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Efficacy and safety of Cimicifuga foetida extract on menopausal syndrome in Chinese women

Chinese Medical Journal 2013年第11期126卷 2034-2038页

作者： ZHENG Ting-ping SUN Ai-jun XUE wei wang Ya-ping JIANG Ying ZHANG Ying LANG Jing-he Department of Obstetrics and Gynecology Peking Union MedicalCollege Hospital Chinese Academy of Medical Sciences & PekingUnion Medical College Beijing 100730 China

Background It is now recognized that Cimicifuga foetida extract is effective in alleviating menopausal symptoms. But the durations reported were usually short. This paper compares the clinical effects of different regimens of three-month course on climacteric symptoms in Chinese women, so as to evaluate the efficacy and safety of Cimicifuga foefida extract. Methods This was a prospective, randomized trial. Ninety-six early menopausal women were recruited and randomly assigned into 3 groups to take different kinds of medicine for 3 months; participants were given Cimicifuga foefida extract daily in group A （n=32）, given estradiol valerate and progesterone capsule cycle sequentially in group B （n=32）, and given estradiol valerate and medroxyprogesterone acetate cycle sequentially in group C （n=32）. The questionnaires of Kupperman menopause index, Menopause-Specific Quality of Life, and Hospital Anxiety and Depression Scale were finished before and after the treatment. The status of vaginal bleeding and breast tenderness was recorded every day. Results Eighty-nine participants （89/96, 92.7%） completed the treatment. Kupperman menopause index decreased after taking the medicine for 3 months in each group （with all P〈0.001）, but the score after the treatment was higher in group A than in the other 2 groups. Except for the score of sexual domain in group A （P=0.103）, the scores of all domains of the Menopause-Specific Quality of Life decreased significantly after the treatment in all groups （with all P〈-0.01）. Score of anxity decreased significantly in group A （P=0.0l 5） and B （P=0.003）. Incidence of breast tenderness was 12.9% （4/31） in groupA, 36.7% （11/30） in group B, and 14.3% （4/28） in group C. Incidence of vaginal bleeding was 6.5% （2/31）in group A, 26.7% （8/30） in group B, and 82.1% （23/28）in group C. Conclusions Cimicifuga foeticla extract is effective and safe in the treatment of menopausal syndrome. It is worth extending its use in the treatment of climacteric c

关键词： Cimicifuga foetida extract menopause Kupperman menopause index menopause-specific quality of life vaginal bleeding breast tenderness

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Effects of somatostatin analogues on human sphincter of Oddi pressure

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 302-305页

作者： Shuo-Dong Wu, Zhen-Hai Zhang, Jing Kong, Yan-jun Li, jun-Zhe Jin, wei wang, Dong-Yan Li and Min-Fei wang Shenyang, China No.2 Department of General Surgery, Second Affilia- ted Hospital, China Medical University, Shenyang 110004, China Department of General Surgery Second Affiliated Hospital China Medical University Shenyang 110004 China. wushuodong@***

BACKGROUND: Somatostatin, a neuropeptide and hor- mone , exists in the biliary tract of several species. The effects of somatostatin and its analogues on the sphincter of Oddi motility have been controversial. The aim of this study was to observe the action of stilamin and sandostatin on the sphincter of Oddi via choledochofiberscope manometry. METHODS: Twenty patients who had had'T' duct after cholecystectomy and choledochotomy were divided into 2 groups randomly: stilamin and sandostatin. They were subjected to manometry via a choledochofiberscope through the'T' duct tract. The following data recorded in- cluded duodenal pressure (DP), sphincter of Oddi basal pressure (SOBP), sphincter of Oddi contractive amplitude (SOCA), frequency of the sphincter of Oddi (SOF), dura- tion of the sphincter of Oddi, and the common bile duct pressure (CBDP). RESULTS: After intravenous administration of stilamin at a dose of 250 μg/h, the mean SOCA increased from 89.18 (26.50) to 128.57(54.21) mmHg (P <0.05). After the ad- ministration of stilamin at a dose of 500 μg/h the mean SO- CA declined to 92.18(42.81) mmHg (P<0.05), and mean SOBP declined from 17.63(13.36) to 8.16(4.01) mmHg (P<0.05). Although SOF had declined from 9.25(2.45) to 7.46(1.52) n/min, it was not significantly influenced. After intravenous administration of sandostatin at a dose of 100 μg, the mean CBDP increased obviously. CONCLUSIONS: Intravenous administration of stilamin at a dose of 250 μg/h stimulates the motility of the sphincter of Oddi whereas the injection of stilamin at a dose of 500 μg/h inhibits its motility. Intravenous injection of sandosta- tin of 100 μg has no effect on the sphincter of Oddi.

关键词： biliary manometry via choledochofiberoscopy sphincter of Oddi somatostatin stilamin sandostatin

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-jun Zhang Wen-wei wang Jing-Shui Zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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固定化酶法高效制备低聚异麦芽糖

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中国食品学报 2017年第8期17卷 101-108页

作者：王君李玮王雪荣毛淑红路福平王正祥天津科技大学化工与材料学院天津300457 山西农业大学食品科学与工程学院山西太谷030801 天津科技大学生物工程学院天津300457

低聚异麦芽糖是一种重要的功能性低聚糖,主要通过酶法转化麦芽糖或麦芽三糖制得。本研究采用环氧基树脂对黑曲霉α-葡萄糖苷酶进行固定化,制得固定化α-葡萄糖苷酶制剂,就其酶学性质,催化效率及其低聚异麦芽糖的转化进行研究。选取4种... 详细信息

低聚异麦芽糖是一种重要的功能性低聚糖,主要通过酶法转化麦芽糖或麦芽三糖制得。本研究采用环氧基树脂对黑曲霉α-葡萄糖苷酶进行固定化,制得固定化α-葡萄糖苷酶制剂,就其酶学性质,催化效率及其低聚异麦芽糖的转化进行研究。选取4种类型的环氧基树脂进行投酶量,离子强度,p H值等酶固定化条件的优化研究,得到最佳树脂GT-3的最优酶固定化条件:离子强度2 mol/L,p H 6.0,投酶量30 mg/g,在25℃下固定48h,固定化α-葡萄糖苷酶酶活达到1.34×104 U/g,酶活力回收率达78.58%。固定化酶的酶学性质与游离酶有差异,最适p H略偏酸,热稳定性有所下降,而酸碱稳定性提高,操作稳定性较好。在45℃,重复50次后,固定化酶活力仍保留86.67%,制得的低聚异麦芽糖占总糖比例达49.28%。

关键词：低聚异麦芽糖 α-葡萄糖苷酶固定化

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高坝竖井泄洪洞、龙抬头放空洞与导流洞"三洞合一"优化布置研究

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四川大学学报（工程科学版） 2003年第2期35卷 10-14页

作者：刘善均许唯临王韦四川大学高速水力学国家重点实验室四川成都610065

通过深入的试验研究和理论分析,表明竖井泄洪洞的泄流能力受平底闸过流能力,竖井尺寸和涡室进口的控制。给出了放空洞泄流能力和最低运行水位计算公式,竖井内壁压力特性与洞径的关系,不设通气井而实现通气和排气问题。泄洪洞与放空洞结... 详细信息

通过深入的试验研究和理论分析,表明竖井泄洪洞的泄流能力受平底闸过流能力,竖井尺寸和涡室进口的控制。给出了放空洞泄流能力和最低运行水位计算公式,竖井内壁压力特性与洞径的关系,不设通气井而实现通气和排气问题。泄洪洞与放空洞结合部的边墙分别向内偏转,其后在洞顶设迎水面为圆弧的折流坎,能有效改善水流流态,且大大降低了施工难度。

关键词：竖井泄洪洞龙抬头放空洞泄流能力导流洞优化布置高坝水库施工期

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Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang jun-Zhao Xiao Yi-Fan wang Tian-Yu wei Jia-wei Jiang Ye wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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The release of nitric oxide contributes to the cardiovascular effects of Angiotensin 1-7 in the nucleus tractus solitarii of rats

The release of nitric oxide contributes to the cardiovascula...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Zhao-Tang WU,jun-Feng PENG,Yang-Kai wang,Hao WU,Yi-Wen wei,Wen-jun YUAN,wei-Zhong wang Department of Physiology,Second Military Medical University,Shanghai 200433,China

Angiotensin 1-7(Ang1-7) in the central nervous system has been demonstrated to be involved in cardiovascular *** objective of this study was to determine the contribution of nitric oxide(NO) mechanism to the cardiovascular effect of Ang 1-7 in the nucleus tractus solitarii(NTS) of *** production of NO in the NTS was significantly increased by about 2.1-fold after intracerebroventricular(ICV) infusion of Ang1-7(100 pmol/day,3 days).Following ICV infusion of Ang1-7(3 days),the protein expression of nNOS but not e/iNOS in the NTS was significantly upregulated by an average of *** with the nNOS inhibitor 7-NI(10- 100 pmol) dose-dependently blunted the decrease in blood pressure,heart rate,and renal sympathetic nerve activity evoked by unilateral microinjection of Ang1-7(25 pmol) into the *** reduction in blood pressure,heart rate, and renal sympathetic nerve activity evoked by unilateral microinjection of the NO precursor L-arginine(2 nmol) into the NTS was significantly enhanced in rats with ICV infusion of Ang1-7(100 pmol,3 days) compared with *** on these data,it is suggested that the release of NO derived from nNOS plays an important role in mediating the cardiovascular effect of Ang 1-7 in the NTS.

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Engineering N3C vacancies in hierarchical porous carbon nitride nanosheets for room temperature ultradeep photocatalytic aerobic oxidative desulfurization

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Science China Chemistry 2025年

作者： Yina Nie weijie Yang Xin wang Xiang Li Lele wei Xiaolin Bai Lin Liu Feng Fu jun Wan College of Chemistry & Chemical Engineering Research Institute of Comprehensive Energy Industrial Technology Shaanxi Key Laboratory of Chemical Reaction Engineering Yan'an University Anhui Engineering Research Center of Carbon Neutrality College of Chemistry and Materials Science Anhui Normal University

The production of ultra-low sulfur clean fuels holds global significance for improving energy efficiency and reducing environmental pollution. Photocatalytic aerobic oxidative desulfurization（PODS） offers an attractive approach to efficiently remove refractory heterocyclic aromatic sulfur compounds under mild conditions. However, the sluggish charge dynamics,insufficient molecule activation, and slow mass transfer within photocatalysts restrict the overall desulfurization efficiency,hindering the widespread application of this technology. Herein, we developed a defective g-C3N4（M1U3CN） photocatalyst with bridged N3Cvacancies and hierarchical porous structures to address these limitations. This catalyst not only demonstrates outstanding dibenzothiophene（DBT） removal efficiency of 99.6% for model oil with high conversion and selectivity but also achieves complete sulfur removal from gasoline as well as 96.7% sulfur removal for distilled diesel at room temperature,successfully achieving ultradeep aerobic oxidative desulfurization. The introduction of rich N3Cvacancies and abundant micromeso-macroporous distribution in M1U3CN enhances kinetic efficiencies by promoting charge carrier separation, mass transfer,and molecular activation simultaneously; resulting in exceptional PODS performance. This work provides a collaborative strategy to overcome kinetic challenges in aerobic oxidative desulfurization via defect and structural engineering of the catalyst.

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Dog vaccination with EgM proteins against Echinococcus granulosus

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Infectious Diseases of Poverty 2018年第1期7卷 593-600页

作者： Zhuang-Zhi Zhang Gang Guo jun Li Bao-Xin Shi Li Zhao Bao-Ping Guo Xu Zhang jun-wei wang Xue-Ting Zheng Wen-Jing Qi Li He Wen-Bao Zhang Xinjiang Veterinary Research Institute Xinjiang Academy of Animal Sciences726 Dongrong StreetNorth Gaoxin DistrictUrumqi 830011XinjiangChina State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaClinical Medicine InstituteThe first Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054XinjiangChina

Background:Dogs play a pivotal role in the transmission of cystic echinococcosis(CE),a zoonosis caused by the tapeworm Echinococcus *** showed previously that dogs vaccinated with two *** adult-worm specific proteins,EgM9 and EgM123,emulsified with Freund’s adjuvants induced significant protective efficacy in terms of reduction in worm burden and egg production after 45 days *** was not known whether this protection can be sustained using adjuvants suitable for use in ***:Recombinant EgM9 and EgM123 were mixed with Quil A or ISCOMs for vaccinating *** three vaccine injections,all the dogs were orally challenge-infected with 200000 protoscoleces of *** 45 days of infection,all the dogs were euthanized and necropsied for collecting and counting *** ***,including the IgG subclasses IgG1 and IgG2,were detected in the sera of vaccinated dogs by *** determine whether the protection efficacy could be maintained after 45 days post-infection,we implemented a longevity trial to count eggs in dog faeces for 170 days after ***:The dogs vaccinated with EgM9 and EgM123 mixed with Quil A and ISCOMs showed similar protective efficacy as the proteins emulsified with Freund’s adjuvants in our previous study in terms of reduction of worms and eggs at 45 days *** longevity trial showed that EgM9 protein-vaccinated group released lower number of eggs per gram compared with the egg counts in the control dogs during the dog trial ***:EgM9 and EgM123 are thus suitable vaccine candidates against *** infection in dogs.

关键词： Echinococcus granulosus EgM proteins Dog vaccine Adjuvant

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蛋白质动力学理论研究中的计算机模拟方法

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物理学进展 1997年第3期17卷 289-319页

作者：王骏王炜南京大学物理系固体物理研究所生物凝聚态物理研究室南京210093

蛋白质是生物体中一种十分重要的高分子物质。蛋白质分子有着自身所特有的化学、物理结构;在溶液中蛋白质分子不仅自身不同部分间存在着相互作用,而且还与溶剂分子间发生着复杂的相互作用,这些都很大程度上影响到分子的结构和演变过程... 详细信息

蛋白质是生物体中一种十分重要的高分子物质。蛋白质分子有着自身所特有的化学、物理结构;在溶液中蛋白质分子不仅自身不同部分间存在着相互作用,而且还与溶剂分子间发生着复杂的相互作用,这些都很大程度上影响到分子的结构和演变过程。为了对蛋白质分子进行模拟,很有必要建立适当的描述蛋白质分子结构的模型,引入合理的模型基元间的相互作用,并采用有效的方法进行模拟,本着贴近现实和方便模拟的原则,在本文中我们系统地总结了近年来蛋白质动力学及其物理特性,特别对其模型、势能及模拟方法进行了着重介绍。为了增加一些感性认识,文中还就实验分析、折叠的协作性、搜寻保守残基和动力学过程的熵效应和阻挫效应等几个专题进行了应用介绍。

关键词：结构模型蛋白质分子动力学计算机模拟

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