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Clinical and genetic analysis of nonketotic hyperglycinemia:A case report

World Journal of Clinical Cases 2022年第22期10卷 7982-7988页

作者： jun-jie ning Feng Li Sheng-Qiu Li Department of Pediatric Intensive Care Unit First People's Hospital of Zigong CityZigong 643000Sichuan ProvinceChina

BACKGROUND Nonketotic hyperglycinemia(NKH)is a rare autosomal recessive genetic disorder of abnormal glycine metabolism caused by insufficient activity of the glycine cleavage enzyme *** is believed to function mainly as an inhibitory neurotransmitter,but it can also act as a co-agonist of the N-methyl-D-aspartate(NMDA)*** accumulation of a large amount of glycine in the brain leads to neuronal and axonal injury via overactivation of NMDA receptors located in the hippocampus,cerebral cortex,olfactory bulb,and cerebellum and to stimulation of the inhibitory function of glycine receptors located in the spinal cord and brain stem,resulting in central apnea,hiccups,and hypotonia in the early stage of the *** SUMMARY The child described in this report had typical clinical manifestations of NKH,such as hiccups,disturbance of consciousness,hypotonia,and convulsions,within the first week after ***-exome genetic testing revealed that the child had a compound heterozygous mutation,namely,c.395C>A(p.S132X)and c.2182G>A(p.G728R),in the GLDC gene,and he was diagnosed with *** treatment,we administered an oral levetiracetam solution and added topiramate and prednisone for epilepsy control,but the epilepsy remained *** diet therapy was started at 6 mo of age,his seizures were significantly reduced,and there were no obvious adverse reactions during ketogenic ***,we found that with the development of the disease,high levels of serum glycine decreased or even disappeared without intervention,and as the disease progressed,the corpus callosum became *** This case shows that plasma glycine levels cannot be used to evaluate the prognosis of NKH,that the development of the corpus callosum can be affected by NKH,and that a ketogenic diet may be effective for seizure control in NKH patients.

关键词： Nonketotic hyperglycinemia Compound heterozygosity GLDC gene Case report

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Disseminated Fusarium bloodstream infection in a child with acute myeloid leukemia:A case report

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World Journal of Clinical Cases 2021年第21期9卷 6049-6055页

作者： jun-jie ning Xue-Mei Li Sheng-Qiu Li Department of PICU First People's Hospital of Zigong CityZigong 643000Sichuan ProvinceChina

BACKGROUND Disseminated Fusarium is rare in healthy *** with hematological tumors may have secondary fungal infections,including Fusarium infections,which are due to tumor bone marrow infiltration or prolonged bone marrow suppression after *** of the lack of typical clinical manifestations and effective antifungal drugs,early diagnosis and treatment of the disease are difficult,and the prognosis is *** SUMMARY The patient in this case was a 13-year-old female child with rash and fever as the first *** had the characteristics of the four stages of skin that are typical of Fusarium *** was diagnosed with disseminated Fusarium infection through skin biopsy and blood culture and diagnosed with Fusarium solani infection based on the morphological characteristics of the blood *** treatment with liposome amphotericin B combined with voriconazole,the child *** This case highlights that for children with secondary agranulocytosis after receiving chemotherapy for hematological malignancies,once typical abnormal skin damage is found,the possibility of Fusarium infection should be considered,and voriconazole alone or in combination with polyenes may be the most effective anti-Fusarium *** B,the traditional drug of disseminated Fusarium disease,has a high mortality rate,and it is not recommended to use it *** neutrophil counts are essential for the treatment of disseminated Fusarium bloodstream infection.

关键词： Fusarium Liposomal amphotericin B Voriconazole Acute myeloid leukemia Agranulocytosis Case report

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Surgical Treatment of Superior Thyroid Artery Aneurysm with Concomitant Thyroid Cancer

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Chinese Medical Journal 2017年第23期130卷 2885-2886页

作者： jun-jie ning Chen Yao Guang-Qi Chang Shen-Ming Wang Department of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080China

In 2015, the incidence rate of thyroid cancer was 4.2/100,000 in China, which accounted for 2.1% of all new cancer cases.[1] Aneurysmsofthecarotidarteryoritsbranchesaccountforonly 0.4% of all peripheral artery aneurysms.[2] The coexistence of these two lesions has seldom been observed. Here, we reported a case of a superior thyroid artery （STA） aneurysm with concomitant thyroid cancer and discussed surgical treatment strategies.

关键词： Aneurysm External Carotid Artery Superior Thyroid Artery Thyroid Cancer

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Microinjection of a growth factor cocktail affects activated microglia in the neocortex of adult rats

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Neural Regeneration Research 2020年第9期15卷 1709-1715页

作者： Ruo-Xu Liu jie Ma ning Guo Shao-jun Liu State Key Laboratory of Proteomics and Department of Neurobiology Institute of Military Cognition and Brain Sciences

Microglia, as the resident immune cells in the central nervous system, play important roles in regulating neuronal processes, such as neural excitability, synaptic activity, and apoptotic cell clearance. Growth factors can activate multiple signaling pathways in central nervous system microglia and can regulate their immune effects, but whether growth factors can affect the morphological characteristics and ultrastructure of microglia has not been reported. After microinjecting 300 nL of a growth factor cocktail, including 10 μg/mL epidermal growth factor, 10 μg/mL basic fibroblast growth factor, 10 μg/mL hepatocyte growth factor and 10 μg/mL insulin-like growth factor into adult rat cortex, we found that the number of IBA1-positive microglia around the injection area increased significantly, indicating local activation of microglia. All CD68-positive labeling co-localized with IBA1 in microglia. Cell bodies and protrusions of CD68-positive cells were strongly attached to or were engulfing neurons. Characteristic huge phagosomes were observed in activated phagocytes by electron microscopy. The phagosomes generally included non-degraded neuronal protrusions and mitochondria, yet they contained no myelin membrane or remnants, which might indicate selective phagocytosis by the phagocytes. The remnant myelin sheath after phagocytosis still had regenerative ability and formed "myelin-like" structures around phagocytes. These results show that microinjection of a growth factor cocktail into the cerebral cortex of rodents can locally activate microglia and induce selective phagocytosis of neural structures by phagocytes. The study was approved by the Institute of Laboratory Animal Science, Beijing Institute of Basic Medical Sciences(approval No. IACUC-AMMS-2014-501) on june 30, 2014.

关键词： adult neocortex CD68 IBA1 microinjection phagocyte selective phagocytosis ultrastructure

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Approximating Special Social Influence Maximization Problems

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Tsinghua Science and Technology 2020年第6期25卷 703-711页

作者： jie Wu ning Wang the Department of Computer and Information Sciences Temple University.PhiladelphiaPA 19122USA the Department of Computer Science Rowan UniversityGlassboroNJ 08028USA

Social Influence Maximization Problems(SIMPs)deal with selecting k seeds in a given Online Social Network(OSN)to maximize the number of eventually-influenced *** is done by using these seeds based on a given set of influence probabilities among neighbors in the *** the SIMP has been proved to be NP-hard,it has both submodular(with a natural diminishing-return)and monotone(with an increasing influenced users through propagation)that make the problem suitable for approximation ***,several special SIMPs cannot be modeled as submodular or monotone *** this paper,we look at several conditions under which non-submodular or non-monotone functions can be handled or *** is a profit-maximization SIMP where seed selection cost is included in the overall utility function,breaking the monotone *** other is a crowd-influence SIMP where crowd influence exists in addition to individual influence,breaking the submodular *** then review several new techniques and notions,including double-greedy algorithms and the supermodular degree,that can be used to address special *** main results show that for a specific SIMP model,special network structures of OSNs can help reduce its time complexity of the SIMP.

关键词： influence maximization online social networks submodular function

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Physical Performance of Migrant Schoolchildren with Marginal and Severe Iron Deficiency in the Suburbs of Beijing

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Biomedical and Environmental Sciences 2009年第4期22卷 333-339页

作者： jie WANG jun-SHENG HUO JING SUN ZHENG-XIANG ning College of Light Industry and Food Sciences South China University of Technology Guangzhou 510641 Guangdong China Institute of Nutrition and Food Safty Chinese Center for Disease Control and Prevention Beijing 100050 China

Objectives To investigate relationship between iron deficiency of different degrees and physical performance and habitual activity of migrant schoolchildren at the age of 11-14 years. Methods Ninety one randomly selected schoolchildren were divided into three groups according to their iron status. Iron status including hemoglobin （Hb）, serum ferritin （SF）, serum iron （SI） and sTfR was determined. Physical performance tests included maximum oxygen consumption （VO2max） and maximum work time. Energy expenditure （EE） and daily physical activity were estimated by recording 24-h heart rate （HR）. Dietary intake was assessed with frequency questionnaires, and physical activity level was estimated with frequency and physical activity questionnaires. Results Severe iron deficiency （IDA） impaired the aerobic capacity and habitual physical activity. When fat-free mass （FFM） was considered, VO2max （VO2max/FFM） was significantly lower in the iron-marginal group than in the iron-adequate groups among girls （P=0.02）, but such a deference was not found among boys （P=0.28）. Aerobic activity and EE at leisure were significantly lower in the severe iron deficient group than in the marginal iron deficient and iron adequate groups. Net HR at leisure time was correlated with lib, log SF, body weight, and FFM （P〈0.05）. Conclusion The functional effect of iron deficiency on physical performance and habitual physical activity rely on the degree of current iron deficiency. Severe iron deficiency significantly impairs both aerobic capacity and habitual physical activity. Iron-marginal deficiency impairs VO2max/FFM in girls, rather than in boys.

关键词： Iron deficiency anemia Iron deficiency Maximum oxygen consumption Heart rate Energy expenditure Physicalactivity Children of migrant workers

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山西重要黍稷种质资源品质性状的初步鉴定与评价

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植物遗传资源学报 2017年第1期18卷 61-69页

作者：王纶王星玉王海岗陈凌王君杰曹晓宁刘思辰康国帅山西省农业科学院农作物品种资源研究所/农业部黄土高原作物基因资源与种质创制重点实验室/杂粮种质资源发掘与遗传改良山西省重点实验室太原030031

营养品质和口感品质是组成黍稷种质子粒品质的重要组成部分。粗蛋白和粗脂肪含量是组成营养品质的主要成分,赖氨酸和可溶性糖含量是组成口感品质的主要成分。通过对山西省有代表性的90份黍稷种质的粗蛋白、粗脂肪、赖氨酸和可溶性糖的测... 详细信息

营养品质和口感品质是组成黍稷种质子粒品质的重要组成部分。粗蛋白和粗脂肪含量是组成营养品质的主要成分,赖氨酸和可溶性糖含量是组成口感品质的主要成分。通过对山西省有代表性的90份黍稷种质的粗蛋白、粗脂肪、赖氨酸和可溶性糖的测定,评价了参试黍稷种质资源的营养品质和口感品质。结果表明,黍稷种质资源的粗蛋白平均含量为11.88%,粗脂肪平均含量为3.69%,赖氨酸平均含量为0.19%,可溶性糖平均含量为2.04%。鉴定筛选出7份粗蛋白含量13.00%、粗脂肪含量4.00%以上的高营养品质种质;15份赖氨酸含量0.20%以上、可溶性糖含量2.00%以上的口感品质优的种质;3份粗蛋白含量13.00%以上、粗脂肪含量4.00%以上、赖氨酸含量0.20%以上和可溶性糖含量2.00%以上的营养品质和口感品质均优的种质。营养品质和口感品质与不同类型种质的相关性分析表明,稷的营养品质好于黍,黍的口感品质好于稷,红粒种质营养品质和口感品质最好,白、褐、复色的种质居中,黄粒的最差;粒形和营养品质及口感品质相关不显著。研究结果为今后优质种质利用提供了参考依据。

关键词：黍稷种质资源营养品质口感品质

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Multipurpose audio watermarking algorithm

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第4期9卷 517-523页

作者： ning CHEN jie ZHU Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China

To make audio watermarking accomplish both copyright protection and content authentication with localization, a novel multipurpose audio watermarking scheme is proposed in this paper. The zero-watermarking idea is introduced into the design of robust watermarking algorithm to ensure the transparency and to avoid the interference between the robust watermark and the semi-fragile watermark. The property of natural audio that the VQ indices of DWT-DCT coefficients among neighboring frames tend to be very similar is utilized to extract essential feature from the host audio, which is then used for watermark ex-traction. And, the chaotic mapping based semi-fragile watermark is embedded in the detail wavelet coefficients based on the instantaneous mixing model of the independent component analysis (ICA) system. Both the robust and semi-fragile watermarks can be extracted blindly and the semi-fragile watermarking algorithm can localize the tampering accurately. Simulation results demonstrate the effectiveness of our algorithm in terms of transparency, security, robustness and tampering localization ability.

关键词： Multipurpose audio watermarking Copyright protection Content authentication

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Suppression of Spiral Waves and Spatiotemporal Chaos Under Local Self-adaptive Coupling Interactions

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Communications in Theoretical Physics 2006年第1期45卷 121-126页

作者： MA jun WU ning-jie YING He-Ping YUAN Li-Hua Department of Physics School of Science Lanzhou University of Technology Lanzhou 730050 China Zhejiang Institute of Modern Physics Zhejiang University Hangzhou 310027 China

In this paper, a close-loop feedback control is imposed locally on the Fitzhugh-Nagumo （FHN） system to suppress the stable spirals and spatiotemporal chaos according to the principle of self-adaptive coupling interaction. The simulation results show that an expanding target wave is stimulated by the spiral waves under dynamic control period when a local area. of 5 × 5 grids is controlled, or the spiral tip is driven to the board of the system, It is also found that the spatiotemporal chaos can be suppressed to get a stable homogeneous state within 50 time units as two local grids are controlled mutually. The mechanism of the scheme is briefly discussed.

关键词： spiral waves spatiotemporal chaos close-loop feedback Fitzhugh-Nagumo (FHN) equation

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Influence of High-Pressure Nitrogenation on the Structure,Magnetism and Microwave Absorption Properties of SmFe_(10)Mo_2

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Acta Metallurgica Sinica(English Letters) 2015年第6期28卷 781-786页

作者： Nai-Kun Sun jie Guo Sheng-jie Du Song-ning Xu Ping-Zhan Si Jin-jun Liu School of Science Shenyang Ligong University College of Materials Science and Engineering China Jiliang University Faculty of Materials Science and Chemical Engineering Ningbo University

Nitrogenation of SmFelolVIo2 powders was performed in a self-made furnace under a high-purity N2 atmo- sphere up to 40 MPa at 500 ℃. Upon nitrogenation at atmospheric pressure, the lattice parameters a and c increase by 0.5% and 2.7%, respectively, whereas the Curie temperature Tc increases from 519 to 633 K. With further increasing the nitrogenation pressure to 20 and 40 MPa, the 1：12 main phase starts to decompose and a large amount of Mo and a-Fe precipitates. This leads to variation of Mo concentration in the 1：12 phase and causes a sharp decrease in Tc and in the coercivity. The relative complex permittivity and permeability of paraffin-SmFeloMO2 composites show multi-resonant behavior. After nitrogenation, the magnetic loss of the powders decreases, which may originate from the influence of eddy currents due to the increase in the particle size.

关键词： High-pressure nitrogenation SmFeloMO2-based compounds Curie temperature Microwaveabsorption

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