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Mechanism of Mingjing Granules in Treating Wet Age-Related Macular Degeneration Based on Network Pharmacology and Experimental Verification

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 22-32页

作者： Xiao-Yu Li Li-Na Liang wei-jun zhang Yun Gao Qiang Chen Eye Function Laboratory Eye HospitalChina Academy of Chinese Medical SciencesBeijingChina China Evidence-Based Medicine Center for Traditional Chinese Medicine BeijingChina Center for East-West Medicine UCLA David Geffen School of MedicineLos AngelesCAUSA

Objective:To analyze the potential mechanism of Mingjing granules in the treatment of wet age-related macular degeneration(wAMD)based on the research methods of network pharmacology and molecular docking approach and to provide a new reference for the currently limited treatment of *** and Methods:We searched TCMSP,GeneCards,OMIM,PharmGkb,TTD,and DrugBank database to screen the main active ingredients of Mingjing granules and their therapeutic targets of *** network of active components and targets was constructed using Cytoscape3.6.1 software,which was also used for the topological analysis of target *** network of Protein-Protein Interactions(PPI)was mapped using the String *** also used R language to do the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway for additional *** docking studies were finished by Chemoffice,Autodock,and ***,the efficacy of the Mingjing granules was examined in animal experiments,in which we used enzyme-linked immunosorbent assay to the contents of vascular endothelial growth factor(VEGF)and matrix metalloproteinase-9(MMP-9)levels in peripheral ***:Active compounds,including quercetin,lignocaine,and kaempferol,were *** network analysis showed that tumor necrosis factor(TNF),MMP-9,epidermal growth factor(EGF),prostaglandin-endoperoxide synthase 2(PTGS2),and caspase-3(CASP3)were related to both Mingjing granules and *** and KEGG pathway analysis showed that these targets were mainly involving lipids and atherosclerosis,TNF,and interleukin-17(IL-17)signaling *** studies suggested that quercetin and luteolin can fit in the binding pocket of four target proteins(CASP3,EGF,PTGS2,and TNF).In the vivo experiment,the Mingjing granules were found to be effective on the expression of VEGF and MMP-9 in peripheral ***:This study initially reveals the multi-constituent,multi-target,and multi-pathway mechanism of action of Ming

关键词： Experimental verification Mingjing granules molecular docking network pharmacology wet age-related macular degeneration

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NνDEx-100 conceptual design report

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Nuclear Science and Techniques 2024年第1期35卷 18-33页

作者： Xi-Guang Cao Yan-Long Chang Kai Chen Emilio Ciuffoli Li-Min Duan Dong-Liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-Yuan Huang Ze-Yu Huang Lei Lang Yu-Lan Li Zhi-Jie Li Tian-Yu Liang jun Liu Chen-Gui Lu Fa-Tai Mai Yuan Mei Hao Qiu Xiang-Ming Sun Xiao-Xing Tang Hu-Lin Wang Qian-Ming Wang Le Xiao Mu-Yun Xiao Jian-Yu Xin Nu Xu Peng Yang Yi-Chen Yang Zhen Yang Zong-Yang Yu Dong-Liang zhang jun-wei zhang Cheng-Xin Zhao Dou Zhu NνDEx-100 collaboration Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Lanzhou University Lanzhou 730000China Central China Normal University Wuhan 430079China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Lawrence Berkeley National Laboratory BerkeleyCA 94720USA North China University of Water Resources and Electric Power Zhengzhou 450045China 不详

Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle *** such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number *** propose developing a time projection chamber (TPC) using high-pressure ^(82)SeF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82Se,called the NvDEx *** being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82Se and the TPC’s ability to distinguish signal and background events using their different topological *** makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββ***-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by *** report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation.

关键词： Neutrinoless double beta decay Time projection chamber ^(82)SeF_(6) China Jinping Underground Laboratory

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Theoretical Studies on the Kinetics and Mechanisms of Reactions for Methyl Vinyl Ether and Ozone

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Chinese Journal of Chemical Physics 2008年第4期21卷 324-332页

作者： Bo Long Ming-qiang Huang Zhen-ya Wang wei-jun zhang Laboratory of Environment Spectroscopy Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences. Hefei 230031 China School of Physics and Information Science Guizhou University for Nationalities Guiyang 550025 China

The interconversion between the two distinct isomers of methyl vinyl ether （MVE）, the formation of the primary ozonides from O3-initated reactions of MVE, the transformation between the primary ozonides, and the subsequent fragmentation were studied using quantum chemical methods at the BHandHLYP/6311＋＋G（d,p） level of theory for optimized geometries and frequency calculations and at the QCISD/631G（d,p） level for the single point energy calculations. The rate coefficients were calculated for the temperature range 280-440 K by using the canonical transition state theory （TST）. For ozone addition to MVE, there are two different possibilities discussed on the basis of two different possible orientations for ozone attack. The results of the theoretical study indicate that although the synperiplanar-MVE is 7.11 kJ/mol more stable than the antiperiplanar-MVE, the antiperiplanar-MVE plays a more important role in formation of the primary ozonides because the primary ozonides formed from the ozone addition antiperiplanar-MVE are more stable and the energy barriers corresponding to transition states are lower. The intereonversion between the primary ozonides formed from the ozone addition to antiperiplanar-MVE is the most accessible compared with the transformations between other primary ozonides. The cleavage of the primary ozonides mainly leads to the formation of the CH2OO, which is in agreement with the experimental estimates. The calculated overall rate constant for the ozone-initiated reactions is 4.8× 10^-17 cm^3/（molecule.s） at 298.15 K, which agrees with the experimental value for ethyl vinyl ether.

关键词： Methyl vinyl ether Ozone Reaction pathway Primary ozonide Interconversion Rate constant Transition state theory

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A New Simplified Zonal Method for Furnace Thermal Radiation Calculation Based on Imaginary Planes

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Journal of Iron and Steel Research International 2014年第4期21卷 419-426页

作者： wei-jun zhang Zhi YI Hai-geng CHEN College of Materials and Metallurgy Northeastern University

When solving the complex radiative heat transfer problems in reheating furnaces, there are a number of difficulties with the traditional zonal methods. To circumvent these difficulties, a new simplified method was pro- posed, which employed imaginary planes, referred to as the imaginary plane model. With the new model, crown wall reduction process was simplified. Therefore, every model zone could be treated as a closed square cavity. It could also solve the problem of radiative blocking in industrial furnaces more effectively. Besides, the new imaginary plane based model may lead to a problem that the denominator was zero. This problem was solved by transforming the ex- pressions of reflex heat flux in the model. The model was capable of dealing with the systems that included black sur- faces. The model was validated by considering the heat transfer in a reheating furnace where the temperature fields in the furnace chamber （including the steel, wall and gas） were obtained. A detailed comparison was made between the simulation and the black box experiment. The results show that the new model developed was valid and accurate.

关键词： imaginary plane zonal method crown wall reduction total radiative exchange area

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FeNi doped porous carbon as an efficient catalyst for oxygen evolution reaction

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 279-287页

作者： jun-wei zhang Hang zhang Tie-Zhen Ren Zhong-Yong Yuan Teresa JBandosz Hebei Provincial Key Laboratory of Green Chemical Technology&High Efficient Energy Saving School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) School of Materials Science and EngineeringNankai UniversityTianjin 300350China Department of Chemistry and Biochemistry The City College of New YorkNew YorkNY 10031USA

Polymer-derived porous carbon was used as a support of iron and nickel species with an objective to obtain an efficient oxygen reduction reaction(OER)*** surface features were extensively characterized using X-ray diffraction,X-ray photoelectron spectroscopy and high-resolution transmission electron *** FeNi-modified carbon the overpotential for OER was very low(280 mV)and comparable to that on noble metal catalyst IrO_(2).The electrochemical properties have been investigated to reveal the difference between the binary alloy-and single metal-doped *** work demonstrates a significant step for the development of low-cost,environmentally-friendly and highly-efficient OER catalysts.

关键词： OER polystyrene salt porous carbon FeNi alloy p/n junction

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Erosion-corrosion investigation of high chromium cast irons using newly designed jet type tester

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中国有色金属学会会刊：英文版 2004年第z1期14卷 405-412页

作者： TU Xiao-hui LIU jun-quan LI wei zhang Feng-hua SU jun-yi School of Materials Science and Engineering Xi''an Jiaotong University Xi''an 710049 China Wear Materials Research Center Guangzhou Research Institute of Nonferrous Metals Guangzhou 510651 China College of Industrial Equipment and Control Engineering South China University of Technology Guangzhou 510640 China Department of Chemistry Ji''nan University Guangzhou 510632 China Wear Materials Research Center Guangzhou Research Institute of Nonferrous Metals Guangzhou 510651 China School of Materials Science and Engineering Xi''an Jiaotong University Xi''an 710049 China

A jet type erosion-corrosion tester was developed for the erosion-corrosion investigation of high-chromium cast irons. During tests the size and the shape of particles in the slurry can be maintained stable. The jet velocity and attack angle can be accurately controlled. The repeatability and ranking consistency of the test results are satisfactory. The test parameters can be adjusted in a wide range, so that the tester can simulate various practical working conditions. Electrochemical test data can be automatically collected and processed. Dynamic polarization curves can be obtained during erosion-corrosion test, which can be used to study the dynamic corrosion *** high chromium cast irons were studied in hot concentrated alkaline slurry. The results show that the erosioncorrosion mass loss rate and dynamic corrosion rate of 295Cr26 iron is lower than that of 185Cr13 under the conditions similar to alumyte processing. The mechanism of erosion-corrosion of 295Cr26 and 185Cr13 was studied by using the tester. The interaction between erosion and corrosion was also quantitatively evaluated.

关键词： erosion-corrosion tester repeatability chromium cast iron hot concentrated alkali

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Exact Periodic Solutions to Generalized BBM Equation and Relevant Conclusions

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Acta Mathematicae Applicatae Sinica 2006年第3期22卷 509-516页

作者： jun-ying An wei-guo zhang University of Shanghai for Science and Technology Shanghai 200093 China

In this paper, we consider generalized BBM equation with nonlinear terms of high *** the case of p=1/2, p=1 and p=2, the exact periodic solutions to G-BBM equation are obtained by means of proper transformation, which degrades the order of nonlinear terms. And we prove that if p ≠ 1/2,p ≠ 1 or p ≠ 2, G-BBM equation does not exist this kind of periodic solution.

关键词： Jacobi elliptic function nonlinear evolution equation periodic solutions

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Detection of Nitric Oxide with Faraday Rotation Spectroscopy at 5.33μm

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Chinese Journal of Chemical Physics 2020年第1期33卷 37-42页

作者： Bo Fang Na-na Yang Chun-hui Wang wei-xiong Zhao Xue-zhe Xu Yang zhang wei-jun zhang Laboratory of Atmospheric Physico-Chemistry Anhui Institute of Optics and Fine MechanicsChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China School of Environmental Science and Optoelectronic Technology University of Science and Technol-ogy of ChinaHefei 230026China

We report the development of a static magnetic eld Faraday rotation spectrometer for NO detection.A 5.33μm continuous-wave quantum cascade laser was used as the probing *** absorption at 1875.81 cm^−1(2Π3=2Q(3/2),v=1←0)was chosen for the *** using a Chernin type multipass cell,a detection precision of 1.15 ppbv(1σ,1s)was achieved with an absorption pathlength of 108 *** value was reduced to 0.43 ppbv by increasing the data-acquisition time to 15 s.

关键词： Faraday rotation spectroscopy Mid-infrared Laser spectroscopy Nitric oxide

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Period-Doubling Cascades and Strange Attractors in Extended Duffing-Van der Pol Oscillator

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Communications in Theoretical Physics 2009年第5期51卷 865-868页

作者： YU jun PAN wei-Zhen zhang Rong-Bo Institute of Nonlinear Science Shaoxing University Shaoxing 312000 China

The dynamical behavior of the extended Duffing-Van der Pol oscillator is investigated numerically in detail. With the aid of some numerical simulation tools such as bifurcation diagrams and Poinearé maps, the different routes to chaos and various shapes of strange attractors are observed. To characterize chaotic behavior of this oscillator system, the spectrum of Lyapunov exponent and Lyapunov dimension are also employed.

关键词： extended Duffing-Van der Pol oscillator bifurcation chaos

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Strain rate response of a Zr-based composite fabricated by Bridgman solidification

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International Journal of Minerals,Metallurgy and Materials 2010年第2期17卷 214-219页

作者： jun-wei Qiao Yong zhang Ji-heng Li Guo-liang Chen State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China

Zr58.5Ti14.3Nb5.2Cu6.1Ni4.9Be11.0 bulk metallic glass matrix composites,containingβ-Zr dendrites,were fabricated by Bridgman solidification at the withdrawal velocity of 1.0 mm/s through a temperature gradient of～45 K/*** to the increasing compressive strain rates,the monotonic increasing and decreasing were obtained for the maximum strength and the fracture strain,*** results show that high strain rate may induce the insufficient time for the interaction between shear bands and the crystalline phase,and early fracture occurs as a *** fractographs are consistent with the mechanical properties,and the failure mode of the present Zr-based composites is in agreement with the frame of the ellipse criterion.

关键词： bulk metallic glass composites Bridgman solidification mechanical properties

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