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Effects of process parameters on semi-solid squeeze casting performance of aluminum alloy scrolls for scroll compressors

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China Foundry 2020年第5期17卷 347-356页

作者： Yong-fei Wang Sheng-dun Zhao Yi Guo jun-ling yang School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an 710049China CAS Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryBeijing 100190China

The aluminum alloy scroll is one of the key parts of the scroll compressors widely used in the air-conditioning,refrigeration,and heat pump *** this work,the semi-solid squeeze casting(SSSC)process was used to fabricate the aluminum alloy *** effects of process parameters including the pouring temperature,mold temperature,and squeezing velocity on the filling and solidification behaviors of the alloys were investigated through simulations based on the power law cut-off(PLCO)material *** show that there is a significant increase in the flow velocity of the slurry,and the area of the high-speed region enlarges with the increase of the pouring *** homogeneity of the temperature and velocity fields in the slurry is improved with an increase in mold *** the filling time and its variation rate decrease with an increase in squeezing *** maximum solidification time exhibits a linear variation with the increase in pouring *** shrinkage area is decreased by increasing the mold *** optimal process parameters of the SSSC process were obtained from simulation analysis,which are the pouring temperature of 595°C,mold temperature of 350°C,and squeezing velocity of 0.3 m·***,the qualified scroll casting was fabricated using the SSSC process under the optimal process parameters.

关键词： semi-solid squeeze casting aluminum alloy scroll compressor numerical simulation experimental verification

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Overview of the immunological mechanisms in hepatitis B virus reactivation:Implications for disease progression and management strategies

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World Journal of Gastroenterology 2024年第10期30卷 1295-1312页

作者： Hui Ma Qing-Zhu Yan Jing-Ru Ma Dong-Fu Li jun-ling yang Department of Clinical Laboratory The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Ultrasound Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Digestive Diseases Center Department of Hepatopancreatobiliary MedicineThe Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

Hepatitis B virus(HBV)reactivation is a clinically significant challenge in disease *** review explores the immunological mechanisms underlying HBV reactivation,emphasizing disease progression and *** delves into host immune responses and reactivation’s delicate balance,spanning innate and adaptive *** factors’disruption of this balance,as are interac-tions between viral antigens,immune cells,cytokine networks,and immune checkpoint pathways,are ***,the roles of T cells,natural killer cells,and antigen-presenting cells are discussed,highlighting their influence on disease *** reactivation’s impact on disease severity,hepatic flares,liver fibrosis progression,and hepatocellular carcinoma is *** strategies,including anti-viral and immunomodulatory approaches,are critically *** role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent *** conclusion,this compre-hensive review furnishes a holistic view of the immunological mechanisms that propel HBV *** a dedicated focus on understanding its implic-ations for disease progression and the prospects of efficient management stra-tegies,this article contributes significantly to the knowledge *** more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches,ultimately enhancing disease management and elevating patient *** dynamic landscape of management strategies is critically scrutinized,spanning anti-viral and immunomodulatory *** role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.

关键词： Hepatitis B virus reactivation Immunological mechanisms Disease progression Management strategies Immune response

Encouraging specific biomarkers-based therapeutic strategies for hepatocellular carcinoma

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World Journal of Clinical Cases 2022年第11期10卷 3321-3333页

作者： Min Yao jun-ling yang De-Feng Wang Li Wang Ying Chen Deng-Fu Yao Research Center of Clinical Medicine&Department of Immunology Medical School of Nantong UniversityNantong 226001Jiangsu ProvinceChina Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Medical Informatics Medical School of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Oncology Affiliated Second Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

The prevention,early discovery and effective treatment of patients with hepatocellular carcinoma(HCC)remain a global medical *** present,HCC is still mainly treated by surgery,supplemented by vascular embolization,radio frequency,radiotherapy,chemotherapy and *** application of multikinase inhibitor sorafenib,chimeric antigen receptor T cells,or PD-1/PD-L1 inhibitors can prolong the median survival of HCC ***,the treatment efficacy is still unsatisfactory due to HCC metastasis and postoperative *** the process of hepatocyte malignant transformation,HCC tissues can express and secrete many types of specific biomarkers,or oncogenic antigen molecules into blood,for example,alpha-fetoprotein,glypican-3,Wnt3a(one of the key signaling molecules in the Wnt/β-catenin pathway),insulin-like growth factor(IGF)-II or IGF-I receptor,vascular endothelial growth factor,secretory clusterin and so *** addition,combining immunotherapy with noncoding RNAs might improve anti-cancer *** biomarkers not only contribute to HCC diagnosis or prognosis,but may also become molecular targets for HCC therapy under developing or clinical *** article reviews the progress in emerging biomarkers in basic research or clinical trials for HCC immunotherapy.

关键词： Hepatocellular carcinoma Immunotherapy Carcinoembryonic proteins Specific biomarkers Wnt/β-catenin pathway Signal molecules

Synthesis of Long-Chain Oligomeric Donor and Acceptors via Direct Arylation for Organic Solar Cells

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Chinese Journal of Chemistry 2024年第5期42卷 523-532页

作者： Yu Wu Xin-Yu He Xu-Min Huang ling-jun yang Peng Liu Na Chen Chang-Zhi Li Shi-Yong Liu Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry College of MaterialsMetallurgical and ChemistryJiangxi University of Science and TechnologyGanzhouJiangxi341000 China Department of Polymer Science and Engineering Zhejiang UniversityHangzhouZhejiang310027 China

The rapid synthesis of structurally complicated electron donors&acceptors still remains a major challenge in organic solar cells(OSC).In this work,we developed a highly efficient strategy to access long-chain oligomeric donor and acceptors for OSC applications.A series of cyclopentadithiophene(CPDT)and benzothiadiazole(BT)-basedπ-conjugated oligomers,i.e.,three oligomeric acceptors(BTDT)n-IC(n=1—3)and one long-chain oligomeric donor(BTDT)4-RD,are facilely synthesized by an atom-and step-economical,and labor-saving direct C—H arylation(DACH)reaction(i.e.,C—H/C—Br cross coupling).Note that(BTDT)4-RD involving five CPDT,four BT and two rhodamine(RD)building blocks is the longest oligomeric donor in the fullerene-free OSC devices ever *** dependence of the structure-property-performance correlation of(BTDT)n-IC(n=1—3)and(BTDT)4-RD on theπ-conjugation lengths is thoroughly investigated by opto-electrochemical measurements,bulk heterojunction(BHJ)OSC devices and ***(BTDT)1-IC:PBDB-T and(BTDT)4-RD:Y6 BHJs achieve power conversion efficiencies of 9.14%and 4.51%,*** findings demonstrate that DACH reaction is a powerful tool to tune the opto-electronic properties and device performances by regulating the lengths ofπ-conjugated oligomers with varied numbers of repeating units.

关键词： Long-chainπ-conjugated oligomer Organic solar cells Direct arylation Atom-economical synthesis Cyclopentadithiophene Benzothiadiazole C—H activation Conjugation Oligomers

Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma

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World Journal of Hepatology 2024年第12期16卷 1480-1492页

作者： jun-ling yang Jie yang Rong-Fei Fang Wen-Li Sai Deng-Fu Yao Min Yao Research Center of Clinical Medicine Affiliated Hospital of Nantong University and Department of ImmunologyMedical School of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Biology Life Science School of Nantong UniversityNantong 226009Jiangsu ProvinceChina Department of Gastroenterology Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGROUND Angiopoietin-2(Ang-2)level is related to hepatocellular carcinoma(HCC)***,the dynamic expression and regulatory mechanism of Ang-2 remain *** To investigate Ang-2 levels in chronic liver diseases and validate early monitoring value with a dynamic model in *** Sprague-Dawley rats in hepatocarcinogenesis were induced with diet 2-fluo-renylacet-amide,and grouped based on liver histopathology by hematoxylin and eosin *** expressed genes or Ang-2 mRNA in livers were ana-lyzed by whole-genome ***-2 levels in chronic liver diseases were detected by an enzyme-linked immunosorbent *** Clinical observation reveled that the circulating levels of Ang-2 and hypoxia-inducible factor-1α(HIF-1α)in patients with chronic liver diseases were progressively increased from benign to HCC(P<0.001).Dynamic model va-lidated that the up-regulated Ang-2 in liver and blood was positively correlated with HIF-1αin hepatocarcino-genesis(P<0.001).Mechanistically,Ang-2 was regulated by HIF-1α.When specific HIF-1α-microRNAs transfected into HCC cells,the cell proliferation significantly inhibited,HIF-1αand Ang-2 down-regulated,and also affected epithelial-mesenchymal transition via increasing E-cadherin to block cell invasion or migration with reducing of snail,twist and *** Hypoxia-induced Ang-2 up-regulating expression might serve as a sensitive early monitoring biomarker for hepatocarcinogenesis or HCC metastasis.

关键词： Angiopoietin-2 Hypoxia-inducible factor-1α Hepatocarcinogenesis Dynamic model Metastasis

Chemosensitization of HepG2 cells by suppression of NF-κB/p65 gene transcription with specific-si RNA

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World Journal of Gastroenterology 2015年第45期21卷 12814-12821页

作者： Yun Shi Si-Ye Wang Min Yao Wen-Li Sai Wei Wu jun-ling yang Yin Cai Wen-Jie Zheng Deng-Fu Yao Research Center of Clinical Medicine Affiliated Hospital of Nantong University Department of Immunology Medical School of Nantong University Department of Oncology Affiliated Hospital of Nantong University

AIM: To investigate small interfering RNA(si RNA)-mediated inhibition of nuclear factor-kappa B(NF-κB) activation and multidrug-resistant(MDR) phenotype formation in human Hep G2 cells. METHODS: Total RNA was extracted from human Hep G2 or LO2 cells. NF-κB/p65 m RNA was amplified by nested reverse transcription polymerase chain reaction and confirmed by sequencing. NF-κB/p65 was analyzed by immunohistochemistry. Specific-si RNA was transfected to Hep G2 cells to knock down NF-κB/p65 expression. The effects on cell proliferation, survival, and apoptosis were assessed, and the level of NF-κB/p65 or P-glycoprotein(P-gp) was quantitatively analyzed by enzyme-linked immunosorbent ***: Hep G2 cells express NF-κB/p65 and express relatively less phosphorylated p65(P-p65) and little P-gp. After treatment of Hep G2 cells with different doses of doxorubicin, the expression of NF-κB/p65, P-p65, and especially P-gp were dose-dependently upregulated. After Hep G2 cells were transfected with NF-κB/p65 si RNA(100 nmol/L), the expression of NF-κB/p65, P-p65, and P-gp were downregulatedsignificantly and dose-dependently. The viability of Hep G2 cells was decreased to 23% in the combination NF-κB/p65 si RNA(100 nmol/L) and doxorubicin(0.5 μmol/L) group and 47% in the doxorubicin(0.5 μmol/L) group(t = 7.043, P < 0.001). CONCLUSION: Knockdown of NF-κB/p65 with si RNA is an effective strategy for inhibiting Hep G2 cell growth by downregulating P-gp expression associated chemosensitization and apoptosis induction.

关键词： Hepatocellular carcinoma Nuclear factorκB Multidru

Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： Yunhan yang Han Jia Tuo Liu Yuzhen yang jun yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

关键词： induced transparency acoustic meta-atom high quality-factor scattering programmable intrinsic parameter

Values of circulating GPC-3 mRNA and alpha-fetoprotein in detecting patients with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2013年第2期12卷 171-179页

作者： Min Yao Deng-Fu Yao Yin-Zhu Bian Wei Wu Xiao-Di Yan Dan-Dan Yu Li-Wei Qiu jun-ling yang Hai-Jian Zhang Wen-Li Sai Jie Chen Department of Immunology Medical School of Nantong University Research Center of Clinical Medicine Affiliated Hospital of Nantong University Department of Oncology Affiliated Yancheng Hospital of Nantong University

BACKGROUND: The prognosis of hepatocellular carcinoma (HCC) is poor and its early diagnosis is of the utmost importance. This study aimed to investigate the values of glypican-3 (GPC-3) expression in the liver and sera and its gene transcription for diagnosis and monitoring of metastasis of HCC. METHODS: Liver GPC-3 was analyzed in HCC tissues from 36 patients by immunohistochemistry and Western blotting. GPC-3 mRNA from circulating peripheral blood mononuclear cells from 123 HCC patients or 246 patients with other diseases or 36 HCC tissues was amplified by RT-PCR, quantitative realtime PCR, and confirmed by DNA sequencing. Circulating GPC-3 level was detected by ELISA. RESULTS: The increasing expression of GPC-3 was observed from non-cancerous to cancerous tissues, with brown granule-like staining localized in tumor parts of atypical hyperplasia and HCC formation. The positive rate of GPC-3 was 80.6% in HCC, 41.7% in their paracancerous tissues, and none in distal cancerous tissues (P<0.001), with no significant difference in differentiation grade and tumor number except for size (Z=2.941, P=0.003). Serum GPC-3 was detected only in HCC (52.8%) and significant difference was found between GPC-3 and tumor size (χ2 =6.318, P=0.012) or HBV infection (χ2 =23.362, P<0.001). Circulating GPC-3 mRNA was detected in 70.7% of HCC tissues, with relation to TNM stage, periportal cancerous embolus, and extra-hepatic metastasis (P<0.001). The combination ofcirculating GPC-3, GPC-3 mRNA and alpha-fetoprotein is of complementary value for HCC diagnosis (94.3%). CONCLUSION: Both GPC-3 overexpression and GPC-3 mRNA abnormality could be used as markers for the diagnosis of HCC and monitoring its metastasis.

关键词： hepatocellular carcinoma glypican-3 immunohistochemistry quantitative real-time PCR gene expression sequencing

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Reversal of multidrug resistance of hepatocellular carcinoma cells by metformin through inhibiting NF-κB gene transcription

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World Journal of Hepatology 2016年第23期8卷 985-993页

作者： Wei Wu jun-ling yang Yi-Lang Wang Han Wang Min Yao Li Wang Juan-Juan Gu Yin Cai Yun Shi Deng-Fu Yao Research Center of Clinical Medicine Affiliated Hospital of Nantong University Department of Oncology the 2nd Affiliated Hospital of Nantong University Department of Liver Surgery Zhongshan Hospital of Fudan University Departments of Immunology Medical College of Nantong University Department of Medical Informatics Medical College of Nantong University Department of Oncology Affiliated Hospital of Nantong University

AIM: To interfere with the activation of nuclear factor-κB(NF-κB) with metformin and explore its effect in reversing multidrug resistance(MDR) of hepatocellular carcinoma(HCC) ***: Expression of P-glycoprotein(P-gp) and NF-κB in human HepG 2 or HepG 2/adriamycin(ADM) cells treated with pC MV-NF-κB-small interference RNA(siR NA) with or without metformin, was analyzed by Western blot or fluorescence quantitative PCR. Cell viability was tested by CCK-8 assay. Cell cycle and apoptosis were measured by flow cytometry and Annexin-V-PE/7-AnnexinV apoptosis detection double staining assay, respectively. RESULTS: P-gp overexpression in HepG 2 and HepG 2/ADM cells was closely related to mdr1 mR NA(3.310 ± 0.154) and NF-κB mR NA(2.580 ± 0.040) expression. NF-κB gene transcription was inhibited by specific siR NA with significant down-regulation of P-gp and enhanced HCC cell chemosensitivity to doxorubicin. After pretreatment with metformin, Hep G2/ADM cells were sensitized to doxorubicin and P-gp was decreased through the NF-κB signaling pathway. The synergistic effect of metformin and NF-κB siR NA were found in HepG 2/ADM cells with regard to proliferation inhibition, cell cycle arrest and inducing cell apoptosis. CONCLUSION: Metformin via silencing NF-κB signaling could effectively reverse MDR of HCC cells by downregulating MDR1/P-gp expression.

关键词： Metformin Reversal Multidrug resistance Hepatocellular carcinoma