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Unilateral branch retinal artery occlusion in association with COVID-19:a case report

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 777-782页

作者： Kunihiko Hirosawa Takenori Inomata Jaemyoung Sung Yuki Morooka Tianxiang Huang Yasutsugu Akasaki Yuichi okumura Ken Nagino Kaho Omori Shintaro Nakao Department of Ophthalmology Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Digital Medicine Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Telemedicine and Mobile Health Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Hospital Administration Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan AI Incubation Farm Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Ophthalmology Tulane University School of MedicineNew OrleansLA 70112USA

Dear Editor,I am Kunihiko Hirosawa of the Department of Ophthalmology at juntendo University Hospital.I am writing to present a case of concomitant Coronavirus Disease 2019(COVID-19)with branch retinal artery occlusion(BRAO).BRAO presents as a sudden,painless loss of vision on the afflicted side and is most often focal in nature[1].

关键词： branch COV occlusion

Re:Association between intestinal neoplasms and celiac disease-beyond celiac disease and more

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 746-747页

作者： Kenji okumura Department of Surgery Westchester Medical Center/New York Medical CollegeValhallaNY 10595United States

The association between celiac disease and enteropathy-associated T cell lymphoma has been *** pathogenesis of the development of malignant neoplasms remains *** addition to celiac disease,we believe that other underl... 详细信息

关键词： Celiac disease Entropathy-associated T cell lymphoma c-MYC JAK-STAT

Ileo-ileal intussusception caused by lymphangioma of the small bowel treated by single-incision laparoscopic-assisted ileal resection

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World Journal of Gastroenterology 2017年第1期23卷 167-172页

作者： Atsushi Kohga Akihiro Kawabe Yuto Hasegawa Kiyoshige Yajima Takuya okumura Kimihiro Yamashita jun Isogaki Kenji Suzuki Akira Komiyama Division of Surgery Fujinomiya City General Hospital Division of Pathology Fujinomiya City General Hospital

Intraabdominal lymphangiomas are uncommon;additionally,those affecting the gastrointestinal tract are rare and account for less than 1%of *** caused by a cystic lymphangioma of the small bowel is extremely *** patient was a20-year-old woman who visited our emergency room with a complaint of abdominal pain.A computed tomography image revealed ileo-ileal intussusception with a leading hypovascular mass measuring 1 cm in a ***-incision laparoscopic-assisted ileal resection was *** surgical specimen consisted of a soft polycystic ***,a pedunculated polyp with a convolutional pattern was ***,the inner surfaces of the cysts were covered with a single layer of endothelial *** immunohistochemical examination,the endothelial cells were partially positive for D2-40 and *** muscle cells were also found around the *** lesion was diagnosed as a cystic *** of cases of small bowel lymphangiomas have previously been *** these,cases with intussusception were very *** is the first case of small bowel intussusception due to lymphangioma treated by singleincision laparoscopic-assisted surgery.

关键词： Intussusception Single-incision laparoscopic-assisted surgery Lymphangioma

Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development

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Neural Regeneration Research 2016年第9期11卷 1394-1395页

作者： Misako okumura Takahiro Chihara Department for Evolutionary Biology Max-Planck Institute for Developmental Biology Department of Biological Science Graduate School of ScienceHiroshima University

Basic helix-loop-helix （bHLH） transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the formation of mechanosensory cells and photoreceptor cells in Drosophila （larman et al., 1993, 1994）. Atonal is expressed in sensory organ precursors and is required and sufficient for the development of chordotonal organs （Jar- man et al., 1993）. Moreover, Atonal expression is observed in the developing eye and is essential for the differentiation of R8 photoreceptors, which are the first photoreceptors that appear during development. Atonal is not involved in the formation of other photoreceptors （R1-R7） directly. However, R8 photore- ceptors recruit other photoreceptors from the surrounding cells （Jarman et al., 1994）.

关键词： ORN Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development

Mechanism of Tonal Noise Generation from Circular Cylinder with Spiral Fin

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Journal of Thermal Science 2014年第6期23卷 552-557页

作者： Ryo Yamashita Hidechito Hayashi Tetsuya okumura Hiromitsu Hamakawa Department of Mechanical Engineering Nagasaki University1-14 Bunkyo machiNagasaki852-8521Japan Department of Mechanical Engineering Oita University700 Dannoharu Oita870-1192Japan

The pitch of the spiral finned tube influences seriously to the acoustic resonance in the heat *** this research,the flow characteristics in relating to the aeolian tone from the finned cylinder are studied by the numerical *** is observed that the tonal noise generated from the finned tube at two pitch *** ratio of the fin pitch to the cylinder diameter is changed at 0.11 and *** tone level increases and the frequency decreases with the pitch *** separation flow from the cylinder generates the span-wise vortices,Karman vortices,and the separation flow from the fin generates the stream-wise *** the fin pitch ratio is small,the stream-wise vortices line up to span-wise and become weak *** the Karman vortices are remained and integrate in *** the Karman vortex became *** causes the low frequency and the large aeolian tone.

关键词： Aerodynamic Noise Aeolian Tone Karman Vortex Spiral Finned Tube

Analysis for Effects of Temperature Rise of PV Modules upon Driving Distance of Vehicle Integrated Photovoltaic Electric Vehicles

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Energy and Power Engineering 2024年第4期16卷 131-150页

作者： Masafumi Yamaguchi Yasuyuki Ota Taizo Masuda Christian Thiel Anastasios Tsakalidis Arnulf Jaeger-Waldau Kenji Araki Kensuke Nishioka Tatsuya Takamoto Takashi Nakado Kazumi Yamada Tsutomu Tanimoto Yosuke Tomita Yusuke Zushi Kenichi okumura Takashi Mabuchi Akinori Satou Kyotaro Nakamura Ryo Ozaki Nobuaki Kojima Yoshio Ohshita Toyota Technological Institute Nagoya Japan Faculty of Engineering Miyazaki University Miyazaki Japan Toyota Motor Corporation Susono Japan European Commission— Joint Research Centre Ispra Italy Sharp Corporation Nara Japan Toyota Motor Corporation Toyota Japan Nissan Motor Corporation Yokosuka Japan

The development of vehicle integrated photovoltaics-powered electric vehicles (VIPV-EV) significantly reduces CO2 emissions from the transport sector to realize a decarbonized society. Although long-distance driving of VIPV-EV without electricity charging is expected in sunny regions, driving distance of VIPV-EV is affected by climate conditions such as solar irradiation and temperature rise of PV modules. In this paper, detailed analytical results for effects of climate conditions such as solar irradiation and temperature rise of PV modules upon driving distance of the VIPV-EV were presented by using test data for Toyota Prius and Nissan Van demonstration cars installed with high-efficiency InGaP/GaAs/InGaAs 3-junction solar cell modules with a module efficiency of more than 30%. The temperature rise of some PV modules studied in this study was shown to be expressed by some coefficients related to solar irradiation, wind speed and radiative cooling. The potential of VIPV-EV to be deployed in 10 major cities was also analyzed. Although sunshine cities such as Phoenix show the high reduction ratio of driving range with 17% due to temperature rise of VIPV modules, populous cities such as Tokyo show low reduction ratio of 9%. It was also shown in this paper that the difference between the driving distance of VIPV-EV driving in the morning and the afternoon is due to PV modules’ radiative cooling. In addition, the importance of heat dissipation of PV modules and the development of high-efficiency PV modules with better temperature coefficients was suggested in order to expand driving range of VIPV-EV. The effects of air-conditioner usage and partial shading in addition to the effects of temperature rise of VIPV modules were suggested as the other power losses of VIPV-EV.

关键词： Vehicle Integrated Photovoltaics (VIPV) VIPV-Powered Electric Vehicles Driving Distance PV Modules Solar Irradiation Temperature Rise Radiative Cooling

p53 negativity, CDC25B positivity, and metallothionein negativity are predictors of a response of esophageal squamous cell carcinoma to chemoradiotherapy

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World Journal of Gastroenterology 2005年第36期11卷 5696-5700页

作者： Fumiko Sunada Masayuki Itabashi Hisanao Ohkura Toshiyuki okumura Departments of Internal Medicine Pathology Radiology Ibaraki Prefectural Central Hospital and Cancer Center Koibuchi 6528 Tomobe-machi Nishiibaraki-gun Ibaraki-ken Japan

AIM： Esophageal squamous cell carcinoma is generally sensitive to chemoradiotherapy （CRT）, but some cases are not. Using a retrospective analysis, we aimed to identify the predictors of the response by esophageal squamous cell carcinoma to definitive CRT. METHODS： The intensities of expression of p53, Ki67, Bci-2, Bax, olclin D1, VEGF, CDC25B, and metallothionein （MT） were evaluated immunohistochemically in the biopsy specimens obtained before CRT, and the intensities of their expression were tested for correlations with the clinical effects of CRT. RESULTS： The esophageal squamous cell carcinomas with negative p53, positive CDC25B, and negative MT expression were found to be significantly more sensitive to CRT. In addition, p53 positivity and CDC25B positivity respomd well to CRT. CONCLUSION： Esophageal squamous cell carcinomas with negative p53,positive CDC25B, and negative MT expressions respond well to CRT. Even with p53 positivity, if with CDC25B positivity, CRT can be expected. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： p83 CDC25B Metallothionein Chemoradiotherapy Esophageal squamous cell carcinomas

The roles of tubulin-folding cofactors in neuronal morphogenesis and disease

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Neural Regeneration Research 2015年第9期10卷 1388-1389页

作者： Misako okumura Masayuki Miura Takahiro Chihara Department of Genetics Graduate School of Pharmaceutical Sciences The University of Tokyo Core Research for Evolutional Science and Technology Japan Science and Technology Agency

Microtubules play important roles in neuronal morphogenesis, including cellular polarization, neurite growth, and branching. A microtubule is a polymer of a- and β-tubulin heterodimers that are formed by a multistep process assisted by at least five tubulin-fold- ing cofactors （TBCA-E）（Lopez-Fanarraga et al., 2001）. Newly syn- thesized α- and β-tubulins associate with the cytosolic chaperonin complex （CCT）, and then the quasi-native tubulins interact with five tubulin-folding cofactors. The α- and β-tubulins first interact with TBCB and TBCA, which are further transferred to TBCE and TBCD, respectively. The α- and β-tubulins, TBCC, TBCD, and TBCE form a supercomplex, and guanosine triphosphate （GTP） hydrolysis occurs within the supercomplex, releasing a tubulin heterodimer. In addition to their functions in tubulin folding and tubulin heterodimer formation, excess amounts of TBCD or TBCE may interact with tubulin heterodimers, leading to their degrada- tion. Thus, tubulin-folding cofactors may play a role in both the synthesis and degradation of tubulin heterodimers.

关键词： The roles of tubulin-folding cofactors in neuronal morphogenesis and disease Figure

Study of Unsteady Flow Simulation of Backward Impeller with Non-uniform Casing

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Journal of Thermal Science 2017年第3期26卷 208-213页

作者： War War Min Swe Hiroya MORIMATSU Hidechito HAYASHI Tetsuya okumura Ippei ODA Nagasaki University 1-14 Bunkyo-machiNagasaki 852-8521Japan Panasonic Ecology Systems Co. Ltd.4017 Aza Shimonakata takaki-choKasugai486-8522Japan

The flow characteristics of the centrifugal fans with different blade outlet angles are basically discussed on steady and unsteady simulations for a rectangular casing fan. The blade outlet angles of the impellers are 35° and 25° respectively. The unsteady flow behavior in the passage of the impeller 35° is quite different from that in the steady flow behavior. The large flow separation occurs in the steady flow field and unsteady flow field of the impeller 35°, the flow distribution in the circumferential direction varies remarkably and the flow separation on the blade occurs only at the back region of the fan; but the steady flow behavior in the impeller 25° is almost consistent with the unsteady flow behavior, the flow distribution of the circumferential direction doesn't vary much and the flow separation on the blade hardly occurs. When the circumferential variation of the flow in the impeller is large, the steady flow simulation is not coincident to the unsteady flow simulation.

关键词： Centrifugal fan Impeller Blade outlet angles Steady and unsteady simulation Rectangular casing