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How does Hedgehog signaling participate in the cross-interaction of hormones and testis development?

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BIOCELL 2025年第1期49卷 93-107页

作者： jun-jie YU WAN-XI YANG The Sperm Laboratory College of Life SciencesZhejiang UniversityHangzhou310058China

Hedgehog(HH)signaling has been researched for decades and Hedgehog has 3 homologs:Sonic Hedgehog(Shh),Indian Hedgehog(Ihh),and Desert Hedgehog(Dhh).Dhh is the one involved in male gonad and germ cell *** distribution of molecules in Hedgehog signaling in testis indicated that Hedgehog signaling executes important functions during testis *** patients with Dhh signaling deficiency develop dysgenesis of gonads and hormone production which demands further exploration of gonad HH *** results proved the indispensable roles of HH signaling in gonad and germ cell development and the interaction with *** review evaluates HH functions in the testis and how HH affects and is affected by hormones and provides novel insights about HH signaling to the readers.

关键词： Hedgehog signaling Hormone Testis Leydig cell Gonadal dysgenesis

跑步荷载下大跨结构的竖向振动加速度反应谱研究

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工程力学 2017年第3期34卷 173-181页

作者：陈隽熊杰程李果同济大学土木工程防灾国家重点实验室上海200092 同济大学土木工程学院上海200092

采用无线测力鞋垫实测了24人次372条跑步荷载,计算了每条时程所对应的单自由度系统的加速度反应谱,取每位测试者所有的计算反应谱曲线的包络线为其代表谱线,在分析所有代表谱线特点的基础上提出了设计反应谱的形式及其数学表达式,包含... 详细信息

采用无线测力鞋垫实测了24人次372条跑步荷载,计算了每条时程所对应的单自由度系统的加速度反应谱,取每位测试者所有的计算反应谱曲线的包络线为其代表谱线,在分析所有代表谱线特点的基础上提出了设计反应谱的形式及其数学表达式,包含六个部分:三个平台段以及它们之间的连接线。由试验数据的分析确定了不同阻尼比和保证率下各部分设计谱参数的取值,并讨论了结构跨度、跑步步距、高阶振型和边界条件对反应谱的影响,提出了不同谱代表值之间的转换关系。该文给出了设计反应谱的详细使用步骤并通过工程实例验证了其可行性。

关键词：大跨工程结构振动舒适度跑步荷载设计反应谱分段模型

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： jie Bai Jian Hui Jia Yu Wang Chun cheng Yang Qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1) at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1) at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

锐钛矿TiO_2(101)表面电子能带结构的理论研究

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电化学 2017年第1期23卷 45-52页

作者：赵俊杰程俊厦门大学化学化工学院福建厦门361005

二氧化钛作为一种理想的光催化和光电转换半导体材料,受到了广泛的关注和研究,其表面的电子能带结构作为其本征的化学性质之一,决定着表面上氧化还原反应发生的可能性.对二氧化钛表面电子能带结构进行深入研究对于我们从微观上认识并改... 详细信息

二氧化钛作为一种理想的光催化和光电转换半导体材料,受到了广泛的关注和研究,其表面的电子能带结构作为其本征的化学性质之一,决定着表面上氧化还原反应发生的可能性.对二氧化钛表面电子能带结构进行深入研究对于我们从微观上认识并改良二氧化钛这一光电催化材料,以及进一步开发利用更好的光催化材料都具有非常好的指导意义.本论文采用密度泛函理论,计算研究了锐钛矿TiO_2(101)表面的电子能带结构,并通过与金红石TiO_2(110)晶面的对比,系统分析了两个表面电子能带结构的不同以及水分子的溶剂化作用对电子能带结构的影响.

关键词：锐钛矿价带顶导带底电子能级排列密度泛函理论

Flow behavior and dynamic softening mechanism of Pt−10Ir precious alloy

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 225-242页

作者： Xin-pei ZHANG jun-jie HE Lin PI Quan FU Wen-yan ZHOU jun cheng Sheng-wen BAI Xuan ZHOU Yi LIU Yong MAO Materials Genome Institute School of Materials and EnergyYunnan UniversityKunming 650091China Kunming Precious Materials&Technology Co. Ltd.Yunnan Precious Metals Laboratory Co.Ltd.Sino-Platinum Metals Co.Ltd.Kunming 650106China Kunming Institute of Precious Metals Kunming 650106China State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals Sino-Platinum Metals Co.Ltd.Kunming 650106China Shaanxi Key Laboratory of Biomedical Metal Materials Northwest Institute for Non-ferrous Metal ResearchXi’an 710016China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The hot deformation behavior of Pt−10Ir alloy was studied under a wide range of deformation *** a low deformation temperature(950−1150℃),the softening mechanism is primarily dynamic *** addition,dynamic recrystallization by progressive lattice rotation near grain boundaries(DRX by LRGBs)and microshear bands assisted dynamic recrystallization(MSBs assisted DRX)coordinate the ***,it is difficult for the dynamic softening to offset the stain hardening due to a limited amount of DRXed *** a high deformation temperature(1250−1350℃),three main DRX mechanisms associated with strain rates occur:DRX by LRGBs,DRX by a homogeneous increase in misorientation(HIM)and geometric DRX(GDRX).With increasing strain,DRX by LRGBs is enhanced gradually under high strain rates;the“pinch-off”effect is enhanced at low strain rates,which was conducive to the formation of a uniform and fine microstructure.

关键词： platinum alloy hot deformation microstructure evolution dynamic recovery dynamic recrystallization

Characterization of size-resolved aerosol hygroscopicity and liquid water content in Nanjing of the Yangtze River Delta

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Journal of Environmental Sciences 2025年第5期151卷 26-41页

作者： Youling Jiang Yan Ma jun Zheng Nan Ye cheng Yuan School of Environmental Science and Engineering Nanjing University of Information Science and TechnologyNanjing 210044China Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science&TechnologyNanjing 210044China School of Emergency Management Nanjing University of Information Science&TechnologyNanjing 210044China

Aerosol hygroscopicity and liquid water content(ALWC)have important influences on the environmental and climate effect of *** this study,we measured the hygroscopic growth factors(GF)of particles with dry diameters of 40,80,150,and 200 nm during the wintertime in *** the GF-derived hygroscopicity parameter(κ_(gf))and ALWC increased with particle size,but displayed differing diurnal variations,withκ_(gf)peaking around the midday,while ALWC peaking in the early ***,ammonium and oxygenated organic aerosols(OOA)were found as the chemical components mostly strongly correlated with ALWC.A closure study suggests that during midday photo-oxidation and nighttime high ALWC periods,theκof organic aerosols(κ_(org))was underestimated when using previous ***,we re-constructed parameterizations forκ_(org)and the oxidation level of organics for these periods,which indicates a higher hygroscopicity of photochemically formed OOA than the aqueous OOA,yet both being much higher than the generally assumed OOA ***,in a typical high ALWC episode,concurrently increased ALWC,nitrate,OOA as well as aerosol surface area and mass concentrations were observed under elevated ambient *** strongly indicates a coupled effect that the hygroscopic secondary aerosols,in particular nitratewith strong hygroscopicity,led to large increase in ALWC,which in turn synergistically boosted nitrate and OOA formation by heterogeneous/aqueous *** interaction may represent an important mechanism contributing to enhanced formation of secondary aerosols and rapid growth of fine particulate matter under relatively high RH conditions.

关键词： Aerosol hygroscopicity Aerosol liquid water content Photo-oxidation Aqueous/heterogeneous reactions

Residual symmetry and interactions between solitons and periodic waves of the Drinfeld-Sokolov-Satsuma-Hirota system

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Communications in Theoretical Physics 2025年第1期77卷 1-10页

作者： jie-tong Li jun Yu Xi-zhong Liu Institute of Nonlinear Science Shaoxing UniversityShaoxing 312000China

In this paper,the Drinfeld-Sokolov-Satsuma-Hirota(DSSH)system is studied by using residual symmetry and the consistent Riccati expansion(CRE)method,*** residual symmetry of the DSSH system is localized to Lie point symmetry in a properly prolonged system,based on which we get a new Bäcklund transformation for this *** symmetry reduction solutions of the DSSH system are obtained by applying the classical Lie group approach on the prolonged ***,the DSSH system proves to be CRE integrable and new interesting interaction solutions between solitons and periodic waves are generated and analyzed.

关键词： Drinfeld-Sokolov-Satsuma-Hirota system residual symmetry consistent Riccati expansion

lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis

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Oncology Research 2025年第1期33卷 185-198页

作者： ZHOUYANG cheng YUCHEN HUA YANG CAO jun QIN Department of General Surgery Affiliated Hospital of Nantong UniversityNantong226001China Department of Surgery Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Operation Affiliated Hospital of Nantong UniversityNantong226001China

Objective:Gastric cancer(GC)is a globally common cancer characterized by high incidence and mortality *** in the molecular understanding of GC provide promising targets for GC diagnosis and *** non-coding RNAs(lncRNAs)and their downstream regulators are regarded to be implicated in the progression of multiple types of *** have shown that the lncRNA small nucleolar RNA host gene 4(SNHG4)serves as a tumor promoter in various malignancies,while its function in GC has yet to be ***,our study aimed to explore the role and underlying mechanism of SNHG4 in ***:We used qRT-PCR to analyze SNHG4 expression in GC tissues and ***-Meier analysis was used to assess the correlation between SNHG4 expression and the survival rate of GC *** function experiments such as CCK-8,BrdU,colony formation,flow cytometry analysis,and transwell were performed to explore the effects of SNHG4 on GC cell proliferation,apoptosis,cell cycle,migration,and *** also established xenograft mouse models to explore the effect of SNHG4 on GC tumor ***,dual luciferase reporter assay was used to verify the interaction between SNHG4 and miR-409-3p and between miR-409-3p and cAMP responsive element binding protein 1(CREB1).Results:The results indicated that SNHG4 was overexpressed in GC tissues and cell lines,and was linked with poor survival rate of GC ***4 promoted GC cell proliferation,migration,and invasion while inhibiting cell apoptosis and cell cycle arrest in *** in vivo experiment indicated that SNHG4 facilitated GC tumor ***,SNHG4 was demonstrated to bind to ***,CREB1 was directly targeted by *** assays demonstrated that miR-409-3p deficiency reversed the suppressive impact of SNHG4 knockdown on GC cell ***,miR-409-3p was also revealed to inhibit GC cell proliferation,migration,and invasion by targeting CREB1

关键词： Gastric cancer Small nucleolar RNA host gene 4(SNHG4) MicroRNA-409-3p(miR-409-3p) cAMP responsive element binding protein 1(CREB1)

Clinicopathological features and treatment of gastrointestinal schwannomas

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World Journal of Gastroenterology 2025年第5期31卷 32-42页

作者： Peng-cheng Zhang Shu-Hui Wang jun Li Jing-jie Wang Hong-Tan Chen Ai-Qing Li Department of Gastroenterology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Epidemiology&Health Statistics School of Public HealthSchool of MedicineZhejiang UniversityHangzhou 310058Zhejiang ProvinceChina Department of Pathology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Gastrointestinal schwannomas(GIS)are rare neurogenic tumors arising from Schwann cells in the gastrointestinal *** on GIS are limited to small case reports or focus on specific tumor sites,underscoring the diagnostic and thera-peutic challenges they *** To comprehensively examine the clinical features,pathological characteristics,treatment outcomes,associated comorbidities,and prognosis of *** The study population included patients diagnosed with GIS at the First Affiliated Hospital,Zhejiang University School of Medicine,between june 2007 and April *** were retrospectively collected and analyzed from medical records,including demographic characteristics,endoscopic and imaging findings,treatment modalities,pathological evaluations,and follow-up *** In total,229 patients with GIS were included,with a mean age of 56.00 years and a male-to-female ratio of 1:*** mean tumor size was 2.75 cm,and most(76.9%)were located in the ***,6.6%of the patients had other malig-nant *** imaging and endoscopy frequently misdiagnosed GIS as gastrointestinal stromal ***,accurate preoperative diagnosis was achieved using endoscopic ultrasound-guided fine-needle aspiration combined with immunohistochemical analysis,in which S100 and SOX-10 markers were mostly *** tumors were typically managed with endoscopic resection,while larger lesions were treated with surgical ***-up results showed that most patients experienced favorable *** Preoperative diagnosis of GIS via clinical characteristics,endoscopy,and imaging examinations remains challenging but *** therapy provides a minimally invasive and effective option for patients.

关键词： Gastrointestinal schwannoma Diagnosis Treatment Endoscopictherapy Complications