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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum jun kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon kim jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Refractory lipoatrophy treated with autologous whole blood injection:A case report

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World Journal of Clinical Cases 2025年第2期13卷 33-38页

作者： Wonnam kim jun Su Park En Hyung kim Department of Pharmacology School of Korean MedicinePusan National UniversityYangsan 50612GyeongnamSouth Korea Department of Dermatology College of MedicineChungbuk National UniversityCheongju 28644ChungbukSouth Korea Department of Dermatology Chungbuk National University HospitalCheongju 28644ChungbukSouth Korea

BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and *** cutaneous atrophy can spontaneously resolve,several treatment options have been suggested for this *** SUMMARY In this paper,we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood(AWB)injection,as the condition had been unresponsive to fractional laser therapy.A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area,which had appeared six months *** had been only subtle improvement at the margins after fractional CO_(2) laser treatment;therefore,after obtaining informed consent from the patient,AWB treatment was *** month after the first AWB injection,the size and depth of the lesion had noticeably improved,and a slight improvement was also observed in *** Close observation is the initial treatment of choice for steroid induced skin atrophy;however,for patients in need of immediate cosmetic improvement,AWB injection may be a safe and cost-effective alternative.

关键词： Atrophy Corticosteroid Subcutaneous fat Autologous whole blood injection Laser therapy Case report

An Experimental Study of Condensation Heat Transfer in Sub-Millimeter Rectangular Tubes

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Journal of Thermal Science 2004年第4期13卷 350-357页

作者： Jeong seob SHIN Moo Hwan kim Department of Mechanical Engineering POSTECH Pohang KoreaDepartment of Mechanical Engineering POSTECH Pohang Korea

The characteristics of local heat transfer and pressure drops were experimentally investigated using condensing R134a two-phase flow, in single rectangular tubes, with hydraulic diameter of 0.494, 0.658, and 0.972 mm. New experimental techniques were used to measure the in-tube condensation heat transfer coefficient especially for the low heat and mass flows. Tests were performed for a mass flux of 100, 200, 400, and 600 kg/m2s, a heat flux of 5 to 20 kW/m2, and a saturation temperature of 40℃. In this study, effect of heat flux, mass flux, vapor qualities, and hydraulic diameter on flow condensation were investigated and the experimental local condensation heat transfer coefficients and frictional pressure drop are shown. The experimental data of condensation Nusselt number are compared with previous correlations, most of which are proposed for the condensation of pure refrigerant in a relatively large inner diameter round tubes.

关键词： condensation hydraulic diameter rectangular in-tube multiphase flow.

Significant enhancement of photoresponsive characteristics and mobility of MoS2-based transistors through hybridization with perovskite CsPbBr3 quantum dots

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Nano Research 2019年第2期12卷 405-412页

作者： Taeho Noh Heung seob Shin Changwon Seo jun Young kim Jongwon Youn Jeongyong kim Kwang-Sup Lee Jinsoo Joo Department of Physics Korea University Seoul 02841 Republic of Korea Department of Advanced Materials and Chemical Engineering Hannatn University Daejeon 34430 Republic of Korea Department of Energy Science Sungkyunkwan University Suwon 16419 Republic of Korea

Inorganic perovskite CsPbBr3 quantum dots (QDs) are potential nanoscale photosensitizers;moreover,two-dimensional (2-D) molybdenum disulfide (MoS2) has been intensively studied for application in the active layers of optoelectronic *** this study,heterostructures of 2D-monolayered MoS2 with zero-dimensional functionalized CsPbBr3 QDs were prepared,and their nanoscale optical characteristics were *** effect of n-type doping on the MoS2 monolayer after hybridization with perovskite CsPbBr3 QDs was observed using laser confocal microscope photoluminescenca (PL) and Raman ***-effect transistors (FETs) using MoS2 and the MoS2-CsPbBr3 QDs hybrid were also fabricated,and their electrical and photoresponsive characteristics were investigated in terms of the charge transfer *** the MoS2-CsPbBr3 QDs-based FETs,the field effect mobility and photoresponsivity upon light irradiation were enhanced by ~ 4 times and a dramatic ~ 17 times,respectively,compared to the FET prepared without the parovskite QDs and without light *** is noteworthy that the photoresponsivity of the MoS-2-CsPbBr3 QDs-based FETs significantly increased with increasing light power,which is completely contrary to the behavior observed in previous studies of MoS2-based *** increased mobility and significant enhancement of the photoresponsivity can be attributed to the n-type doping effect and efficient energy transfer from CsPbBr3 QDs to *** results indicate that the optoelectronic characteristics of MoS2-based FETs can be significantly improved through hybridization with photosensitive parovskite CsPbBr3 QDs.

关键词： MoS2 perovskite quantum dot transistor photoresponsivity mobility charge transfer

Repair of a large patellar cartilage defect using human umbilical cord blood-derived mesenchymal stem cells:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12665-12670页

作者： jun-seob Song Ki-Taek Hong Ki Jeon Song Seok jung kim Department of Orthopedic Surgery Gangnam JS HospitalSeoul 06053South Korea Department of Orthopedic Surgery Uijeongbu Street Mary’s HospitalCollege of MedicineThe Catholic University of KoreaUijeongbu 11765GyeonggidoSouth Korea

BACKGROUND Patellar dislocation may cause cartilage defects of various *** defects commonly require surgical treatment;however,conventional treatments are *** SUMMARY A 15-year-old male with a large patellar cartilage defect due to patellar dislocation was treated via human umbilical cord blood-derived mesenchymal stem cell(hUCB-MSC)*** our knowledge,this is the first report of this treatment for this *** patient recovered well as indicated by good visual analog scale,International Knee Documentation Committee and McMaster Universities Osteoarthritis Index *** resonance imaging showed cartilage regeneration 18 mo *** Umbilical cord blood-derived hUCB-MSCs may be a useful treatment option for the repair of large patellar cartilage defects.

关键词： Cartilage defect Umbilical cord Mesenchymal stem cells Patellar dislocation Magnetic resonance imaging Case report

Effects of humic acid on phytodegradation of petroleum hydrocarbons in soil simultaneously contaminated with heavy metals

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Journal of Environmental Sciences 2011年第12期23卷 2034-2041页

作者： Soyoung Park Ki seob kim Jeong-Tae kim Daeseok Kang Kijune Sung Department of Ocean Engineering Pukyong National University Busan 608-737 Korea Department of Ecological Engineering Pukyong National University Busan 608-737 Korea

The use of humic acid （HA） to enhance the efficiency of phytodegradation of petroleum hydrocarbons in soil contaminated with diesel fuel was evaluated in this study. A sample of soil was artificially contaminated with commercially available diesel fuel to an initial total petroleum hydrocarbons （TPH） concentration of 2300 mg/kg and four heavy metals with concentrations of 400 mg/kg for Pb, 200 mg/kg for Cu, 12 mg/kg for Cd, and 160 mg/kg for Ni. Three plant species, Brassica campestris, Festuca arundinacea, and Helianthus annuus, were selected for the phytodegradation experiment. Percentage degradation of TPH in the soil in a control pot supplemented with HA increased to 45% from 30% without HA. The addition of HA resulted in an increases in the removal of TPH from the soil in pots planted with B. campestris, F. arundinacea, and H. annuus, enhancing percentage degradation to 86%, 64%, and 85% from 45%, 54%, and 66%, respectively. The effect of HA was also observed in the degradation of n-alkanes within 30 days. The rates of removal of n-alkanes in soil planted with B. campestris and H. annuus were high for n-alkanes in the range of C11–C28. A dynamic increase in dehydrogenase activity was observed during the last 15 days of a 30-day experimental period in all the pots amended with HA. The enhanced biodegradation performance for TPHs observed might be due to an increase in microbial activities and bioavailable TPH in soils caused by combined effects of plants and HA. The results suggested that HA could act as an enhancing agent for phytodegradation of petroleum hydrocarbons in soil contaminated with diesel fuel and heavy metals.

关键词： phytodegradation TPHs humic acid n-alkanes DHA combined effects

Determination of efficient superfinishing conditions for mirror surface finishing of titanium

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Journal of Central South University 2012年第1期19卷 155-162页

作者： kim Jin-seob LIM Eun-seong junG Yoon-gyo School of Mechatronics Changwon National UniversityChangwon 641-773Korea

To determine mirror surface finishing conditions and efficient and economical superfinishing conditions for pure titanium and titanium alloys, an abrasive film is used when superfinishing is performed under varying conditions. These conditions include the workpiece rotation speed, the oscillation speed, the contact pressure of the roller, the hardness of the roller, and the type of abrasive film. The superfinishing device is applied to polishing a thin and long cylindrical bar. A micro-finishing film and a lapping film were used as abrasive films. A1203 grains or SiC grains were used as abrasives. The surface roughness of a polished workpiece was measured using a stylus-type surface-roughness measuring instrument. As a result, the conditions to improve the polishing surface efficiently include high values for the workpiece rotation speed, oscillation speed and contact pressure. The roller hardness has no effect on the efficient polishing conditions. The mirror finish of a surface can be created using lapping film of 3 μm with Al2O3 grains after polishing to a steady surface roughness under the efficient polishing conditions.

关键词： superfinishing mirror surface finishing abrasive film surface roughness titanium optimal polishing time

Development of twin wheel creep-feed grinding machine using continuous dressing for machining of aircraft rotary wing

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Journal of Central South University 2011年第3期18卷 704-710页

作者： kim Jin-seob HWANG Jong-dae junG Yoon-gyo School of Mechatronics Changwon National University

The purpose of this study is to develop a twin wheel creep-feed grinding machine using continuous dressing to machine precise axisymmetric turbine blades that have been difficult to machine using a conventional creep-feed *** order to develop such a machine,3D-modeling and machine simulations were performed and a twin wheel creep-feed grinding machine was ***,the axisymmetric precision of the machined workpieces through practical machining was evaluated and the quality of the continuous dressing effect of the developed machine was *** addition,experimental considerations for a proper dresser-to-wheel speed ratio and proper feed rate of the dresser were carried *** a result,a twin wheel creep-feed grinding machine with continuous dressing is developed through machine simulation,manufacturing and performance *** condition for the dresser feed rate is 0.3μm/*** cases of large dressor-to-wheel speed ratio,grinding efficiency can be enhanced,but the surface roughness shows a conflicting *** twin wheel creep-feed grinding machine has satisfactory appraisal with regard to surface roughness,flatness,and *** surface roughness below 0.1μm can be obtained for the blade of ***,in order to perform precise machining,it is necessary to improve the structure of the twin wheel creep-feed grinding machine.

关键词： creep-feed grinding twin wheel surface roughness grinding force continuous dressing flatness parallelism

3D engineered tissue models for studying human-specific infectious viral diseases

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Bioactive Materials 2023年第3期21卷 576-594页

作者： Kyeong seob Hwang Eun U Seo Nakwon Choi Jongbaeg kim Hong Nam kim Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul02792Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul03722Republic of Korea Yonsei-KIST Convergence Research Institute Yonsei UniversitySeoul03722Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea

Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic multi-organ *** on the infection route and virus type,infectious diseases are classified as respiratory,nervous,immune,digestive,or skin *** these infectious diseases can widely spread in the com-munity and their catastrophic effects are severe,identification of their causative agent and mechanisms un-derlying their pathogenesis is an urgent *** infection-associated mechanisms have been studied in two-dimensional(2D)cell culture models and animal models,they have shown limitations in organ-specific or human-associated pathogenesis,and the development of a human-organ-mimetic system is ***,three-dimensional(3D)engineered tissue models,which can present human organ-like physiology in terms of the 3D structure,utilization of human-originated cells,recapitulation of physiological stimuli,and tight cell–cell interactions,were ***,recent studies have shown that these models can recapitulate infection-associated *** this review,we summarized the recent advances in 3D engineered tissue models that mimic organ-specific viral ***,we briefly described the limitations of the current 2D and animal models in recapitulating human-specific viral infection ***,we provided an overview of recently reported viral infection models,focusing particularly on organ-specific infection ***,a future perspective that must be pursued to reconstitute more human-specific infectious diseases is presented.

关键词： 3D engineered tissue model Infectious viral disease Infection route Pathology In vivo-mimicking