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Linkage Map Construction and Quantitative Trait Loci Analysis for Bolting Based on a Double Haploid Population of Brassica rapa

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Journal of Integrative Plant Biology 2007年第5期49卷 664-671页

作者： xu Yang Yang-jun Yu Feng-Lan Zhang Zhi-Rong Zou Xiu-Yun Zhao De-Shuang Zhang Jia-Bing xu College of Horticulture Northwest A & F University Yangling 712100 China National Engineering Research Center for Vegetables Beijing 100089 China

Early bolting of Chinese cabbage （Brassica rapa L.） during spring cultivation often has detrimental effects on the yield and quality of the harvested products. Breeding late bolting varieties is a major objective of Chinese cabbage breeding programs. In order to analyze the genetic basis of bolting traits, a genetic map of B. rapa was constructed based on amplified fragment-length poiymorphism （AFLP）, sequence-related amplified poiymorphism （SRAP）, simple sequence repeat （SSR）, random amplification of polymorphic DNA （RAPD）, and isozyme markers. Marker analysis was carried out on 81 double haploid （DH） lines obtained by microspore culture from F1 progeny of two homozygous parents： B. rapa L. ssp. pekinensis （BY）（an extra-early bolting Chinese cabbage line） and B. rapa L. ssp. rapifera （MM）（an extra-late bolting European turnip line）. A total of 326 markers including 130 AFLPs, 123 SRAPs, 16 SSRs, 43 RAPDs and 14 isozymes were used to construct a linkage map with 10 linkage groups covering 882 cM with an average distance of 2.71 cM between loci. The bolting trait of each DH line was evaluated by the bolting index under controlled conditions. Quantitative trait loci （QTL） analysis was conducted using multiple QTL model mapping with MapQTL5.0 software. Eight QTLs controlling bolting resistance were identified. These QTLs, accounting for 14.1% to 25.2% of the phenotypic variation with positive additive effects, were distributed into three linkage groups. These results provide useful information for molecular marker-assisted selection of late bolting traits in Chinese cabbage breeding programs.

关键词： bolting index Chinese cabbage doubled haploid population genetic map quantitative trait Ioc

Clinical development of CAR T cell therapy in China:2020 update

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Cellular & Molecular Immunology 2021年第4期18卷 792-804页

作者： Jianshu wei Yelei Guo Yao Wang Zhiqiang Wu Jian Bo Bin Zhang jun Zhu weidong Han Department of Bio-Therapeutic The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Hematology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Hematopoietic Stem Cell Transplantation The Fifth Medical CenterChinese PLA General HospitalBeijing 100071China Key Laboratory of Carcinogenesis and Translational Research Departments of LymphomaRadiology and Nuclear MedicinePeking University Cancer Hospital and InstituteBeijing 100036China

Chimeric antigen receptor(CAR)T-cell therapy has achieved significant success in the treatment of hematological *** recent years,fast-growing CAR T clinical trials have actively explored their potential application *** to the data from the *** website,China became the country with the most registered CAR T trials in September *** of june 30,2020,the number of registered CAR T trials in China has reached *** addition,as many as 150 other CAR T trials have been registered on *** CAR T therapy is flourishing in China,there are still some problems that cannot be *** this review,we aim to systematically summarize the clinical practice of CAR T-cell therapy in *** review will provide an informative reference for colleagues in the field,and a better understanding of the history and current situation will help us more reasonably conduct research and promote cooperation.

关键词： chimeric antigen receptor clinical trials China

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考虑现实约束的模糊多准则投资组合优化模型

系统工程理论与实践 2013年第10期33卷 2462-2470页

作者：刘勇军张卫国徐维军华南理工大学工商管理学院广州510640

针对模糊环境中资产收益和换手率均为模糊变量的投资组合问题,考虑了资产组合的基数约束、投资比例的边界约束、资产的流动性以及分散化程度约束,建立了一个以资产组合收益、偏度最大,同时资产组合风险、不确定性以及模糊性最小为目标... 详细信息

针对模糊环境中资产收益和换手率均为模糊变量的投资组合问题,考虑了资产组合的基数约束、投资比例的边界约束、资产的流动性以及分散化程度约束,建立了一个以资产组合收益、偏度最大,同时资产组合风险、不确定性以及模糊性最小为目标的多准则投资组合优化模型.然后,利用加权极大-极小模糊目标规划方法将所提出的模型转化为单目标规划问题,进而设计了一个遗传算法来对其进行求解.最后,通过一个实例来阐明所提出模型的实用性以及算法的有效性.研究结果表明:本模型能够有效地刻画不同投资者的投资意图,所设计的算法是有效的.

关键词：投资组合现实约束多准则决策遗传算法

Sphincter of Oddi laxity:An important factor in hepatolithiasis

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World Journal of Gastroenterology 2010年第8期16卷 1014-1018页

作者： Liang, Ting-Bo Liu, Yu Bai, xue-Li Yu, jun Chen, wei Zhejiang Univ Affiliated Hosp 1Dept Hepatobiliary & Pancreat S Key Lab Multiorgan TransplantatMinist Publ Hlth Key Lab Organ Transplantat Zhejiang ProvSch Med Hangzhou 310003 Zhejiang Peoples R China

AIM:To evaluate the importance of sphincter of Oddi laxity (SOL) in hepatolithiasis (HL).METHODS:Subjects included 98 patients diagnosed with HL between 2002 and 2007. Detailed histories were taken and the subjects were monitored until July 2008. HL patients were divided into two groups:Group included 45 patients with SOL,and Group included 53 patients without. Recurrence and reoperation indices of both groups were calculated and ***:The recurrence index was 0.135 in Group and 0.018 in Group fldex was 0.070 in Group and 0.010 in Group (P <0.001). The mean frequency of biliary operation was 2.07in Group (P = 0.001). Differences between the two groups are ***:HL patients with SOL tend to have a higher risk of recurrence and a larger demand for re-operation than those without this condition.

关键词： Sphincter of Oddi laxity Hepatolithiasis Recurrence index Reoperation index Choledochojeju-nostomy

Role of magnetic fields on the outer crust in a magnetar

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Chinese Physics C 2024年第7期48卷 160-167页

作者：蒋威陈晏军 Department of Physics and Electronic Science Changsha University of Science and TechnologyChangsha 410114China Hunan Provincial Key Laboratory of Flexible Electronic Materials Genome Engineering Changsha 410114China

We explore the properties of 4110 nuclides from Z=5 to Z=82 with the Sky3D code and the composition of the outer crust in magnetars under extreme magnetic *** effects of the variation in nuclear masses due to magnetic fields on the outer crust are comprehensively *** neutron-drip transition pressure,equation of state,and neutron fraction in the outer crust are also discussed.

关键词： outer crust in a magnetar magnetic fields nuclear masses Sky3D code

Application of Omega vortex identification method in cavity buffeting noise

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Journal of Hydrodynamics 2021年第2期33卷 259-270页

作者： Yang-hui Zhang Xing-jun Hu wei Lan Yi-chen Liu Mo Wang Jing-yu Wang State Key Laboratory of Automobile Simulation and Control Jilin UniversityChangchun 130025China

The cavity buffeting noise is related to the free shear layer oscillation and the periodic vortex shedding,where weak vortices coexist with strong vortices and the strong shear phenomenon also exists at the opening of the ***,it is of great significance to accurately capture vortices at the opening for the control of the cavity buffeting *** paper first compares the Omega vortex identification method with the Q andλ2criteria based on the large eddy simulation(LES)of the backward-facing step flow,and it is found that the Omega method enjoys the following advantages:it is not sensitive to a moderate threshold change andΩ=0.52 can be used as a fixed threshold,it can capture both the strong and weak vortices at the same time;and it will not be contaminated by the *** the Omega(Ω)method is applied to the LES of the cavity buffeting noise:the mechanism of the cavity buffeting noise is studied based on a simple cavity model firstly,and then the effects of the incoming boundary layer thicknesses and the incoming boundary layer shapes on the cavity buffeting noise are *** results show that:theΩmethod clearly captures the processes of the vortex generation,development,collision and fragmentation,verifying that the generation of the cavity buffeting noise is related to the free shear layer oscillation and the periodic vortex shedding;as the thickness of the incoming boundary layer increases,the free shear layer becomes more stable and the Helmholtz resonance is avoided effectively,thereby the cavity buffeting noise is reduced effectively,adding a convexity upstream of the cavity opening to interfere the shape of the incoming boundary layer to reduce the acoustic feedback effect can reduce the cavity buffeting noise effectively.

关键词： Vortex identification Omega(Ω) buffeting noise boundary layer

Guest ions pre-intercalation strategy of manganese-oxides for supercapacitor and battery applications

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Journal of Energy Chemistry 2021年第9期30卷 480-493页

作者： Lina Chen Chongyang Hao Yamin Zhang Youri wei Linna Dai jun Cheng Hongqiang Zhang Lijie Ci State Key Lab of Advanced Welding and Joining School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055GuangdongChina Key Laboratory for Liquid-Solid Structural Evolution&Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061ShandongChina

Optimization of intrinsic structure of electrode materials plays decisive roles in promoting the development of energy storage systems to meet the fast-growing requirements in the *** engineering has been proved to be an effective way to obtain adequate active sites,preferable ion diffusion channels and stable structure,thus enhance the performance of *** in-depth understanding of the correlation among synthesis,structure and performance will significantly promote the development of excellent materials and energy storage ***,in this review,recent advances in regards to cation preintercalation engineering in Mn-based electrode materials for rechargeable metal ion batteries are systematically *** guest cations can expand interlayer space to promote ion diffusion kinetics,serve as pillars to stabilize structure,control composition and valence to switch electrochemical behavior,thus improve the overall performance of secondary ***,the existing challenges and perspectives are provided for the interlayer engineering and its promotion to battery industry.

关键词： Interlayer engineering Electrode materials Energy storage devices

Data Mining and Systems Pharmacology to Elucidate Effectiveness and Mechanisms of Chinese Medicine in Treating Primary Liver Cancer

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Chinese Journal of Integrative Medicine 2022年第7期28卷 636-643页

作者： ZHANG Zhen LI jun-wei ZENG Pu-hua GAO Wen-hui TIAN xue-fei Department of Internal Medicine College of Integrated Chinese and Western Medicine of Hunan University of Chinese MedicineChangsha 410208China Hunan Key Laboratory of TCM Prescription and Syndromes Translational Medicine Hunan University of Chinese MedicineChangsha 410208China Department of Pharmacy Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina the First Affiliated Hospital Southern University of Science and Technology)5.Department of OncologyAffiliated Hospital of Hunan Academy of Traditional Chinese MedicineChangsha 410006China

Objective: To identify specific Chinese medicines(CM) that may benefit patients with primary liver cancer(PLC), and to explore the mechanism of action of these medicines. Methods: In this retrospective, singlecenter study, prescription information from PLC patients was used in combination with Traditional Chinese Medicine Inheritance Supports System to identify the specific core drugs. A system pharmacology approach was employed to explore the mechanism of action of these medicines. Results: Taking CM more than 6 months was significantly associated with improved survival outcomes. In total, 77 putative targets and 116 bioactive ingredients of the core drugs were identified and included in the analysis(Pjun and interleukin-6. Conclusions: Receiving CM for 6 months or more improves survival for the patients with PLC. The core drugs that really benefit for PLC patients likely regulates the tumor microenvironment and tumor itself.

关键词： Chinese medicine primary liver cancer system pharmacology bioinformatics tumor microenvironment

A decrease in macular microvascular perfusion after retinal detachment repair with silicone oil

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 875-880页

作者： wei Fang Jing Zhai Jian-Bo Mao Hai-Dong Li Zhen-Bin Qian Chao-Qiao Chen Jia-Hao xu Li-jun Shen Yi-Qi Chen The Eye Hospital of Wenzhou Medical University School of Opthalmology&OptometryWMUZhejiang Eye HospitalHangzhou 310000Zhejiang ProvinceChina

AIM:To observe whether silicone oil(SO)tamponade could decrease macular perfusion after retinal detachment ***:A prospective observational case-control *** diagnosed with primary macular off rhegmatogenous retinal detachment undergoing successful retinal repair surgery with vitrectomy were strictly *** coherence tomography angiography findings were compared between SO and air tamponade *** postoperative visiting points were set(1 and 3 mo).RESULTS:Totally 29 patients(29 eyes)were *** cases had SO tamponade while 9 cases were with air *** the first visiting point,superficial parafoveal vessel density(PFSVD)significantly decreased in the SO group(P=0.0403),especially in the superior quadrant or superior-hemi area(P=0.0089,0.0426,respectively).Parafoveal deep vessel density(PFDVD)had no difference between the two *** the second visiting point,all quadrants of PFSVD reduced significantly in the SO group(P=0.0256,0.0001,0.0031,<0.0001 in temporal,superior,nasal,and inferior area,respectively),but PFDVD remained no *** the air group,all areas of PFSVD showed significantly improving from the first visit to the second one(P=0.0324,0.0001,0.0371,0.0026,in temporal,superior,nasal,and inferior area,respectively);however,almost all quadrants of PFDVD showed no changes during this *** the SO group,both PFSVD and PFDVD showed no obvious changes between the two visiting ***,parafoveal full retinal thickness in the SO group reduced significantly at both visiting points over the air tamponade,while the foveal avascular zone area showed no difference in the two ***:After retinal detachment surgery with vitrectomy and SO tamponade,superficial macular perfusion and full retinal thickness could decrease obviously when compared to air *** reduction process could persist throughout the tamponade period.

关键词： macular perfusion vessel density silicone oil optical coherence tomography angiography retinal detachment