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Overview of the immunological mechanisms in hepatitis B virus reactivation:Implications for disease progression and management strategies

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World Journal of Gastroenterology 2024年第10期30卷 1295-1312页

作者： Hui Ma Qing-Zhu Yan Jing-Ru Ma Dong-Fu Li jun-ling yang Department of Clinical Laboratory The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Ultrasound Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Digestive Diseases Center Department of Hepatopancreatobiliary MedicineThe Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

Hepatitis B virus(HBV)reactivation is a clinically significant challenge in disease *** review explores the immunological mechanisms underlying HBV reactivation,emphasizing disease progression and *** delves into host immune responses and reactivation’s delicate balance,spanning innate and adaptive *** factors’disruption of this balance,as are interac-tions between viral antigens,immune cells,cytokine networks,and immune checkpoint pathways,are ***,the roles of T cells,natural killer cells,and antigen-presenting cells are discussed,highlighting their influence on disease *** reactivation’s impact on disease severity,hepatic flares,liver fibrosis progression,and hepatocellular carcinoma is *** strategies,including anti-viral and immunomodulatory approaches,are critically *** role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent *** conclusion,this compre-hensive review furnishes a holistic view of the immunological mechanisms that propel HBV *** a dedicated focus on understanding its implic-ations for disease progression and the prospects of efficient management stra-tegies,this article contributes significantly to the knowledge *** more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches,ultimately enhancing disease management and elevating patient *** dynamic landscape of management strategies is critically scrutinized,spanning anti-viral and immunomodulatory *** role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.

关键词： Hepatitis B virus reactivation Immunological mechanisms Disease progression Management strategies Immune response

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Synthesis of Long-Chain Oligomeric Donor and Acceptors via Direct Arylation for Organic Solar Cells

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Chinese Journal of Chemistry 2024年第5期42卷 523-532页

作者： Yu Wu Xin-Yu He Xu-Min Huang ling-jun yang Peng Liu Na Chen Chang-Zhi Li Shi-Yong Liu Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry College of MaterialsMetallurgical and ChemistryJiangxi University of Science and TechnologyGanzhouJiangxi341000 China Department of Polymer Science and Engineering Zhejiang UniversityHangzhouZhejiang310027 China

The rapid synthesis of structurally complicated electron donors&acceptors still remains a major challenge in organic solar cells(OSC).In this work,we developed a highly efficient strategy to access long-chain oligomeric donor and acceptors for OSC applications.A series of cyclopentadithiophene(CPDT)and benzothiadiazole(BT)-basedπ-conjugated oligomers,i.e.,three oligomeric acceptors(BTDT)n-IC(n=1—3)and one long-chain oligomeric donor(BTDT)4-RD,are facilely synthesized by an atom-and step-economical,and labor-saving direct C—H arylation(DACH)reaction(i.e.,C—H/C—Br cross coupling).Note that(BTDT)4-RD involving five CPDT,four BT and two rhodamine(RD)building blocks is the longest oligomeric donor in the fullerene-free OSC devices ever *** dependence of the structure-property-performance correlation of(BTDT)n-IC(n=1—3)and(BTDT)4-RD on theπ-conjugation lengths is thoroughly investigated by opto-electrochemical measurements,bulk heterojunction(BHJ)OSC devices and ***(BTDT)1-IC:PBDB-T and(BTDT)4-RD:Y6 BHJs achieve power conversion efficiencies of 9.14%and 4.51%,*** findings demonstrate that DACH reaction is a powerful tool to tune the opto-electronic properties and device performances by regulating the lengths ofπ-conjugated oligomers with varied numbers of repeating units.

关键词： Long-chainπ-conjugated oligomer Organic solar cells Direct arylation Atom-economical synthesis Cyclopentadithiophene Benzothiadiazole C—H activation Conjugation Oligomers

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Encouraging specific biomarkers-based therapeutic strategies for hepatocellular carcinoma

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World Journal of Clinical Cases 2022年第11期10卷 3321-3333页

作者： Min Yao jun-ling yang De-Feng Wang Li Wang Ying Chen Deng-Fu Yao Research Center of Clinical Medicine&Department of Immunology Medical School of Nantong UniversityNantong 226001Jiangsu ProvinceChina Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Medical Informatics Medical School of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Oncology Affiliated Second Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

The prevention,early discovery and effective treatment of patients with hepatocellular carcinoma(HCC)remain a global medical *** present,HCC is still mainly treated by surgery,supplemented by vascular embolization,radio frequency,radiotherapy,chemotherapy and *** application of multikinase inhibitor sorafenib,chimeric antigen receptor T cells,or PD-1/PD-L1 inhibitors can prolong the median survival of HCC ***,the treatment efficacy is still unsatisfactory due to HCC metastasis and postoperative *** the process of hepatocyte malignant transformation,HCC tissues can express and secrete many types of specific biomarkers,or oncogenic antigen molecules into blood,for example,alpha-fetoprotein,glypican-3,Wnt3a(one of the key signaling molecules in the Wnt/β-catenin pathway),insulin-like growth factor(IGF)-II or IGF-I receptor,vascular endothelial growth factor,secretory clusterin and so *** addition,combining immunotherapy with noncoding RNAs might improve anti-cancer *** biomarkers not only contribute to HCC diagnosis or prognosis,but may also become molecular targets for HCC therapy under developing or clinical *** article reviews the progress in emerging biomarkers in basic research or clinical trials for HCC immunotherapy.

关键词： Hepatocellular carcinoma Immunotherapy Carcinoembryonic proteins Specific biomarkers Wnt/β-catenin pathway Signal molecules

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Regioselective Decomposition of 11-Substituted-16α,17α- methyleneazopregna-1,4-dien-3,20-dione

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Chinese Chemical Letters 2006年第1期17卷 12-14页

作者： Bing yang jun yang ling ling WENG Hu ZHENG The West China School of Pharmacy Sichuan University Chengdu 610041

Regioselective decomposition of 11-substituted- 16α, 17α-methyleneazopregna- 1,4-dien- 3, 20-dione Ⅰ proceeded smoothly through thermal decomposition in the presence of BF3·Et2O or HClO4 with high yields. Ⅰ was converted to 11-substituted-16-methylpregna-1, 4, 16（17）-trien-3, 20-dione Ⅱ by the thermal decomposition, while with HClO4 ad a catalyst, 11-substituted-16α, 17α-methylenepregna-1, 4-dien-3, 20-dione Ⅲ was the main product. However, when BF3·Et2O was used as catalyst, a mixture of Ⅱ and Ⅲ（1 ： 3） was obtained.

关键词： Methyleneazopregnanes methylenepregnancs regioselective decomposition,

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Structural engineered living materials

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Nano Research 2024年第2期17卷 715-733页

作者： yang Geng Zian Jia ling Li 635 Prices Fork Road Department of Mechanical EngineeringVirginia Polytechnic Institute and State UniversityBlacksburg VA24061USA

Biological structural materials not only exhibit remarkable mechanical properties but also often embody dynamic characteristics such as environmental responsiveness,autonomy,and self-healing,which are difficult to achieve in conventional engineering *** merging materials science,synthetic biology,and other disciplines,engineered living materials(ELMs)provide a promising solution to combine living organisms with abiotic components,thus facilitating the construction of functional“living”*** natural materials,ELMs possess vitality and hold immense application potential in areas such as medicine,electronics,and construction,captivating increasing research attention *** an emerging branch of ELMs,structural ELMs aim to mimic living biological structural materials by achieving desired mechanical performance while maintaining important“living”*** we summarize the recent progress and provide our perspectives for this emerging research *** first summarize the superiority of structural ELMs by reviewing biological structural materials and biomimetic material design ***,we provide a systematic discussion on the definition and classifications of structural ELMs,their mechanical performance,and physiological ***,we summarize some critical challenges faced by structural ELMs and highlight directions of future *** hope this review article can provide a timely summary of the state of the art and relevant perspectives for future development of structural ELMs.

关键词： structural materials engineered living materials(ELMs) structural ELMs composites mechanical properties

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Light(Science & Applications) 2024年第2期13卷 333-346页

作者： Yifan Sun Qian Li ling-jun Kong Xiangdong Zhang Key Laboratory of advanced optoelectronic quantum architecture and measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081BeijingChina

Compared with electrical neural networks,optical neural networks(ONNs)have the potentials to break the limit of the bandwidth and reduce the consumption of energy,and therefore draw much attention in recent *** far,several types of ONNs have been ***,the current ONNs cannot realize the acceleration as powerful as that indicated by the models like quantum neural *** to construct and realize an ONN with the quantum speedup is a huge ***,we propose theoretically and demonstrate experimentally a new type of optical convolutional neural network by introducing the optical *** is called the correlated optical convolutional neural network(COCNN).We show that the COCNN can exhibit“quantum speedup”in the training *** character is verified from the two *** is the direct illustration of the faster convergence by comparing the loss function curves of the COCNN with that of the traditional convolutional neural network(CNN).Such a result is compatible with the training performance of the recently proposed quantum convolutional neural network(QCNN).The other is the demonstration of the COCNN’s capability to perform the QCNN phase recognition circuit,validating the connection between the COCNN and the ***,we take the COCNN analog to the 3-qubit QCNN phase recognition circuit as an example and perform an experiment to show the soundness and the feasibility of *** results perfectly match the theoretical *** proposal opens up a new avenue for realizing the ONNs with the quantum speedup,which will benefit the information processing in the era of big data.

关键词： process quantum convolution

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Carbon dots-derived three-dimensional-ordered macroporous host with high penetrability and catalytic activity for LSBs under lean electrolyte

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Rare Metals 2024年第6期43卷 2560-2573页

作者： Jiao-Zi Duan Hua-Yu Pei Quan yang Xue Li Xin Ba Xue Yong jun-ling Guo Si-Yu Lu Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001China Country State Center for International Cooperation On Designer Low-Carbon&Environmental Materials School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Hubei Institute of Quality Supervision Inspection Wuhan 430061China Department of Chemistry University of SheffieldSheffeld S37HFUK

The practical energy density of lithium-sulfur batteries(LSBs)is seriously limited by the high electrolyte-to-sulfur ratios(E/S).The E/S can be reduced by employing hosts with easy-to-infiltrate structure that ensures the uniform distribution of a lean electrolyte and high catalytic activity that can suppress"shuttle effect"via accelerating the slow conversion of soluble poly sulfides to insoluble *** the easy-to-infiltrate structures,the three-dimensional-ordered macroporous(3DOM)structure is easier to scale preparation and more suitable for the existing industrial ***,it is difficult to obtain the 3DOM with(1)high penetrability due to the high viscosity of frequently-used organic polymer precursors and(2)high catalytic activity due to the low confinement effect,meaning that uniformly dispersed small-sized catalytic materials are difficult to load on ***,using carbon dots(CDs)with both organic and inorganic properties as a precursor and aggregation limiting agent,a 3DOM host with high penetrability and homodispersed Ni particles of small sizes(Ni-CDs-3DOM)was *** this host:(1)CDs precursor with suitable viscosity can improve the penetrability.(2)CDs can effectively inhibit the agglomeration of Ni particles.(3)Uniformly dispersed small-size Ni particles offer high-efficiency catalytic activity toward sulfur ***,the Ni-CDs-3DOM/sulfur cathode exhibits high sulfur utilization and stable cycling performance even under high sulfur loading(5.5 mg·cm^(-2))and low E/S(6.5μl·mg^(-1)).This work indicates the usefulness of CDs in constructing hosts for LSBs with high energy density.

关键词： Lithium-sulfur batteries Carbon dots Catalytic action Easy-to-infiltrate structure Lean electrolyte

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A Novel Design of a Pre-separation Panel Structure to Protect Against the Impact of an Explosion in an Aircraft Plenum Chamber

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Acta Mechanica Solida Sinica 2024年第1期37卷 166-180页

作者： Zongxing Liu Xiang yang jun Liu School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China COMAC Shanghai Aircraft Design and Research Institute Shanghai 201210China

To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blast ***,the dynamic strain response and morphology of impact damage of the new pre-separation panel were measured in an impact damage ***,the commercial software LS-DYNA was used to calculate the propagation of the blast shock wave,and the results were compared with empirical equations to verify the rationality of the numerical calculation ***,the fluid–structure coupling method was used to calculate the damage process of the pre-separation panel structure under the impact of an explosion wave and an impact *** calculated results were in good agreement with the test results,which showed the rationality of the calculation method and the *** residual strength of the damaged pre-separation panel was significantly higher than that of the original damaged *** results show that the new pre-separation panel structure is reasonable and has certain significance for guiding the design of plenum chambers with strong resistance to implosion for aircraft fuselages.

关键词： Pre-separation panel structure Explosive response Residual strength Aircraft plenum chamber Least risk bomb location

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Deflagration and detonation induced by shock wave focusing at different Mach numbers

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Chinese Journal of Aeronautics 2024年第2期37卷 249-258页

作者： Zezhong yang jun CHENG Bo ZHANG School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China

Shock wave focusing is an effective way to create a hot spot or a high-pressure and hightemperature region at a certain place,showing its unique usage in detonation initiation,which is beneficial for the development of detonation-based *** flame propagation behavior after the autoignition induced by shock wave focusing is crucial to the formation and self-sustaining of the detonation *** this study,wedge reflectors with two different angles(60°and 90°)and a planar reflector are employed,and the Mach number of incident shock waves ranging from 2.0 to 2.8 is utilized to trigger different flame propagation *** pressure transducers and the high-speed schlieren imaging system are both employed to investigate the shock-shock collision and ignition *** results reveal a total of four flame propagation modes:deflagration,DDT(Deflagration-to-Detonation Transition),unsteady detonation,and direct *** detonation wave formed in the DDT and unsteady detonation mode is only approximately 75%-85%of the Chapman-Jouguet(C-J)speed;meanwhile,the directly induced detonation wave speed is close to the C-J *** waves,which are strong evidence for the existence of detonation waves,are discovered in *** usage of wedge reflectors significantly reduces the initial pressure difference ratio needed for direct detonation *** also provide a practical method for differentiating between detonation and deflagration modes,which involves contrasting the speed of the reflected shock wave with the speed of the theoretically nonreactive reflected shock *** findings should serve as a reference for the detonation initiation technique in advanced detonation propulsion engines.

关键词： Deflagration Detonation Hydrogen Ignition Shock wave focusing

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Multiwavelength Observations of the Infrared Dust Bubble N75 and its Surroundings

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Research in Astronomy and Astrophysics 2024年第4期24卷 262-270页

作者： Quan-ling Cui Chuan-Peng Zhang jun-Jie Wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China College of Science Qiqihar UniversityQiqihar 161006China Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 550000China

Infrared dust bubbles play an important role in the study of star formation and the evolution of the interstellar *** this work,we study the infrared dust bubble N75 and the infrared dark cloud G38.93 mainly using the tracers C^(18)O,HCO^(+),HNC and N_(2)H^(+)observed by the 30 m IRAM *** also study the targets using data from large-scale surveys:GLIMPSE,MIPSGAL,GRS,NRAO VLA Sky Survey and Bolocam Galactic Plane *** found that the C^(18)O emission is morphologically similar to the Spitzer IRAC 8.0μm ***1.1 mm cold dust emission of G38.93 shows an elongated structure from southwest to *** ionized gas from G38.93 is surrounded by polycyclic aromatic hydrocarbon emission,which may be excited by radiation from *** found that the identified young stellar objects tend to cluster around G38.93 and are mostly in class II with several class I cases distributed around N75,but no class II *** also found evidence of expanding feedback,which could have triggered star formation.

关键词： ISM:bubbles infrared:ISM galaxies:star formation

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