检索结果-南通市图书馆

Up-regulation of HCN2 channels in a thalamocortical circuit mediates allodynia in mice

National Science Review 2023年第2期10卷 107-122页

作者： jun-ma yu Rui Hu yu mao Yingju Tai Sen Qun Zhi Zhang Danyang Chen Yan Jin Department of Anesthesiology The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei) Department of Anesthesiology The First Affiliated Hospital of Anhui Medical University Department of Biophysics and Neurobiology Division of Life Sciences and Medicine University of Science and Technology of China Stroke Center and Department of Neurology The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China

Chronic pain is a significant problem that afflicts individuals and society,and for which the current clinical treatment is inadequate.In addition,the neural circuit and molecular mechanisms subserving chronic pain remain largely uncharacterized.Herein we identified enhanced activity of a glutamatergic neuronal circuit that encompasses projections from the ventral posterolateral nucleus(VPLGlu) to the glutamatergic neurons of the hindlimb primary somatosensory cortex(S1HLGlu),driving allodynia in mouse models of chronic pain.Optogenetic inhibition of this VPLGlu→S1HLGlucircuit reversed allodynia,whereas the enhancement of its activity provoked hyperalgesia in control mice.In addition,we found that the expression and function of the HCN2(hyperpolarization-activated cyclic nucleotide-gated channel 2) were increased in VPLGluneurons under conditions of chronic pain.Using in vivo calcium imaging,we demonstrated that downregulation of HCN2 channels in the VPLGluneurons abrogated the rise in S1HLGluneuronal activity while alleviating allodynia in mice with chronic pain.With these data,we propose that dysfunction in HCN2 channels in the VPLGlu→S1HLGluthalamocortical circuit and their upregulation occupy essential roles in the development of chronic pain.

关键词： chronic pain HCN2 channels neural circuit in vivo recordings

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Attribute Reduction of Hybrid Decision Information Systems Based on Fuzzy Conditional Information Entropy

引用

Computers, materials & Continua 2024年第5期79卷 2063-2083页

作者： Xiaoqin ma jun Wang Wenchang yu Qinli Zhang School of Big Data and Artificial Intelligence Chizhou UniversityChizhou247000China Anhui Education Big Data Intelligent Perception and Application Engineering Research Center Chizhou247000China

The presence of numerous uncertainties in hybrid decision information systems(HDISs)renders attribute reduction a formidable task.Currently available attribute reduction algorithms,including those based on Pawlak attribute importance,Skowron discernibility matrix,and information entropy,struggle to effectively manages multiple uncertainties simultaneously in HDISs like the precise measurement of disparities between nominal attribute values,and attributes with fuzzy boundaries and abnormal values.In order to address the aforementioned issues,this paper delves into the study of attribute reduction withinHDISs.First of all,a novel metric based on the decision attribute is introduced to solve the problem of accurately measuring the differences between nominal attribute values.The newly introduced distance metric has been christened the supervised distance that can effectively quantify the differences between the nominal attribute values.Then,based on the newly developed metric,a novel fuzzy relationship is defined from the perspective of“feedback on parity of attribute values to attribute sets”.This new fuzzy relationship serves as a valuable tool in addressing the challenges posed by abnormal attribute values.Furthermore,leveraging the newly introduced fuzzy relationship,the fuzzy conditional information entropy is defined as a solution to the challenges posed by fuzzy attributes.It effectively quantifies the uncertainty associated with fuzzy attribute values,thereby providing a robust framework for handling fuzzy information in hybrid information systems.Finally,an algorithm for attribute reduction utilizing the fuzzy conditional information entropy is presented.The experimental results on 12 datasets show that the average reduction rate of our algorithm reaches 84.04%,and the classification accuracy is improved by 3.91%compared to the original dataset,and by an average of 11.25%compared to the other 9 state-of-the-art reduction algorithms.The comprehensive analysis of these research results clearly indicates that

关键词： Hybrid decision information systems fuzzy conditional information entropy attribute reduction fuzzy relationship rough set theory(RST)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Paeoniflorin,the main Monomer Component of Paeonia lactiflora,Exhibits Anti-inflammatory Properties in Osteoarthritis Synovial Inflammation

引用

Chinese Journal of Integrative Medicine 2024年第5期30卷 433-442页

作者： CHEN Pu ZHOU jun RUAN An-min ma yu-feng WANG Qing-fu Department of Orthopaedic Surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Department of Orthopaedic Surgery Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Orthopaedic Surgery Beijing Longfu HospitalBeijing 100010China

Objective:To explore the mechanism of paeoniflorin(PF)on osteoarthritis(OA)synovial inflammation from network pharmacology to experimental pharmacology.Methods:Targets of OA were constructed by detecting the database of network database platforms(Therapeutic Target database,Drug Bank and Gene Cards),and the targets of PF were constructed by Pub Chem and Herbal Ingredients'Targets database.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of these co-targeted genes were conducted via Database for Annotation,Visualization,and Integrated Discovery(DAVID)database,and protein-protein interaction(PPI)networks were conducted via the search tool for the retrieval of interacting genes(STRING)database.Cell counting kit-8(CCK-8)assay was performed to assess the potential toxicity of PF on human OA fibroblast-like synoviocytes(FLS),quantitative real-time polymerase chain reaction(q PCR),enzyme-linked immunosorbent assay(ELISA)and Western blot were used to verify the potential mechanism of PF in synovial inflammation.Results:Twenty-six co-targeted genes were identified.GO enrichment results showed that these co-targeted genes were most likely localized in the cytoplasm,and the biological processes mainly involved'cellular response to hypoxia''lipopolysaccharide(LPS)-mediated signaling pathway'and'positive regulation of gene expression'.KEGG pathway analysis indicated that these co-targeted genes may function through pathways associated with'hypoxia-inducible factor-1(HIF-1)signaling pathway'and'tumornecrosis factor(TNF)signaling pathway'.The PPI network showed that the top 3 hub genes were TP53,TNF,and CASP3.Molecular docking results showed that PF was well docking with TNF.CCK-8 showed no potential toxicity of 10,20 and 50μmol/L PF on human OA FLS.And PF significantly decreased the expression levels of interleukin-1β,interleukin-6,TNF-αmatrix metalloproteinase 13(MMP13),and a disintegrin and metalloproteinase with thrombospondin motifs 5(ADAMTS5)and TNF-αin LPS-induced OA FLS.Conclusion:PF exhibited

关键词： paeoniflorin osteoarthritis synovial inflammation tumor necrosis factor-α network pharmacology Paeonia lactiflora

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Progress and prospects of chiral nanomaterials for biosensing platforms

引用

Rare Metals 2024年第6期43卷 2469-2497页

作者： yu-Cheng Ouyang Bong-jun Yeom yuan Zhao Wei ma School of Food Science and Technology State Key Laboratory of Food Science and ResourcesJiangnan University Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan University Department of Chemical Engineering Hanyang University

Chiral nanomaterials have distinct chiroptical properties of preferential interactions to circularly polarized lights.Chirality-based biosensors have emerged for detection of biomolecules,ions and cells in recent years.This review provides an extensive overview of biosensors based on chiral nanomaterials,starting with approaches to chiral nanomaterials construction in terms of fabrication strategies.Fabrication of chiral nanomaterials and their biosensor applications is presented for different material types,with special emphasis on the role and importance of material properties and signal generation in detection.We assessed the technological prospects of the emerging fields of chiral construction,circularly polarized luminescence,Raman optical activity and so on along with their current challenges.Prospective venues for future research on chiral nanomaterials in fabrication,biosensing,disease diagnosis and treatment are also presented in the review.

关键词： Chiral nanomaterials Circular dichroism Biosensors

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

SciCN:A Scientific Dataset for Chinese Named Entity Recognition

引用

Computers, materials & Continua 2024年第3期78卷 4303-4315页

作者： Jing Yang Bin Ji Shasha Li jun ma Jie yu College of Computer National University of Defense TechnologyChangsha410073China

Named entity recognition(NER)is a fundamental task of information extraction(IE),and it has attracted considerable research attention in recent years.The abundant annotated English NER datasets have significantly promoted the NER research in the English field.By contrast,much fewer efforts are made to the Chinese NER research,especially in the scientific domain,due to the scarcity of Chinese NER datasets.To alleviate this problem,we present aChinese scientificNER dataset–SciCN,which contains entity annotations of titles and abstracts derived from 3,500 scientific papers.We manually annotate a total of 62,059 entities,and these entities are classified into six types.Compared to English scientific NER datasets,SciCN has a larger scale and is more diverse,for it not only contains more paper abstracts but these abstracts are derived from more research fields.To investigate the properties of SciCN and provide baselines for future research,we adapt a number of previous state-of-theart Chinese NER models to evaluate SciCN.Experimental results show that SciCN is more challenging than other Chinese NER datasets.In addition,previous studies have proven the effectiveness of using lexicons to enhance Chinese NER models.Motivated by this fact,we provide a scientific domain-specific lexicon.Validation results demonstrate that our lexicon delivers better performance gains than lexicons of other domains.We hope that the SciCN dataset and the lexicon will enable us to benchmark the NER task regarding the Chinese scientific domain and make progress for future research.The dataset and lexicon are available at:https://***/yangjingla/SciCN.git.

关键词： Named entity recognition dataset scientific information extraction lexicon

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Active components of Dengzhan Shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca^(2+)/CaMKII pathway

引用

Journal of Pharmaceutical Analysis 2024年第3期14卷 435-438页

作者： Congyu ma Ning Sheng jun Wu Lulu Wang Jiandong Jiang Haibo yu Jinlan Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China

Abnormal synaptic plasticity causes cognitive deficits.Hippocampal long-term potentiation(LTP)is a critical synaptic plasticity process[1].Rescuing impaired LTP is challenging;hence,novel agents are required for LTP facilitation.Chinese medicine Dengzhan Shengmai(DzSM)has shown notable clinical efficacy against cognitive deficits[2].However,it remains unclear how DzSM modulates cognition.Our previous study[3]revealed the influence of DZSM on glutamatergic and GABAergic synapses following chronic cerebral hypoperfusion(CCH),which motivated us to assess how DzSM affects synaptic functions.

关键词： impaired impairment hence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simultaneous type III congenital esophageal atresia and patent ductus arteriosus in a low-weight patient: A case report

引用

World Journal of Clinical Cases 2024年第3期12卷 560-564页

作者： Yong-yu ma jun-Ru Chen Shi-Wu Yang Shu-yu Wang Xin Cao jun Wu Faculty of Pediatrics Children’s Hospital Affiliated to Kunming Medical UniversityKunming 650103Yunnan ProvinceChina Department of Cardiothoracic Surgery Kunming Children’s HospitalKunming 650103Yunnan ProvinceChina

BACKGROUND We report a low-birth-weight child(1.8 kg)with neonatal type III congenital esophageal atresia(CEA)combined with symptomatic patent ductus arteriosus(PDA).After comprehensive evaluation,esophageal anastomosis was performed on postnatal day 11 after excluding surgical contraindications,and arterial catheter ligation was performed at the same time.Concurrent surgery for CEA combined with PDA has not been clearly reported in the literature.CASE SUMmaRY We report a 6-day-old female child with type III CEA and PDA.The patient presented with foam at the mouth after birth,cough and shortness of breath after feeding.At another hospital,she was considered to have neonatal pneumonia,neonatal jaundice and congenital heart disease and transferred to our hospital.After iodine oil radiography of the esophagus and echocardiography we con-firmed diagnosis of CEA and PDA.The diameter of the PDA was 8 mm,with obvious left to right shunting.We performed right rear extrapleural orificium fistula ligation and esophageal anastomosis,and ligation of PDA via left axilla straight incision after 5 d of hospitalization.The operations were successful,and the incision healed after 12 d,and the patient was discharged.We re-examined the patient 1 mo after surgery.She did not vomit when she ate rice flour.Esophageal angiography showed no stricture of the anastomotic stoma.The patient weighed 3.2 kg.CONCLUSION For CEA patients with multiple risk factors,comprehensive,timely and accurate diagnosis and evaluation,and early treatment may improve prognosis.

关键词： Congenital esophageal atresia Patent ductus arteriosus Low weight One-stage operation Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Risk assessment of oil and gas investment environment in countries along the Belt and Road Initiative

引用

Petroleum Science 2024年第2期21卷 1429-1443页

作者： Bao-jun Tang Chang-Jing Ji yu-Xian Zheng Kang-Ning Liu Yi-Fei ma jun-yu Chen Center for Energy and Environmental Policy Research Beijing Institute of TechnologyBeijing100081China School of management and Economics Beijing Institute of TechnologyBeijing100081China Collaborative Innovation Center of Electric Vehicles in Beijing BeijingChina Sustainable Development Research Institute for Economy and Society of Beijing BeijingChina Institute of Carbon Neutrality ShanghaiTech UniversityShanghai201210China

With the implementation of the Belt and Road Initiative, China is deepening its cooperation in oil and gas resources with countries along the Initiative. In order to better mitigate risks and enhance the safety of investments, it is of significant importance to research the oil and gas investment environment in these countries for China's overseas investment macro-layout. This paper proposes an indicator system including 27 indicators from 6 dimensions. On this basis, game theory models combined with global entropy method and analytic hierarchy process are applied to determine the combined weights, and the TOPSIS-GRA model is utilized to assess the risks of oil and gas investment in 76 countries along the Initiative from 2014 to 2021. Finally, the GM(1,1) model is employed to predict risk values for 2022-2025. In conclusion, oil and gas resources and political factors have the greatest impact on investment environment risk, and 12 countries with greater investment potential are selected through cluster analysis in conjunction with the predicted results. The research findings may provide scientific decisionmaking recommendations for the Chinese government and oil enterprises to strengthen oil and gas investment cooperation with countries along the Belt and Road Initiative.

关键词： Belt and Road Initiative Oil and Gas Investment Risk assessment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-entropy oxide-supported platinum nanoparticles for efficient hydrogen evolution reaction

引用

Rare Metals 2024年第4期43卷 1537-1546页

作者： Ming-yu Fan Jia-jun Wang jun Zhao Hong Zhang Tian-Yi ma Xiao-Peng Han Wen-Bin Hu School of materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Key Laboratory of Advanced Ceramics and Machining Technology Tianjin University School of National University of Singapore and Tianjin University International Campus of Tianjin University School of Science RMIT University

High-entropy oxides（HEOs） are a new class of single-phase structures with unique electronic and catalytic properties;therefore,it is worthwhile to explore their applications in electrocatalysis.In this study,a Pt/（FeCoNiCrAl）3O4nanohybrid using HEO as a support was developed as an efficient catalyst for the hydrogen evolution reaction（HER）.Pt/（FeCoNiCrAl）3O4exhibited high HER activity with a low overpotential of 22 mV at10 ma·cm-2,outperforming other binary,ternary,and quaternary supports.The HER activity of Pt/（FeCoNiCrAl）3O4was higher than that of a commercial Pt/C with a significantly lower Pt loading.The catalyst exhibited good activity and long-term stability（60 h） in an electrolytic water-splitting device.This good activity can be attributed to the fact that the introduction of Pt effectively facilitates electronic interactions between Pt and the HEO.In addition,the HEO substrate was more favorable for dispersing Pt particles,optimizing the electrochemical specific surface area,and significantly reducing the charge resistance of the HER.This study extends the application of HEOs in electrocatalysis and demonstrates the promising prospects of HEOs as supports for electrocatalysts.

关键词： High-entropy oxides Hydrogen evolution reaction Nanohybrid Water electrolysis

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Span-based joint entity and relation extraction augmented with sequence tagging mechanism

引用

Science China(Information Sciences) 2024年第5期67卷 84-98页

作者： Bin JI Shasha LI Hao XU Jie yu jun ma Huijun LIU Jing YANG College of Computer National University of Defense Technology

Span-based joint extraction simultaneously conducts named entity recognition(NER) and relation extraction(RE) in a text span form. However, since previous span-based models rely on span-level classifications, they cannot benefit from token-level label information, which has been proven advantageous for the task. In this paper, we propose a sequence tagging augmented span-based network(STSN), a spanbased joint model that can make use of token-level label information. In STSN, we construct a core neural architecture by deep stacking multiple attention layers, each of which consists of three basic attention units.On the one hand, the core architecture enables our model to learn token-level label information via the sequence tagging mechanism and then uses the information in the span-based joint extraction; on the other hand, it establishes a bi-directional information interaction between NER and RE. Experimental results on three benchmark datasets show that STSN consistently outperforms the strongest baselines in terms of F1,creating new state-of-the-art results.

关键词： joint extraction named entity recognition relation extraction span sequence tagging mechanism

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：