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Mechanism and application of an online intelligent evaluation model for energy consumption of a reheating furnace

Journal of Iron and Steel Research International 2023年第1期30卷 102-111页

作者： xiang-jun bao Jing Xu Guang Chen Xu Chen Hong-guang Zhang Yi-ming Shen Wei Zhai Department of Thermal Energy School of Energy and EnvironmentAnhui University of TechnologyMa’anshan 243002AnhuiChina Department of Metallurgical Engineering School of Energy and EnvironmentAnhui University of TechnologyMa’anshan 243002AuhuiChina Department of Construction and Environmental Engineering School of Architectural EngineeringAnhui University of TechnologyMa’anshan 243002AnhuiChina Ma’anshan Iron and Steel Co. Ltd.Ma’anshan 243003AnhuiChina

An online model was proposed to identify the reasons behind changes in the energy consumption of the reheating furnace of a steel processing *** heat conversion of the furnace was analyzed and integrated with the fuel consumption of the furnace to obtain a model of the energy *** with the mechanism analysis,the basic parameters affecting energy consumption were determined,and four key influencing factors were obtained:furnace output,furnace charging temperature,furnace tapping temperature,and steel *** specific calculation method of the contribution of each influencing factor was derived to define the conditions of the baseline energy consumption,while the online data were used to calculate the energy value and the actual performance value of the baseline energy *** contribution of each influencing factor was determined through *** cloud platform was used for database reconstruction and programming to realize the online intelligent evaluation of the energy consumption of the reheating ***,a case study of the evaluation of the practical energy consumption of a steel rolling furnace in a steel plant was *** intelligent evaluation results were quantified and displayed online,and the performance of the system in reducing production line energy consumption was demonstrated.

关键词： Online intelligent evaluation Model mechanism Contribution Data reconstruction

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Overexpression of connexin 45 in rat mesenchymal stem cells improves the function as cardiac biological pacemakers

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Chinese Medical Journal 2010年第12期123卷 1571-1576页

作者： TONG Min YANG xiang-jun GENG bao-yu HAN Lian-huan ZHOU Ya-feng ZHAO Xin LI Hong-xia Department of Cardiology First Affiliated Hospital of SoochowUniversity Suzhou Jiangsu 215006 China

Background Extensive research toward creating a biological pacemaker by enhancement of inward depolarizing current has been performed. However, studies have mainly focused on inducing spontaneous activity and have not adequately addressed ways to improve pacemaker function. In this study we attempted to improve pacemaker function by altering connexin expression in rat mesenchymal stem cells （MSCs） to a phenotype similar to native sinus node pacemaker cells. Methods To generate a biological pacemaker, MSCs were transduced with a cardiac pacemaker gene- hyperpolarization-activated cyclic nucleotide-gated channel 4 （HCN4）, via transfection with a lentiviral vector. Funny current （If） in HCN4~ MSCs was recorded by voltage-clamp. Overexpression of connexin 45 （gene Gja7） in MSCs was achieved by transfection with the plasmid pDsRED2-N1-Gja7-RFP. Double-immunolabelling with anti-connexin 43 and anti-connexin 45 antibodies were used to identify the gap junction channels. The effects of the genetically modified MSCs on cardiomyocyte excitability were determined in MSCs cocultured with neonatal rat ventricular myocytes. Spontaneous action potentials of neonatal rat ventricular myocytes were recorded by current-clamp. Results High level time- and voltage-dependent inward hyperpolarization current that was sensitive to 4 mmol/L Cs＋ was detected in HCN4＋ MSCs, confirming that HCN4 acted as Ir channels in MSCs. Connexin 43 and connexin 45 were simultaneously detected in CX45＋ MSCs. Beating frequency was （82±8） beats per minute （n=-5） in myocytes cocultured with non-transfected control MSCs, versus （129±11） beats per minute （n=-5） in myocytes cocultured with HCN4＋ MSCs. Myocytes cocultured with MSCs cotransfected with HCN4 and connexin 45 had the highest beating frequency at （147±9） beats per minute （n=5）. Conclusion These findings demonstrate that overexpression of connexin 45 and subsequent formation of heteromeric connexin 45/connexin 43 gap junction channels in HCN4 expressing

关键词： pacemaker gap junction hyperpolarization-activated cyclic nucleotide-gated cation channel connexin45 gene therapy heart

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Cholesterol regulates arterial constriction to angiotensin Ⅱ of simulated weightless rats

Cholesterol regulates arterial constriction to angiotensin ...

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第十二届全国营养科学大会

作者： jun-xiang bao Zhong-Chao Wang Yao-Ping Cheng Jin-Ma Xiao-Ping Xie Yao-Ming Chang Department Aerospace Hygiene Fourth Military Medical University

Weightlessness or simulated weightlessness would induce functional adaptation of arteries eliciting postflight orthostatic intolerance, but the change of angiotensin Ⅱ(Ang Ⅱ) elicited vasoconstriction has never been *** are invaginations on cell membrane enriched of cholesterol and sphingolipids crucial for the contraction of vascular smooth muscle cells(VSMCs). We tried to postulate how the vasoconstriction to Ang Ⅱ was adapted by simulated weightlessness, the role of caveolae in the adaptation and whether cholesterol could regulates the effect. 4 wk hindlimb-unweighted(HU) rat was used to simulate the effect of weightlessness. Abdominal aorta(AA), thoracic aorta(TA) and carotid artery(CA) were isolated from control(CON) or HU rats, and then the vasoconstriction to Ang Ⅱ was measured by isometric force recording. Morphology of caveolae was explored by the method of transmission electron microscope(TEM). The binding of angiotensin Ⅱ type 1 receptor(AT1) and caveolin-1(cav-1), the structural protein of caveolae, was detected through coimmunoprecipitation and Western blot. We first found maximal developing force(Emax) of the Ang II elicited vasoconsitriction was decreased in AA, unchanged in TA and increased in CA after HU, while EC50 of the response was increased significantly in all the three arteries so did the extent of AT1 desensitization upon activation. Next, we found caveolae amount on VSMCs of AA, TA and CA was reduced by HU, while the protein content of cav-1 did not change. Ang II promoted the binding of AT1 and cav-1 which could be prevented significantly by HU in all the three arteries. Both the caveolae amount and the binding of AT1 and cav-1 could be recovered by pretreatment of cholesterol(10 m M, 1h). Correspondingly, EC50 of the response, as well as AT1 desensitization in the three arteries were also be reinstated on chol incubation. The result indicates modified caveolae on VSMCs interfere with the binding of AT1 and cav-1 facilitating

关键词： cholesterol caveolae vasoconstrictor reactivity angiotensin Ⅱ,vascular remodeling hindlimb unweighting

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-jun Ma bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal [3 + 2] cycladdition Cu/SPDO complex DFT calculations

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Alterations in arterial responsiveness,superoxide level and VCAM-1 expression of cerebral artery in hindlimb unweighting rats

Alterations in arterial responsiveness,superoxide level and ...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Ran ZHANG,Le-Jian LIN,jun-xiang bao,Yun-Gang BAI,Huan LIU,Jin MA Department of Aerospace Physiology,the Fourth Military Medical University,Xi''an 710032,China

＜正＞The aim of this work was to investigate the effects of simulated microgravity on arterial responsiveness, superoxide levels and VCAM-1 expression of cerebral artery in *** Sprague-Dawley rats were randomly divided into control and hindlimb unweighting *** 4 weeks,arterial responsiveness of middle cerebral artery was determined by pressure *** oxidation-sensitive dye dihydroethidium was used to detect the superoxide levels of basilar artery by laser scanning confocal *** expression of the VCAM-1 protein of the basilar artery was determined by Immunohistochemical staining and Western *** studies showed that 4-week hindlimb unweighting resulted in enhanced myogenic tone and vasoconstrictor responses in middle cerebral *** results revealed positive staining of VCAM-1 on endothelial cells in basilar arteries from HU compared with CON *** blot analysis confirmed an upregulated expression of VCAM-1 protein in these arteries from HU *** superoxide levels were observed in all layers of the basilar arteries from HU *** data suggested that the HU induced enhancement of vasoconstriction may involve alterations in superoxide levels and VCAM-1 content.

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Studies on the Binding of Sodium Dodecyl Sulfate to Cellulase

Studies on the Binding of Sodium Dodecyl Sulfate to Cellulas...

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第七届全国酶学学术讨论会

作者： Jin xiang, jun-bao Fan, Nan Chen, Hong Xu, Yi Liang (Laboratory of Structural Biology, College of Life Sciences, Wuhan University, Wuhan 430072, China, E-mail: liangyi@***)

Lipid-protein interaction is an important and inevitable biological *** low solubility of lipids in water,however,restricts studies on lipid-proteininteraction,and therefore model studies are designed using detergents in place *** are indispensable as solubilizing agents in the isolation andpurification of *** the correct use of detergents it is necessary to have an

关键词： isothermal titration calorimetry fluorescence titration cellulase sodium dodecyl sulfate binding affinity protein unfolding

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痒疹样营养不良型大疱性表皮松解症1例

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中国皮肤性病学杂志 2017年第1期31卷 72-73页

作者：王小兵张磊刘伟军罗保香陈琳琦赵静江西省皮肤病专科医院江西南昌330001

患者女,45岁。臀部、小腿、足背丘疹、斑块、水疱伴瘙痒4年。曾诊断为"湿疹",糖皮质激素治疗无效。臀部、双小腿胫前、足背对称性分布暗红色丘疹及斑块,部分斑块上可见水疱,Nikolsky征阴性,局部见瘢痕及粟丘疹,可见甲营养不良。皮损组... 详细信息

患者女,45岁。臀部、小腿、足背丘疹、斑块、水疱伴瘙痒4年。曾诊断为"湿疹",糖皮质激素治疗无效。臀部、双小腿胫前、足背对称性分布暗红色丘疹及斑块,部分斑块上可见水疱,Nikolsky征阴性,局部见瘢痕及粟丘疹,可见甲营养不良。皮损组织病理示:表皮下水疱形成,疱内未见嗜酸性粒细胞,直接免疫荧光结果 Ig G,Ig A,Ig M,C3均阴性。诊断:痒疹样营养不良型大疱性表皮松解症。

关键词：表皮松解大疱性营养不良型痒疹样

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Adaptive sampling for mesh spectrum editing

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第7期7卷 1193-1200页

作者： ZHAO xiang-jun ZHANG Hong-xin bao Hu-jun State Key Lab of CAD ＆ CG Zhejiang University Hangzhou 310027 China College of Computer Science and Engineering Xuzhou Normal University Xuzhou 221116 China

A mesh editing framework is presented in this paper, which integrates Free-Form Deformation (FFD) and geometry signal processing. By using simplified model from original mesh, the editing task can be accomplished with a few operations. We take the deformation of the proxy and the position coordinates of the mesh models as geometry signal. Wavelet analysis is em- ployed to separate local detail information gracefully. The crucial innovation of this paper is a new adaptive regular sampling approach for our signal analysis based editing framework. In our approach, an original mesh is resampled and then refined itera- tively which reflects optimization of our proposed spectrum preserving energy. As an extension of our spectrum editing scheme, the editing principle is applied to geometry details transferring, which brings satisfying results.

关键词： Mesh editing Adaptive sampling Digital geometry processing

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液化石油气与煤气中毒检验的异同

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中国司法鉴定 2004年第1期 15-17页

作者：卓先义卜俊向平沈保华司法部司法鉴定科学技术研究所上海200063

目的研究液化石油气与煤气中毒鉴定的异同。方法将实验小白鼠、SD大鼠及家兔分别经液化石油气和煤气染毒,测定中毒后血中碳氧血红蛋白饱和度(HbCO%)及丙烷。结果煤气中毒家兔体内碳氧血红蛋白饱和度达及49.95%;煤气中毒死亡小白鼠及... 详细信息

目的研究液化石油气与煤气中毒鉴定的异同。方法将实验小白鼠、SD大鼠及家兔分别经液化石油气和煤气染毒,测定中毒后血中碳氧血红蛋白饱和度(HbCO%)及丙烷。结果煤气中毒家兔体内碳氧血红蛋白饱和度达及49.95%;煤气中毒死亡小白鼠及大鼠体内HbCO%大于60%;液化石油气中毒死亡的家兔、小白鼠及大鼠血中检出丙烷,而体内HbCO%与正常的家兔、小白鼠及大鼠体内HbCO%无明显差异。结论煤气中毒可通过测定其体内HbCO%进行鉴定;液化石油气中毒后体内HbCO%未见明显升高,可通过测定血中丙烷进行鉴定。

关键词：液化石油气煤气中毒检验检验方法检查工作

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Alterations of coronary arterial reactivity in simulated microgravity rats

Alterations of coronary arterial reactivity in simulated mic...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Yu-Yang ZHANG~1,Ran ZHANG~1,Yun-Gang BAI~2,jun-xiang bao~2,Hao TANG~2,Le-Jian LIN~2,Jiu-Hua CHENG~2, Hai-Chang WANG~1,Jin MA~2 1 Department of Cardiovascular Diseases,Xijing Hospital 2 Department of Aerospace Physiology,the Fourth Military Medical University,Xi''an 710032,China

＜正＞To investigate the alterations of small coronary arteries caused by microgravity and the relationship between coronary arterial adaptive changes and postflight orthostatic intolerance,we established simulated microgravity rat model by 4-week tail suspension（TS）,studied alterations in arterial reactivity of small coronary arteries through isolated arteries ring technology,observed ultrastructure changes of coronary arteries,and measured the endothelial nitric oxide synthase（eNOS） and inducible nitric oxide synthase（iNOS） protein expressions by Western blot analysis. Data derived from our study demonstrates that the KCl/phenylephrine（PE）-induced vasoconstrictive function and acetylcholine（ACh）/sodium nitroprusside（SNP）-induced vasodilative function were decreased in the isolated arteries from TS rats（P＜0.05）.The sensitivity of small coronary arterial rings to KCl/ACh was significantly decreased in TS rats（P＜0.05）.Pathological ultrastructural changes were observed in the coronary arterial endothelium of TS *** eNOS protein expression in the coronary arteries of TS rats was attenuated（P＜0.05） and no detectable expression of iNOS protein was observed in either TS or CON *** conclusion,our study provides evidence that low homodynamic state of coronary system induced by simulated microgravity may cause functional and structural adaptive changes of coronary arteries and it may participate in the mechanism of postflight orthostatic intolerance.

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