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Exploring the Nanomechanical Properties of a Coordination-bond Based Supramolecular Polymer

Chinese Journal of Polymer Science 2022年第12期40卷 1613-1622,I0008页

作者： Rui-Xiang Yao jun-juan shi Ke-Huan Li Xin Liu Hou-Yu Zhang Ming Wang Wen-Ke Zhang State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Institute of Theoretical Chemistry College of ChemistryJilin UniversityChangchun 130012China

Due to their dynamic nature and strength tunability,metallo-supramolecular polymers have been introduced into various *** mechanical strength of the metallo-supramolecular polymers in the system directly influences the mechanical properties(e.g.,the toughness)of the ***,it is necessary to explore the mechanical behavior of the metallo-supramolecular ***,we present a single-molecule method to systematically explore the chain structure and mechanical properties of metallo-supramolecular polymer by using a loop protected ***,we found that the mechanical stability of the individual chain,which is determined by the strength of terpyridine-Fe^(2+) -terpyridine(tpy-Fe^(2+)-tpy)bonds,was about 0.6–1.0 nN,depending on the pulling *** value is around three times higher than those measured using old *** addition,the unique loop protected structure further reduces the interference of non-specific polymer-AFM tip(or polymer-substrate)interactions on the quantification of the actual strength and kinetic parameter of noncovalent interactions in supramolecular ***,the single chain flexibility of the metallo-supramolecular polymer was investigated and found to be comparable to the corresponding covalent *** findings provide a new way to explore the force response of supramolecular polymers composed of metal-ligand interactions and will be useful for the design of metallo-supramolecular polymer-based functional materials with tailored mechanical properties.

关键词： Supramolecular polymer Single-molecule force spectroscopy Coordination chemistry Polymer mechanochemistry

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面向物联网中的支持节点移动的MAC协议

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计算机工程与设计 2018年第6期39卷 1570-1573页

作者：王喜军高士娟郑州工业应用技术学院信息工程学院河南郑州451150

多数媒介接入控制(medium access control,MAC)协议仅关注静态网络,然而,物联网中的多数节点是移动的。为此,提出面向物联网中的支持节点移动的MAC(mobility-supporting MAC,MS-MAC)协议。交互控制包,建立邻居节点,利用节点密度和距离... 详细信息

多数媒介接入控制(medium access control,MAC)协议仅关注静态网络,然而,物联网中的多数节点是移动的。为此,提出面向物联网中的支持节点移动的MAC(mobility-supporting MAC,MS-MAC)协议。交互控制包,建立邻居节点,利用节点密度和距离计算节点权值,择优选择转发节点,减少传输跳数,引用竞争避免算法消除由隐藏终端节点产生的竞争和拥塞问题。实验数据表明,与MoX-MAC、MOBINET、ME-ContikiMAC相比,MS-MAC协议在端到端传输时延、能耗性能方面得到有效提高。

关键词：物联网媒介接入控制权值移动竞争避免算法

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia Xiu-jun Zhan Charity Ngina Qing-Rui Zhang Xiao-Ge Li Qi-Bao Jiang shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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Ru(Ⅱ)-catalyzed ortho-amidation and decarboxylation of aromatic acids: a versatile route to meta-substituted N-aryl benzamides

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Science China Chemistry 2015年第8期58卷 1286-1291页

作者： Xian-Ying shi Xue-Fen Dong juan Fan Ke-Yan Liu jun-Fa Wei Chao-jun Li Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education) Key Laboratory for Macromolecular Science of Shaanxi Province School of Chemistry and Chemical Engineering Shaanxi Normal University Department of Chemistry McGill University

Carboxylate as a promising and valuable directing group has attracted a great deal of ***,employing it as a traceless direction group has rarely been *** developed the ruthenium-catalyzed amidation of substituted benzoic acids with isocyanates via directed C–H functionalization followed by decarboxylation to afford the corresponding metasubstituted N-aryl benzamides,in which the carboxylate serves as a unique,removable directing ***,this protocol can provide an efficient alternative to access meta-substituted N-aryl benzamides,which are much more difficult to prepare than ortho-substituted analogues.

关键词： amides decarboxylation amidation C-H functionalization homogeneous catalysis

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Contact Model of Revolute Joint with Clearance Based on Fractal Theory

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Chinese Journal of Mechanical Engineering 2018年第6期31卷 34-44页

作者： shi-Hua Li Xue-Yan Han jun-Qi Wang Jing Sun Fu-juan Li Parallel Robot and Mechatronic System Laboratory of Hebei Province Yanshan University

The contact sti ness of a mechanical bonding surface is an important parameter in determining the normal and radial contact force. To improve the calculation accuracy of the contact force model, the surface roughness of the bonding surface and the energy loss that necessarily occurs during the impact process should be considered com?prehensively. To study the normal contact force of a revolute joint with clearance more accurately in the case of dry friction, a nonlinear sti ness coe cient model considering the surface roughness was established based on fractal theory, which considers the elastic, elastic?plastic, and plastic deformations of the asperities of the contact surface during the contact process. On this basis, a modified nonlinear spring damping model was established based on the Lankarani–Nikravesh contact force model. The laws influencing the surface roughness, recovery coe cient, initial velocity, and clearance size on the impact force were revealed, and were compared with the Lankarani–Nikravesh model and a hybrid model using MATLAB. The maximum impact force was obtained using a modified contact force model under di erent initial velocities, di erent clearances, and di erent degrees of surface roughness, and the calculated results were then compared with the experiment results. This study indicates that the modified model can be used more widely than other models, and is suitable for both large and small clearances. In particular, the modified model is more accurate when calculating the contact force of a revolute joint with a small clearance.

关键词： Fractal theory Modified contact model Surface roughness Lankarani–Nikravesh model

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Building a reference indicator model using co-kriging interpolation to determine the geographical origin of the flighted spongy moth complex in China

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Insect Science 2024年第5期31卷 1603-1616页

作者： Zeshi Qin Yixia Cao Yan Wang jun Ding Wuja Xia juan shi Sino-French Joint Laboratory for Invasive Forest Pests in Eurasia Beijing Forestry UniversityBeijingChina Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityBeijingChina China Certification and Inspection Group Beijing Co. Ltd.BeijingChina Tibetan Autonomous Prefecture of Huangnan Forestry and Grassland Administration QinghaiChina

Using stable isotopes to detect and analyze the geographical origin of insects represents an important traceability technology,which requires a rich isotope *** this study,we representatively sampled the Chinese provinces where flighted spongy moth complex(FSMC)has been reported and,for the first time,used co-kriging interpolation to predict the distribution patterns of FSMC s13C values in the main distribution *** 2020 to 2022,we set up 60 traps in 12 provinces and cities in China and collected 795 ***,6 main climatic factors were obtained by multi-collinearity screening from 21 types of meteorological data collected at the sample plots,and a correlation analysis was carried out by combining longitude,latitude,and altitude data with the s13C val-ues of ***,we performed a co-kriging interpolation using the 2 climatic factors with the highest correlation(isothermality and altitude)and the s13C values of FSMC.A cross-validation was performed to systematically test 11 candidate models and select the best semi-variogram model(Exponential"),which was then used to build a co-kriging interpolation *** geographical distribution patterns of the FSMC s13C values ob-tained from the 2 interpolation models(i.e.,interpolated with isothermality and altitude,respectively)were almost the ***,the s13C values varied significantly at the regional scale,showing regular changes in spatial ***,the reference indi-cator map of the 813C values generated from stable isotopes can be used to greatly improve the efficiency of discrimination analyses on the geographical origin of FSMC.

关键词： C stable isotope environmental similarity flighted spongy moth complex(FSMC) geographical origin

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Numerical study on indoor environment and thermal comfort in train station waiting hall with two different air-conditioning modes

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Building Simulation 2021年第2期14卷 337-349页

作者： Biyao Zhuang juan shi Zhenqian Chen Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education of China School of Energy and EnvironmentSoutheast UniversityNanjing210096China

With the increasing size of the waiting hall,the large-area use of transparent envelope materials makes the interior surface temperature of the envelope too high,which puts forward higher requirements for the control of environment and thermal comfort *** this paper,the characteristics of indoor temperature distribution,relative humidity distribution and thermal comfort under the all air system(AAs)and the radiant floor cooling and wall cooling combined with air supply system(RC/ASs)were investigated in the large *** computational fluid dynamics(CFD)method was used,and the performance of the CFD model was validated by comparing the measured results with CFD simulation results in the *** numerical results clearly showed that the temperature and relative humidity indoors could satisfy the design requirement both in the AAs and RC/*** indoor air distribution in most areas under the RC/ASs was more uniform based on the indoor heat and humidity requirements under the cooling load of measured *** the AAs,the total cooling capacity of air conditioning unit was the highest when indoor thermal comfort was the best,that meant that to achieve the best working condition,the air-conditioning system need high energy ***,the RC/ASs addressed the problem that the temperature around the seated passengers in the waiting area was relatively high in the *** paper will provide reference for the air conditioning system design in the similar large spaces in the future.

关键词： radiant floor cooling radiant wall cooling large spaces thermal comfort

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MicroRNA-670 aggravates cerebral ischemia/reperfusion injury via the Yap pathway

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Neural Regeneration Research 2021年第6期16卷 1024-1030页

作者： shi-Jia Yu Ming-jun Yu Zhong-Qi Bu Ping-Ping He juan Feng Department of Neurology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Neurosurgery Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Apoptosis is an important programmed cell death process involved in ischemia/reperfusion *** are considered to play an important role in the molecular mechanism underlying the regulation of cerebral ischemia and reperfusion ***,whether miR-670 can regulate cell growth and death in cerebral ischemia/reperfusion and the underlying mechanism are poorly *** this study,we established mouse models of transient middle artery occlusion and Neuro 2a cell models of oxygen-glucose deprivation and reoxygenation to investigate the potential molecular mechanism by which miR-670 exhibits its effects during cerebral ischemia/reperfusion injury both in vitro and in *** results showed that after ischemia/reperfusion injury,miR-670 expression was obviously *** miR-670 expression was inhibited with an miR-670 antagomir,cerebral ischemia/reperfusion injury-induced neuronal death was obviously *** miR-670 overexpression was induced by an miR-670 agomir,neuronal apoptosis was *** addition,we also found that miR-670 could promote Yap degradation via phosphorylation and worsen neuronal apoptosis and neurological *** of miR-670 reduced neurological impairments after cerebral ischemia/reperfusion *** results suggest that microRNA-670 aggravates cerebral ischemia/reperfusion injury through the Yap pathway,which may be a potential target for treatment of cerebral ischemia/reperfusion *** present study was approved by the Institutional Animal Care and Use Committee of China Medical University on February 27,2017(IRB No.2017PS035K).

关键词： apoptosis cerebral ischemia and reperfusion injury microRNA miR-670 neurological function neuron non-coding RNA pathway

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Sperm chromatin structure assay results after swim-up are related only to embryo quality but not to fertilization and pregnancy rates following IVF

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Asian Journal of Andrology 2011年第6期13卷 862-866页

作者： Zhi-Hong Niu Hui-juan shi Hui-Qin Zhang Ai-jun Zhang Yi-juan Sun Yun Feng IVF Unit Department of Obstetrics and Gynecology Ruijin Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200025 China Shanghai Institute of Planned Parenthood Research Shanghai 200032 China

The aim of this study was to investigate whether the sperm chromatin structure assay （SCSA） results after swim-up are related to fertilization rates, embryo quality and pregnancy rates following in vitrofertilization （IVF）. A total of 223 couples undergoing IVF in our hospital from October 2008 to September 2009 were included in this study. Data on the IVF process and sperm chromatin structure assay results were collected. Fertilization rate, embryo quality and IVF success rates of different DNA fragmentation index （DFI） subgroups and high DNA stainability （HDS） subgroups were compared. There were no significant differences in fertilization rate, clinical pregnancy or delivery rates between the DFI and HDS subgroups. However, the group with abnormal DFI had a lower good embryo rate. So, we concluded that the SCSA variables, either DFI or HDS after swim-up preparation, were not valuable in predicting fertilization failure or pregnancy rate, but an abnormal DFI meant a lower good embryo rate following IVF.

关键词： embryo fertilization in-vitro fertilization sperm chromatin structure assay

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