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Network meta-analysis of combination strategies in metastatic hormone-sensitive prostate cancer

Asian Journal of Andrology 2024年第4期26卷 402-408页

作者： Shan-Shan Wang Xiao-Jie Bian jun-long wu Bei-He Wang Sheng Zhang Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China.

This study compared different doublet and triplet therapies for efficacy and safety in metastatic hormone-sensitive prostate cancer(mHSPC).PubMed,EMBASE,and the Cochrane Library were comprehensively searched for eligible randomized controlled trials(RCTs)published from inception to October *** included abiraterone,apalutamide,enzalutamide,docetaxel,darolutamide,and androgen deprivation therapy(ADT),either as doublet or triplet *** outcomes examined were overall survival(OS),progression-free survival(PFS),castration-resistant prostate cancer(CRPC)-free survival,time to symptomatic skeletal event(SSE),and *** surface under the cumulative ranking curve(SUCRA)was determined to identify the preferred *** RCTs were *** combination of darolutamide,docetaxel,and ADT had the highest SUCRA of 84.3 for OS,followed by combined abiraterone,docetaxel,and ADT(SUCRA=71.6).The highest SUCRAs for PFS were observed for triplet therapies(abiraterone,docetaxel,and ADT[SUCRA=74.9],followed by enzalutamide,docetaxel,and ADT[SUCRA=74.3])and other androgen receptor axis-targeted therapy-based doublet therapies(SUCRAs:26.5–59.3).Darolutamide,docetaxel,and ADT had the highest SUCRAs,i.e.,80.8 and 84.0 regarding CRPC-free survival and time to SSE,*** Grade>3 adverse events(AEs),the SUCRAs of triplet therapies(SUCRAs:14.8–31.5)were similar to that of docetaxel and ADT(SUCRA=39.5).Three studies had a low risk of bias in all categories;the remaining studies had at least an unclear risk of bias in at least one *** therapy demonstrated potentially enhanced effectiveness than doublet therapy in mHSPC,with acceptable safety *** might be the optimal option for triplet therapy in combination with docetaxel and ADT.

关键词： androgen antagonist androgen receptor antagonist docetaxel meta-analysis prostatic neoplasm

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Microglia Research in the 100th Year Since Its Discovery

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Neuroscience Bulletin 2020年第3期36卷 303-306页

作者： Anthony DUmpierre long-jun wu Department of Neurology Mayo ClinicRochesterMN 55905USA Department of Neuroscience Mayo ClinicJacksonvilleFL 32224USA Department of Immunology Mayo ClinicRochesterMN 55905USA

In 1919,Pio del Rio-Hortega first described a class of cells residing in the brain with a tiny soma and branched architecture distinguishable from astrocytes and *** cells,called microglia or mesoglia,have come to be appreciated as resident immune cells in the central nervous system(CNS).In the year 2019,we review the three most recent advances in microglia research in this 100th year since their discovery(Fig.1).We first discuss their transcriptional diversity,which allows us to appreciate the heterogeneity of microglia across species,development,diseases,and brain *** also highlight recent stem cell-based approaches that allow us to study human microglia.

关键词： diseases glia appreciate

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Microglial voltage-gated proton channel Hv1 in spinal cord injury

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Neural Regeneration Research 2022年第6期17卷 1183-1189页

作者： Jiaying Zheng Madhuvika Murugan Lingxiao Wang long-jun wu Department of Neurology Mayo ClinicRochesterMNUSA Department of Neurosurgery Rutgers Robert Wood Johnson Medical SchoolPiscatawayNJUSA Department of Neuroscience Mayo ClinicJacksonvilleFLUSA Department of Immunology Mayo ClinicRochesterMNUSA

After spinal cord injury,microglia as the first responders to the lesion display both beneficial and detrimental *** microglia phagocyte and eliminate cell debris,release cytokines to recruit peripheral immune cells to the injury *** activated microglia can aggravate the secondary damage by producing extravagant reactive oxygen species and pro-inflammatory *** studies demonstrated that the voltage-gated proton channel Hv1 is selectively expressed in microglia and regulates microglial activation upon *** mouse models of spinal cord injury,Hv1 deficiency ameliorates microglia activation,resulting in alleviated production of reactive oxygen species and pro-inflammatory *** reduced secondary damage subsequently decreases neuronal loss and correlates with improved locomotor *** review provides a brief historical perspective of advances in investigating voltage-gated proton channel Hv1 and home in on microglial *** discuss recent studies on the roles of Hv1 activation in pathophysiological activities of microglia,such as production of NOX-dependent reactive oxygen species,microglia polarization,and tissue acidosis,particularly in the context of spinal cord ***,we highlight the rationale for targeting Hv1 for the treatment of spinal cord injury and related disorders.

关键词： Hv1 proton channel ion channels microglia NADPH oxidase pH regulation reactive oxygen species spinal cord injury

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Getting a Sense of ATP in Real Time

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Neuroscience Bulletin 2022年第7期38卷 834-836页

作者： Anthony D.Umpierre Koichiro Haruwaka long-jun wu Department of Neurology Mayo ClinicRochesterMN55905USA Department of Neuroscience Mayo ClinicJacksonvilFL32224USA Department of Immunology Mayo ClinicRochesterMN55905USA

Adenosine 5'-triphosphate(ATP)is a purinergic signal that can be sensed by all major cell classes in the *** is a key signal released during periods of physical damage/injury,inflammation,and neurological events,such as *** ATP signaling in the living brain is complicated by its fast enzymatic degradation,its action at multiple receptors,and its somewhat elusive.

关键词： signal damage somewhat

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The Macrophage IL-23/IL-17A Pathway:A New Neuro-Immune Mechanism in Female Mechanical Pain

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Neuroscience Bulletin 2022年第4期38卷 453-455页

作者： Zhi Tan Zhen-Jia Lin long-jun wu Li-jun Zhou Department of Physiology and Pain Research Center Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Department of Neurology Mayo ClinicRochesterMN 55905USA

Considerable clinical evidence has demonstrated that the prevalence and severity of many chronic pain syndromes differ across sex,and are more predominant in womenthan inmen[l]But most preclinical research on chronic pain mechanisms has been performed primarily in male *** is generally understood that inflammatory responses in the peripheral and central nervous systems are critical for chronic pain[2,3],Given that sex dimorphism influences immunity in various diseases[4].

关键词： immunity clinical pain

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Chemogenetic and Optogenetic Manipulations of Microglia in Chronic Pain

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Neuroscience Bulletin 2023年第3期39卷 368-378页

作者： Sebastian Parusel Min-Hee Yi Christine L.Hunt long-jun wu Department of Neurology Mayo ClinicRochesterMN 55905USA Faculty of Psychology and Neuroscience Maastricht UniversityMaastricht MD6200The Netherlands Department of Pain Medicine Mayo ClinicJacksonvilleFL 32224USA Department of Neuroscience Mayo ClinicJacksonvilleFL 32224USA Department of Immunology Mayo ClinicRochesterMN 55905USA

Chronic pain relief remains an unmet medical *** research points to a substantial contribution of glia-neuron interaction in its ***,microglia play a crucial role in the development of chronic *** better understand the microglial contribution to chronic pain,specific regional and temporal manipulations of microglia are ***,two new approaches have emerged that meet these *** tools allow the expression of designer receptors exclusively activated by designer drugs(DREADDs)specifically in ***,optogenetic tools allow for microglial manipulation via the activation of artificially expressed,light-sensitive ***-and optogenetic manipulations of microglia in vivo are powerful in interrogating microglial function in chronic *** review summarizes these emerging tools in studying the role of microglia in chronic pain and highlights their potential applications in microglia-related neurological disorders.

关键词： Chronic pain Microglia Optogenetics Chemogenetics DREADDs ReaChR

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FSAP aggravated endothelial dysfunction and neurological deficits in acute ischemic stroke due to large vessel occlusion

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Signal Transduction and Targeted Therapy 2022年第2期7卷 466-478页

作者： Dai-Shi Tian Chuan Qin Luo-Qi Zhou Sheng Yang Man Chen jun Xiao Ke Shang Dale BBosco long-jun wu Wei Wang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430030 WuhanChina'2Department of NeurologyMayo ClinicRochesterMN 55905USA

Revascularization and angiogenesis,as substrates of sustained collateral circulation,play a crucial role in determining the severity and clinical outcome of acute ischemic stroke(AIS)due to large vessel occlusion(LVO).Developing an adjunct biomarker to help identify and monitor collateral status would aid stroke diagnosis and *** screen the potential biomarkers,proteomic analysis was performed in this study to identify those distinct plasma protein profiles in AIS due to LVO with different collateral ***,we found that levels of Plasma Factor VII Activating Protease(FSAP)significantly increased in those AIS patients with poor collaterals,and were correlated with worse neurological ***,both in vitro and in vivo models of ischemic stroke were used to explore pathological mechanisms of FSAP in endothelial *** demonstrated that the FSAP inhibitor,high-molecular-weight hyaluronan(HMW-HA),enhanced the pro-angiogenic vascular factors,improved the integrity of brain blood barrier,and promoted newly formed cerebral microvessels in the ischemic penumbra,consequently improving neurological *** elucidate the pathways that might contribute to revascularization during LVO,we applied transcriptomic analysis via unbiased RNA sequencing and showed that Wnt signaling was highly involved in FSAP mediated endothelial ***,inhibition of Wnt5a largely reversed the protective effects from HMW-HA treatment,implying that FSAP might aggravate endothelial dysfunction and neurological deficits by regulating Wnt5a ***,FSAP may represent a potential biomarker for collateral status after LVO and a promising therapeutic target to be explored in the treatment of stroke.

关键词： Wnt5a neurological protective

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Insula and the Immune System:More than mere Co-existence?

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Neuroscience Bulletin 2022年第10期38卷 1271-1273页

作者： Panagiotis Kerezoudis Charles L.Howe long-jun wu Brian N.Lundstrom Jamie J.Van Gompel Department of Neurologic Surgery Mayo ClinicRochesterMNUSA Department of Neurology Mayo ClinicRochesterMNUSA

Does the Brain Regulate the Immune System?While long considered to be separate entities,increasing evidence has demonstrated that thebrain and theperipheral immune system interact through bidirectional feedback[1].The brain hosts a vibrant immune environment(*** and perivascular macrophages)that is responsible for maintaining the integrity of the central nervous system[2].In addition,the brain is the central regulator of the rest of the body and its homeostasis.

关键词： Immune homeostasis Ins

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Enhanced energy density and fast-charging ability via directional particle configuration

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Journal of Energy Chemistry 2024年第3期90卷 152-164,I0005页

作者： Xiongwei wu Shanguang lv Jiabao Li Xingrong Yin Xuewen wu jun Liu Jie Zhang Yuhan Yu Bei long Hunan Yinfeng New Energy Co.Ltd. Changsha 410019HunanChina

The limited energy density of lithium-ion capacitors poses a significant obstacle to their widespread application,primarily stemming from the inability of the electrodes to simultaneously fulfill both high energy density and rapid charging *** data demonstrate that a directional particle configuration can enhance charging speed while maintaining high-capacity density,but it is rarely ***,we have developed a particle-level electrochemical model capable of reconstructing an electrode with a directional particle *** employing this method,an investigation was conducted to explore how the spatial morphology characteristics of particle configuration impact the energy storage characteristics of *** demonstrate that rational particle configuration can effectively enhance the transport of lithium ions and create additional space for lithium-ion *** the same particle size distribution,the best electrode can increase the discharge capacity by up to132.4% and increase the charging SOC by 11.3% compared to the ordinary electrode under the condition of 6 *** findings provide a further understanding of the energy storage mechanism inside the anisotropic particle distribution electrode,which is important for developing high-performance lithium-ion capacitors.

关键词： Supercapacitor Gradient design strategies Energy storage Charge transport

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Geochemical identification of a source rock affected by migrated hydrocarbons and its geological significance:Fengcheng Formation,southern Mahu Sag,junggar Basin,NW China

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Petroleum Science 2024年第1期21卷 100-114页

作者： Wen-long Dang Gang Gao Xin-Cai You Ke-Ting Fan jun wu De-Wen Lei Wen-jun He Yong Tang State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum(Beijing)Beijing102249China School of GeoSciences China University of Petroleum(Beijing)Beijing102249China Exploration&Development Institute Xinjiang Oil Field CompanyKaramay834000XinjiangChina

The Fengcheng Formation is a crucial source rock and the primary reservoir for oil accumulation in the Mahu *** oils are distributed throughout the Fengcheng Formation,ranging from the edge to the interior of the sag in the southern Mahu *** crude oils originate from in-situ source rocks in shallowly buried areas and the inner deep *** migration,the crude oil from the inner deep sag affects the source rocks close to carrier beds,leading to changes in the organic geochemical characteristics of the source *** changes might alter source rock evaluations and oil-source *** on data such as total organic carbon(TOC),Rock-Eval pyrolysis of source rocks,and gas chromatography-mass spectrometry(GC-MS)of the saturated fraction,and considering the geological characteristics of the study area,we define the identification characteristics of source rock affected by migrated hydrocarbons and establish the various patterns of influence that migrated hydrocarbons have on the source rock of the Fengcheng Formation in the southern Mahu *** source rocks of the Fengcheng Formation are mostly fair to good,containing mainly Type II organic matter and being thermally mature enough to generate *** rocks affected by migrated hydrocarbons exhibit relatively high hydrocarbon contents(S1/TOC>110 mg HC/g TOC,Extract/TOC>30%,HC:hydrocarbon),relatively low Rock-Eval Tmax values,and relatively high tricyclic terpane contents with a descending and mountain-shaped ***,biomarker composition parameters indicate a higher thermal maturity than in-situ source *** a comparison of the extract biomarker fingerprints of adjacent reservoirs and mudstones in different boreholes,three types of influence patterns of migrated hydrocarbons are identified:the edge-influence of thin sandstone-thick mudstone,the mixed-influence of sandstone-mudstone interbedded,and the full-influence of thick sandstone-thin *** finding reminds

关键词： Organic geochemistry Source rock Influence of migrated hydrocarbons Fengcheng Formation Southern Mahu Sag

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