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Inhibition of Cancer Cell Migration and Glycolysis by Terahertz Wave Modulation via Altered Chromatin Accessibility

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Research 2022年第4期2022卷 381-396页

作者： Lan Suno Yangmei Li Yun Yu Peiliang Wang Shengquan zhu KaijieWu Yan Liu Ruixing Wang Li min Chao Chan Innovation Laboratory of Terahertz Biophysics National Innovation Institute of Defense TechnologyBeijing 100071China School of Psychological and Cognitive Sciences Peking UniversityBeijing 100871China Aerospace Information Research Institute School of ElectronicElectrical and Communication EngineeringUniversity of the Chinese Academy of SciencesBeijing 100049China Key Laboratory of Electromagnetic Illumination and Sensing Technology Chinese Academy of SciencesBeijing 100190China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Beijing Key Laboratory for Precancerous Lesion of Digestive Disease National Clinical Research Center for Digestive DiseaseBeijing100171China School of Physics Peking UniversityBeijing 100871China

Metastasis and metabolic disorders contribute to most cancer deaths and are potential drug targets in cancer treatment. However, corresponding drugs inevitably induce myeloid suppression and gastrointestinal toxicity. Here, we report a nonpharmaceutical and noninvasive electromagnetic intervention technique that exhibited long-term inhibition of cancer cells. Firstly, we revealed that optical radiation at the specific wavelength of 3.6 μm (i.e., 83 THz) significantly increased binding affinity between DNA and histone via molecular dynamics simulations, providing a theoretical possibility for THz modulation- (THM-) based cancer cell intervention. Subsequent cell functional assays demonstrated that low-power 3.6 μm THz wave could successfully inhibit cancer cell migration by 50% and reduce glycolysis by 60%. Then, mRNA sequencing and assays for transposase-accessible chromatin using sequencing (ATAC-seq) indicated that low-power THM at 3.6 μm suppressed the genes associated with glycolysis and migration by reducing the chromatin accessibility of certain gene loci. Furthermore, THM at 3.6 μm on HCT-116 cancer cells reduced the liver metastasis by 60% in a metastatic xenograft mouse model by splenic injection, successfully validated the inhibition of cancer cell migration by THM in vivo. Together, this work provides a new paradigm for electromagnetic irradiation-induced epigenetic changes and represents a theoretical basis for possible innovative therapeutic applications of THM as the future of cancer treatments.

关键词： drugs Together migration

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主动网络中主动节点的安全机制及模型研究

自动化应用 2024年第12期65卷 250-252页

作者：曹敏杨俊斌张志强朱飑凯山西警察学院山西太原030401

随着信息技术的迅速发展,主动网络作为一种新型网络模型正逐渐引起研究者和产业界的关注。在探讨主动网络中主动节点的安全机制及模型方面,首先简要介绍主动网络体系,其次探讨主动节点的相关安全技术,最后聚焦于安全模型的建立,旨在为... 详细信息

随着信息技术的迅速发展,主动网络作为一种新型网络模型正逐渐引起研究者和产业界的关注。在探讨主动网络中主动节点的安全机制及模型方面,首先简要介绍主动网络体系,其次探讨主动节点的相关安全技术,最后聚焦于安全模型的建立,旨在为建立更可靠和安全的主动网络环境提供理论支持和实践指导。

关键词：主动网络网络安全主动权能

Successful individualized endodontic treatment of severely curved root canals in a mandibular second molar:A case report

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World Journal of Clinical Cases 2022年第14期10卷 4632-4639页

作者： Lai-jun Xu Jian-Ying Zhang Zi-Hua Huang Xiang-zhu Wang Hunan Key Laboratory of Oral Health Research Hunan 3D Printing Engineering Research Center of Oral CareHunan Clinical Research Center of Oral Major Diseases and Oral HealthAcademician Workstation for Oral-maxilofacial and Regenerative Medicine and Xiangya Stomatological HospitalXiangya School of StomatologyCentral South UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND The incidence rate of severely curved root canals in mandibular molars is low,and the root canal treatment of mandibular molars with this aberrant canal anatomy may be technically *** SUMMARY A 26-year-old Chinese female patient presented with intermittent and occlusal pain in the left mandibular second *** patient had undergone filling restoration for caries before endodontic *** the aid of cone beam computed tomography(CBCT),a large periapical radiolucency was observed,and curved root canals in a mandibular second molar were confirmed,depicting a severe and curved distolingual *** treatments,including novel individualized preparation skills and techniques and the use of bioceramic materials as an apical barrier,were performed,and complete healing of the periapical lesion and a satisfactory effect were *** A case of severely curved root canals in a mandibular second molar was successfully treated and are reported *** complex anatomy of the tooth and the postoperative effect were also evaluated via the three-dimensional reconstruction of CBCT images,which accurately identified the aberrant canal *** devices and biomaterial applications combined with novel synthesis techniques can increase the success rate of intractable endodontic treatment.

关键词： Cone beam computed tomography Canal curvature Mandibular second molar Root canal therapy Case report

合并胃癌的急性缺血性脑卒中患者的抗血小板治疗有效性及安全性研究

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中国现代医生 2024年第3期62卷 1-4页

作者：吕水清朱德斌姚林华闵晶晶湖州市第一人民医院神经内科浙江湖州313000 湖州市第一人民医院消化内科浙江湖州313000

目的探讨合并胃癌的急性缺血性脑卒中(acute ischemic stroke,AIS)患者应用阿司匹林抗血小板治疗的有效性及安全性。方法回顾性分析2018年1月至2022年10月在湖州市第一人民医院住院治疗的89例合并胃癌的AIS患者的临床资料。根据是否... 详细信息

目的探讨合并胃癌的急性缺血性脑卒中(acute ischemic stroke,AIS)患者应用阿司匹林抗血小板治疗的有效性及安全性。方法回顾性分析2018年1月至2022年10月在湖州市第一人民医院住院治疗的89例合并胃癌的AIS患者的临床资料。根据是否进行抗血小板治疗,将患者分为治疗组59例和未治疗组30例,比较两组患者的临床特点和预后情况,并分析合并胃癌的AIS患者抗血小板治疗并发消化道出血的临床特点及影响因素。结果治疗组患者的年龄小于未治疗组,且既往多有抗血小板治疗用药史、高血压病和心血管病史,差异有统计学意义(P<0.05);治疗组患者抗血小板治疗后美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分及改良Rankin评分量表(modified Rankin scale,m Rs)均低于未治疗组,差异有统计学意义(P<0.05);治疗组出血发生率高于未治疗组(P<0.05),且多以轻度血红蛋白下降为主。多因素Logistic分析提示,慢性肾功能不全、胃癌病灶直径≥2cm及T1~T2分期是合并胃癌的AIS患者服用阿司匹林后并发消化道出血的危险因素。结论合并胃癌的AIS患者进行阿司匹林抗血小板治疗可有效改善脑血管功能,降低脑神经受损程度,但当该类患者的T分期为T1~T2、合并慢性肾功能不全及胃癌病灶直径≥2cm时易并发消化道出血。

关键词：急性缺血性脑卒中胃癌安全性有效性

非小细胞肺癌患者miR-221、miR-630表达及与预后的关系分析

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实用医院临床杂志 2024年第5期21卷 131-135页

作者：赵剑孙燃汪巧许亚军戴敏安徽省芜湖市第二人民医院安徽芜湖241000 皖南医学院安徽芜湖241000

目的分析非小细胞肺癌(NSCLC)miR-221、miR-630表达及与预后的关系。方法采集198例NSCLC患者癌组织及癌旁组织标本,检测miR-221、miR-630表达,分析与病理特征关系,Kaplan-Meier法分析2年生存情况,Cox回归分析miR-221、miR-630表达与预... 详细信息

目的分析非小细胞肺癌(NSCLC)miR-221、miR-630表达及与预后的关系。方法采集198例NSCLC患者癌组织及癌旁组织标本,检测miR-221、miR-630表达,分析与病理特征关系,Kaplan-Meier法分析2年生存情况,Cox回归分析miR-221、miR-630表达与预后的关系。结果癌组织miR-221表达高于癌旁组织,miR-630表达低于癌旁组织(P<0.05)。TNM分期Ⅲ~Ⅳ期、有淋巴结转移的NSCLC患者肿瘤组织miR-221表达高于TNM分期Ⅰ~Ⅱ期、无淋巴结转移患者(P<0.05);TNM分期Ⅲ~Ⅳ期、肿瘤直径≥4 cm、有淋巴结转移的NSCLC患者肿瘤组织miR-630表达低于TNM分期Ⅰ~Ⅱ期、肿瘤直径<4 cm、无淋巴结转移患者(P<0.05)。Kaplan-Meier分析显示,miR-221高表达者2年生存率为55.56%,低于miR-221低表达者的79.63%;miR-630高表达者2年生存率为75.96%,高于miR-630低表达的50.00%(P<0.05)。Cox回归分析显示,TNM分期、淋巴结转移及miR-221、miR-630表达是NSCLC预后的影响因素(P<0.05)。Spearman相关分析显示,miR-221与miR-630表达呈负相关性(P<0.05)。结论NSCLC患者miR-221表达升高,miR-630表达降低,且与TNM分期、淋巴结转移和预后相关,可作为NSCLC患者潜在预后评估的标记物。

关键词：非小细胞肺癌 miR-221 miR-630 预后

Successful treatment of obstructing colonic cancer by combining self-expandable stent and neoadjuvant chemotherapy: A case report

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World Journal of Clinical Cases 2019年第3期7卷 335-339页

作者： zhu-Lin Li Zhen-jun Wang Jia-Gang Han Yong Yang Department of General Surgery Beijing Chaoyang Hospital affiliated to Capital Medical University

BACKGROUND Surgery 5-10 d after stent insertion was recommended by the European Society of Gastrointestinal Endoscopy for obstructing colonic cancer. For some obstructive patients, this may be not a good choice. Here, we report the successful treatment of obstructing colonic cancer by combining self-expandable stent and neoadjuvant *** SUMMARY The patient was a 72-year-old man who was admitted with a chief complaint of abdominal pain for more than 1 mo. Computed tomography(CT) scanning revealed that there was a mass in the descending colon, which led to intestinal obstruction. On admission, a series of therapeutic measures, such as fasting and water deprivation, gastrointestinal decompression, total parenteral nutrition, and octreotide acetate, were taken to improve the obstructive symptoms. At the same time, a self-expandable metal stent was successfully placed across the stenosis,and a biopsy was obtained and diagnosed as adenocarcinoma. CT scanning 14 d after insertion of the stent revealed that the intestine was swollen *** chemotherapy with modified FOLFOX6(mFOLFOX6) was administered. After two courses of mFOLFOX6, CT scanning showed clearly that swelling of the intestine was improved. Subsequently, the patient underwent left hemi-colectomy without stoma placement. The postoperative course was uneventful, and he has been disease-free for 6 mo after *** This modified treatment strategy may provide an alternative therapy for patients with obstructing colonic cancers.

关键词： Stent Colorectal neoplasms Intestinal obstruction Chemotherapy Case report

Paraquat Resistance in Leaf Discs of P_(SAG12)-IPT Modified Gerbera Is Relatedto the Activities of Superoxide Dismutase,Catalase,and Dehydroascorbate Reductase

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Agricultural Sciences in China 2007年第4期6卷 446-451页

作者： LAI Qi-xian BAO Zhi-yi zhu zhu-jun MAO Bi-zeng QIAN Qiong-qiu Department of Horticulture Zhejiang University/Key Laboratory of Horticultural Plant Development and Biotechnology Ministry of Agriculture Hangzhou 310029 P.R.China Institute ofBiotechnology Zhejiang University Hangzhou 310029 P.R.China Zhejiang Forestry University Lin ＇ an 311300 P R. China

In this paper, using in vitro leaf disc culture system, the changes of contents of chlorophylls, carotenoids, soluble protein, thiobarbituric acid reactive substance （TBARS）, and activities of antioxidant enzymes were investigated during the incubation of leaf discs of PSAG12-IPT modified gerbera in 0, 25, 50 μmol L^-1 paraquat （PQ） under continuous light intensity of 130 0tool m-2 s-1, compared with the control plant （wild type）. The results showed that PQ treatment significantly decreased the contents of chlorophylls, carotenoids, and soluble protein, therefore, promoted leaf senescence. However, the decreases in the leaf discs of modified gerbera were considerably smaller. The activities of superoxide dismutase （SOD）, catalase （CAT）, and dehydroascorbate reductase （DHAR） were significantly increased by PQ treatment and with the increasing of PQ concentration, particularly in the modified plants. The activities of ascorbate peroxidase （APX） and guaiacol peroxidase （GPX） could not be detected in the leaf discs of PQ treatments, which suggested that they were labile to the oxidative stress induced by PQ. As a product of lipid peroxidation, TBARS significantly increased in content with the increase of PQ concentration, while its concentration in the modified plants was significantly lower than that of control plants. Therefore, it could be concluded that the chimeric gene PSAG12-IPTtransfonnexi gerbera leaves had higher antioxidative potential, thus causing the delay of senescence under oxidative stress induced by PQ.

关键词： antioxidant enzymes gerbera leaf senescence paraquat oxidative stress PSAG12-IPT

大补阴丸联合去氧孕烯炔雌醇片治疗肾阴虚型青春期异常子宫出血的效果观察

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中国妇幼保健 2024年第11期39卷 1945-1948页

作者：贺俊霞姚娅丹杨晓敏浙江中医药大学附属嘉兴中医院妇科浙江嘉兴314000

目的观察大补阴丸联合去氧孕烯炔雌醇片治疗肾阴虚型青春期异常子宫出血的效果。方法选取2020年1月—2022年1月浙江中医药大学附属嘉兴中医院收治的100例肾阴虚型异常子宫出血患者,采用随机数字表法分为对照组(50例)和研究组(50例)。对... 详细信息

目的观察大补阴丸联合去氧孕烯炔雌醇片治疗肾阴虚型青春期异常子宫出血的效果。方法选取2020年1月—2022年1月浙江中医药大学附属嘉兴中医院收治的100例肾阴虚型异常子宫出血患者,采用随机数字表法分为对照组(50例)和研究组(50例)。对照组采用去氧孕烯炔雌醇片治疗,研究组采用大补阴丸联合去氧孕烯炔雌醇片治疗。对比两组治疗前后中医证候积分、治疗有效率、控制止血时间、完全止血时间、基础体温(BBT)双向率、激素水平及不良反应发生率。结果研究组治疗后中医证候积分显著低于对照组(P<0.05)。研究组治疗有效率为96.00%,高于对照组(82.00%),差异有统计学意义(χ2=5.005,P<0.05)。研究组控制止血时间、完全止血时间均短于对照组(均P<0.05)。研究组BBT双向率为6.00%,低于对照组的20.00%(P<0.05)。研究组复发率为2.00%,低于对照组的14.00%(P<0.05)。研究组治疗后卵泡刺激素(FSH)、雌激素受体、孕激素受体水平均高于对照组(均P<0.05)。研究组不良反应发生率为4.00%,低于对照组的16.00%(P<0.05)。结论大补阴丸联合去氧孕烯炔雌醇片治疗肾阴虚型异常子宫出血的疗效显著。

关键词：大补阴丸去氧孕烯炔雌醇片肾阴虚型青春期异常子宫出血疗效

Stability of NiCrAlY coating/titanium alloy system under pure thermal exposure

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Rare Metals 2017年第8期36卷 659-665页

作者： Xiao-min Peng An-Ru Wu Li-jun Dong You-Rui Tao Wei-Guo Gao Xiang-Lin Zhou State Key Laboratory of Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China School of Mechanical Engineering Hunan Institute of EngineeringXiangtan 411101China

In this paper,NiCrAlY coating was deposited on TC4 titanium alloy using arc ion plating,and the stability of NiCrAlY coating/TC4 substrate system under pure thermal exposure was analyzed in a wide temperature *** the thermal exposure,β→γ′→γphase transformation takes place in the NiCrAlY *** NiCrAlY coating phases totally decompose above the allotropic transformation temperature of *** allotropic transformation ofα-Ti to β-Ti of the substrate significantly influences the stability of NiCrAlY coating/TC4 substrate *** coating elements are mainly consumed by interfacial reactions below the allotropic transformation temperature of *** the allotropic transformation temperature of TC4,NiCrAlY coating elements are mainly consumed by element dissolution in β-*** NiCrAlY coating totally degrades for the dissolution of coating elements in the substrate to form thickβ-Ti stabilized layer.

关键词： NiCrAlY coating Titanium alloy Stability Pure thermal exposure Degradation