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Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases

Neural Regeneration Research 2020年第10期15卷 1807-1813页

作者： jun-mou hong Yi-Da Hu Xiao-Qing Chai Chao-Liang Tang Department of Vascular Surgery Zhongshan HospitalXiamen UniversityXiamenFujian ProvinceChina Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Activin receptor-like kinase 1(ALK1)is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta(TGFβ)receptor ***1 is specifically expressed in vascular endothelial cells,and its dynamic changes are closely related to the proliferation of endothelial cells,the recruitment of pericytes to blood vessels,and functional differentiation during embryonic vascular *** pathophysiology of many cerebrovascular diseases is today understood as a disorder of endothelial cell function and an imbalance in the proportion of vascular ***,mutations in ALK1 and its co-receptor endoglin are major genetic risk factors for vascular arteriovenous *** studies have shown that ALK1 is closely related to the development of cerebral aneurysms,arteriovenous malformations,and cerebral *** this review,we describe the various roles of ALK1 in the regulation of angiogenesis and in the maintenance of cerebral vascular homeostasis,and we discuss its relationship to functional dysregulation in cerebrovascular *** review should provide new perspectives for basic research on cerebrovascular diseases and offer more effective targets and strategies for clinical diagnosis,treatment,and prevention.

关键词： activin receptor-like kinase 1 aneurysm atherosclerotic plaque endoglin extracellular matrix protein intracranial arteriovenous malformation matrix metalloproteinase pericyte transforming growth factor beta 1 pathway vascular development

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急性踝关节损伤治疗方法的选择策略

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中国骨伤 2017年第6期30卷 489-491页

作者：梁晓军赵宏谋西安交通大学附属红会医院足踝外科

踝关节是人体负重最大的关节,由3块骨骼和11条韧带组成。急性踝关节损伤在临床常见,其中踝关节外侧副韧带损伤是全身最常见的韧带损伤,而踝关节骨折居关节内骨折之首。美国国家创伤数据库资料显示,踝关节骨折占足踝部骨折的55.7%[1]。

关键词：踝关节骨折损伤

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Topology Optimization of Self-Supporting Structures for Additive Manufacturing with Adaptive Explicit Continuous Constraint

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Computer Modeling in Engineering & Sciences 2022年第8期132卷 451-469页

作者： jun Zou Haolei mou College of Safety Science and Engineering Civil Aviation University of ChinaTianjin300300China

The integration of topology optimization(TO)and additive manufacturing(AM)technologies can create significant synergy benefits,while the lack of AM-friendly TO algorithms is a serious bottleneck for the application of TO in *** this paper,a TO method is proposed to design self-supporting structures with an explicit continuous self-supporting constraint,which can be adaptively activated and tightened during the optimization *** TO procedure is suitable for various critical overhang angles(COA),which is integrated with build direction assignment to reduce performance ***,a triangular directional self-supporting constraint sensitivity filter is devised to promote the downward evolution of structures and maintain *** numerical examples are presented;all the test cases have successfully converged and the optimized solutions demonstrate good *** the meanwhile,a fully self-supporting design can be obtained with a slight cost in performance through combination with build direction assignment.

关键词： Topology optimization additive manufacturing self-supporting constraint build direction assignment gradual evolution

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Intraoperative endoscopic sphincterotomy for common bile duct stones during laparoscopic cholecystectomy

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World Journal of Gastroenterology 2000年第3期6卷 448-450页

作者： De Fei hong Ming Gao Urs Bryner Xiu jun Cai Yi Ping mou Department of General Surgery Sir Run Run Shaw HospitalZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology Sir Run Run Shaw HospitalZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Lorna Linda University Medical Center United States

INTRODUCTION The advent of laparoscopic cholecystectomy(LC)inthe late 1980s gained widespread acceptance withina short period of time and has become the preferredtreatment for symptomatic gallstones,but themanagement of coexisting gallbladder and commonbile duct(CBD)stones has remained controversialbecause the various strategies proposed have *** fact,choledocholithiasis

关键词： laparoscopic cholecystectomy common bile duct stones endoscopic sphincterotomy

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Rescue axonal defects by targeting mitochondrial dynamics in hereditary spastic paraplegias

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Neural Regeneration Research 2019年第4期14卷 574-577页

作者： Yongchao mou Xue-jun Li Department of Biomedical Sciences University of Illinois College of Medicine Rockford Department of Bioengineering University of Illinois at Chicago

Impaired axonal development and degeneration underlie debilitating neurodegenerative diseases including hereditary spastic paraplegia, a large group of inherited diseases. Hereditary spastic paraplegia is caused by retrograde degeneration of the long corticospinal tract axons, leading to progressive spasticity and weakness of leg and hip muscles. There are over 70 subtypes with various underlying pathophysiological processes, such as defective vesicular trafficking, lipid metabolism, organelle shaping, axonal transport, and mitochondrial dysfunction. Although hereditary spastic paraplegia consists of various subtypes with different pathological characteristics, defects in mitochondrial morphology and function emerge as one of the common cellular themes in hereditary spastic paraplegia. Mitochondrial morphology and function are remodeled by mitochondrial dynamics regulated by several key fission and fusion mediators. However, the role of mitochondrial dynamics in axonal defects of hereditary spastic paraplegia remains largely unknown. Recently, studies reported perturbed mitochondrial morphology in hereditary spastic paraplegia neurons. Moreover, downregulation of mitochondrial fission regulator dynamin-related protein 1, both pharmacologically and genetically, could rescue axonal outgrowth defects in hereditary spastic paraplegia neurons, providing a potential therapeutic target for treating these hereditary spastic paraplegia. This mini-review will describe the regulation of mitochondrial fission/fusion, the link between mitochondrial dynamics and axonal defects, and the recent progress on the role of mitochondrial dynamics in axonal defects of hereditary spastic paraplegia.

关键词： hereditary spastic paraplegia axonal degeneration mitochondrial dynamics fission fusion dynamin-related protein 1 mitochondrial dysfunction induced pluripotent stem cells

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Synthesis and characterization of A1 doped δ-laminar crystal sodium silicate

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Chinese Chemical Letters 2009年第4期20卷 462-464页

作者： Xue Jing Yang Ya Ling Yang Wei Zhen mou Sheng Liu jun hong Chai Faculty of Life Science and Technology Kunming University of Science and Technology Kunming 650224 China Kunming Fruit Business and Economics Co. Ltd. Kunming 650106 China

An modified laminar crystal sodium silicate （A1-SKS-6） was synthesized by spray drying and high temperature crystallization using sodium silicate as silicon source, A1 atom as inorganic source and hexadecyltrimethy ammonium bromide （CTMAB） as the structure template. The hydrothermal stability of product was at least 1 h. The synthesized material was characterized by XRD and SEM. The results indicated that shape and intensity of XRD diffraction peak at 20 took changes, but raw material 8 phase crystal form kept unchanged, and assured high Ca^2＋ and Mg^2＋ binding capacity of the products. The Ca^2＋ and Mg^2＋ binding capacity of product is up to 380 mg Ca/g and 410mg Mg/g respectively. It was found that the hole of product became smaller and appeared rod structure based on SEM. The hydrothermal stability was increased due to the pillaring of AI atom.

关键词： A1 doping δ-Laminar crystal sodium silicate Detergent builder Stability

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An Image Encryption Algorithm Based on BP Neural Network and Hyperchaotic System

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China Communications 2020年第5期17卷 21-28页

作者： Feifei Yang jun mou Yinghong Cao Ran Chu School of Information Science and Engineering Dalian polytechnic UniversityDalian 116034China

To reduce the bandwidth and storage resources of image information in communication transmission, and improve the secure communication of information. In this paper, an image compression and encryption algorithm based on fractional-order memristive hyperchaotic system and BP neural network is proposed. In this algorithm, the image pixel values are compressed by BP neural network, the chaotic sequences of the fractional-order memristive hyperchaotic system are used to diffuse the pixel values. The experimental simulation results indicate that the proposed algorithm not only can effectively compress and encrypt image, but also have better security features. Therefore, this work provides theoretical guidance and experimental basis for the safe transmission and storage of image information in practical communication.

关键词： BP neural network fractional-order hyperchaotic system image encryption algorithm secure communication

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A rare case of gastrointestinal bleeding caused by gastric capillary hemangioma

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Gastroenterology Report 2023年第1期11卷 548-550页

作者： Yu-Zhen Bi Si-Jia Yan Li-Min Zhou hong mou Yan Sun jun Zhang Department of Gastroenterology Chun’an Country First People’s Hospital(Zhejiang Provincial People’s HospitalChun’an Branch)Chun’anZhejiangP.R.China Key Laboratory of Gastroenterology of Zhejiang Province Zhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)HangzhouZhejiangP.R.China

Introduction Gastric hemangioma is a rare neoplasm,accounting for0.05%of gastrointestinal tumors[1].Its submucosal location and dense vascular structure make diagnosis challenging and endoscopic investigations are pivotal in its *** to the risk of bleeding,biopsy may not always be *** most frequently reported symptoms of gastric hemangioma are abdominal pain and upper gastrointestinal bleeding[2].In this report,we present a case of gastric hemangioma in which the initial clinical manifestation was gastrointestinal ***-operative pathological examination revealed a gastric capillary hemangioma.

关键词： gastrointestinal hemangioma bleeding

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基于三矩形谐振腔非通MIM波导的四重法诺传感

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原子与分子物理学报 2025年第3期42卷 116-123页

作者：王叶壮沈宏君陈俊坤王雅雯宁夏大学物理学院银川750000

为了得到高灵敏度的生物传感器,设计了一种可以激发出四重法诺共振的非通金属-绝缘体-金属(Metal-Insulator-Metal,MIM)波导传感器.采用了上下对称结构,由一个竖放矩形谐振腔和两个横放矩形谐振腔与总线波导共同作用而得到了四重法诺共... 详细信息

为了得到高灵敏度的生物传感器,设计了一种可以激发出四重法诺共振的非通金属-绝缘体-金属(Metal-Insulator-Metal,MIM)波导传感器.采用了上下对称结构,由一个竖放矩形谐振腔和两个横放矩形谐振腔与总线波导共同作用而得到了四重法诺共振.采用了有限时域差分方法计算了此结构的传输特性与Z方向的归一化磁场,并详细分析了其法诺共振的产生机理.通过计算结构几何参数调节后的透射光谱,从而得出了四处法诺共振峰透射率和共振位置可以通过改变结构几何参数而获得独立调节.此外还发现在结构中添加不同浓度的葡萄糖溶液可以实现高折射率传感灵敏度(S),获得最高灵敏度2736.98nm/RIU,可以看出此结构对于折射率变化有很高的灵敏度,这为设计和优化纳米级别的折射率传感器提供了新的思路,还可以应用于电路构建前进行性能测试.

关键词：金属-绝缘体-金属传感器谐振腔法诺共振灵敏度

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng jun-hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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