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Progress in Natural Science:Materials International 2019年第3期29卷 356-361页

作者： Haijun Wu Xiaoqing Zuo Shanpeng Wang jun-wen yin Yan-Ning Zhang Jialin Chen School of Materials Science and Engineering Kunming University of Science and Technology State Key Laboratory of New Technologies for Comprehensive Utilization of Rare and Precious Metals Beijing Computational Science Research Center Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China

Design efficient electrocatalysts become significant for the hydrogen evolution reaction （HER） in alkaline ***,the HER performance on Pt-Co（OH）2 has been investigated by using DFT *** with pure Pt,the Pt-Co（OH）2 shows excellent hydrogen binding energy （-0.29 eV） and hydrogen adsorption free energy （0.02 eV）.More strikingly,the water dissociation process on Pt-Co（OH）2 is an exothermic reaction while that of Pt is an endothermic reaction,demonstrating that the Pt-Co（OH）2is an excellent catalyst for HER in alkaline *** the two-step electrodepositions was used to fabricate Pt-Co（OH）2 on the carbon paper （CP）.The Pt-Co（OH）2/CP shows the lowest overpotential of only 37.6 mV at a current density of 10 mA cm-2in 0.1M KOH,the smallest Tafel slope of58 mV dec-1and the good stability for 20000s without obvious degradation.

关键词： OH Theoretical and experimental design of Pt-Co HER electrocatalyst for efficient HER performance in alkaline solution

NUMERICAL SIMULATION AND ANALYSIS ON THE HEMODYNAMICS OF AN ELASTIC ANEURYSM

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Journal of Hydrodynamics 2008年第2期20卷 216-224页

作者： ZHAO jun-wei yin wen-yi DING Guang-hong YANG Xin-jian SHI Wan-chao ZHANG Xiao-long Department of Mechanics and Engineering Science Fudan University Shanghai 200433 China Beijing Institute ofNeurosurgery Beijing 100050 China Huashan Hospital Affiliated to Fudan University Shanghai 200040 China

Intracranial aneurysms are pathological dilatations which endanger people＇s health. Hemodynamics is thought to be an important factor in the pathogenesis and treatment of aneurysms. To date, the bulk of investigations into hemodynamics have been conducted by making use of mathematically idealized models for rigid aneurysms and associated arteries. However the walls of aneurysms and associated arteries are elastic in vivo. This study shows the differences of the simulation between elastic and rigid wall models. The numerical simulation of elastic aneurysm model is made fi＇om a representative Digital Subtraction Angiography （DSA） image and calculated with CFD software to get the wall deformation and the velocity field. Then the results are analyzed. By comparing the simulation results of the two models from their velocity vectors and shear stress distribution, many differences can be noted. The main difference exists in the distribution of velocity magnitude at some sections, with one outlet having obviously off-center distribution for the elastic wall model. The currents of the distribution of wall shear stress along the wall of aneurysm simulated in rigid and elastic wall models were similar. But there were apparent differences between the two models on the values of wall shear stress especially at the neck of aneurysm. The off-center distribution of velocity magnitude affects the distribution of wall shear stress and the exchange of substance through the wall. The analysis demonstrated clearly that the results of 2-D elastic numerical simulation were in good agreement with the clinical and pathological practice. The results of this study play an important role in the formation, growth, rupture and prognosis of an aneurysm on clinic application.

关键词： aneurysm 2-D numerical simulation elastic wall medical image

A Novel Chinese Equation for Accurately Estimating Glomerular Filtration Rate:a Multi-center Large Study

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A Novel Chinese Equation for Accurately Estimating Glomerula...

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

2018年中国药理学会定量药理学专业委员会学术年会

作者： Dai-yang Li wen-jun yin Ling-yun Zhou Xiao-cong Zuo Department of Pharmacy The Third Xiangya HospitalCentral South University

Objective Glomerular filtration rate(GFR) is the best index of renal function but hard to directly measure,thus,using estimated GFR(eGFR) equations clinically becomes *** the inaccuracy of existing eGFR equations in Chinese,we aimed to develop a new eGFR equation in 2772 patients(1730 for development and 1042 for internal validation) and validated in 5799 patients(external validation) in 3 representative Class-Ⅲ/Grade-A hospitals from 2 regions of *** After excluding patients using drugs affecting serum creatinine(Scr) to improve accuracy,we established a novel eGFR equation(Xiangya equation) by linear regression,taking Tc-DTPA renal dynamic imaging as *** addition,we first evaluated the performance of 12 Scrbased eGFR equations including C-G,MDRD,CKD-EPI,and published Chinese/Asian equations in a multi-center Chinese large *** In equation development and internal validation,Xiangya equation performed better than other 12 equations in both inpatients and outpatients,especially with better accuracy(30% accuracy [P30],79.21% and 84.33%,respectively).Results of external validation showed that Xiangya equation yielded the greatest P among all eGFR equations,and P for other 12 reported equations was<75%(P≥75% is considered sufficient for making good clinical decisions based on K/DOQI Guidelines),less than that of the Xiangya *** This new equation could replace other existing eGFR equations and will be widely used for Chinese general clinical use.

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian yin Fan wen Zhigang Tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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不同灌溉定额对枸杞生长和产量的影响

节水灌溉 2016年第10期 6-9,14页

作者：马旭郑艳军李文证尹娟宁夏回族自治区同心县水利局宁夏吴忠750013 宁夏大学土木与水利工程学院银川750021 旱区现代农业水资源高效利用教育部工程中心银川750021 宁夏节水灌溉与水资源调控工程技术研究中心银川750021

针对宁夏同心县枸杞灌溉水资源紧缺的生产实际,采用大田滴灌试验,研究了不同灌溉定额、不同种植方式(覆膜和不覆膜)对枸杞的生长及产量的影响。研究结果表明:1灌溉定额为1 620m3/hm2时,枸杞枝条长度最大;覆膜与不覆膜枸杞枝条生长速度... 详细信息

针对宁夏同心县枸杞灌溉水资源紧缺的生产实际,采用大田滴灌试验,研究了不同灌溉定额、不同种植方式(覆膜和不覆膜)对枸杞的生长及产量的影响。研究结果表明:1灌溉定额为1 620m3/hm2时,枸杞枝条长度最大;覆膜与不覆膜枸杞枝条生长速度均在开花初期最快;与覆膜相比,不覆膜的枸杞枝条生长速度峰值推迟10d出现;2覆膜和不覆膜条件下,灌溉定额为1 620m3/hm2时叶绿素含量均最高;灌溉定额一定时,覆膜的叶绿素含量高于不覆膜的;3覆膜和不覆膜条件下,灌溉定额为1 620m3/hm2时,枸杞产量均最高;当灌溉定额小于等于1 620m3/hm2时,覆膜的产量比不覆膜的高,当灌溉定额大于1 620m3/hm2时,覆膜的产量比不覆膜的低;当灌溉定额小于等于1 620m3/hm2时,枸杞产量随着灌水量的增加而增加,当灌溉定额大于1 620m3/hm2时,枸杞产量随着灌水量的增加而降低,说明过多的灌水不利于枸杞生长。覆膜滴灌条件下,灌溉定额为1 620m3/hm2适合在当地枸杞高效节水生产中推广应用。

关键词：枸杞灌溉定额覆膜产量生长

Engineering of Fe d-band center in Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles via orbital coupling for high-efficiency oxygen reduction electrocatalysis

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Nano Research 2025年第1期18卷 129-139页

作者： Jiayi Liu Jingwen yin yingzi Lin Mingxin Pang Huan Pang Songtao Zhang Lin Xu jun Yang Yawen Tang Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023Chin a 2 State Key Laboratory of Multiphase Complex Systems Center of MesoscienceInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009China Testing Center Yangzhou UniversityYangzhou 225009China

The deliberate engineering of the d-band center of metal site represents an effective strategy to boost the intrinsic electrocatalytic performance toward the oxygen reduction reaction(ORR).Herein,following a heterointerfaceinduced orbital coupling rationale,we report a judicious design of an efficient ORR electrocatalyst consisting of Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles in-situ encased into N-doped carbon nanofibers(abbreviated as Fe_(3)O_(4)/CeO_(2)@N-CNFs hereafter).The theoretic calculations uncover that the Fe_(3)O_(4)/CeO_(2)heterointerface-triggered orbital coupling can cause the down shift of the d-band center positions of Fe sites,which leads to the weakened chemisorption of oxygenated groups and lowered energy barrier for the potential-determining step,ultimately dramatically boosting the ORR intrinsic *** a consequence,the well-designed Fe_(3)O_(4)/CeO_(2)@N-CNFs display admirable ORR activity with a half-wave potential of 0.84 V and outstanding structural/electrochemical stability in an alkaline electrolyte,surpassing the commercial Pt/C benchmark and a majority of recently reported Fe_(3)O_(4)-based *** encouragingly,the Fe_(3)O_(4)/CeO_(2)@N-CNFsincorporated Zn-air battery outperforms the Pt/C-assembled counterpart with higher power density,larger energy density,and excellent cycling stability,serving as a competent candidate for ORR-involved renewable energy *** study offers an innovative approach for the rational manipulation of the d-band center and interfacial electron behavior of active sites toward the optimization of electrocatalytic performance.

关键词： hetero-nanoparticles electrospinning interfacial engineering orbital coupling oxygen reduction reaction

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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi Dennis Yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run Song Shiyi yin Jiannan Wu junqiang Yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

天津海河流域水中细菌抗消毒剂基因检测与大肠杆菌对苯扎溴铵抗性研究

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中国消毒学杂志 2017年第5期34卷 397-400页

作者：乐凯强王华然杨忠委李君文尹静军事医学科学院卫生学环境医学研究所天津300050

目的了解天津海河流域水体中细菌抗消毒剂基因携带情况与大肠杆菌对季铵盐类消毒剂抗性水平,为季铵盐类消毒剂安全性评价提供依据。方法采用PCR技术和肉汤稀释法,对海河流域水样进行抗消毒剂基因检测与大肠杆菌对季铵盐类抗性水平进行... 详细信息

目的了解天津海河流域水体中细菌抗消毒剂基因携带情况与大肠杆菌对季铵盐类消毒剂抗性水平,为季铵盐类消毒剂安全性评价提供依据。方法采用PCR技术和肉汤稀释法,对海河流域水样进行抗消毒剂基因检测与大肠杆菌对季铵盐类抗性水平进行研究。结果从海河流域8处水样中,均检出qacE、qacE△1和qacG基因,其中6处水样检出ydgE和ydgF基因,4处水样检出sugE(p)和emrE基因,所有水样中均未检出qacA/B基因。苯扎溴铵对海河水中细菌的MIC值和MBC值均≥90 mg/L,高于大肠杆菌标准株的60 mg/L。结论天津海河流域存在抗苯扎溴铵的细菌,细菌季铵盐类消毒剂抗性基因携带率较高。

关键词：海河流域水体抗消毒剂基因苯扎溴铵