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中国药理学通报 2015年第8期31卷 1040-1043页

作者：孙越华朱清李俊旭南通大学药学院江苏南通226001

该文概括了青藤碱近年来药理学作用的一些研究热点领域,包括抗炎、免疫抑制以及抗肿瘤等作用,加上本课题组对青藤碱镇痛作用的研究,对青藤碱的以上药理学作用及其作用机制进行归纳,以期为临床应用提供更好的依据。

关键词：青藤碱免疫抗肿瘤镇痛作用药理学作用综述

A Peculiar Type of Neurons in Submucous Nervous Plexus of the Gut in Guinea-Pig——A Preliminary Histological Study

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解剖学报 1989年第3期 277-277页

作者： (li jun xu Yanli Yang Jin liu Shaojie Department of Histology and Embryology,Capital Institute of Medicine,Beijing)

The submucous plexus of the gastrointe-stinal tract in 20 guinea pigs were studied byhistochemical methods for Nissl bodies andacetylcholinesterase (AChE) and by the immu-nohistochemical technique for somatostatin(SOM).We discovered that some neurons inthe submucous plexus were located against thelymphatic vessel walls or even protruded towardthe lumen and that only a basement membrane

关键词： A Peculiar Type of Neurons in Submucous Nervous Plexus of the Gut in Guinea-Pig A Preliminary Histological Study

Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng xu Sheng Pang liangwei Cong Guoyu Qian Dong Wang Laishi li Yusheng Wu Zhi Wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

1-MT Enhances Potency of Tumor Cell Lysate-pulsed Dendritic Cells against Pancreatic Adenocarcinoma by Downregulating the Percentage of Tregs

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第3期30卷 344-348页

作者：李元栋徐钧邹浩军王春友 Pancreatic Surgery Center of Union Hospital Tongji Medical CollegeHuazhong University of Science and Technology

This study examined whether 1-methyl-tryptophan [1-MT,an indoleamine 2,3-dioxygenase(IDO) inhibitor] could reduce CD4+CD25+ regulatory T cells(Tregs) proliferation and improve the anti-tumor efficacy of dendritic cells(DCs) pulsed with tumor cell lysate in the mice bearing pancreatic *** models of pancreatic adenocarcinoma were established in C57BL/6 mice by subcutaneous injection of Pan02 *** mice which were subcutaneously injected with PBS served as *** expression of IDO was determined in tumor draining lymph nodes(TDLNs) and spleens of the murine pancreatic adenocarcinoma *** prevalence of Tregs was measured in the TDLNs and spleens before and after 1-MT *** dendritic cells were pulsed with tumor cell lysate for preparing DC *** DC vaccine,as a single agent or in combination with 1-MT,was administered to pancreatic adenocarcinoma *** anti-tumor efficacy was determined after different treatments by regular observation of tumor *** results showed that the levels of IDO mRNA and protein in tumor-bearing mice were significantly higher than those in the normal control *** percentage of Tregs in the spleen and TDLNs was also higer in tumor-bearing mice than in normal control mice(P<0.05).Foxp3 expression was significantly lower in the TDLNs and spleens of tumor-bearing mice administrated with 1-MT than that in normal control ***,in the mice that were administered 1-MT plus DC vaccine,the tumor was increased more slowly than in mice treated with DC vaccine or 1-MT alone,or PBS on day 36(P<0.01).Our results indicated that 1-MT may enhance anti-tumor efficacy of dendritic cells pulsed with tumor cell lysate by downregulating the percentage of Tregs.

关键词： 1-methyl-tryptophan Treg cells pancreatic adenocarcinoma indoleamine 2,3-dioxygenase Foxp3

聚合物分离膜表面仿生共沉积改性及其性能研究

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高分子学报 2019年第12期50卷 1298-1304页

作者：安坦于辉徐丽君徐志康万灵书教育部高分子合成与功能构造重点实验室浙江大学高分子科学与工程学系

发展了一种基于单酚化合物阿魏酸和铜离子的新型表面沉积体系,通过液相共沉积方法在不同基底表面构建了共沉积涂层.考察了组分比例和沉积时间等因素对沉积行为的影响.在最佳沉积条件下制备了涂层改性聚丙烯微孔膜,通过扫描电子显微镜、... 详细信息

发展了一种基于单酚化合物阿魏酸和铜离子的新型表面沉积体系,通过液相共沉积方法在不同基底表面构建了共沉积涂层.考察了组分比例和沉积时间等因素对沉积行为的影响.在最佳沉积条件下制备了涂层改性聚丙烯微孔膜,通过扫描电子显微镜、衰减全反射傅里叶变换红外光谱仪、X射线光电子能谱仪、固体表面zeta电位分析仪和水接触角测试仪等对膜表面进行了表征,并将其应用于油水分离和染料吸附.结果表明,改性膜表面具有良好的亲水性以及强烈的荷负电性,对水包油乳液具有优异的分离性能以及良好的渗透通量;同时,改性膜对荷正电染料具备优良的吸附能力.研究结果有望丰富单酚类化合物的沉积行为研究,发展新型表面沉积体系.

关键词：表面沉积阿魏酸聚丙烯微孔膜油水分离染料吸附

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang li Shan Guo Zhuang Tong Xiaotao Zhou xu li Zhaohui Hou Shuquan liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode

Facile synthesis of hybridized Co/Fe-ZIF under solvent-free conditions for efficient oxidation evolution reaction electrocatalysis

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Nano Research 2025年第1期18卷 362-372页

作者： YinSheng xu Zihan li Zhonghan Cheng Somboon Chaemchuen State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Department of Chemical Engineering Faculty of EngineeringMahidol UniversityNakhon Pathom 73170Thailand State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

Developing non-noble catalyst synthesis under green conditions with efficient electrochemical reactions is a challenging task in green energy *** meet this challenge,the synthesis of hybridized non-noble cobalt and iron in the zeolitic-imidazole framework(Co/Fe-ZIF)through a solid-state thermal(SST)method is *** the obtained Co/Fe-ZIF structure,iron atoms are uniformly dispersed and randomly hybridized with primary cobalt atoms and imidazole linker,similar to the structure of *** hybridized Co/Fe-ZIF shows potential as an electrocatalyst for oxidation evolution reaction(OER).The optimal iron-incorporating catalyst,Co/Fe_(0.2)-ZIF,demonstrates remarkable performance with a minimized overpotential of 285 mV at the current density(j)of 10 mA·cm^(-2)in 1 M *** synergistic effect of iron and cobalt ions on the catalyst provides active sites that bind to intermediate(OOH^(*))more strongly and facilitate high electron charge transfer,enhancing efficient ***,the synergistic Co/Fe_(0.2-)ZIF catalyst demonstrates excellent durable reaction time compared to non-iron catalyst(ZIF-67)and conventional catalyst(RuO_(2)).

关键词： zeolitic-imidazole frameworks solid-state thermal method solvent-free synthesis electrocatalyst oxidation evolution reaction

Prediction model of mercury accumulation in fish of reservoirs

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Journal of Environmental Sciences 2000年第S1期12卷 59-65页

作者： JIN li\|jun\+1, xu Xiao\|qing\+2, HUI Yang\+2, ZHANG Xiao\|hua\+2 (1.Department of Environmental Science and Engineering, Nanjing University, Nanjing 210093, China 2.Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China)

Creation of hydroelectric reservoirs in a certain large water system of China has led to a marked rise in mercury content of fish. Correlation analysis and stepwise regression of R (ratio of mercury content in carp from 12 reservoirs and that from rivers of the same water system) and various hydrologic parameters demonstrated that the ratio of catchment area and runoff was the crucial limiting factor. Other limiting factors were the ratio of flooding area of land and reservoir area of dead storage capacity, and the reciprocal of reservoir area. On this basis, the prediction equations of mercury accumulation in carp after reservoir construction, with one and two parameter respectively, were obtained. All these prediction models were proved to be of high precision.

关键词： reservoir mercury contamination prediction model carp