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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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增添微量元素对苦荞芽菜黄酮酚酸类物质的影响

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江西农业大学学报 2017年第1期39卷 55-63页

作者：王珺儒马麟李文飞唐晓慧赵钢彭镰心赵江林成都大学药学与生物工程学院四川成都610106 成都大学国家杂粮加工技术研发分中心四川成都610106 西华大学食品与生物工程学院四川成都610039

以7种微量元素无机盐为考察因素,采用单因素和正交试验设计,探究增添使用微量元素无机盐的营养液对苦荞芽菜中多种黄酮酚酸类物质的影响。结果显示,配合添加7种微量元素无机盐处理对苦荞芽菜中多种黄酮酚酸类物质(除荭草素之外)及其总... 详细信息

以7种微量元素无机盐为考察因素,采用单因素和正交试验设计,探究增添使用微量元素无机盐的营养液对苦荞芽菜中多种黄酮酚酸类物质的影响。结果显示,配合添加7种微量元素无机盐处理对苦荞芽菜中多种黄酮酚酸类物质(除荭草素之外)及其总量的影响具有显著性差异,其影响大小依次为:ZnSO_4·7H_2O、CuSO_4·5H_2O、MnSO_4·4H_2O、EDTA-2Na、(NH_4)_6Mo_7O_(24)·4H_2O、FeSO_4·7H_2O和H_3BO_3,最优因素组合为FeSO_4·7H_2O(13.9 mg/L)、EDTA-2Na(37.2 mg/L)、H_3BO_3(1.43 mg/L)、MnSO_4·4H_2O(0.22 mg/L)、ZnSO4·7H_2O(0.08 mg/L)、CuSO_4·5H_2O(1.07 mg/L)、(NH_4)_6Mo_7O_(24)·4H_2O(0.03 mg/L);此条件下苦荞芽菜的生长量极显著增加,黄酮酚酸类物质总量显著增加,最高可达62.58±2.79 mg/g DW(Dry Weight)。

关键词：微量元素苦荞芽菜黄酮类酚酸类

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Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson's disease

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Neural Regeneration Research 2025年第3期20卷 808-810页

作者： Iqira Saeed linlin ma Griffith Institute for Drug Discovery Griffith UniversityNathanBrisbaneQLDAustralia School of Environment and Science Griffith University NathanBrisbaneQLDAustralia

Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.

关键词： homeostasis clinical subsequent

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Harnessing therapeutic potential of induced pluripotent stem cell–derived endothelial cells for remyelination in the central nervous system

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Neural Regeneration Research 2025年第6期20卷 1715-1716页

作者： Dan ma Nona Pop Aston Medical School College of Health and Life SciencesAston UniversityBirminghamUK

Myelin is the protective sheath surrounding nerve fibers, and its damage(demyelination) occurs in many central nervous system(CNS) diseases, including multiple sclerosis(MS), traumatic injury, neurodegenerative diseases such as Alzheimer's disease, and mental disorders such as schizophrenia(Barateiro et al., 2016). Repair of damaged myelin sheaths(remyelination) often fails in MS, leading to neuronal loss and irreversible functional deficits.

关键词： myelin protective diseases

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magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang ma Qin Tan Zhaoning Li Jingwei Xiu Jiafeng Wang Tianle Cheng Dong He Qiang Sun Xuhang ma Francesco Lamberti Zhubing He Department of materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DmacPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Nickle oxide magnetron sputter Defect Stability Perovskite solar cell

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Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and materials 2025年第2期32卷 498-503页

作者： Liang Chu Haoyu Shen Hudie Wei Hongyu Chen Guoqiang ma Wensheng Yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

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Nanoplatform-based cellular reactive oxygen species regulation for enhanced oncotherapy and tumor resistance alleviation

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Chinese Chemical Letters 2023年第9期34卷 85-99页

作者： Meifang Wang Ping’an ma jun lin State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

The cancer cells realize their proliferation and metastasis activities based on the special redox adaptation to increased reactive oxygen species(ROS)level,which inversely makes them sensitive to external interference with their redox *** view of this,in recent decades,researchers have made great efforts to construct a series of novel nanoplatform-based ROS-mediated cancer therapies through increasing ROS generation and inhibiting the ROS ***,the multidrug resistance and thermoresistance of tumor are closely related to tumor redox ***,numerous works have shown that ROS regulation in cancer cells can intervene in the expression,function and stability of related proteins to achieve reversal of tumor *** this review,the recent researches about ROS-regulating nanoagents on cancer therapy and tumor resistance alleviation have been well ***,the challenges and research directions of ROS-regulating nanoagents for future clinical translation are also discussed.

关键词： Nanoagents ROS regulation ROS-mediated cancer therapy Multidrug resistance Thermoresistance

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Effects of electromagnetic induction and noise on the regulation of sleep wake cycle

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Science China(Technological Sciences) 2019年第12期62卷 2113-2119页

作者： JIN WuYin WANG An ma jun lin Qian School of Mechanical and Electronical Engineering Lanzhou University of TechnologyLanzhou 730050China Department of Physics Lanzhou University of TechnologyLanzhou 730050China Editorial Department of Journal of Lanzhou University of Technology Lanzhou 730050China

As an exploration of electromagnetic induction effects on homeostatic regulation of sleep wake cycle, a magnetic flux term coupled with membrane current is proposed as an equivalent induction current act on a physiologically-motivated mathematical model, to study the effects of electromagnetic induction and its noise on the sleep wake cycle. The basic model includes 2 simplified Hodgkin-Huxley type neurons connected via glutamate(Glu) synapses, one of which additionally contains hypocretin/orexin(Hcrt/ox) as the functionally relevant co-transmitter. The numerical results suggest that when a constant current(DC) stimulus is applied to the model, the average fire frequency of the Hcrt/ox neuron could be modified from gamma to delta frequency with increased the intensity of electromagnetic induction, but the local Glu neuron transforms active into sleep ***, the homeostatic regulation function has better robustness to electromagnetic induction and its noise than the current or conductance noise, even there is a similar stochastic resonance phenomenon. For the circadian current input case, the time of wake up is delayed and fall asleep is advanced when the electromagnetic induction and its noise is considered. Furthermore, the effects of electromagnetic noise on the regulation is not significant, but only to inhibit the neuronal discharge activities and change the time of wake up and fall asleep of the Glu neuron, characterized by the sleep duration is slightly prolonged with increasing the strength of noise intensity.

关键词： electromagnetic induction sleep wake cycle noise neural model

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锂电池中串扰行为的研究进展

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聊城大学学报（自然科学版） 2025年第1期38卷 34-42页

作者：马君中国科学院青岛生物能源与过程研究所、青岛储能产业技术研究院山东青岛266101 山东能源研究院山东青岛266101 青岛新能源山东省实验室山东青岛266101

高安全和高能量密度的锂电池是加快能源转型的重要支撑技术。但是锂电池存在电、化、力和热失效行为,导致电池容量损失、寿命下降和安全性降低,严重阻碍了高能量密度和高安全锂电池的发展。本文从正极与负极协同作用的视角,阐述了锂电... 详细信息

高安全和高能量密度的锂电池是加快能源转型的重要支撑技术。但是锂电池存在电、化、力和热失效行为,导致电池容量损失、寿命下降和安全性降低,严重阻碍了高能量密度和高安全锂电池的发展。本文从正极与负极协同作用的视角,阐述了锂电池中电/化/力/热串扰行为的最新研究进展及相应的解决策略,对比分析了使用电解液的常规锂电池与使用固态电解质的全固态锂电池在电/化/力/热串扰失效行为方面的相似之处与不同之处,并且总结了电/化/力耦合串扰行为的新观点,展望了进一步深刻认识并解决锂电池电/化/力/热耦合串扰行为的重要研究方向。

关键词：锂电池全固态正极负极串扰

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Bandgap characteristics analysis and graded design of a novel metamaterial for flexural wave suppression

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Applied mathematics and Mechanics(English Edition) 2025年第1期46卷 1-24页

作者： Fan YANG Zhaoyang ma Xingming GUO Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Shanghai Institute of Aircraft Mechanics and Control

A novel elastic metamaterial is proposed with the aim of achieving lowfrequency broad bandgaps and bandgap regulation. The band structure of the proposed metamaterial is calculated based on the Floquet-Bloch theorem, and the boundary modes of each bandgap are analyzed to understand the effects of each component of the unit cell on the bandgap formation. It is found that the metamaterials with a low elastic modulus of ligaments can generate flexural wave bandgaps below 300 Hz. Multi-frequency vibrations can be suppressed through the selective manipulation of bandgaps. The dual-graded design of metamaterials that can significantly improve the bandgap width is proposed based on parametric studies. A new way that can regulate the bandgap is revealed by studying the graded elastic modulus in the substrate. The results demonstrate that the nonlinear gradient of the elastic modulus in the substrate offers better bandgap performance. Based on these analyses, the proposed elastic metamaterials can pave the way for multi-frequency vibration control, low-frequency bandgap broadening, and bandgap tuning.

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