition,immunoactivation, and cell-specific vulnerability in the olfactory bulb of C57BL/6 mice

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Zoological Research 2025年第01期 209-224页

作者： Xiao-Qing Mi Bao-Chen Liu Le Qu Yu Yuan Hui Li ao-Yang Xu Yu-Lin Zhang jun-Xia Xie Ning Song School of Basic Medicine Institute of Brain Science and Disease Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Brain Diseases Qingdao University School of Life Science and Technology ShanghaiTech University

Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however, its abnormal accumulation is also implicated in various neurological disorders. The olfactory bulb(OB), an early target in neurodegenerative diseases, acts as a gateway for environmental toxins and contains diverse neuronal populations with distinct roles. This study explored the cell-specific vulnerability to iron in the OB using a mouse model of intranasal administration of ferric ammonium citrate(FAC). Olfactory function was assessed through olfactory discrimination tests, while iron levels in OB tissues, cerebrospinal fluid(CSF), and serum were quantified using inductively coupled plasma mass spectrometry(ICP-MS), immunohistochemical staining,and iron assays. Transcriptomic changes and immune responses were assessed using RNA sequencing and immune cell infiltration analysis. Results showed that intranasal FAC administration impaired olfactory function,accompanied by iron deposition in the olfactory mucosa and OB, as well as damage to olfactory sensory ***, these effects occurred without elevations in CSF or serum iron levels. OB iron accumulation activated multiple immune cells, including microglia and astrocytes,but did not trigger ferroptosis. Spatial transcriptomic sequencing of healthy adult mouse OBs revealed significant cellular heterogeneity, with an abundance of neuroglia and neurons. Among neurons, GABAergic neurons were the most prevalent, followed by glutamatergic and dopaminergic neurons, while cholinergic and serotonergic neurons were sparsely distributed. Under iron-stressed conditions, oligodendrocytes, dopaminergic neurons, and glutamatergic neurons exhibited significant damage, while GABAergic neurons remained *** findings highlight the selective vulnerability of neuronal and glial populations to iron-induced stress,offering novel insights into the loss of specific cell types in the OB during iron

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An experimental study on the magnetic field permeability of an inductive-pulsed plasma thruster

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Chinese Physics B 2025年第2期34卷 342-350页

作者： Bi-xuan Che Jian-jun Wu Mou-Sen Cheng Xiao-Kang Li Yu Zhang Da-Wei Guo College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

Inductive-pulsed plasma thruster is an in-space propulsion device that generates thrust by ionizing and accelerating plasma through pulsed electromagnetic *** this paper,the correlation between plasma structure evolution and magnetic field permeability is studied using a B-dot probe array system,combing with high-speed camera and electrical parameter *** discussions explained the mechanism how the magnetic permeation characteristics affect the energy deposition between circuit and plasma.

关键词： inductive-pulsed plasma thruster electric propulsion B-dot probe plasma structure

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Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway

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World Journal of Gastroenterology 2025年第6期31卷 44-61页

作者： Han-Ning xuan Yuan Hyun Sung Kim Gye Ryeol Park Jae Eun Ryu Ji Eun Kim In Young Kang Hye Young Kim Seung Min Lee Ju Hee Oh Eileen L Yoon Dae Won jun Department of Internal Medicine Hanyang University School of MedicineSeoul 04763South Korea Department of Pathology Hanyang University School of MedicineSeoul 04763South Korea Department of Translational Medicine Graduate School of Biomedical Science and EngineeringHanyang UniversitySeoul 04763South Korea Department of Obstetrics and Gynecology Institute of Women’s Medical Life ScienceYonsei Cancer CenterSeverance HospitalYonsei University College of MedicineSeoul 04763South Korea Department of Internal Medicine Sanggye Paik HospitalInje University College of MedicineSeoul 01757South Korea

BACKGROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver *** study aims to specifically investigate the role of MLKL’s adenosine triphosphate(ATP)-binding pocket in facilitating necroptosis-independent pathways that may contribute to liver disease *** focusing on this mechanism,we seek to identify potential therapeutic targets that can modulate MLKL activity,offering new strategies for the prevention and treatment of liver-related *** To investigate the possibility of using the ATP-binding pocket-associated,necro-ptosis-independent MLKL pathway as a target for liver *** Cell death following necroptosis stimuli was evaluated using cell proliferation assays,flow cytometry,and electron microscopy in various *** human liver organoid system was used to evaluate whether the MLKL ATP pocket-binding inhibitor could attenuate ***,alcoholic and non-alcoholic fatty liver diseases animal models were used to determine whether MLKL ATP pocket inhibitors could attenuate liver *** While an MLKL ATP pocket-binding inhibitor did not prevent necroptosis-induced cell death in RAW 264.7 cells,it did reduce the necroptosis-led expression of CXCL2,ICAM,and ***,MLKL ATP pocket inhibitor diminishes the expression of CXCL2,ICAM,and VCAM by inhibiting the IκB kinase and nuclear factor kappa-B pathways without inducing necroptosis-induced cell death in two-dimensional cell culture as well as the human-derived liver organoid *** MLKL ATP-binding inhibitor was ineffective in non-alcoholic fatty liver disease animal models,MLKL ATP-binding inhibitor attenuated hepatic inflammation in the alcoholic liver disease *** MLKL ATP pocket-binding inhibitor exerted anti-inflammatory effects through the necroptosis-independent MLKL pathway in an animal model of alcoholic liver disease.

关键词： RAW 264.7 cell Cell death Necroptosis Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease

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New scoring system for the evaluation obstructive degrees based on computed tomography for obstructive colorectal cancer

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 122-132页

作者： Xin-Chang Shang-Guan jun-Rong Zhang Chao-Nan Lin Shuai Chen Yong Wei Wen-xuan Chen Lin Pan Li-Qin Huang Shao-Hua Zheng Xian-Qiang Chen Department of Emergency Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina College of Physics and Information Engineering Fuzhou UniversityFuzhou 350001Fujian ProvinceChina

BACKGROUND The degree of obstruction plays an important role in decision-making for obstructive colorectal cancer(OCRC).The existing assessment still relies on the colorectal obstruction scoring system(CROSS)which is based on a comprehensive analysis of patients’complaints and eating *** data collection relies on subjective descriptions and lacks objective ***,a scoring system for the evaluation of computed tomography-based obstructive degree(CTOD)is urgently required for *** To explore the relationship between CTOD and CROSS and to determine whether CTOD could affect the short-term and long-term *** Of 173 patients were *** was obtained using k-means,the ratio of proximal to distal obstruction,and the proportion of nonparenchymal areas at the site of *** was integrated with the CROSS to analyze the effect of emergency intervention on ***-term and long-term outcomes were compared between the *** CTOD severe obstruction(CTOD grade 3)was an independent risk factor[odds ratio(OR)=3.390,95%confidence interval(CI):1.340-8.570,P=0.010]via multivariate analysis of short-term outcomes,while CROSS grade was *** the CTOD-CROSS grade system,for the non-severe obstructive(CTOD 1-2 to CROSS 1-4)group,the complication rate of emergency interventions was significantly higher than that of non-emergency interventions(71.4%vs 41.8%,P=0.040).The postoperative pneumonia rate was higher in the emergency intervention group than in the non-severe obstructive group(35.7%vs 8.9%,P=0.020).However,CTOD grade was not an independent risk factor of overall survival and progression-free *** CTOD was useful in preoperative decision-making to avoid unnecessary emergency interventions and complications.

关键词： Obstructive colorectal cancer Scoring system Computed tomography-based obstructive degree Colorectal obstruction scoring system Emergency intervention

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Synthesis of lutetium hydrides at high pressures

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Matter and Radiation at Extremes 2025年第1期10卷 98-104页

作者： Yuan-ao Peng Han-Yu Wang Fu-Hai Su Pu Wang Hai-An Xu Lin Liu Lun-xuan Yu Ross T.Howie Wan Xu Eugene Gregoryanz Xiao-Di Liu University of Science and Technology of China Hefei 230026China Key Laboratory of Materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China Centre for Science at Extreme Conditions and School of Physics and Astronomy University of EdinburghEdinburgh EH93FDUnited Kingdom Center for High Pressure Science and Technology Advanced Research Shanghai 201203China

High-pressure synthesis of lutetium hydrides from molecular hydrogen(H_(2))and lutetium(Lu)is systematically investigated using synchrotron X-ray diffraction,Raman spectroscopy,and visual *** demonstrate that the reaction pathway between H_(2)and Lu invariably follows the sequence Lu→LuH_(2)→LuH_(3)and exhibits a notable time dependence.A comprehensive diagram representing the formation and synthesis of lutetium hydrides as a function of pressure and time is *** findings indicate that the synthesis can be accelerated by elevated temperature and decelerated by increased ***,two critical pressure thresholds at ambient temperature are identified:the synthesis of LuH_(2)from Lu commences at a minimum pressure of~3 GPa,while~28 GPa is the minimum pressure at which LuH_(2)fails to transform into LuH_(3)within a time scale of *** underscores the significant impact of temporal factors on synthesis,with the reaction completion time increasing sub-linearly with rising ***,the cubic phase of LuH_(3)can be obtained exclusively through compressing the trigonal LuH_(3)phase at~11.5 *** also demonstrate that the bandgap of LuH_(3)slowly closes under pressure and is noticeably lower than that of LuH_(2).

关键词： synthesis ambient representing

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Dual-phase medium-entropy diboride-carbide ceramics with metal element exchange during sintering

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JOURNAL OF ADVANCED CERAMICS 2025年第1期14卷 91-100页

作者： Peng, Pai Liu, Ji-xuan Xin, Xiao-Ting Bao, Weichao Liang, Yongcheng Xu, Fangfang Zhang, Guo-jun Donghua Univ Inst Funct Mat Coll Mat Sci & Engn Coll Phys Shanghai 201620 Peoples R China Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine M Shanghai 200050 Peoples R China

Multiphase composition design is a strategy for optimizing the microstructures and properties of ceramic materials through mutual inhibition of grain growth, complementary property improvement, or even mutually reinforcing effects. More interesting phenomena can be expected if chemical interactions between the constituent phases exist. In this study, spark plasma sintering was used to prepare fully dense dual-phase (Zr,Hf,Ta)B2-(Zr,Hf,Ta)C ceramics from self-synthesized equimolar medium-entropy diboride and carbide powders. The obtained ceramics were composed of two distinct solid solution phases, the Zr-rich diboride phase and the Ta-rich carbide phase, indicating that metal element exchange occurred between the starting equimolar medium-entropy diboride and carbide phases during sintering. Owing to the mutual grain-boundary pinning effect, finegrained dual-phase ceramics were obtained. The chemical driving force originating from metal element exchange during the sintering process is considered to promote the densification process of the ceramics. The metal element exchange between the medium-entropy diboride and carbide phases significantly increased the Young's modulus of the dual-phase ceramics. The dual- phase medium-entropy 50 vol% (Zr,Hf,Ta)B2-50 vol% (Zr,Hf,Ta)C ceramics with the smallest grain size exhibited the highest hardness of 22.4 +/- 0.2 GPa. It is inferred that optimized comprehensive properties or performance of dual-phase high-entropy or medium-entropy ceramics of diborides and carbides can be achieved by adjusting both the volume content and the metal element composition of the corresponding starting powders of diborides and carbides.

关键词： medium-entropy diboride medium-entropy carbide dual-phase medium-entropy ceramics metal element exchange densification mechanical properties

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Mechanistic insights into the amelioration effects of diabetic cardiomyopathy by berberine:an integrated systems pharmacology study and experimental validation

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Traditional Medicine Research 2025年第3期10卷 42-55页

作者： Hui-Min Ji Wen Yang Yu Hua Yi-xuan Sun ao-Di Li Yue Jiang Zi-Qi Ye Min Lei Xi-Ying Guo Xiu-Fen Liu Ning-Hua Wu Huan-Bo Cheng Qing-Jie Chen School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Hubei Key Laboratory of Diabetes and Angiopathy Medicine Research InstituteXianning Medical CollegeHubei University of Science and TechnologyXianning 437100China School of Basic medical Sciences Medicine Research InstituteXianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Jin License Holding Zhengtang Pharmaceutical Co. Ltd.Huangshi 435100China

Background:Diabetic cardiomyopathy(DCM)is a type of cardiomyopathy caused by long-term diabetes,characterized by abnormal myocardial structure and function,which can lead to heart ***(BBR),a quaternary ammonium alkaloid isolated from Coptidis Rhizoma,a traditional Chinese medicine,has superior anti-diabetic and heart-protective *** purpose of this study is to assess the impact of BBR on ***:This study used a systems pharmacology approach to evaluate the related proteins and signalling pathways between BBR and DCM targets,combined with experimental validation using diabetic mouse heart *** and pathological changes were observed using Hematoxylin-eosin,Masson’s trichrome stain and wheat germ agglutinin *** and western blot were used to determine protein ***:The results indicate that BBR and DCM share 21 core relevant targets,with cross-targets predominantly located in mitochondrial,endoplasmic reticulum,and plasma membrane *** exerts its main effects in improving DCM by maintaining mitochondrial integrity,particularly involving the PI3K-AKT-GSK3βand apoptosis signalling *** addition,post-treatment changes in the key targets of BBR,including cysteine aspartate specific protease(Caspase)-3,phosphoinositide 3-kinase(PI3K)and mitochondria-related proteins,are suggestive of its ***:BBR crucially improves DCM by maintaining mitochondrial integrity,inhibiting apoptosis,and modulating PI3K-AKT-GSK3β*** studies must address animal model limitations and validate clinical efficacy to understand BBR’s mechanisms fully and its potential clinical use.

关键词： berberine apoptosis integrated systems pharmacology diabetic cardiomyopathy

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侧面柱碰撞工况电池包碰撞安全性快速预测

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汽车工程 2025年第1期47卷 117-126页

作者：马骋浩申宗玹汪俊敖文宏邢伯斌夏勇清华大学智能绿色车辆与交通全国重点实验室北京100084 中国汽车工程研究院股份有限公司重庆401122 长春理工大学长春130022

为更全面地开展电动汽车侧面柱碰撞安全性分析,采用区域细化方案建立了电池包有限元模型,并应用于整车和电池包两个层级的碰撞仿真。依据事故统计结果,考察了包含国标工况在内不同碰撞速度、位置和角度组合下的整车侧面柱碰撞响应。考... 详细信息

为更全面地开展电动汽车侧面柱碰撞安全性分析,采用区域细化方案建立了电池包有限元模型,并应用于整车和电池包两个层级的碰撞仿真。依据事故统计结果,考察了包含国标工况在内不同碰撞速度、位置和角度组合下的整车侧面柱碰撞响应。考虑到整车层级仿真成本较高,采用碰撞速度调节和质量补偿方法建立了电池包层级参数化模型,用于开展大规模侧面柱碰撞仿真。基于能量法提出了一种电池包层级碰撞响应的快速预测模型,可实时判断不同侧面柱碰撞条件下的电池包变形情况和机械失效风险。经验证,该模型的平均预测误差为3.22%。

关键词：电池包碰撞安全性侧面柱碰撞有限元仿真快速预测

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α相对亚稳β钛合金Ti-5.5Cr-5Al-4Mo-3Nb-2Zr在3.5%NaCl溶液中应力腐蚀行为的影响

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稀有金属材料与工程 2025年第1期54卷 209-217页

作者：刘璇张浩宇王圣元周舸程军陈立佳沈阳工业大学辽宁沈阳110870 西北有色金属研究院陕西西安710016

设计了一种亚稳β钛合金Ti-5.5Cr-5Al-4Mo-3Nb-2Zr,利用不同热处理方式获得3种具有不同α相的微观组织,利用SEM、TEM、电化学实验及慢应变速率拉伸实验研究α相对该合金应力腐蚀行为的影响,结果表明:经过650℃/6 h时效处理次生α_s相粗... 详细信息

设计了一种亚稳β钛合金Ti-5.5Cr-5Al-4Mo-3Nb-2Zr,利用不同热处理方式获得3种具有不同α相的微观组织,利用SEM、TEM、电化学实验及慢应变速率拉伸实验研究α相对该合金应力腐蚀行为的影响,结果表明:经过650℃/6 h时效处理次生α_s相粗化(组织编号:M1),经过两相区的790℃/0.5 h固溶处理形成粗大的初生α_p相(组织编号:M2),经过790℃/0.5 h固溶处理与650℃/6 h时效处理同时存在粗大的初生α_(p)相、细小的次生α_(s)相(组织编号:M3)。电化学实验结果表明M3的自腐蚀电流密度相对最低为1.10×10^(-8)A/cm^(2),极化电阻相对最高为2.30×10^(10)Ω·cm^(2),其耐腐蚀性能最好,其次为M2,M1最差。慢应变速率拉伸实验结果表明M3具有相对最低的应力腐蚀敏感性指数为5.0%,其应力腐蚀开裂敏感性相对最低。该合金的应力腐蚀开裂机制为氢吸附促进位错运动和氢促进局部塑性变形的相互作用。

关键词：亚稳β钛合金应力腐蚀 α相电化学实验慢应变速率拉伸实验

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Broadcast group-oriented encryption secure against chosen ciphertext attack

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Journal of Systems Engineering and Electronics 2007年第4期18卷 811-817页

作者： Ma Chunbo ao jun Li Jianhua School of Information Security Engineering Shanghai Jiaotong Univ. Shanghai 200030 P. R. China The State Key Laboratory of Information Security Beijing 100049 P. R. China State Key Laboratory for Radar Signal Processing Xidian Univ Xi'an 710071 P. R. China

A novel broadcast encryption scheme for group communication scenarios in distributed networks is presented. In the scheme, anyone is allowed to encrypt a message and distribute it to a designated group. Each member in the designated group has the ability to independently decrypt a ciphertext. In contrast to traditional broadcast encryption, all the valid receivers in the proposed scheme compose the designated group. To take advantage of this property, a tab for the group is set and the matching private key for each member is generated. In addition, before decrypting a ciphertext, anyone in the scheme can verify the ciphertext, to ensure that the ciphertext is correct. This property is very important for large-scale group communication, as the gateway can filter incorrect ciphertext and alleviate the receiver＇s workload. Finally, a proof in the random oracle model is given, to show that the proposed scheme is secure against the adaptively chosen ciphertext attack.

关键词： broadcast group-oriented encryption chosen ciphertext attack public verification

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