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Copper homeostasis and neurodegenerative diseases

Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi li Kaifei xu Guoqing Wang Feng Zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

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Tailoring light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao li Hong Zhou Zhihao Ren Cheng xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei li Qianqian liang li xu Changsheng Ding Yu liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

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Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian Luo Chuanhui xu linxi li Yunxiang Ji Yezhong Wang Yingjia li Yongyi Ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang li Xiaomei Tang Jinyu Zeng Yige Song Chao xu Kai Zhao Guoqiang liu Youming Lu Xinyan li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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基于网格搜索随机森林算法的工矿复垦区土地利用分类

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农业工程学报 2017年第14期33卷 250-257,F0003页

作者：陈元鹏罗明彭军还王军周旭李少帅中国地质大学(北京)土地科学技术学院北京100083 国土资源部土地整治中心北京100035

为提高工矿复垦区遥感影像土地利用分类精度,为土地复垦监测工作提供数据支持,该文探讨了基于网格搜索(Grid-Search)的随机森林(random forest)复垦区土地利用分类方法。研究利用GF-1影像、DEM(digital elevation model)和野外调查等数... 详细信息

为提高工矿复垦区遥感影像土地利用分类精度,为土地复垦监测工作提供数据支持,该文探讨了基于网格搜索(Grid-Search)的随机森林(random forest)复垦区土地利用分类方法。研究利用GF-1影像、DEM(digital elevation model)和野外调查等数据,以随机森林分类算法为框架,采用基于OOB(Out-of-Bag)误差的网格搜索法对算法进行参数寻优,结合影像光谱、地形、纹理、空间信息,计算选取了33个特征变量,构建了4种变量组合模型开展随机森林分类试验,4个组合模型的分类精度分别达到82.79%、84.91%、86.75%、88.16%。为去除33个特征变量中的冗余信息、降低影像波段变量维度、缩短分类执行时间并保证影像分类精度,试验分别利用变量重要性估计和Relief F方法进行特征选择后再次执行随机森林分类,将分类结果与不同组合模型、不同分类方法进行比较,结果表明:基于网格搜索参数寻优的随机森林算法在多特征变量的影像分类中可以达到88.16%的分类精度,在利用不同方法降维后依然可以将分类精度保持在85%以上,精度优于相同特征变量下的SVM(support vector machine)和MLC(maximum likelihood classification)分类方法;在效率方面,随机森林分类方法执行时间优于SVM,并且在处理多维特征变量时能力更强。由此可见,采用基于网格搜索的随机森林方法对工矿复垦区土地利用信息进行分类提取可以得到较高的精度,基于该方法开展遥感影像解译可为土地复垦监测工作提供技术支持和理论参考。

关键词：土地复垦土地利用工矿复垦区随机森林网格搜索多特征变量特征选择

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行为药理学:历史与现状

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神经药理学报 2011年第1期1卷 55-64页

作者：李俊旭美国纽约州立大学布法罗分校药理学与毒理学系

行为药理学作为药理学的一个分支,其发展历史已有50余年。从1955年Peter Dews发表其代表性论文《Studies on behavior.I》以来,行为药理学从无到有,已经发展成为一个活跃的、生机勃勃的新学科。本文拟回顾行为药理学的发展历程,理清其... 详细信息

行为药理学作为药理学的一个分支,其发展历史已有50余年。从1955年Peter Dews发表其代表性论文《Studies on behavior.I》以来,行为药理学从无到有,已经发展成为一个活跃的、生机勃勃的新学科。本文拟回顾行为药理学的发展历程,理清其历史发展的脉络,并就行为药理学当前发展的状况作一综述。本文还将提出行为药理学研究中所应注意的几个问题供讨论。

关键词：行为药理学历史现状

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基于“五性一体”课堂教学模式的研究与实践

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宁波工程学院学报 2017年第1期29卷 91-96页

作者：王宇李俊徐力宁波工程学院浙江宁波315211

以"3I特质"为培养目标,研究基于"五性一体"的课堂教学模式,解决了课堂教学在教学内容、教学方法、教学评价方面存在的一些具体问题。该课堂教学模式在计科13级学生的《计算机组成与体系结构》课程的教学中发挥了相应的作用。

关键词：教学模式课堂教学改革 3I特质过程考核

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多电子反应高能锂二次电池正极材料的研究进展

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化工新型材料 2017年第10期45卷 37-39页

作者：黄思李军许帅军李雪峰李少芳广东工业大学轻工化工学院广州510006

如何提升正极材料的容量以改善锂离子电池性能是最近研究热点,基于多电子反应机制是提高锂离子电池能量密度的有效途径。综述了近年来基于多电子反应锂离子电池正极材料的研究状况,重点阐述了以聚阴离子型化合物、金属氟化物及单质硫为... 详细信息

如何提升正极材料的容量以改善锂离子电池性能是最近研究热点,基于多电子反应机制是提高锂离子电池能量密度的有效途径。综述了近年来基于多电子反应锂离子电池正极材料的研究状况,重点阐述了以聚阴离子型化合物、金属氟化物及单质硫为代表的正极材料的最新研究进展,展望了基于多电子反应体系的构筑对新型化学电源和相关能源材料发展的指导意义。

关键词：多电子反应高比能量锂离子电池正极材料

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Supramolecular Frameworks of Trimolybdenum（Ⅳ） Cluster Templated by Protonated N-containing Heterocycles

Supramolecular Frameworks of Trimolybdenum（Ⅳ） Cluster Tem...

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中国化学会第五届全国结构化学学术会议

作者： jun Zhao li xu State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou,Fujian,350002,P.R.China.

＜正＞Supramolecular hybrid materials based on covalent and non-covalent interactions has been one of the most active areas of research in recent years due to their intriguing structural diversities and potential *** studies have been carried to understand the role of counter-cations in the formation of the supramolecular *** influences of the

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