检索结果-南通市图书馆

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

引用

Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing liu li-Fei Song Zheng-Zhi Wu qian-qian Jiang Shao-Yu liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atmospheric reductive catalytic fractionation of lignocellulose integrated with one-pot catalytic conversion of carbohydrate yielding valuable lignin monomers and platform chemicals from corn straw

引用

Green Energy & Environment 2025年第1期10卷 161-172页

作者： Meng-Ying liu Zhe-Hui Zhang Xue-Qi Wang qian Sun Chen Zhang Yu li Zhuohua Sun Katalin Barta Feng Peng Tong-Qi Yuan State Key Laboratory of Efficient Production of Forest Resources Beijing Forestry UniversityBeijing100083China Beijing Key Laboratory of lignocellulosic Chemistry Beijing Forestry UniversityBeijing100083China Department of Chemistry Organic and Bioorganic ChemistryUniversity of GrazHeinrichstrasse 28/II8010 GrazAustria

Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent ***,taking advantage of the“lignin first”strategy,corn straw is converted to valuable chemicals including lignin monomers,furfural and 5-methoxymethylfurfural via a two steps *** key of this research lies in the development of a green and low-cost catalytic process utilizing magnetic Raney Ni catalyst and high boiling point ethylene *** utilization of neat ethylene glycol as the sole slovent under atmospheric conditions obviates the need for additional additives,thereby facilitating the entire process to be conducted in glass flasks and rendering it highly convenient for scaling *** the initial step,depolymerization of corn straw lignin resulted in a monomer yield of 18.1 wt%.Subsequently,in a dimethyl carbonate system,the carbohydrate component underwent complete conversion in a one-pot process,yielding furfural and 5-methoxymethylfurfural as the primary products with an impressive yield of 47.7%.

关键词： Atmospheric reductive catalytic fractionation Corn straw Ethylene glycol Raney Ni 5-Methoxymethylfurfural

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The design of Real-time Distributed Arrival Time Control System in a cell manufacturing

The design of Real-time Distributed Arrival Time Control Sys...

引用

2011 Chinese Control and Decision Conference（CCDC）

作者： Bin Gao is with the school of Information Science and Engineering,Key Lab of Integrated Automation of Process Industry of MOE,Northeastern University,Shenyang,110004,jun Gong,qian li,Jiafu Tang

In this study a real-time distributed arrival time control system in a cell manufacturing system for JIT-oriented production environment is *** distributed arrival time control （DATC） system is introduced to improve the scalability and practicality of the assembly cells manufacturing systems in heterarchical manufacturing *** simulation experiments are implemented to present the advantage of this new control system under JIT *** results indicate that DATC used in assembly cells was effective and can handle a wide range of variability with little change in mean squared *** research also shows that distributed arrival time control system can provide the stability of the scheduling of manufacturing system.

关键词： Distributed arrival time control Just in Time Heterarchical manufacturing system

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Co@C-N as an electronic mediator anchored with Cu2O nanoparticles enables efficient photoreduction of CO2 to CO with nearly 100% selectivity

引用

Science China Chemistry 2025年

作者： Xingbin Pan Xiuzheng Deng Jingshan Fan Jiangchuan liu Changhai liu Zhongyu li qian liang Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology CNPC-CZU Innovation Alliance School of Petrochemical Engineering Changzhou University School of Materials Science & Engineering Changzhou University

Solar-driven CO2conversion into value-added chemical provides an attractive strategy for sustainable development. However,the enhanced CO2photoreduction performance with target product selectivity remains a major challenge. Here, we develop a novel strategy involving Cu2O nanoparticles in situ grown on the surface of ZIF-67-derived Co@C-N nanocages （CC） to create abundant active sites and appropriate heterointerfaces. A remarkable CO selectivity of 95.7%with a yield of 117.39μmol g-1h-1and an apparent quantum efficiency as high as 1.88%at 420 nm was obtained over CC-60 catalyst in pure water, which was 87.6times higher than that of pure Cu2O. Theoretical calculations and experiments indicated that Co@C-N nanocages as charge mediator not only rapidly trap photogenerated electrons to promote charge separation efficiency, but also regulate the d-band center of Cu atoms to move to the Fermi energy level, thereby optimizing the reaction kinetics to facilitate the highly selective conversion of the key intermediate *CO desorption to CO.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

富亮氨酸重复超家族新成员LRRC4的克隆与在脑瘤中的表达分析

引用

生物化学与生物物理进展 2002年第2期29卷 233-239页

作者：王洁如钱骏董利李小玲谭琛李江张必成周洁李桂源中南大学湘雅医学院肿瘤研究所长沙410078

在染色体 7q31 32多种肿瘤杂合性丢失 (lossofheterozygosity ,LOH)高频区 ,采用表达序列标签(expressedsequencetag ,EST)介导的定位候选克隆策略获得了一个定位于人染色体 7q31 32的新基因 (GenBank登录号 :AF196 976 ) .该基因编码 6... 详细信息

在染色体 7q31 32多种肿瘤杂合性丢失 (lossofheterozygosity ,LOH)高频区 ,采用表达序列标签(expressedsequencetag ,EST)介导的定位候选克隆策略获得了一个定位于人染色体 7q31 32的新基因 (GenBank登录号 :AF196 976 ) .该基因编码 6 5 3个氨基酸 ,蛋白质理论pI m :6 5 8 72 7ku .它包含七个典型的LRR、一个IgC2样结构域 .此外 ,它还包含一个N端信号肽、一个C端跨膜区 .其结构特征表明它是富亮氨酸重复(leucine richrepeat,LRR)超家族的新成员 .经过人类基因组命名委员会的同意 ,将该基因命名为LRRC4.此外 ,通过序列相似性匹配还获得了定位于小鼠 6号染色体的LRRC4的同源基因 (GenBank登录号 :AF2 90 5 42 ) .RNA印迹和RT PCR检测发现LRRC4在正常人脑组织相对特异表达 ,而在多种原发性脑瘤表达明显下调或缺失 .综合考虑LRRC4基因的序列特征及表达谱。

关键词：富亮氨酸重复超家族新成员 LRRC4 脑瘤基因表达

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高职生网络心理健康迷局及其消解

引用

湖北函授大学学报 2017年第18期30卷 57-58,61页

作者：陈林钱俊姚丽扬州工业职业技术学院江苏扬州225127

本文通过调查,发现网络场域下高职学生的心理健康问题和表现,阐述网络生活方式对高职学生个体和群体的心理影响,并从网络思想政治教育的视角提出解决高职学生网络心理健康问题的方法和途径。

关键词：高职生网络心理健康

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermally triggered topological polymerization in diacetylene-functionalized covalent organic framework toward enhanced memristive properties

引用

Science China Chemistry 2025年

作者： Panke Zhou Yuxing Huang Ziyue Yu Cong Zhang qian Chen Yiping li Chao lin Xiong Chen State Key Laboratory of Photocatalysis on Energy and Environment Key Laboratory of Advanced Carbon-Based Functional MaterialsCollege of Chemistry Fuzhou University

The development of stimuli-responsive switching memory devices and the elucidation of their switching mechanisms in specific environments are crucial for advancing the field of molecular electronics. Herein, we propose two distinct two-dimensional covalent organic frameworks (COFs), namely Py-EDA and Py-BDA, incorporating acetylene (-C≡C-) or diacetylene(-C≡C-C≡C-) moieties, respectively, targeting fabricate memory devices exhibiting stimuli-responsive switching *** findings demonstrate that the incorporation of acetylene units effectively modulates the electronic band structure and enhances the degree ofπ-conjugation, resulting in devices that exhibit typical bipolar nonvolatile memory performance. Notably,upon thermal treatment, the memory behavior of the ITO/Py-BDA/Ag device transitions to a write-once-read-many-times(WORM) mode, displaying decreased SET voltage, increased ON/OFF current ratio, and remarkable retention reliability and cycle stability. This switching behavior is attributed to the occurrence of interlayer solid-state topological polymerization at 350℃, leading to the transformation of diacetylene columnar arrays into enyne chains within Py-BDA, thereby further promoting interlayer charge transfer and separation.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于ANSYS Workbench的滚压工艺参数分析

引用

组合机床与自动化加工技术 2016年第10期 137-139页

作者：贺俊钱怡李树方陈江峰江南大学机械工程学院江苏无锡214122 无锡亿利大机械有限公司江苏无锡214142

为了研究滚压工艺参数对液压缸内孔表面加工精度的影响,文章根据实际生产建立了比较合理的液压缸滚压加工简化模型,基于ANSYS Workbench对建立的简化模型进行了主要工艺参数的有限元模拟分析。通过分析比较,指出过盈量是影响滚压加工效... 详细信息

为了研究滚压工艺参数对液压缸内孔表面加工精度的影响,文章根据实际生产建立了比较合理的液压缸滚压加工简化模型,基于ANSYS Workbench对建立的简化模型进行了主要工艺参数的有限元模拟分析。通过分析比较,指出过盈量是影响滚压加工效果的最主要因素。同时讨论了在过盈量一定时,进给量和滚压速度对加工精度的影响。并对液压缸厚度问题进行了有限元模拟分析,分析表明,液压缸厚度对滚压精度也存在一定的影响,并且过厚的液压缸会造成材料的浪费。该研究为滚压加工的实际生产应用提供了有价值参考。

关键词：液压缸滚压加工 ANSYS Workbench 有限元模拟

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

引用

Tungsten 2025年第1期7卷 195-213页

作者： Zhi-Peng Zhu Dian Jia William Yi Wang jun-Lei Yin Xing-Yu Gao Shu-Feng Yang Hai-Feng Song Jin-Shan li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

关键词： First-principles calculations Phase stability TCP phases Thermodynamic properties W–Re alloy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

表达序列标签数据库搜索鉴定小鼠UBAP1基因及其数字化表达分析

引用

生物化学与生物物理进展 2002年第2期29卷 323-327页

作者：钱骏董利张必成王洁如周鸣李忠花李伟芳李小玲李桂源中南大学湘雅医学院肿瘤研究所

UBAP1(ubiquitinassociatedprotein 1)基因是最近克隆的一个定位于人类染色体 9p2 1 2 2鼻咽癌杂合性丢失高频区的泛肽相关蛋白家族新成员 .为了深入研究UBAP1基因的功能 ,利用计算机对表达序列标签(expressedsequencetag ,EST)、UniGen... 详细信息

UBAP1(ubiquitinassociatedprotein 1)基因是最近克隆的一个定位于人类染色体 9p2 1 2 2鼻咽癌杂合性丢失高频区的泛肽相关蛋白家族新成员 .为了深入研究UBAP1基因的功能 ,利用计算机对表达序列标签(expressedsequencetag ,EST)、UniGene等数据库进行综合搜索分析 ,结合cDNA克隆测序的方法 ,成功地获得了UBAP1基因在小鼠中的同源基因 .小鼠UBAP1基因cDNA全长为 2 6 76bp ,编码一个由 44 1个氨基酸组成的蛋白质 ,在其蛋白质C端只有一个泛肽相关功能域 (UBAdomain) .与人UBAP1基因相比 ,两者编码的氨基酸序列有 89%相同 .基于EST的数字化表达分析显示UBAP1基因在小鼠正常组织中广泛高表达 .

关键词：表达序列标签数据库搜索小鼠 UBAP1基因数字化表达分析鼻咽癌组织表达基因克隆

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：