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Mitigation of black carbon emissions could immediately reduce 6.3% of glacier melting in the Qilian Mountains

Advances in Climate Change Research 2024年第4期15卷 725-736页

作者： Ji-Zu CHEN Wen-Tao DU Shi-Chang KANG Xiang QIN Wei-jun SUN Li-Hui LUO yang LI jun-hua yang You-Yan JIANG Qilian Shan Station of Glaciology and Eco-environment Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Geography and Environment Shandong Normal UniversityJinan 250014China Zhangye Meteorological Bureau Zhangye 734000China Lanzhou Regional Climate Center Lanzhou 730020China Institute of International Rivers and Eco-security Yunnan UniversityKunming 650500China Gansu Provincial Industry Technology Center of Inteligent Equipment and Big Data for Disaster Prevention Northwest Institute of Eco-Environment and ResourcesChinese Academy of ScienceLanzhou 730000China

Global warming in tandem with surface albedo reduction caused by black carbon(BC)deposition on glaciers accelerated glacier melting;however,their respective contributions remain *** in the Qilian Mountains are crucial for the development of oases in the Hexi Corridor;however,their area has decreased by more than 20%over the past ***,this study developed a dynamic deposition model for light-absorbing particles(LAPs),coupled with a surface energy and mass balance *** comprehensively assessed the effects of BC and warming on the melting of a typical glacier in the Qilian Mountains based on the coupled *** on the glacier surface caused 13.1%of annual glacier-wide melting,of which directly deposited atmospheric BC reduced the surface albedo by 0.02 and accounted for 9.1%of glacier *** air temperature during 2000-2010 has increased by 1.5°C relative to that during the 1950s,accounting for 51.9%of current glacier ***,BC emission have increased by 4.6 times compared to those of the early Industrial Revolution recorded in an ice core,accounting conservatively for 6.3%of current glacier *** BC emissions has a limited influence on current glacier melting;however,in the long-term,mitigation should exert a noteworthy impact on glacier melting through the self-purification of glaciers.

关键词： Glacier Melting Black carbon Simulation Qilian Mountains

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Oral administration of geranylgeranylacetone plus local somatothermal stimulation: A simple, effective, safe and operable preconditioning combination for conferring tolerance against ischemia-reperfusion injury in rat livers

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World Journal of Gastroenterology 2005年第36期11卷 5725-5731页

作者： Ning Fan Guang-Shun yang jun-hua Lu Ning yang Hai-Bin Zhang Department of Laparoscopy Affiliated Eastern Hospital of Hepatobiliary Surgery Second Military Medical University Shanghai 200438 China

AIM： To explore a simple, effective, safe and operable pretreatment for conferring tolerance against ischemia- reperfusion （I-R） injury in rat livers. METHODS： Forty-five rats were divided into five groups （each group n = 9）. Group C： control group; group G： geranylgeranylacetone （GGA） was administered without heat stress; group S： local heat stress alone; group WG： GGA plus whole-body heat stress; group SG： GGA administration plus local heat stress. After completion of the I-R procedure, the ischemic-reperfused liver lobes in five groups were resected and tested for heat shock protein （HSP70） by RT-PCR, Western blotting analysis and immunohistochemical staining. The blood samples were collected for ALT and AST measurement at the end of occlusion of blood supply, 30 min after reperfusion, 24, 48, 72 h after surgery from the inferior vena cava. Survival was monitored for 1 wk. RESULTS： The production of HSP70 after I-R injury increased, the liver enzyme levels after reperfusion decreased rapidly, and the survival rates increased in groups C-SG. CONCLUSION： The combination of GGA plus local somatothermal stimulation is a simple, effective, safe and operable pretreatment to induce HSP70 in patients with liver tumor and cirrhosis before hepatectomy and in donors before harvesting graft for liver transplantation.2005 The WJG Press and Elsevier Inc. All rights reserved.

关键词： Ischemia-reperfusion injury Heat shock protein Geranylgeranylacetone, Local somatothermal stimulation

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Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease

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Neural Regeneration Research 2018年第4期13卷 709-716页

作者： Ya-Ru Wen jun-hua yang Xiao Wang Zhi-Bin Yao Department of Anatomy and Neurobiology Zhongshan School of MedicineSun Yat-sen University Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen University

Impaired amyloid-β clearance from the brain is a core pathological event in Alzheimer＇s *** therapeutic effect of current pharmacotherapies is unsatisfactory,and some treatments cause severe side *** meningeal lymphatic vessels might be a new route for amyloid-β *** study investigated whether promoting dural lymphangiogenesis facilitated the clearance of amyloid-β from the ***,human lymphatic endothelial cells were treated with 100 ng/m L recombinant human vascular endothelial growth factor-C（rh VEGF-C） *** microscopy verified that rh VEGF-C,a specific ligand for vascular endothelial growth factor receptor-3（VEGFR-3）,significantly promoted tube formation of human lymphatic endothelial cells in *** an in vivo study,200 μg/m L rh VEGF-C was injected into the cisterna magna of APP/PS1 transgenic mice,once every 2 days,four times in *** staining demonstrated high levels of dural lymphangiogenesis in Alzheimer＇s disease *** week after rh VEGF-C administration,enzyme-linked immunosorbent assay results showed that levels of soluble amyloid-β were decreased in cerebrospinal fluid and *** Morris water maze test demonstrated that spatial cognition was *** results indicate that the upregulation of dural lymphangiogenesis facilities amyloid-β clearance from the brain of APP/PS1 mice,suggesting the potential of the VEGF-C/VEGFR-3 signaling pathway as a therapeutic target for Alzheimer＇s disease.

关键词： nerve regeneration dura mater lymphangiogenesis amyloid-β Alzheimer's disease recombinant haman vascular endothelial growth factor-C lymphatic endothelial cells lymphatic clearance neural regeneration

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Multifunctional phase change film with high recyclability, adjustable thermal responsiveness, and intrinsic self-healing ability for thermal energy storage

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Journal of Energy Chemistry 2024年第10期97卷 216-227页

作者： Bo yang Xuelai Zhang jun Ji Weisan hua Miaomiao Jiang Institute of Cool Thermal Storage Technology Shanghai Maritime University

Phase change materials(PCMs) present promising potential for guaranteeing safety in thermal management ***,most reported PCMs have a single application in energy storage for thermal management systems,which does not meet the growing demand for multi-functional *** this paper,the flexible material and hydrogen-bonding function are innovatively combined to design and prepare a novel multi-functional flexible phase change film(PPL).The 0.2PPL-2 film exhibits solid-solid phase change behavior with energy storage density of 131.8 J/g at the transition temperature of42.1℃,thermal cycling stability(500 cycles),wide-temperature range flexibility(0-60℃) and selfhealing ***,the PPL film can be recycled up to 98.5% by intrinsic ***,the PPL film can be tailored to the desired colors and configurations and can be cleverly assembled on several thermal management systems at ambient temperature through its flexibility combined with shape-memory *** interestingly,the transmittance of PPL will be altered when the ambient temperature changes(60℃),conveying a clear thermal ***,the thermal energy storage performance of the PPL film is successfully tested by human thermotherapy and electronic device temperature control *** proposed functional integration strategy provides innovative ideas to design PCMs for multifunctionality,and makes significant contributions in green chemistry,highefficiency thermal management,and energy sustainability.

关键词： Energy storage Multifunctional material Phase change film Recyclability Self-healing

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Pancreatic neuroendocrine tumor detected by technetium-99m methoxy-2-isobutylisonitrile single photon emission computed tomography/computed tomography:A case report

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World Journal of Clinical Cases 2023年第12期11卷 2825-2831页

作者： Chang-Jiang Liu hua-jun yang Yan-Chun Peng De-Yu huang Department of Nuclear Medicine Xingyi People’s HospitalXingyi 562400Guizhou ProvinceChina Department of Pulmonary and Critical Care Medicine Xingyi People’s HospitalXingyi 562400Guizhou ProvinceChina Department of Hepatobiliary Pancreatic and Splenic SurgeryXingyi People’s HospitalXingyi 562400Guizhou ProvinceChina Department of Pathology Xingyi People’s HospitalXingyi 562400Guizhou ProvinceChina

BACKGROUND Pancreatic neuroendocrine tumors(NETs)account for about 1%–2%of pancreatic tumors and about 8%of all *** tomography(CT),magnetic resonance imaging,and endoscopic ultrasound are common imaging modalities for the diagnosis of pancreatic ***,somatostatin receptor imaging is of great value for diagnosing pancreatic ***,we report the efficacy of technetium-99m methoxy-2-isobutylisonitrile(99mTc-MIBI)single photon emission CT(SPECT)/CT for detecting pancreatic *** SUMMARY A 57-year-old woman presented to our hospital with a 1-d history of persistent upper abdominal distending *** distending pain in the upper abdomen was aggravated after eating,with nausea and *** blood test results showed a high neutrophil percentage,low leukomonocyte and monocyte percentages,and low leukomonocyte and eosinophil ***,liver and kidney function,and tumor markers alpha-fetoprotein,carcinoembryonic antigen,and cancer antigen(CA)125,CA72-4,CA19-9,and CA153 were *** CT showed a mass,with multiple calcifications between the pancreas and the *** boundary between the mass and the pancreas and spleen was poorly ***-enhanced CT revealed that the upper abdominal mass was unevenly and gradually enhanced.99mTc-MIBI SPECT/CT revealed that a focal radioactive concentration,with mild radioactive concentration extending into the upper abdominal mass,was present at the pancreatic body and *** 99mTc-MIBI SPECT/CT manifestations were consistent with the final pathological diagnosis of pancreatic *** 99mTc-MIBI SPECT/CT appears to be a valuable tool for detecting pancreatic NETs.

关键词： Neuroendocrine tumors Pancreas Tc-99m-Methoxy-2-isobutylisonitrile Single photon emission computed tomography X-ray computed tomography Case report

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Evaluation of regional bulbar redness using an imagebased objective method

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 71-76页

作者： Wen-Juan Zhao Fang Duan Zhong-Ting Li hua-jun yang Qiang huang Kai-Li Wu Zhongshan Ophthalmic Center State Key Laboratory of OphthalmologySun Yat-sen University

AIM: To develop an image-based objective method to precisely evaluate regional ocular bulbar injection. · METHODS: Six healthy adult volunteers were photographed in four orientations(superior,inferior,nasal and temporal sides) with and without stimulating eye drops. Six line segments(covering 30°) were drawn 4mm away from the limbus on each image using ImageJ software. The graph peaks,which were derived from the areas under the line segments and corresponded to the cross-sectional grey-level of the vessels,were analyzed to obtain peak area,peak height/width(PH/PW),and peak numbers. Different-sized areas were selected to calculate the pixels based on the edge-detection algorithm. Also,conjunctival and superficial scleral vessels were analyzed separately. ·RESULTS: This method had a smaller coefficient of variation,especially for PH/PW,in all four orientations. Hyperaemia parameters changed the least after challenging in the superior region. Moreover,95% of the PH/PW ratios were greater than 0.87 in conjunctival vessels and less than 1.00 in superficial scleral vessels. PH/PW significantly increased in conjunctival vessels and changed less in superficial scleral vessels. ·CONCLUSION: A new method of objectively assessing bulbar injection based on ocular surface images was developed. This method can be used to quantify ocular regional injection and to distinguish the superficial scleral and conjunctival vessels.

关键词： ocular surface hyperaemia image analysis ImageJ

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Multisensory Conflict Impairs Cortico-Muscular Network Connectivity and Postural Stability: Insights from Partial Directed Coherence Analysis

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Neuroscience Bulletin 2024年第1期40卷 79-89页

作者： Guozheng Wang Yi yang Kangli Dong Anke hua Jian Wang jun Liu Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou 310058China Taizhou Key Laboratory of Medical Devices and Advanced Materials Research Institute of Zhejiang University-TaizhouTaizhou 318000China Department of Sports Science College of EducationZhejiang UniversityHangzhou 310058China Center for Psychological Science Zhejiang UniversityHangzhou 310058China

Sensory conflict impacts postural control,yet its effect on cortico-muscular interaction remains *** aimed to investigate sensory conflict's influence on the cortico-muscular network and postural *** used a rotating platform and virtual reality to present subjects with congruent and incongruent sensory input,recorded EEG(electroencephalogram)and EMG(electromyogram)data,and constructed a directed connectivity *** results suggest that,compared to sensory congruence,during sensory conflict:(1)connectivity among the sensorimotor,visual,and posterior parietal cortex generally decreases,(2)cortical control over the muscles is weakened,(3)feedback from muscles to the cortex is strengthened,and(4)the range of body sway increases and its complexity *** results underline the intricate effects of sensory conflict on cortico-muscular *** the sensory conflict,the brain adaptively decreases the integration of conflicting *** this integrated information,cortical control over muscles may be lessened,whereas the muscle feedback may be enhanced in compensation.

关键词： Cortico-muscular interaction Postural control Virtual reality Electroencephalogram Electromyography Sensory integration

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Safflower Yellow Inhibits Progression of Hepatocellular Carcinoma by Modulating Immunological Tolerance via FAK Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 339-347页

作者： JI hua-feng yang Zi-qiang HAN jun-jun LI He-fang JIN Zhao-qing CHEN Wei-qing CHEN Fei-hua GONG Mou-chun Department of General Surgery First People's Hospital of Hangzhou Lin'an DistrictHangzhou(311300)China

Objective To explore the anti-tumor effect of safflower yellow(SY)against hepatocellular carcinoma(HCC)and the underlying potential *** An in vitro model was established by mixing Luc-Hepa1-6 cells and CD3^(+)CD8^(+)T cells,followed by adding programmed cell death protein 1(PD-1)antibody(Anti-mPD-1)with or without *** apoptosis was detected by flow cytometry and the level of inflammatory cytokines was determined by enzyme-linked immunosorbent *** protein levels of programmed cell death 1 ligand 1(PD-L1),chemokine ligand(CCL5),C-X-C motif chemokine ligand 10(CXCL10)were measured by Western *** in situ animal model was established in mice followed by treatment with anti-mPD-1 with or without *** imaging was monitored with an AniView 100 imaging *** establish the FAK-overexpressed Luc-Hepa1-6 cells,cells were transfected with adenovirus containing pcDNA3.1-FAK for 48 *** The fluorescence intensity,apoptotic rate,release of inflammatory cytokines,and CCL5/CXCL10 secretion were dramatically facilitated by anti-mPD-1(P<0.01),accompanied by an inactivation of PD-1/PD-L1 axis,which were extremely further enhanced by SY(P<0.05 or P<0.01).Increased fluorescence intensity,elevated percentage of CD3+CD8+T cells,facilitated release of inflammatory cytokines,inactivated PD-1/PD-L1 axis,and increased CCL5/CXCL10 secretion were observed in Anti-mPD-1 treated mice(P<0.01),which were markedly enhanced by SY(P<0.05 or P<0.01).Furthermore,the enhanced effects of SY on inhibiting tumor cell growth,facilitating apoptosis and inflammatory cytokine releasing,suppressing the PD-1/PD-L1 axis,and inducing the CCL5/CXCL10 secretion in Anti-mPD-1 treated mixture of Luc-Hepa1-6 cells and CD3+CD8+T cells were abolished by FAK overexpression(P<0.01).Conclusion SY inhibited the progression of HCC by mediating immunological tolerance through inhibiting FAK.

关键词： hepatocellular carcinoma safflower yellow Chinese medicine tumor microenvironment programmed cell death protein 1 focal adhesion kinase

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Clinical observation of gastrointestinal function recovery in patients after hepatobiliary surgery

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 76-84页

作者： hua-jun Zeng Jing-Jing Liu Ying-Chun yang Department of General Practice Nanyang First People's HospitalNanyang 473000Henan ProvinceChina Department of Anesthesiology Chinese People’s Armed Police Force Hospital of BeijingBeijing 100027China Department of Anesthesiology Beijing Fengtai HospitalBeijing 100071China

BACKGROUND The liver is an important metabolic and digestive organ in the human body,ca-pable of producing bile,clotting factors,and *** To investigate the recovery of gastrointestinal function in patients after hepato-biliary surgery and identify effective rehabilitation *** A total of 200 patients who underwent hepatobiliary surgery in our hospital in 2022 were selected as the study *** were divided into a control group and a study group based on the extent of the surgery,with 100 patients in each *** control group received routine treatment,while the study group re-ceived targeted interventions,including early enteral nutrition support,drinking water before gas discharge,and large bowel enema,to promote postoperative gastrointestinal function *** recovery of gastrointestinal function was compared between the two *** Compared with the control group,patients in the study group had better recovery of bowel sounds and less accumulation of fluids in the liver bed and gallbladder fossa(P<0.05).They also had shorter time to gas discharge and first meal(P<0.05),higher overall effective rate of gastrointestinal function recovery(P<0.05),and lower incidence of postoperative complications(P<0.05).CONCLUSION Targeted nursing interventions(early nutritional support,drinking water before gas discharge,and enema)can effectively promote gastrointestinal function recovery in patients undergoing hepatobiliary surgery and reduce the incidence of complications,which is worthy of promotion.

关键词： Liver and gallbladder patients Gastrointestinal function Postoperative recovery

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Applications of Self-Collimated Properties of Photonic Crystal in 3D Imaging Lidar System

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Journal of Electronic Science and Technology 2011年第1期9卷 78-80页

作者： Ying Zhu hua-jun yang the School of Physical Electronics University of Electronic Science and Technology of China Chengdu 610054 China

Photonic crystals （PCs） are increasingly attracting attention due to their ability to control light *** this paper,the dispersion properties of a two-dimensional （2D） square lattice PCs with plane- wave expansion （PWE） method are presented,the equi-frequency contours and the band structure are analyzed,and the alignment transmission characteristics are simulated by using the finite difference time domain （FDTD） *** addition,for the wavelength of 1.55 m,a kind of application structure with the lattice constant a=405 nm and the radius of air holes R=135 nm which can restrict the transmission of beams in photonic crystal without defect is proposed and *** structure which can collimate the output beam and compress its divergence angle is easy to *** has wide application prospects in optical communication and three-dimensional （3D） imaging lidar systems.

关键词： Lidar photonic crystals plane-wave expansion self-collimation.

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