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Full sexual maturity-cycle exposure to environmentally relevant concentrations of 17β-estradiol decreases reproductive capacity of zebrafish

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Journal of Environmental Sciences 2024年第3期137卷 580-592页

作者： Yongkang Zhang Yuanjun jiang qian Sun Meng Li Sheng Chen Jingyu Liang Chunsheng Liu College of Fisheries Huazhong Agricultural UniversityWuhan 430070China School of Environmental Studies China University of GeosciencesWuhan 430074China

17β-Estradiol(E2)has been widely detected in natural water and treatment with E2 induces potential endocrine disrupting effects in ***,effects on fish fecundity and steroid system after treatment with environmentally relevant concentrations of E2 for the full sexual maturation cycle remain *** this study,zebrafish were treatment with 0,10 or100 ng/L E2 from embryo to adult stage,and effects on gonadal development and differentiation,steroid hormone levels,transcription of genes associated with the hypothalamic-pituitary-gonadal-liver(HPG)axis in adults and fertilization rate of offspring were *** results showed that treatment with E2 lead to increased number of feminization in *** females,E2 decreased cumulative amount of spawning and inhibited the maturation of *** males,E2 inhibited the maturation and motility of sperm,as well as decreased the movement speed of *** adverse effects on sperm might be responsible for the reduced fertilization observed in *** addition,treatment with E2 changed the levels of steroid hormones in zebrafish gonad and altered the transcriptional levels of genes associated with HPG axis,which is responsible for the regulation of germ cells maturation and gonadal development in ***,these results suggested that treatment with environmentally relevant concentrations of E2 for the full sexual maturity cycle resulted in adverse effects on reproduction in zebrafish.

关键词： Environmental estrogen Zebrafish Fecundity Gonadal development Endocrine disruption

Lipid metabolism analysis in esophageal cancer and associated drug discovery

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Journal of Pharmaceutical Analysis 2024年第1期14卷 1-15页

作者： Ruidi Jiao Wei jiang Kunpeng Xu qian Luo Luhua Wang Chao Zhao Bionic Sensing and Intelligence Center Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong518000China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenGuangdong518116China School of Medicine Southern University of Science and TechnologyShenzhenGuangdong518000China University of Chinese Academy of Sciences Beijing100049China Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong518000China

Esophageal cancer is an upper gastrointestinal malignancy with a bleak *** is still being explored in depth due to its complex molecular mechanisms of occurrence and *** play a crucial role in cells by participating in energy supply,biofilm formation,and signal transduction processes,and lipid metabolic reprogramming also constitutes a significant characteristic of malignant *** and more studies have found esophageal cancer has obvious lipid metabolism abnormalities throughout its beginning,progress,and treatment *** inhibition of tumor growth and the enhancement of antitumor therapy efficacy can be achieved through the regulation of lipid ***,we reviewed and analyzed the research results and latest findings for lipid metabolism and associated analysis techniques in esophageal cancer,and comprehensively proved the value of lipid metabolic reprogramming in the evolution and treatment resistance of esophageal cancer,as well as its significance in exploring potential therapeutic targets and biomarkers.

关键词： Lipid metabolism Esophageal cancer Progression Treatment resistance New therapeutic targets

Multifunctional phase change film with high recyclability, adjustable thermal responsiveness, and intrinsic self-healing ability for thermal energy storage

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Journal of Energy Chemistry 2024年第10期97卷 216-227页

作者： Bo Yang Xuelai Zhang jun Ji Weisan Hua Miaomiao jiang Institute of Cool Thermal Storage Technology Shanghai Maritime University

Phase change materials(PCMs) present promising potential for guaranteeing safety in thermal management ***,most reported PCMs have a single application in energy storage for thermal management systems,which does not meet the growing demand for multi-functional *** this paper,the flexible material and hydrogen-bonding function are innovatively combined to design and prepare a novel multi-functional flexible phase change film(PPL).The 0.2PPL-2 film exhibits solid-solid phase change behavior with energy storage density of 131.8 J/g at the transition temperature of42.1℃,thermal cycling stability(500 cycles),wide-temperature range flexibility(0-60℃) and selfhealing ***,the PPL film can be recycled up to 98.5% by intrinsic ***,the PPL film can be tailored to the desired colors and configurations and can be cleverly assembled on several thermal management systems at ambient temperature through its flexibility combined with shape-memory *** interestingly,the transmittance of PPL will be altered when the ambient temperature changes(60℃),conveying a clear thermal ***,the thermal energy storage performance of the PPL film is successfully tested by human thermotherapy and electronic device temperature control *** proposed functional integration strategy provides innovative ideas to design PCMs for multifunctionality,and makes significant contributions in green chemistry,highefficiency thermal management,and energy sustainability.

关键词： Energy storage Multifunctional material Phase change film Recyclability Self-healing

Output Feedback Stabilization of High-Order Nonlinear Time-Delay Systems With Low-Order and High-Order Nonlinearities

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1304-1306页

作者： Meng-Meng jiang Kemei Zhang Xue-jun Xie School of Mathematics Science Liaocheng UniversityLiaocheng 252059China School of Mathematics Science Qufu Normal UniversityQufu 273165China Institute of Automation Qufu Normal UniversityQufu 273165China

Dear Editor,to This letter deals with the output feedback stabilization of a class of high-order nonlinear time-delay systems with more general low-order and high-order *** constructing reduced-order observer,based on homogeneous domination theory together with the adding a power integrator method,an output feedback controller is developed guarantee the equilibrium of the closed system globally uniformly asymptotically stable.

关键词： Nonlinear stabilization guarantee

Review and prospects on the low-voltage Na_(2)Ti_(3)O_(7) anode materials for sodium-ion batteries

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Journal of Energy Chemistry 2024年第1期88卷 446-460,I0011页

作者： jun Dong Yalong jiang Ruxing Wang Qiulong Wei Qinyou An Xiaoxing Zhang Hubei Key Laboratory for High-efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of TechnologyWuhan 430068HubeiChina State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200HubeiChina Xiamen Key Laboratory of High-Performance Metals and Materials College of MaterialsXiamen UniversityXiamen 361005FujianChina State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina

Due to its low cost and natural abundance of sodium,Na-ion batteries(NIBs)are promising candidates for large-scale energy storage *** development of ultralow voltage anode materials is of great significance in improving the energy density of ***-voltage anode materials,however,are severely lacking in *** all the reported insertion oxides anodes,the Na_(2)Ti_(3)O_(7) has the lowest operating voltage(an average potential of 0.3 V ***^(+)/Na)and is less likely to deposit sodium,which has excellent potential for achieving NIBs with high energy densities and high *** significant progress has been made,achieving Na_(2)Ti_(3)O_(7) electrodes with excellent performance remains a severe *** paper systematically summarizes and discusses the physicochemical properties and synthesis methods of Na_(2)Ti_(3)O_(7).Then,the sodium storage mechanisms,key issues and challenges,and the optimization strategies for the electrochemical performance of Na_(2)Ti_(3)O_(7) are classified and further ***,remaining challenges and future research directions on the Na_(2)Ti_(3)O_(7) anode are *** review offers insights into the design of high-energy and high-safety NIBs.

关键词： Sodium-ion batteries Low-voltage anode materials Na_(2)Ti_(3)O_(7) Electrochemical performances Electrochemical mechanism

Predicting hepatocellular carcinoma: A new non-invasive model based on shear wave elastography

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World Journal of Gastroenterology 2024年第25期30卷 3166-3178页

作者： Dong jiang Yi qian Yi-jun Gu Ru Wang Hua Yu Hui Dong Dong-Yu Chen Yan Chen Hao-Zheng jiang Bi-Bo Tan Min Peng Yi-Ran Li Department of Ultrasound Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Pathology Shanghai Eastern Hepatobiliary Surgery HospitalThird Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of College of Art and Science Case Western Reserve UniversityClevelandOH 44106United States Ultrasound Diagnosis PLA Naval Medical CenterShanghai 200437China

BACKGROUND Integrating conventional ultrasound features with 2D shear wave elastography(2D-SWE)can potentially enhance preoperative hepatocellular carcinoma(HCC)*** To develop a 2D-SWE-based predictive model for preoperative identification of *** A retrospective analysis of 884 patients who underwent liver resection and pathology evaluation from February 2021 to August 2023 was conducted at the Oriental Hepatobiliary Surgery *** patients were divided into the modeling group(n=720)and the control group(n=164).The study included conventional ultrasound,2D-SWE,and preoperative laboratory *** logistic regression was used to identify independent predictive factors for RESULTS In the modeling group analysis,maximal elasticity(Emax)of tumors and their peripheries,platelet count,cirrhosis,and blood flow were independent risk indicators for *** factors yielded an area under the curve of 0.77(95%confidence interval:0.73-0.81)with 84%sensitivity and 61%*** model demonstrated good calibration in both the construction and validation cohorts,as shown by the calibration graph and Hosmer-Lemeshow test(P=0.683 and P=0.658,respectively).Additionally,the mean elasticity(Emean)of the tumor periphery was identified as a risk factor for microvascular invasion(MVI)in malignant liver tumors(P=0.003).Patients receiving antiviral treatment differed significantly in platelet count(P=0.002),Emax of tumors(P=0.033),Emean of tumors(P=0.042),Emax at tumor periphery(P<0.001),and Emean at tumor periphery(P=0.003).CONCLUSION 2D-SWE’s hardness value serves as a valuable marker for enhancing the preoperative diagnosis of malignant liver lesions,correlating significantly with MVI and antiviral treatment efficacy.

关键词： Shear wave elastography Predicting model Microvascular invasion Antiviral treatment Hepatocellular carcinoma

A Novel Predictive Model for Edge Computing Resource Scheduling Based on Deep Neural Network

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 259-277页

作者： Ming Gao Weiwei Cai Yizhang jiang Wenjun Hu Jian Yao Pengjiang qian School of Artificial Intelligence and Computer Science Jiangnan UniversityWuxi214122China The Center for Intelligent Systems and Applications Research School of Artificial Intelligence and Computer ScienceJiangnan UniversityWuxi214122China School of Information Engineering Huzhou UniversityHuzhou313000China

Currently,applications accessing remote computing resources through cloud data centers is the main mode of operation,but this mode of operation greatly increases communication latency and reduces overall quality of service(QoS)and quality of experience(QoE).Edge computing technology extends cloud service functionality to the edge of the mobile network,closer to the task execution end,and can effectivelymitigate the communication latency ***,the massive and heterogeneous nature of servers in edge computing systems brings new challenges to task scheduling and resource management,and the booming development of artificial neural networks provides us withmore powerfulmethods to alleviate this ***,in this paper,we proposed a time series forecasting model incorporating Conv1D,LSTM and GRU for edge computing device resource scheduling,trained and tested the forecasting model using a small self-built dataset,and achieved competitive experimental results.

关键词： Edge computing resource scheduling predictive models

Potassium isotopic signatures of modern offshore detrital sediments from different climatic regimes and the implications

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Science China Earth Sciences 2024年第2期67卷 405-419页

作者： jun MU Tianyu CHEN qian YU Shichao AN Jianfang CHEN Xuefa SHI Weiqiang LI State Key Laboratory for Mineral Deposits Research School of Earth Sciences and EngineeringNanjing UniversityNanjing210023China Ministry of Education Key Laboratory for Coast and Island Development School of Geography and Ocean ScienceNanjing UniversityNanjing210023China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou310012China Key Laboratory of Marine Geology and Metallogeny First Institute of OceanographyMinistry of Natural ResourcesQingdao266061China

Potassium isotopes are a novel tracer for continental *** K isotope studies on chemical weathering generally targeted weathering profiles under a particular climate region,yet the effects of chemical weathering on K isotopes under different climatic backgrounds remain ***,little is known about the K isotope signatures of modern unconsolidated detrital ***,we report K isotopic data of surficial seafloor sediments from continental shelves along the east coast of China(ECC),as well as those around the tropical Hainan island in the northern South China *** ECC sediments have a relatively narrow distribution ofδ^(41)K(with reference to NIST3141a)values,which range from(-0.40±0.01)‰to(-0.57±0.04)‰,with an average of(-0.51±0.09)‰.By contrast,δ^(41)K values of Hainan offshore sediments display a larger variation,ranging from(-0.28±0.07)‰to(-0.67±0.02)‰.Theδ^(41)K values of Hainan offshore sediments exhibit negative correlations with the chemical index of alteration(CIA),Al/K,Ti/K,and total iron(FeT),which underlines the control of chemical weathering on K isotopic signatures of detritus inputs into *** also measured Mg isotope compositions for the same samples;interestingly,the variability inδ^(26)Mg of the samples is small(~0.24‰)for all ECC and Hainan offshore sediments,andδ^(26)Mg values do not show clear correlations with indexes of chemical *** study demonstrates the link between K isotopic variability of detrital sediments and climatic conditions including rainfall intensity,which indicates that K isotopes of the detrital component of marine sediments could be applied to study Earth’s climate in deep ***δ^(41)K values of the offshore detrital sediments are significantly less variable than those of pelagic marine sediments,highlighting the importance of distinguishing the effects of diagenesis and neoformation of clay minerals from continental weathering in attempts to study deep-time climate-weathering

关键词： Potassium isotopes Magnesium isotopes Chemical weathering Detrital sediments Climatic regimes Mean annual precipitation

CNN-LSTM based incremental attention mechanism enabled phase-space reconstruction for chaotic time series prediction

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Journal of Electronic Science and Technology 2024年第2期22卷 77-90页

作者： Xiao-qian Lu jun Tian qiang Liao Zheng-Wu Xu Lu Gan Bidding and Purchasing Center University of Electronic Science and Technology of ChinaChengdu611731China Yibin Research Institute University of Electronic Science and Technology of ChinaYibin644000China School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu611731China

To improve the prediction accuracy of chaotic time series and reconstruct a more reasonable phase space structure of the prediction network,we propose a convolutional neural network-long short-term memory(CNN-LSTM)prediction model based on the incremental attention ***,a traversal search is conducted through the traversal layer for finite parameters in the phase ***,an incremental attention layer is utilized for parameter judgment based on the dimension weight criteria(DWC).The phase space parameters that best meet DWC are selected and fed into the input ***,the constructed CNN-LSTM network extracts spatio-temporal features and provides the final prediction *** model is verified using Logistic,Lorenz,and sunspot chaotic time series,and the performance is compared from the two dimensions of prediction accuracy and network phase space ***,the CNN-LSTM network based on incremental attention is compared with long short-term memory(LSTM),convolutional neural network(CNN),recurrent neural network(RNN),and support vector regression(SVR)for prediction *** experiment results indicate that the proposed composite network model possesses enhanced capability in extracting temporal features and achieves higher prediction ***,the algorithm to estimate the phase space parameter is compared with the traditional CAO,false nearest neighbor,and C-C,three typical methods for determining the chaotic phase space *** experiments reveal that the phase space parameter estimation algorithm based on the incremental attention mechanism is superior in prediction accuracy compared with the traditional phase space reconstruction method in five networks,including CNN-LSTM,LSTM,CNN,RNN,and SVR.

关键词： Chaotic time series Incremental attention mechanism Phase-space reconstruction