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MMP14 is a diagnostic gene of intrahepatic cholangiocarcinoma associated with immune cell infiltration

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World Journal of Gastroenterology 2023年第19期29卷 2961-2978页

作者： jun Wu Yang Guo Zhi-Fan Zuo Zi-Wei zhu Lei Han China Medical University The General Hospital of Northern Theater Command Training Base for GraduateShenyang 110016Liaoning ProvinceChina Department of Hepatobiliary Surgery The General Hospital of Northern Theater CommandShenyang 110016Liaoning ProvinceChina Gynecological Radiotherapy Ward Liaoning Provincial Cancer HospitalShenyang 110801Liaoning provinceChina

BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a malignant tumor of the hepatobiliary system with concealed onset,strong invasiveness and poor *** To explore the disease characteristic genes that may be helpful in the diagnosis of ICC and affect immune cell *** We downloaded two ICC-related human gene expression profiles from GEO database as the training group(GSE26566 and GSE32958 datasets)for difference analysis,and performed enrichment analysis on differential *** least absolute shrinkage and selection operator(LASSO),support vector machinerecursive feature elimination(SVM-RFE)and random forest(RF),three machine learning algorithms,were used to screen the characteristic *** verification was carried out on GSE107943 and The Cancer Genome Atlas,two verification *** operating characteristic curve and area under the curve(AUC)were used to evaluate the diagnostic efficacy of genes for *** and ssGSEA algorithms were used to evaluate the effect of characteristic genes on immune infiltration *** Protein Atlas(HPA)was used to analyze the protein expression level of the target *** A total of 1091 differential genes were obtained in the training *** analysis showed that the above genes were mainly enriched in small molecular catabolism,complement and coagulation cascade,bile secretion and other functions and *** characteristic genes were screened by LASSO regression,19 by SVM-RFE algorithm,and 30 by RF *** algorithms were used in combination to determine the characteristic gene of ICC:*** verification group confirmed that the genes had a high diagnostic accuracy(AUC values of the training group and the verification group were 0.960,0.999,and 0.977,respectively).Comprehensive analysis of immune infiltration showed that MMP14 could affect the infiltration of monocytes,activated memory CD4 T cells,resting memory CD4 T cells,and other immune cells

关键词： Intrahepatic cholangiocarcinoma MMP14 Machine learning Immune infiltration Characteristic gene Diagnostic markers

PDCA管理模式在神经外科盲插鼻空肠管的应用效果

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中国医药指南 2024年第14期22卷 185-188页

作者：许亚婷朱瑞英孙敏王晓芬晋江市医院(上海市第六人民医院福建医院)神经外科晋江362200

目的探析PDCA管理模式在盲插鼻空肠管的应用效果。方法回顾性分析77例神经外科行盲插空肠管患者的病历资料。根据置管时间完成分组,分别命名为对照组(n=33,给予常规盲插鼻空肠管法)、观察组(n=34,运用PDCA管理模式护理干预盲插鼻空肠管... 详细信息

目的探析PDCA管理模式在盲插鼻空肠管的应用效果。方法回顾性分析77例神经外科行盲插空肠管患者的病历资料。根据置管时间完成分组,分别命名为对照组(n=33,给予常规盲插鼻空肠管法)、观察组(n=34,运用PDCA管理模式护理干预盲插鼻空肠管)。对比两组患者盲插鼻空肠管成功率、护理人员满意程度、护理质量评价情况。结果观察组患者盲插鼻空肠管成功率高于对照组(P<0.05)。观察组患者对护理服务质量满意度评价高于对照组(P<0.05)。对两种模式下的护理质量进行评价,观察组创新精神、团队精神、质量意识、临床思维能力、解决问题能力评分高于对照组(P<0.05)。结论应用PDCA管理模式有助于提高盲插鼻空肠管成功率,为患者提供更好的护理体验,对护理工作而言有积极的影响。

关键词： PDCA管理盲插鼻空肠管护理评价护理质量

The prognosis of trabeculectomy in primary angleclosure glaucoma patients

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 66-72页

作者： jun-Dong zhu Li-Lian Xie Zhi-Yuan Li Xiao-He Lu Department of Ophthalmology Zhujiang Hospital of Southern Medical University Department of Ophthalmology the First People’s Hospital of Chenzhou CitySouthern Medical University

AIM: To evaluate whether the level of thrombospondin-1(TSP-1) in aqueous humor can predict the prognosis of trabeculectomy in patients with primary angle-closure glaucoma(PACG). METHODS: This case-control study involved 26 patients with PACG who experienced a failed trabeculectomy(case group) and 78 age-and sex-matched patients with PACG who underwent successful trabeculectomy(control group). Aqueous humor was collected at the time of trabeculectomy and tested for TSP-1 and TGF-β2 levels with an enzyme-linked immunosorbent assay method. Logistic regression modeling was used to assess the risk factors for failed trabeculectomy. RESULTS: The mean TSP-1 aqueous concentrations were significantly higher in the case group(20.67±9.79 ng/mL) than the control group(5.17±2.29 ng/mL)(Pming growth factor-β2(TGF-β2) aqueous concentrations were significantly different between the case and control group, at 3633.25 and 1090.24 pg/mL, respectively(P<0.001). Logistic regression analysis revealed TSP-1 level as an independent risk factor for a failed trabeculectomy(OR=3.540; 95%CI=1.092-11.482). CONCLUSION: The aqueous humor TSP-1 and TGF-β2 levels are higher in PACG eyes with failed trabeculectomy than with successful trabeculectomy at one year. The aqueous humor TSP-1 level is an independent risk factor associated with failed trabeculectomy.

关键词： thrombospondin-1 prognosis primary angleclosure glaucoma

Non-Markovianity of a qubit coupled with an isotropic Lipkin–Meshkov–Glick bath

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Chinese Physics B 2015年第10期24卷 59-66页

作者：田立君提敏敏翟向东 Department of Physics Shanghai University

We study the non-Markovianity of the single qubit system coupled with an isotropic Lipkin-Meshkov-Glick（LMG）model by an effective method proposed by Breuer et al.（Breuer H P and Piilo J 2009 Europhys. Lett. 85 5004）. It is discovered that the non-Markovianity is concerned with the quantum phase transitions（QPTs）. In the open system, we present that the strong coupling inside the bath and the strong interaction between the system and bath can enhance the degree of non-Markovianity. Moreover, the non-Markovianity is stronger and more sensitive for the bath in the symmetric phase than the symmetry broken phase.

关键词： non-Markovianity qubit dynamics LMG model

Dedication on the Occasion of Professor Xiaqi Ding's 80th Birthday

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Acta Mathematicae Applicatae Sinica 2008年第3期24卷 353-354页

作者： Dao-min Cao Gui-qiang Chen Yan-yan Li Xi-ping zhu Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China Department of Mathematics Northwestern University Evanston USA Department of Mathematics Rutgers University Piscataway NJ 08854 USA Department of Mathematics Zhongshan University Guangzhou 510275 China

This volume is dedicated to Professor Xiaqi Ding, an academician of the Chinese Academy of Sciences, on the occasion of his eightieth birthday.

关键词： Orlicz Space Cultural Revolution Distinguished Research Tricomi Problem Hermitian Expansion

Controlling the reaction kinetics in solution for uniform nanoshells of metal sul?des with sub-nanometer accuracy

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Science Bulletin 2019年第4期64卷 232-235页

作者： Shu-Yi Duan Zi-Xiao Wu jun-Yu Piao De-Shan Bin Yong-Gang Sun Xi-Jie Lin An-min Cao Li-jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology and CAS Research/Education Center for Excellence in Molecular Sciences Institute of ChemistryChinese Academy of Sciences (CAS) University of Chinese Academy of Sciences (UCAS) Institute of Chemical Materials China Academy of Engineering Physics

Core-shell nanostructiKes have found broad potentials in a large variety of applications including catalysis, biomedicine, and energy conversion/storage devices [1,2]. The unique structural configuration endows the compos让e a capability to combine advantages of both core and shell materials, and deliver optimized properties through a rational design of the components [3]. Accordingly, numerous research efforts have been directed to the synthesis control of the coating materials to build desired nanoshells. Particularly, silica-based core-shell structures have witnessed enormous success benefiting from the flexible synthesis capability ensured by the Stober process, which provides favorable growth kinetics in solution to build precise configuration of silica nanoshells su让ed for their applications, for example, silica-based nanocapsules for controlled drug delivery [4].

关键词： Core-shell variety applications

High-Order Local Discontinuous Galerkin Method with Multi-Resolution WENO Limiter for Navier-Stokes Equations on Triangular Meshes

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Communications in Computational Physics 2023年第5期33卷 1217-1239页

作者： Yizhou Lu jun zhu Shengzhu Cui Zhenming Wang Linlin Tian Ning Zhao State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsJiangsu 210000P.R.China Key Laboratory of Mathematical Modeling and High Performance Computing of Air Vehicles Nanjing University of Aeronautics and AstronauticsJiangsu 210000P.R.China Jiangsu Key Laboratory of Hi-Tech Research for Wind Turbine Design Nanjing University of Aeronautics and AstronauticsJiangsu 210000P.R.China College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsJiangsu 210000P.R.China

In this paper,a new multi-resolution weighted essentially non-oscillatory(MR-WENO)limiter for high-order local discontinuous Galerkin(LDG)method is designed for solving Navier-Stokes equations on triangular *** MR-WENO limiter is a new extension of the finite volume MR-WENO *** new limiter uses information of the LDG solution essentially only within the troubled cell itself,to build a sequence of hierarchical L^(2)projection polynomials from zeroth degree to the highest degree of the *** an example,a third-order LDGmethod with associated same orderMR-WENO limiter has been developed in this paper,which could maintain the original order of accuracy in smooth regions and could simultaneously suppress spurious oscillations near strong shocks or contact *** linear weights of such new MR-WENO limiter can be any positive numbers on condition that their summation is *** is the first time that a series of different degree polynomials within the troubled cell are applied in a WENO-type fashion to modify the freedom of degrees of the LDG solutions in the troubled *** MR-WENO limiter is very simple to construct,and can be easily implemented to arbitrary high-order accuracy and in higher dimensions on unstructured *** spatial reconstruction methodology improves the robustness in the numerical simulation on the same compact spatial stencil of the original LDG methods on triangular *** classical viscous examples are given to show the good performance of this third-order LDG method with associated MR-WENO limiter.

关键词： Local discontinuous Galerkin method multi-resolution WENO limiter triangular meshes Navier-Stokes equations

基于Fas/FasL信号通路对桂药生精胶囊治疗少精子症的临床研究

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检验医学与临床 2024年第11期21卷 1543-1547页

作者：戴芳唐亚平买鹏宇张泽朝朱闽广西中医药大学附属瑞康医院检验科广西南宁530011 广西中医药大学基础医学院广西南宁530200 广西中医药大学附属瑞康医院科技科广西南宁530011 广西中医药大学附属瑞康医院男性科广西南宁530011

目的探讨桂药生精胶囊对少精子症(肾精亏虚型)患者的精子浓度(SC)、前向运动精子比例(PR)、PR+非前向运动精子比例(NP)、精子总数、精子脂肪酸合成酶(Fas)信使RNA(mRNA)、脂肪酸合成酶配体(FasL)mRNA表达水平及精浆Fas蛋白、FasL蛋白表... 详细信息

目的探讨桂药生精胶囊对少精子症(肾精亏虚型)患者的精子浓度(SC)、前向运动精子比例(PR)、PR+非前向运动精子比例(NP)、精子总数、精子脂肪酸合成酶(Fas)信使RNA(mRNA)、脂肪酸合成酶配体(FasL)mRNA表达水平及精浆Fas蛋白、FasL蛋白表达水平的影响。方法选取2019年10月至2020年3月就诊于广西中医药大学附属瑞康医院男性科门诊的少精子症(肾精亏虚型)患者60例,随机分为对照组和治疗组,每组30例。对照组采用左卡尼汀治疗,治疗组在对照组的基础上联合桂药生精胶囊治疗,12周为1个疗程。观察治疗前后两组患者的SC、PR、PR+NP、精子总数、精子Fas mRNA、FasL mRNA和精浆Fas蛋白、FasL蛋白表达水平。结果治疗组总有效率比对照组高(P0.05)。治疗后两组患者精子SC、PR、PR+NP和精子总数均比治疗前高(P0.05)。治疗后两组精浆Fas蛋白表达水平低于治疗前(P0.05)。治疗后两组患者精子Fas mRNA和FasL mRNA表达水平低于治疗前(P<0.05),且治疗组Fas mRNA表达水平低于对照组(P<0.05)。结论桂药生精胶囊能明显提高少精子症(肾精亏虚型)患者的SC、PR、精子总数,降低精子Fas mRNA及精浆Fas蛋白的表达水平。

关键词：桂药生精胶囊少精子症肾精亏虚型脂肪酸合成酶脂肪酸合成酶配体

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Interactions of Shear Bands in a Ductile Metallic Glass

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Journal of Iron and Steel Research International 2016年第1期23卷 48-52页

作者： Li-shan HUO jun-qiang WANG jun-tao HUO Yuan-yun ZHAO He MEN Chun-tao CHANG Xin-min WANG Run-wei LI Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Materials Technology & EngineeringChinese Academy of Sciences Zhejiang Province Key Laboratory of Magnetic Materials and Application Technology Ningbo Institute of Materials Technology & EngineeringChinese Academy of Sciences

Shear bands play a key role in the plastic deformation of metallic glasses（MGs）.Even though there are extensive studies on the initiation and propagation of shear bands,the interactions among them have not been systematically studied *** interactions between the primary shear bands（PSBs）and secondary shear bands（SSBs）in a ductile Zr-based MG were *** residual stress near PSBs can deflect the propagation direction and reduce the propagation velocity of SSBs,which contributes to the plasticity and toughness of the *** was demonstrated that the probability and strength of the interactions between PSBs and SSBs would become stronger for MGs with larger Young′s modulus and smaller shear modulus,i.e.,larger Poisson′s *** results are valuable in understanding the plastic deformation of MGs and may be helpful in designing new MGs with desirable mechanical properties.

关键词： bulk metallic glass shear band interaction plasticity serration