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World Journal of Clinical Cases 2022年第19期10卷 6349-6359页

作者： jun-hyung cho So-Young Jin Digestive Disease Center Soonchunhyang University HospitalSeoul 04401South Korea Department of Pathology Soonchunhyang University HospitalSeoul 04401South Korea

Helicobacter pylori (H. pylori) infection is highly prevalent in East Asia. The overallseroprevalence rate of H. pylori infection is 44.2% in China, 37.6%-43.2% in Japan,and 51.0% in South Korea. H. pylori can cause peptic ulcer disease and gastriccancer. East Asian countries have high rates of gastric cancer (age-standardizedincidence rate: 20-30 per 100000). The Kyoto global consensus report emphasizedthat H. pylori gastritis should be considered the main cause for the development ofgastric cancer. H. pylori treatment guidelines in China, Japan, and South Koreahave recently been revised according to data from each of those ***, emerging antibiotic resistance is an important barrier to H. pylorieradication. The recommended H. pylori treatment regimens differ among thosethree East Asian countries. In this review, recent guidelines and up-to-dateresearch on H. pylori treatment regimens from China, Japan, and South Korea arediscussed.

关键词： Helicobacter pylori Treatment Antibiotic resistance China Japan South Korea

Ever-changing endoscopic treatment for early gastric cancer:Yesterday-today-tomorrow

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World Journal of Gastroenterology 2014年第37期20卷 13273-13283页

作者： Mi-Young Kim jun-hyung cho Joo Young cho Digestive Disease Center Soonchunhyang University Hospital

Endoscopic resection has been an optimal treatment for selected patients with early gastric cancer(EGC) based on advances in endoscopic instruments and techniques. As endoscopic submucosal dissection(ESD) has been widely used for treatment of EGC along with expanding ESD indication, concerns have been asked to achieve curative resection for EGC while guaranteeing precise prediction of lymph node metastasis(LNM). Recently, new techniques including ESD or endoscopic full-thickness resection combined with sentinel node navigation enable minimal tumor resection and a laparoscopic lymphadenectomy in cases of EGC with high risk of LNM. This review covers the development and challenges of endoscopic treatment for EGC. Moreover, a new microscopic imaging and endoscopic techniques for precise endoscopic diagnosis and minimally invasive treatment of EGC are introduced.

关键词： Endoscopic resection Early gastric cancer Confocal laser endomicroscopy Sentinel node navigation Hybrid natural orifice transluminal endoscopic surgery

Standard vs magnifying narrow-band imaging endoscopy for diagnosis of Helicobacter pylori infection and gastric precancerous conditions

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World Journal of Gastroenterology 2021年第18期27卷 2238-2250页

作者： jun-hyung cho Seong Ran Jeon So-Young Jin Suyeon Park Digestive Disease Center Soonchunhyang University HospitalSeoul 04401South Korea Department of PathologySoonchunhyang University HospitalSeoul 04401South Korea Department of Pathology Soonchunhyang University HospitalSeoul 04401South Korea Department of Medical Biostatistics Soonchunhyang University HospitalSeoul 04401South Korea

BACKGROUND Advances in endoscopic imaging enable the identification of patients at high risk of gastric ***,there are no comparative data on the utility of standard and magnifying narrow-band imaging(M-NBI)endoscopy for diagnosing Helicobacter pylori(***)infection,gastric atrophy,and intestinal *** To compare the diagnostic performance of standard and M-NBI endoscopy for *** gastritis and precancerous *** In 254 patients,standard endoscopy findings were classified into mosaic-like appearance(type A),diffuse homogenous redness(type B),and irregular redness with groove(type C).Gastric mucosal patterns visualized by M-NBI were classified as regular round pits with polygonal sulci(type Z-1),more dilated and linear pits without sulci(type Z-2),and loss of gastric pits with coiled vessels(type Z-3).RESULTS The diagnostic accuracy of standard and M-NBI endoscopy for *** gastritis was 93.3%and 96.1%,*** gastric precancerous conditions,the accuracy of standard and M-NBI endoscopy was 72.0%vs 72.6%for moderate to severe atrophy,and 61.7%vs.61.1%for intestinal metaplasia in the corpus,*** to type A and Z-1,types B+C and Z-2+Z-3 were significantly associated with moderate to severe atrophy[odds ratio(OR)=5.56 and 8.67]and serum pepsinogen I/II ratio of≤3(OR=4.48 and 5.69).CONCLUSION Close observation of the gastric mucosa by standard and M-NBI endoscopy is useful for the diagnosis of *** gastritis and precancerous conditions.

关键词： Endoscopy Magnifying narrow-band imaging Helicobacter pylori Gastric atrophy Intestinal metaplasia Pepsinogen

Clinical applicability of gastroscopy with narrow-band imaging for the diagnosis of Helicobacter pylori gastritis, precancerous gastric lesion, and neoplasia

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World Journal of Clinical Cases 2020年第14期8卷 2902-2916页

作者： jun-hyung cho Seong Ran Jeon So-Young Jin Digestive Disease Center Soonchunhyang University HospitalSeoul 04401South Korea Department of Pathology Soonchunhyang University HospitalSeoul 04401South Korea

Premalignant gastric lesions such as atrophic gastritis and intestinal metaplasia frequently occur in subjects with long-term Helicobacter pylori(***)*** regular arrangement of collecting venules(RAC)is seen in the normal gastric corpus,whereas mucosal swelling and redness without RAC are observed in ***-infected *** successful *** eradication,the presence of atrophic gastritis and/or gastric intestinal metaplasia(GIM)is a risk factor for gastric *** the development of advanced imaging technologies,recent studies have reported the usefulness of narrow-band imaging(NBI)for endoscopic diagnosis of atrophic gastritis and *** NBI endoscopy with magnification(M-NBI),atrophic gastritis is presented as irregular coiled microvessels and loss of gastric *** M-NBI endoscopic findings of GIM are a light blue crest and a white opaque *** on the microvascular patterns,fine network,core vascular,and unclear patterns are useful for predicting gastric dysplasia in polypoid *** diagnosis of early gastric cancer(EGC),a systematic classification using M-NBI endoscopy has been proposed on the basis of the presence of a demarcation line and an irregular microvascular/microsurface ***,M-NBI endoscopy has been found to be more accurate for determining the horizontal margin of EGC compared to conventional *** this review,we present up-to-date results on the clinical usefulness of gastroscopy with NBI for the diagnosis of *** gastritis,precancerous gastric lesion,and neoplasia.

关键词： Gastroscopy Narrow-band imaging Magnification Helicobacter pylori Atrophic gastritis Intestinal metaplasia Dysplasia Cancer

Magnifying endoscopy for the diagnosis of specialized intestinal metaplasia in short-segment Barrett's esophagus

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World Journal of Gastroenterology 2013年第41期19卷 7089-7096页

作者： Nam Seok Ham Jae Young Jang Sung Woo Ryu Ji Hye Kim Eui Ju Park Woong Cheul Lee Kwang Yeun Shim Soung Won Jeong Hyun Gun Kim Tae Hee Lee Sung Ran Jeon jun hyung cho Joo Young cho So Young Jin Ji Sung Lee Institution for Digestive Research Digestive Disease CenterDepartment of Internal MedicineSoonchunhyang University HospitalSeoul 140-743South Korea Department of Pathology Soonchunhyang University HospitalSeoul 140-743South Korea Biostatistical Consulting Unit Soonchunhyang University HospitalSeoul 140-743South Korea

AIM:To determine whether magnified observation of short-segment Barrett’s esophagus(BE)is useful for the detection of specialized intestinal metaplasia(SIM).METHODS:Thirty patients with suspected short-segment BE underwent magnifying endoscopy up to×*** magnified images were analyzed with respect to their pit-patterns,which were simultaneously classified into five epithelial types[Ⅰ(small round),Ⅱ(straight),Ⅲ(long oval),Ⅳ(tubular),Ⅴ(villous)]by Endo’s ***,a 0.5%solution of methylene blue(MB)was sprayed over columnar *** patterns of the magnified image and MB staining were *** were obtained from the regions previously observed by magnifying endoscopy and MB ***:Three of five patients with a typeⅤ(villous)epithelial pattern had SIM,whereas 21 patients with a non-typeⅤepithelial patterns did not have *** sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of pit-patterns in detecting SIM were 100%,91.3%,92.3%,60%and100%,respectively(P=0.004).Three of the 12 patients with positive MB staining had SIM,whereas 14patients with negative MB staining did not have *** sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of MB staining in detecting SIM were 100%,60.9%,65.4%,25%and100%,respectively(P=0.085).The specificity and accuracy of pit-pattern evaluation were significantly superior compared with MB staining for detecting SIM by comparison with the exact McNemar’s test(P=0.0391).CONCLUSION:The magnified observation of a shortsegment BE according to the mucosal pattern and its classification can be predictive of SIM.

关键词： Short-segment Barrett’s esophagus Magnifying endoscopy Methylene blue chromoendoscopy Specialized intestinal metaplasia Dysplasia Esophageal adenocarcinoma Diagnosis

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum jun Kim Seungyon Koh Hyo Jin cho Xuelian Jin Byung Gon Kim jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

A New Encryption Mechanism Supporting the Update of Encrypted Data for Secure and Efficient Collaboration in the Cloud Environment

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 813-834页

作者： Chanhyeong cho Byeori Kim Haehyun cho Taek-Young Youn Department of Cyber Security Dankook UniversityYongin16890Republic of Korea Department of Software Soongsil UniversitySeoul07027Republic of Korea

With the rise of remote collaboration,the demand for advanced storage and collaboration tools has rapidly ***,traditional collaboration tools primarily rely on access control,leaving data stored on cloud servers vulnerable due to insufficient *** paper introduces a novel mechanism that encrypts data in‘bundle’units,designed to meet the dual requirements of efficiency and security for frequently updated collaborative *** bundle includes updated information,allowing only the updated portions to be reencrypted when changes *** encryption method proposed in this paper addresses the inefficiencies of traditional encryption modes,such as Cipher Block Chaining(CBC)and Counter(CTR),which require decrypting and re-encrypting the entire dataset whenever updates *** proposed method leverages update-specific information embedded within data bundles and metadata that maps the relationship between these bundles and the plaintext *** utilizing this information,the method accurately identifies the modified portions and applies algorithms to selectively re-encrypt only those *** approach significantly enhances the efficiency of data updates while maintaining high performance,particularly in large-scale data *** validate this approach,we conducted experiments measuring execution time as both the size of the modified data and the total dataset size *** show that the proposed method significantly outperforms CBC and CTR modes in execution speed,with greater performance gains as data size ***,our security evaluation confirms that this method provides robust protection against both passive and active attacks.

关键词： Cloud collaboration mode of operation data update efficiency

Three-Stage Transfer Learning with AlexNet50 for MRI Image Multi-Class Classification with Optimal Learning Rate

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 155-183页

作者： Suganya Athisayamani A.Robert Singh Gyanendra Prasad Joshi Woong cho School of Computing Sastra Deemed to be UniversityThanjavur613401India Department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203India Department of AI and Software Engineering Kangwon National UniversitySamcheok25913Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok25913Republic of Korea

In radiology,magnetic resonance imaging(MRI)is an essential diagnostic tool that provides detailed images of a patient’s anatomical and physiological *** is particularly effective for detecting soft tissue ***,radiologists manually interpret these images,which can be labor-intensive and time-consuming due to the vast amount of *** address this challenge,machine learning,and deep learning approaches can be utilized to improve the accuracy and efficiency of anomaly detection in MRI *** manuscript presents the use of the Deep AlexNet50 model for MRI classification with discriminative learning *** are three stages for learning;in the first stage,the whole dataset is used to learn the *** the second stage,some layers of AlexNet50 are frozen with an augmented dataset,and in the third stage,AlexNet50 with an augmented dataset with the augmented *** method used three publicly available MRI classification datasets:Harvard whole brain atlas(HWBA-dataset),the School of Biomedical Engineering of Southern Medical University(SMU-dataset),and The National Institute of Neuroscience and Hospitals brain MRI dataset(NINS-dataset)for *** hyperparameter optimizers like Adam,stochastic gradient descent(SGD),Root mean square propagation(RMS prop),Adamax,and AdamW have been used to compare the performance of the learning ***-dataset registers maximum classification *** evaluated the performance of the proposed classification model using several quantitative metrics,achieving an average accuracy of 98%.

关键词： MRI tumors classification AlexNet50 transfer learning hyperparameter tuning optimizer

Scalable Ir‑Doped NiFe_(2)O_(4)/TiO_(2)Heterojunction Anode for Decentralized Saline Wastewater Treatment and H_(2)Production

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Nano-Micro Letters 2025年第3期17卷 1-18页

作者： Sukhwa Hong Jiseon Kim Jaebeom Park Sunmi Im Michael R.Hoffmann Kangwoo cho Division of Environmental Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 790−784Korea Linde Laboratory California Institute of TechnologyPasadenaCA 91125USA Institute for Convergence Research and Education in Advanced Technology(I‑CREATE) Yonsei University International CampusIncheon 21983Republic of Korea

Wastewater electrolysis cells(WECs)for decentralized wastewater treatment/reuse coupled with H_(2)production can reduce the carbon footprint associated with transportation of water,waste,and energy *** study reports Ir-doped NiFe_(2)O_(4)(NFI,~5 at%Ir)spinel layer with TiO_(2)overlayer(NFI/TiO_(2)),as a scalable heterojunction anode for direct electrolysis of wastewater with circumneutral pH in a single-compartment *** dilute(0.1 M)NaCl solutions,the NFI/TiO_(2)marks superior activity and selectivity for chlorine evolution reaction,outperforming the benchmark IrO_(2).Robust operation in near-neutral pH was *** including operando X-ray absorption spectroscopy unveiled crucial roles of TiO_(2) which serves both as the primary site for Cl−chemisorption and a protective layer for NFI as an ohmic *** electrolysis of NH4+-laden synthetic wastewater demonstrated that NFI/TiO_(2)not only achieves quasi-stoichiometric NH_(4)^(+)-to-N_(2)conversion,but also enhances H_(2)generation efficiency with minimal competing reactions such as reduction of dissolved oxygen and reactive *** scaled-up WEC with NFI/TiO_(2)was demonstrated for electrolysis of toilet wastewater.

关键词： Wastewater electrolysis cell Ir-doped NiFe_(2)O_(4) Reactive chlorine species Decentralized H_(2)production On-site wastewater treatment

Solution‑Processed Thin Film Transparent Photovoltaics:Present Challenges and Future Development

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Nano-Micro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu Munerah M.S.Almutairi Jie Ma Aisling Stewart Zhaohui Xing Mengxia Liu Bo Hou Yuljae cho UM-SJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Physics and Astronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy Sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovoltaics Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is essential for modern society to sustain economic *** soaring demand for the electrical energy,together with an awareness of the environmental impact of fossil fuels,has been driving a shift towards the utilization of solar ***,traditional solar energy solutions often require extensive spaces for a panel installation,limiting their practicality in a dense urban *** overcome the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric *** TPV advancements are focused on improving both transparency and power output to rival commercially available silicon solar *** this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve *** of merit and theoretical limits of TPVs are discussed to comprehensively understand the status of current TPV *** we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film photovoltaics(PVs),including colloidal quantum dot PVs,metal halide perovskite PVs and organic *** applications of TPVs are also reviewed,with emphasis on agrivoltaics,smart windows and ***,current challenges and future opportunities in TPV research are pointed out.

关键词： Transparent semiconductors Solution-processable transparent solar cell Emerging solar cell materials Buildingintegrated photovoltaics