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Rare Metals 2024年第2期43卷 624-634页

作者： xing-Yuan Zhang Mei-Na Lei Shan Tian Jian-Gan Wang State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU)Xi’an710072China

High-energy-density Li-S batteries are subjected to serious sulfur deactivation and short cycle lifetime caused by undesirable polysulfide shuttle effect and frantic lithium dendrite *** this work,a controllable cage-confinement strategy to fabricate molybdenum carbide(Moc)nanoclusters as a high-efficient sulfiphilic and lithiophilic regulator to mitigate the formidable issues of Li-S batteries is *** sub-2 nm Moc nanoclusters not only guarantee robust chemisorption and fast electrocatalytic conversion of polysulfides to enhance the sulfur electrochemistry,but also homogenize Li^(+) flux to suppress the lithium dendrite *** a consequence,the Moc-modified separator endows the batteries with boosted reaction kinetics,promoted sulfur utilization,and improved cycling stability.A reversible capacity of 701 mAh·g^(−1) at a high rate of 5.0c and a small decay rate of 0.076%per cycle at 1.0c.over 600 cycles are *** study offers a rational route for design and synthesis of bifunctional nanoclusers with both sulfiphilicity and lithiophilicity for high-performance Li-S batteries.

关键词： Li-S batteries Nanocluster Electrocatalyst Polysulfide shuttle Li dendrites

Exploration of the complex origins of primary constipation

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World Journal of clinical cases 2024年第24期12卷 5476-5482页

作者： xing-Lin Zeng Lian-jun Zhu Xiang-Dong Yang Sc.ool of clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina colorectal and Anal Surgery Chengdu Anorectal HospitalChengdu 610015Sichuan ProvinceChina

constipation is a common gastrointestinal disorder characterized by infrequentbowel movements and difficulty in passing *** can significantly affect anindividual's quality of life and overall *** the causes ofconstipation is important for its effective management and *** thispaper,we have reviewed the primary causes of constipation or functional *** constipation is a bowel disorder associated with colonic.oranorectal sensorimotor or neuromuscular *** per the literature,it ismultifac.orial and involves fac.ors such as decreased interstitial cells of cajal,altered colonic motility,enteric nervous system dysfunction,intestinal flora disturbances,and psyc.ological *** symptoms include difficulty indefecation,decreased frequency of defecation,or a feeling of incomplete evacuation.A comprehensive evaluation and management of constipation require aninterdisciplinary approach incorporating dietary modifications,lifestyle changes,pharmacotherapy,and psyc.ological *** research is imperativeto explain the intricate mechanisms underlying constipation and develop targetedtherapies for improved patient outcomes.

关键词： Primary constipation Pathogenesis fac.ors Treatment

开放大学教师发展机制研究——基于组织协同模型的分析视角

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成人教育 2024年第2期44卷 45-52页

作者：邢俊北京开放大学培训学院北京100081

我国开放大学教师发展呈现出顶层设计缺乏、培训力量分散、培训模式单一、学习路径不清晰、行政力量主导被动的发展状态。组织协同模型为开放大学的教师发展机制的建立提供了可行的运行路径。基于开放大学教师发展的独特性、系统性、广... 详细信息

我国开放大学教师发展呈现出顶层设计缺乏、培训力量分散、培训模式单一、学习路径不清晰、行政力量主导被动的发展状态。组织协同模型为开放大学的教师发展机制的建立提供了可行的运行路径。基于开放大学教师发展的独特性、系统性、广泛性,建立专业的开放大学教师发展组织及联盟,以促进开放大学教师教学发展、专业发展、组织发展。

关键词：开放大学教师发展机制组织协同模型

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基于多尺度流模型的视觉异常检测研究

自动化学报 2024年第3期50卷 640-648页

作者：毛国君吴星臻邢树礼福建理工大学计算机科学与数学学院福州350118 福建省大数据挖掘与应用技术重点实验室福州350118

针对现有异常检测(Anomaly detection,AD)模型计算效率低和检测性能差等问题,提出一种多尺度流模型(Multi-scale normalizing flow,MS-Flow),通过多尺度交叉融合实现高效的视觉图像异常识别.具体地,在流模型(Normalizing flow,NF)内部... 详细信息

针对现有异常检测(Anomaly detection,AD)模型计算效率低和检测性能差等问题,提出一种多尺度流模型(Multi-scale normalizing flow,MS-Flow),通过多尺度交叉融合实现高效的视觉图像异常识别.具体地,在流模型(Normalizing flow,NF)内部构建层级式的多尺度架构来避免多通道数据的冗余交叉计算,同时保证网络的多尺度表达能力.此外,设计的层级感知模块通过逐层级的多粒度特征融合,在细粒度级别表达多尺度特征,有效地提高分布估计的精确性.该方法是一个平衡检测精度与计算效率的解决方案.在两个公开数据集上的实验表明,所提方法相较于以往的检测模型能够获得更高的检测精度(在MVTec AD和BTAD数据集上的平均AURoc(Area under the receiver operating characteristics)分别为99.7%和96.0%),同时具有更高的计算效率,浮点运算次数(Floating point operations,FLoPs)约为cS-Flow的1/8.

关键词：异常检测流模型层级感知多尺度特征

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高光谱遥感影像半监督分类研究进展

遥感学报 2024年第1期28卷 20-41页

作者：杨星方乐缘岳俊湖南大学电气与信息工程学院长沙410080 鹏城实验室深圳518055 中南大学自动化学院长沙410083

随着高光谱遥感技术的迅猛发展和应用需求的不断增加,高光谱遥感影像分类成为领域的研究热点。尽管监督学习已在高光谱遥感影像分类中取得了不错的效果,但在许多情况下,获取大规模标记样本来训练监督分类算法是困难和昂贵的。因此,利用... 详细信息

随着高光谱遥感技术的迅猛发展和应用需求的不断增加,高光谱遥感影像分类成为领域的研究热点。尽管监督学习已在高光谱遥感影像分类中取得了不错的效果,但在许多情况下,获取大规模标记样本来训练监督分类算法是困难和昂贵的。因此,利用半监督分类技术对高光谱遥感影像精准分类是一项重要的研究内容。本文首先简要介绍了高光谱遥感影像发展现状和部分应用场景。其次,本文对近年来高光谱遥感影像半监督分类研究的进展进行了综述,着重讨论了低密度分割法、生成式模型、基于分歧(差异)的方法和基于图的方法四种典型半监督分类方法的关键技术和优劣。最后,进一步讨论了半监督分类技术的潜力,为今后研究工作的优化提供思路。

关键词：高光谱遥感影像半监督分类低密度分割法生成式模型图神经网络

Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1

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World Journal of Gastrointestinal oncology 2024年第3期16卷 1006-1018页

作者： jun-jun Lin Ye-cai Lu Department of Gastrointestinal Surgery Chaohu Hospital of Anhui Medical UniversityChaohu 238000Anhui ProvinceChina

BAcKGRoUND colorectal cancer(cRc)is one very usual tumor together with higher death ***-specific protease 21(USP21)has been confirmed to take part into the regulation of cRc progression through serving as a ***,the promotive function of USP21 has also discovered in the progression of ***1 has illustrated to be modulated by USP7,USP22 and USP51 in ***,the regulatory functions of USP21 on ZEB1 in cRc progression need more *** To investigate the relationship between USP21 and ZEB1 in cRc *** The mRNA and protein expressions were assessed through RT-qPcR,western blot and IHc *** interaction between USP21 and ZEB1 was evaluated through co-IP and GST pull down *** cell proliferation was detected through colony formation *** cell migration and invasion abilities were determined through Transwell *** stemness was tested through sphere formation *** tumor growth was evaluated through in vivo mice *** In this work,USP21 and ZEB1 exhibited higher expression in cRc,and resulted into poor ***,the interaction between USP21 and ZEB1 was further *** was demonstrated that USP21 contributed to the stability of ZEB1 through modulating ubiquitination *** addition,USP21 streng-thened cell proliferation,migration and stemness through regulating *** last,through in vivo assays,it was illustrated that USP21/ZEB1 axis aggravated tumor *** For the first time,these above findings manifested that USP21 promoted tumorigenicity and stemness of cRc by deubiquitinating and stabilizing *** discovery suggested that USP21/ZEB1 axis may provide novel sights for the treatment of cRc.

关键词： Ubiquitin-specific protease 21 ZEB1 Stemness colorectal cancer

PRaG 3.0 therapy for human epidermal growth fac.or receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong Kong Mei-Ling Xu jun-jun Zhang Guang-Qiang chen Zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong Zhao chen-Yang Zhang Rong-Zheng chen Peng-Fei xing Li-Yuan Zhang center for cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BAcKGRoUND Pancreatic ductal adenocarcinoma(PDAc)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth fac.or receptor 2(HER-2)immunohistochemistry(IHc)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAc with IHc mismatch repair proficient but HER-2 IHc weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of Rc48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-mac.ophage colony-stimulating fac.or and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral cD8^(+) Temra and cD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAc patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth fac.or receptor 2 Novel combination therapy case report

Long-chain Alkenones in the South Yellow Sea Sediments and Their Indicative Significance for Haptophytes Species

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Journal of ocean University of china 2024年第5期23卷 1287-1296页

作者： XU Yakun YANG Xinxin XIAo Rui xing Lei Key Laboratory of Marine chemistry Theory and Engineering Technology Ministry of EducationOcean University of ChinaQingdao 266100China Laboratory of Marine Ecology and Environment Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

Long-chain alkenones(LcAs)have been widely used as important biomarkers in palaeoceanographic ***,the commonly used LcAs proxies are mainly based on c_(37) alkenones,and it is still lack of the studies about the distribution and in-dications of LcAs with different chain lengths other than c_(37) ***,the composition and distribution of LcAs were ana-lyzed in surface sediments from the southern Yellow Sea(SYS)and a sedimentary core(A02-c)from the central Yellow Sea(YS)mud *** results showed that c_(37),c_(38) and c_(39) alkenones were the major LcAs in surface sediments of the SYS,and the relative contents of c_(38:2)Et,c_(37:2)Me,c_(37:3)Me,c_(38:2)Me,c_(38:3)Et,c_(38:3)Me,c_(39:2)Et and c_(39:3)Et were 18.3%-59.8%,22.6%-41.2%,7.4%-23.0%,6.6%-15.4%,3.8%-13.3%,3.6%-8.7%,2.8%-6.0% and 0.7%-3.0%,*** the relationships of U_(38Me)^(K)-U_(38Et)^(K) and U_(37)^(K')-U_(38Et)^(K) indicate that LcAs are mainly derived from Emiliania huxleyi(***).High ratios of total c_(37) alkenones to total c_(38) alkenones(K_(37)/K_(38))(1-1.2)were found in the central SYS,corresponding to the relatively high abundance of ***;while low ratios of K_(37)/K_(38)(0.7-0.9)were observed at nearshore area of the SYS where Gephyrocapsa oceanica(***)has rela-tively high *** spatial distribution of K_(37)/K_(38) ratio is also consistent with that of coc.olithophores nannofossil in the *** addition,K_(37)/K_(38) ratio in core A02-c varied from 0.7 to 1.1 with a gradual decreasing trend during the past 5.5 *** suggests that the relative abundance of *** decreased gradually,caused by the changes in the Yellow Sea Warm current(YSWc)and the East Asian Winter Monsoon(EAWM)during this period.

关键词： alkenones southern Yellow Sea sediment Yellow Sea Warm current

Risk fac.ors associated with intraoperative persistent hypotension in pancreaticoduodenec.omy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1582-1591页

作者： xing-jun Wang Xi-chen Xuan Zhao-chu Sun Shi Shen Fan Yu Na-Na Li Xue-chun chu Hui Yin You-Li Hu Department of Anesthesia and Perioperative Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BAcKGRoUND Intraoperative persistent hypotension(IPH)during pancreaticoduodenec.omy(PD)is linked to adverse postoperative outcomes,yet its risk fac.ors remain *** To clarify the risk fac.ors associated with IPH during PD,ensuring patient safety in the perioperative *** A retrospective analysis of patient records from January 2018 to December 2022 at the First Affiliated Hospital of Nanjing Medical University identified fac.ors associated with IPH in *** fac.ors included age,gender,body mass index,American Society of Anesthesiologists classification,comorbidities,medication history,operation duration,fluid balance,blood loss,urine output,and blood gas *** was defined as sustained mean arterial pressureolonged deoxyepinephrine infusion for>30 min despite additional deoxyepinephrine and fluid *** Among 1596 PD patients,661(41.42%)experienced *** logistic regression identified key risk fac.ors:increased age[odds ratio(oR):1.20 per decade,95%confidence interval(cI):1.08-1.33](Ponger surgery duration(oR:1.15 per additional hour,95%cI:1.05-1.26)(Pood loss(oR:1.18 per 250-mL increment,95%cI:1.06-1.32)(Povel finding was the association of arterial blood ca^(2+)ol/L with IPH(oR:2.03,95%cI:1.65-2.50)(PcoNcLUSIoN IPH during PD is independently associated with older age,prolonged surgery,increased blood loss,and lower plasma ca^(2+).

关键词： Risk fac.ors Pancreaticoduodenec.omy Perioperative period Intraoperative persistent hypotension Retrospective cohort study

A refined representation method of the particle size distribution curve based on grading entropy

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Partic.ology 2024年第5期88卷 302-311页

作者： xing Li Qun chen Zhaozhao Liu cheng Zhou chen Wang chen chen State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

The particle size distribution(PSD)curve is an important expression of the basic properties of the *** characteristic parameters such as median particle size D_(50),effective particle size D_(10),and some combinations of characteristic parameters can only represent some points of the PSD curve,failing to represent all information of the PSD *** this paper,a fraction characteristic parameter F that could reflect the fraction size variation of the PSD curve was introduced based on grading *** a new presentation method of the A-B-F three parameters was proposed for a refined representation of the PSD *** was found that the newly constructed model not only better represents the differences in the width of PSD curves but also has a higher sensitivity than the A-B two-parameter model proposed by Lő*** PSD curves with similar distributions,the new presentation method has a higher degree of discrimination than that of the D_(50)-c_(u)-c_(c) three-parameter or the four-parameter combination G_(c) proposed by ***,the application of this new method in describing the spatial nonuniformity distribution of depositions and predicting the soil hydraulic conductivity was *** research results can provide a reference for the refined representation of PSD curves.

关键词： Grading entropy Particle size distribution curve Refined representation