检索结果-南通市图书馆

Expression of kallikrein-related peptidase 7 is decreased in prostate cancer

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2015年第1期17卷 106-110,I0010页

作者： Chong-Yu Zhang Yu Zhu Wen-Bin Rui jun Dai zhou-jun Shen Department of Urology Ruijin Hospital School of Medicine Shanghai Jiaotong University Shanghai China.

Recent evidence suggests that the human kallikrein 7 （KLK7） is differentially regulated in a variety of tumors. The aim of this study was to determine the expression of kallikrein-related peptidase 7 and KLK7 in our large collection of prostate samples. Between August 2000 and December 2012, 116 patients with histologically confirmed prostate cancer （PCa） and 92 with benign prostate hyperplasia （BPH） were recruited into the study. Using immunohistochemistry, quantitative reverse transcription polymerase chain reaction （RT-PCR） and western blot, kallikrein-related peptidase 7 expression in BPH and PCa tissues was determined at the mRNA and protein levels. The relationships between kallikrein-related peptidase 7 mRNA expression and clinicopathological features were analyzed. A total of 64 of 92 （69.57%） benign cases showed positive staining for KLK7 and 23 of 116 （19.83%） malignant cases showed positive, the difference of KLK7 expression between PCa and BPH was statistically significant （P〈 0.001）. The expression level of kallikrein-related peptidase 7 mRNA was significantly decreased in PCa tissues compared with that in BPH tissues and normal prostate tissue. Kallikrein-related peptidase 7 mRNA exhibited different expression patterns in terms of localization depending on pathological category of PCa. Similarly, our western immunoblot analyses demonstrated that the protein expression levels of KLK7 was lower in PCa than in BPH tissues and normal prostate tissue. Kallikrein-related peptidase 7 and KLK7 expression are down-regulated in PCa and lower expression of kallikrein-related peptidase 7 closely correlates with higher Gleason score and higher prostate-specific antigen level.

关键词： human kallikrein 7 kallikrein-related peptidase 7 prostate cancer prostate-specific antigen

The synthesis and molecular recognization of the polyamine transporter of hydrazine-modified diamine conjugates

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第1期19卷 99-101页

作者： jun jun zhou Hao Huang Song Qiang Xie Yu XiaWang Jin Zhao Chao Jie Wang Institute of Natural Products ＆ Medicinal Chemistry Henan University Kaifeng 475001 China Chemistry Department Henan University Kaifeng 475001 China Pharmacy College Henan University Kaifeng 475001 China

A series of four novel hydrazine-modified diamine conjugates （7a-b, 8a-b） were synthesized and evaluated for cytotoxicity against Melanoma B 16, α-difluoromethylornithine （DFMO）-treated B 16, spermidine （SPD）-treated B 16, Mouse leukemia L 1210 and Hela cell lines. Both the DFMO-B 16 and SPD-B 16 experiments indicated that conjugates 7a-b and 8a-b could recognize the polyamine transporter （PAT） and enter the cells in part or in whole via PAT, although they were not as efficient as the reference, 9- anthracenemethyl homospermidine （1）. 2007 Chao Jie Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Polyamine conjugate Synthesis Bioevaluation

Cybersecurity Landscape on Remote State Estimation:A Comprehensive Review

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 851-865页

作者： Jing zhou jun Shang Tongwen Chen the Department of Electrical and Computer Engineering University of AlbertaEdmonton AB T6G 1H9Canada the Department of Control Science and Engineering and Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai 200092China

Cyber-physical systems(CPSs)have emerged as an essential area of research in the last decade,providing a new paradigm for the integration of computational and physical units in modern control *** state estimation(RSE)is an indispensable functional module of ***,it has been demonstrated that malicious agents can manipulate data packets transmitted through unreliable channels of RSE,leading to severe estimation performance *** paper aims to present an overview of recent advances in cyber-attacks and defensive countermeasures,with a specific focus on integrity attacks against ***,two representative frameworks for the synthesis of optimal deception attacks with various performance metrics and stealthiness constraints are discussed,which provide a deeper insight into the vulnerabilities of ***,a detailed review of typical attack detection and resilient estimation algorithms is included,illustrating the latest defensive measures safeguarding RSE from ***,some prevalent attacks impairing the confidentiality and data availability of RSE are examined from both attackers'and defenders'***,several challenges and open problems are presented to inspire further exploration and future research in this field.

关键词： Cyber-attacks Kalman filtering remote state estimation unreliable transmission channels

Investigation on UV-curing Reprocessable Thermosets Bearing Hindered Urea Bonds and Their Composites with Modified Zinc Oxide Nanoparticles

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第6期42卷 751-765页

作者： jun-Hao zhou Li-Ming Tang Key Laboratory of Advanced Materials of Ministry of Education of China Department of Chemical EngineeringTsinghua UniversityBeijing100084China

In this study,a series of hindered urea bond(HUB)containing polyurethane-urea methacrylate prepolymers and a none HUB containing polyurethane methacrylate prepolymer were prepared using isobornyl methacrylate as the reactive diluent via one-pot *** prepolymers were characterized fully by various ***,their thermosets were fabricated via UV curing in presence of a photo initiator,and their mechanical property and thermal behavior were investigated and *** from the none HUB containing thermoset,the HUB containing thermosets(defined as PUT)could be recycled and reprocessed by hot press under relatively mild conditions with high recovery ratio of mechanical ***,zinc oxide(ZnO)nanoparticles were modified with 3-(trimethoxysilyl)propyl methacrylate and the modified ZnO(defined as ZnO-TPM)was dispersed and polymerized into PUT matrix to prepare their *** influence of ZnO-TPM on the mechanical performance of the composites was evaluated,which indicated that the Young’s modulus and tensile strength increased gradually to the maximum values at ZnO-TPM content of 1 wt%and then *** composites also displayed good reprocessability with improved recovery ratio compared to the pure PUT *** addition,the composite materials exhibited strong UV absorption capacity,implying their potential application in the circumstance where UV-shielding was required.

关键词： Polyurethane-urea methacrylate Hindered urea bond ZnO nanoparticles Reprocessing UV curing

Synthesis and biological evaluation of hydrazino-containing polyamine skeletons as drug delivery system

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2011年第1期22卷 119-122页

作者： Jian Hong Wang jun jun zhou Song Qing Xie Qian Li Jin Zhao Chao Jie Wang Key Lab of Natural Medicinal and Immunotechnology of Henan Province Henan University Kaifeng 475004 China

A new series of polyamine-toxic cargo conjugates was synthesized with aryl aldehydes conjugating to hydrazino-containing triamine skeletons. The in vitro cytotoxicity of target compounds was evaluated in several cancer cell lines （e.g., L I 210, HeLa and B16） and the cellular entry of these polyamine conjugates via polyamine transporter was investigated on SPD- or DFMO-treated B 16 cell line. Of these compounds, 6c show significant cytotoxicity on L 1210, HeLa and B 16 cell lines （IC50 value, 3.74 μmol/L, 5.66μmol/L and 4.04 μmol/L, respectively）. The polyamine transporter assay demonstrated the suitability of hydrazino-containing polyamine backbones for application as vectors in drug delivery systems.

关键词： Polyamine conjugates Polyamine transporter Synthesis Biological activity

Bayesian inference of neutron-skin thickness and neutron-star observables based on effective nuclear interactions

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 97-105页

作者： Jia zhou jun Xu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Physics Science and Engineering Tongji UniversityShanghai 200092China

We have obtained the constraints on the density dependence of the symmetry energy from neutron-skin thickness data by parityviolating electron scatterings and neutron-star observables using a Bayesian approach,based on the standard Skyrme-HartreeFock(SHF)model and its extension as well as the relativistic mean-field(RMF)*** the neutron-skin thickness data(neutron-star observables)mostly constrain the symmetry energy at subsaturation(suprasaturation)densities,they may more or less constrain the behavior of the symmetry energy at suprasaturation(subsaturation)densities,depending on the energy-density functional *** showing the final posterior density dependence of the symmetry energy,we also compare the slope parameters of the symmetry energy at 0.10 fm-3as well as the values of the symmetry energy at twice saturation density from three effective nuclear *** present work serves as a comparison study based on relativistic and non-relativistic energy-density functionals,for constraining the nuclear symmetry energy from low to high densities using a Bayesian approach.

关键词： symmetry energy neutron skin neutron star

同方期刊数据库

An adaptive energy regulation in a memristive map linearized from a circuit with two memristive channels

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第3期76卷 42-50页

作者： Feifei Yang Ping zhou jun Ma School of Science Chongqing University of Posts and TelecommunicationsChongqing 430065China College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhou 730050China Department of Physics Lanzhou University of TechnologyLanzhou 730050China

Nonlinear circuits can show multistability when a magnetic flux-dependent memristor(MFDM) or a charge-sensitive memristor(CSM) is incorporated into a one branch circuit,which helps estimate magnetic or electric field *** this paper,two different kinds of memristors are incorporated into two branch circuits composed of a capacitor and a nonlinear resistor,thus a memristive circuit with double memristive channels is *** circuit equations are presented,and the dynamics in this oscillator with two memristive terms are ***,the memristive oscillator is converted into a memristive map by applying linear transformation on the sampled time series for the memristive *** Hamilton energy function for the memristive oscillator is obtained by using the Helmholtz theorem,and it can be mapped from the field energy of the memristive *** energy function for the dual memristive map is suggested by imposing suitable weights on the discrete energy *** dynamical behaviors of the new memristive map are investigated,and an adaptive law is proposed to regulate the firing mode in the memristive *** work will provide a theoretical basis and experimental guidance for oscillator-to-map transformation and discrete map energy calculation.

关键词： Hamilton energy dual memristive map adaptive energy regulation

Energy-information trade-off induces continuous and discontinuous phase transitions in lateral predictive coding

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 79-85页

作者： Zhen-Ye Huang Ruyi zhou Miao Huang Hai-jun zhou Key Laboratory for Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China Minjiang Collaborative Center for Theoretical Physics Minjiang UniversityFuzhou 350108China

Lateral predictive coding is a recurrent neural network that creates energy-efficient internal representations by exploiting statistical regularity in sensory ***,we analytically investigate the trade-off between information robustness and energy in a linear model of lateral predictive coding and numerically minimize a free energy *** observed several phase transitions in the synaptic weight matrix,particularly a continuous transition that breaks reciprocity and permutation symmetry and builds cyclic dominance and a discontinuous transition with the associated sudden emergence of tight balance between excitatory and inhibitory *** optimal network follows an ideal gas law over an extended temperature range and saturates the efficiency upper bound of energy *** results provide theoretical insights into the emergence and evolution of complex internal models in predictive processing systems.

关键词： predictive coding recurrent neural network phase transition internal model free energy

Derivatives of Intersection Local Time for Two Independent Symmetricα-stable Processes

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第5期40卷 1273-1292页

作者： Huan zhou Guang jun SHEN Qian YU Department of Mathematics Anhui Normal UniversityWuhu 241002P.R.China Department of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106P.R.China Key Laboratory of Mathematical Modelling and High Performance Computing of Air Vehicles(NUAA) MIITNanjing 211106P.R.China

In this paper,we consider the derivatives of intersection local time for two independent d-dimensional symmetricα-stable processes X^(α) and X^(α)with respective indices α and α.We first study the sufficient condition for the existence of the derivatives,which makes us obtain the exponential integrability and H?lder *** we show that this condition is also necessary for the existence of derivatives of intersection local time at the ***,we also study the power variation of the derivatives.

关键词： Symmetric stable processes intersection local time exponential integrability power variation