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本科层次职业教育发展的国际现状比较与启示

湖北开放职业学院学报 2025年第2期38卷 54-55,62页

作者：孙世娟南京工业职业技术大学江苏南京210023

职业教育是现代教育体系的重要组成部分。大力发展本科层次职业教育是实现职业教育“不同类型、同等重要”的重大举措。本科层次职业教育已成为职业教育研究的重要关注点。基于此,本文对德国、美国、英国、澳大利亚和日本的本科层次职... 详细信息

职业教育是现代教育体系的重要组成部分。大力发展本科层次职业教育是实现职业教育“不同类型、同等重要”的重大举措。本科层次职业教育已成为职业教育研究的重要关注点。基于此,本文对德国、美国、英国、澳大利亚和日本的本科层次职业教育发展现状进行了对比和研究,指出本科层次职业教育发展要明确办学定位、人才培养目标和发展战略,人才培养要与市场需求匹配,构建一体化发展模式并急需转变大众对职业教育的传统观念。

关键词：本科职业教育国际现状比较启示

MicroRNA-670 aggravates cerebral ischemia/reperfusion injury via the Yap pathway

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Neural Regeneration Research 2021年第6期16卷 1024-1030页

作者： shi-Jia Yu Ming-jun Yu Zhong-Qi Bu Ping-Ping He juan Feng Department of Neurology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Neurosurgery Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Apoptosis is an important programmed cell death process involved in ischemia/reperfusion *** are considered to play an important role in the molecular mechanism underlying the regulation of cerebral ischemia and reperfusion ***,whether miR-670 can regulate cell growth and death in cerebral ischemia/reperfusion and the underlying mechanism are poorly *** this study,we established mouse models of transient middle artery occlusion and Neuro 2a cell models of oxygen-glucose deprivation and reoxygenation to investigate the potential molecular mechanism by which miR-670 exhibits its effects during cerebral ischemia/reperfusion injury both in vitro and in *** results showed that after ischemia/reperfusion injury,miR-670 expression was obviously *** miR-670 expression was inhibited with an miR-670 antagomir,cerebral ischemia/reperfusion injury-induced neuronal death was obviously *** miR-670 overexpression was induced by an miR-670 agomir,neuronal apoptosis was *** addition,we also found that miR-670 could promote Yap degradation via phosphorylation and worsen neuronal apoptosis and neurological *** of miR-670 reduced neurological impairments after cerebral ischemia/reperfusion *** results suggest that microRNA-670 aggravates cerebral ischemia/reperfusion injury through the Yap pathway,which may be a potential target for treatment of cerebral ischemia/reperfusion *** present study was approved by the Institutional Animal Care and Use Committee of China Medical University on February 27,2017(IRB No.2017PS035K).

关键词： apoptosis cerebral ischemia and reperfusion injury microRNA miR-670 neurological function neuron non-coding RNA pathway

Ru(Ⅱ)-catalyzed ortho-amidation and decarboxylation of aromatic acids: a versatile route to meta-substituted N-aryl benzamides

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Science China Chemistry 2015年第8期58卷 1286-1291页

作者： Xian-Ying shi Xue-Fen Dong juan Fan Ke-Yan Liu jun-Fa Wei Chao-jun Li Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education) Key Laboratory for Macromolecular Science of Shaanxi Province School of Chemistry and Chemical Engineering Shaanxi Normal University Department of Chemistry McGill University

Carboxylate as a promising and valuable directing group has attracted a great deal of ***,employing it as a traceless direction group has rarely been *** developed the ruthenium-catalyzed amidation of substituted benzoic acids with isocyanates via directed C–H functionalization followed by decarboxylation to afford the corresponding metasubstituted N-aryl benzamides,in which the carboxylate serves as a unique,removable directing ***,this protocol can provide an efficient alternative to access meta-substituted N-aryl benzamides,which are much more difficult to prepare than ortho-substituted analogues.

关键词： amides decarboxylation amidation C-H functionalization homogeneous catalysis

中医药调控TLR4信号通路干预非酒精性脂肪肝的实验研究进展

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中国实验方剂学杂志 2025年第5期31卷 291-299页

作者：苏志威薛娟孙俊范恒朱锐计春燕湖北中医药大学湖北省中西医结合医院华中科技大学附属协和医院

非酒精性脂肪肝(NAFLD)是一种与代谢密切相关的慢性肝病，主要特征为肝细胞内脂质异常沉积。近年来，随着肥胖及代谢综合征的患病率不断上升，NAFLD已成为全球最常见的慢性疾病。NAFLD的发病机制复杂多样，涉及糖脂代谢、氧化应激及炎... 详细信息

非酒精性脂肪肝(NAFLD)是一种与代谢密切相关的慢性肝病，主要特征为肝细胞内脂质异常沉积。近年来，随着肥胖及代谢综合征的患病率不断上升，NAFLD已成为全球最常见的慢性疾病。NAFLD的发病机制复杂多样，涉及糖脂代谢、氧化应激及炎症反应等多个信号通路的交叉调控，其中Toll样受体4(TLR4)信号通路在NAFLD的发生与进展中起关键作用。TLR4通路异常激活，促使促炎性细胞因子释放，诱导氧化应激并加重胰岛素抵抗，从而加速NAFLD的恶化。研究表明，中医药在调控TLR4信号通路方面展现出潜在的治疗作用，能够显著改善NAFLD的症状及病理特征。该综述总结了近5年国内外关于中药通过TLR4信号通路干预NAFLD的实验研究进展，涵盖了多糖、萜类、生物碱、黄酮类等多种中药活性成分及中药复方。研究发现，中药活性成分及复方通过多靶点、多途径调节TLR4信号通路，能有效改善脂质代谢紊乱，减轻胰岛素抵抗，调节肠道菌群，并抑制炎症反应与氧化应激，从而延缓NAFLD的进程。通过深入分析NAFLD的病理机制，探讨TLR4信号通路作为治疗靶点的潜力，为中医药在NAFLD治疗中的应用提供理论支持，并为未来的临床研究和新药开发提供新的视角和方向，以推动NAFLD治疗策略的创新和发展。

关键词：非酒精性脂肪肝 Toll样受体(4TLR4)信号通路机制中医药

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文档级神经机器翻译综述

软件学报 2025年第1期36卷 152-183页

作者：吕星林李军辉陶仕敏杨浩张民苏州大学计算机科学与技术学院江苏苏州215006 华为翻译中心北京100080

机器翻译(machine translation,MT)研究旨在构建一个自动转换系统,将给定源语言序列自动地转换为具有相同语义的目标语言序列.由于机器翻译广阔的应用场景,使其成为自然语言理解领域乃至人工智能领域的一个重要的研究方向.近年来,端到... 详细信息

机器翻译(machine translation,MT)研究旨在构建一个自动转换系统,将给定源语言序列自动地转换为具有相同语义的目标语言序列.由于机器翻译广阔的应用场景,使其成为自然语言理解领域乃至人工智能领域的一个重要的研究方向.近年来,端到端的神经机器翻译(neural machine translation,NMT)方法显著超越了统计机器翻译(statistical machine translation,SMT)方法,成为目前机器翻译研究的主流方法.然而,神经机器翻译系统通常以句子为翻译单位,在面向文档的翻译场景中,将文档中每个句子独立地进行翻译,会因脱离文档的篇章语境引起一些篇章级的错误,如词语错翻、句子间不连贯等.因此将文档级的信息融入到翻译的过程中去解决跨句的篇章级错误是更加自然和合理的做法,文档级的神经机器翻译(document-level neural machine translation,DNMT)的目标正是如此,成为机器翻译研究的热门方向.调研了近年来在文档级神经机器翻译研究方向的主要工作,从篇章评测方法、使用的数据集和模型方法等方面系统地对当前研究工作进行了归纳与阐述,目的是帮助研究者们快速了解文档级神经机器翻译研究现状以及未来的发展和研究方向.同时在文中也阐述了在文档级神经机器翻译的一些展望、困难和挑战,希望能带给研究者们一些启发.

关键词：神经机器翻译 Transformer模型文档上下文篇章评测

拟南芥转录因子ATAF1介导植物热形态建成的研究

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四川大学学报(自然科学版) 2025年第1期62卷 190-197页

作者：师皓钰陈娟张大伟四川大学生命科学学院生物资源与生态环境教育部重点实验室成都610065

热形态建成是植物应对环境温度变化的重要机制,本研究旨在探讨NAC家族中的转录因子ATAF1如何参与调控这一过程.我们通过构建转基因植株,分析ATAF1在温和高温条件下的表达模式,研究其在不同温度下的转录水平和蛋白质积累情况,以及ATAF1... 详细信息

热形态建成是植物应对环境温度变化的重要机制,本研究旨在探讨NAC家族中的转录因子ATAF1如何参与调控这一过程.我们通过构建转基因植株,分析ATAF1在温和高温条件下的表达模式,研究其在不同温度下的转录水平和蛋白质积累情况,以及ATAF1对叶柄和下胚轴伸长的影响.结果显示,温和高温条件抑制了ATAF1的转录和蛋白质积累,并且在温和高温下ATAF1对叶柄和下胚轴的伸长具有抑制作用.综上所述,本研究揭示了转录因子ATAF1在植物热形态建成中的重要作用.

关键词：热形态建成转录因子 ATAF1 NAC家族拟南芥

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Contact Model of Revolute Joint with Clearance Based on Fractal Theory

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Chinese Journal of Mechanical Engineering 2018年第6期31卷 34-44页

作者： shi-Hua Li Xue-Yan Han jun-Qi Wang Jing Sun Fu-juan Li Parallel Robot and Mechatronic System Laboratory of Hebei Province Yanshan University

The contact sti ness of a mechanical bonding surface is an important parameter in determining the normal and radial contact force. To improve the calculation accuracy of the contact force model, the surface roughness of the bonding surface and the energy loss that necessarily occurs during the impact process should be considered com?prehensively. To study the normal contact force of a revolute joint with clearance more accurately in the case of dry friction, a nonlinear sti ness coe cient model considering the surface roughness was established based on fractal theory, which considers the elastic, elastic?plastic, and plastic deformations of the asperities of the contact surface during the contact process. On this basis, a modified nonlinear spring damping model was established based on the Lankarani–Nikravesh contact force model. The laws influencing the surface roughness, recovery coe cient, initial velocity, and clearance size on the impact force were revealed, and were compared with the Lankarani–Nikravesh model and a hybrid model using MATLAB. The maximum impact force was obtained using a modified contact force model under di erent initial velocities, di erent clearances, and di erent degrees of surface roughness, and the calculated results were then compared with the experiment results. This study indicates that the modified model can be used more widely than other models, and is suitable for both large and small clearances. In particular, the modified model is more accurate when calculating the contact force of a revolute joint with a small clearance.

关键词： Fractal theory Modified contact model Surface roughness Lankarani–Nikravesh model

Building a reference indicator model using co-kriging interpolation to determine the geographical origin of the flighted spongy moth complex in China

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Insect Science 2024年第5期31卷 1603-1616页

作者： Zeshi Qin Yixia Cao Yan Wang jun Ding Wuja Xia juan shi Sino-French Joint Laboratory for Invasive Forest Pests in Eurasia Beijing Forestry UniversityBeijingChina Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityBeijingChina China Certification and Inspection Group Beijing Co. Ltd.BeijingChina Tibetan Autonomous Prefecture of Huangnan Forestry and Grassland Administration QinghaiChina

Using stable isotopes to detect and analyze the geographical origin of insects represents an important traceability technology,which requires a rich isotope *** this study,we representatively sampled the Chinese provinces where flighted spongy moth complex(FSMC)has been reported and,for the first time,used co-kriging interpolation to predict the distribution patterns of FSMC s13C values in the main distribution *** 2020 to 2022,we set up 60 traps in 12 provinces and cities in China and collected 795 ***,6 main climatic factors were obtained by multi-collinearity screening from 21 types of meteorological data collected at the sample plots,and a correlation analysis was carried out by combining longitude,latitude,and altitude data with the s13C val-ues of ***,we performed a co-kriging interpolation using the 2 climatic factors with the highest correlation(isothermality and altitude)and the s13C values of FSMC.A cross-validation was performed to systematically test 11 candidate models and select the best semi-variogram model(Exponential"),which was then used to build a co-kriging interpolation *** geographical distribution patterns of the FSMC s13C values ob-tained from the 2 interpolation models(i.e.,interpolated with isothermality and altitude,respectively)were almost the ***,the s13C values varied significantly at the regional scale,showing regular changes in spatial ***,the reference indi-cator map of the 813C values generated from stable isotopes can be used to greatly improve the efficiency of discrimination analyses on the geographical origin of FSMC.

关键词： C stable isotope environmental similarity flighted spongy moth complex(FSMC) geographical origin

基于机器学习的老年全身麻醉颈椎术后谵妄发生风险模型的构建与验证

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军事护理 2025年第2期42卷 58-61,66页

作者：徐娟刘婷婷高俊蒋云芬中国人民解放军联勤保障部队第九〇四医院骨科江苏无锡214000 常州市中医医院骨科江苏常州314000

目的构建并筛选出评估效能最佳的老年全身麻醉颈椎术后谵妄发生风险模型,为临床干预提供依据。方法 2021年5月至2023年10月,采用便利抽样法选取某院老年全身麻醉颈椎术后患者323例为训练集,将同期另一所医院的同类患者233例为验证集。... 详细信息

目的构建并筛选出评估效能最佳的老年全身麻醉颈椎术后谵妄发生风险模型,为临床干预提供依据。方法 2021年5月至2023年10月,采用便利抽样法选取某院老年全身麻醉颈椎术后患者323例为训练集,将同期另一所医院的同类患者233例为验证集。根据术后3 d是否发生谵妄,将其分为谵妄组和非谵妄组。采用单因素及二元Logistic回归分析确定术后危险因素,采用列线图、决策树CART、随机森林构建风险模型,通过受试者工作曲线(receiver operator characteristic, ROC)分析不同模型的评估效能。结果单因素分析及二元Logistic回归分析确定,术中输血、术后脑脊液渗漏、糖尿病、手术时长等均为老年全身麻醉颈椎术后谵妄发生的危险因素(均P<0.05),据此建立列线图模型。决策树CART模型分析显示年龄为根节点,手术时长、糖尿病、术中输血等为子节点。随机森林模型筛选出年龄、手术时长、术中输血、糖尿病等7个重要变量。在训练集和验证集,列线图模型、决策树CART模型、随机森林模型评估的曲线下面积分别为0.888和0.895、0.874和0.884、0.911和0.911,随机森林模型与决策树CART模型的差异均有统计学意义(均P<0.05)。结论三种模型对老年全身麻醉颈椎术后谵妄均有评估价值,随机森林模型效能最优。

关键词：全身麻醉颈椎术后谵妄列线图决策树CART 随机森林