检索结果-南通市图书馆

Circadian disturbance induces erectile dysfunction by impairing endothelial function

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2024年第2期26卷 205-211页

作者： Tao Li Yi-Ting Jiang Xin-Zhu Qi Peng Chen jun-hao zhang Fu Luo jun Qiao Jiang Gu Guang-Shi Du Qiang Wang Department of Urology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Urology Guizhou Provincial People's HospitalGuiyang 550002China Department of Otorhinolaryngology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Guizhou Institute for Food and Drug Control Guiyang 550004China Department of Reproductive Center Guizhou Provincial People's HospitalGuiyang 550002China Translational Medicine Research Center of Guizhou Medical University Guiyang 550025China

In order to explore the impact of circadian disturbance on erectile function,we randomly divided 24 adult male rats into groups of control(light on at 8:00 *** off at 8:00 p.m.),dark/dark(DD;constant dark),light/light(LL;constant light),and shift dark/light(DL;light off at 8:00 *** on at 8:0o p.m.).Four weeks later,erectile function was measured and corpora cavernosa were harvested for *** maximum intracavernous pressure(mlcP)and mCP/mean arterial pressure(MAP)ratio in the DD,LL,and DL groups were significantly lower than that in the control *** LL and DL groups showed significantly attenuated endothelial nitric oxide synthase(eNOS),while DD,LL,and DL showed reduced neuronal nitric oxide synthase(nNOS)at both mRNA and protein *** production of nitric oxide(NO)and cyclic guanosinemonophosphate(cGMP)was inhibited by altered light/dark cycles to varying *** disturbance impaired endothelial function and contributed to erectile *** the core circadian elements,mRNA expression of circadian locomotor output cycles kaput(Clock)and brain/muscle aryl-hydrocarbon receptor nuclear translocator-like protein 1(Bmal1)was elevated in the DL group,but their protein expression was not significantly ***,LL,and DL increased period 1(Per1)and Per3 levels,while LL and DL increased PER1 *** significant difference was found for Per2levels,and PER2 and PER3 concentrations were not significantly ***,LL and DL significantly increased cryptochrome-1(CRY1)and CRY2 at both mRNA and protein *** altered light/dark rat model showed that circadian disturbance contributed to erectile dysfunction probably by impairing endothelial ***,the core circadian elements were detected in the corpora cavernosa,but these were ***,which circadian element regulates erectile function and how it works need further analysis.

关键词： circadian disturbance endothelial function erectile function light/dark cycle NO/cGMP

Preparation of bifunctional electrocatalyst by recycling heavy metal ions from wastewater using EDTAD-functionalized MOF as highly efficient adsorbent

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第10期43卷 5105-5116页

作者： Yue Qian Pei-Xue Fu Rui-Ze Yin Han-Ni Yang Si-Yang Li Wei-Wei Xiong Fen-Fen Zheng jun-hao zhang Ai-Hua Yuan Huan Pang School of Environmental and Chemical Engineering Jiangsu University of Science and Technology School of Chemistry and Chemical Engineering Yangzhou University

The recovery and subsequent reuse of heavy metal ions from industrial wastewater are crucial for promoting sustainable development,but they also presen significant *** this article,ethylenediaminetetraacetic dianhydride （EDTAD）,which possesses strong metal chelating ability,is covalently attached to MIL-101-NH2（Fe）,resulting in a significant improvement in the removal rate of heavy metal ions in ***,the recovered waste metal ions are transformed into high-performance FeNi3/NiFe2O4@NC dual-functional oxygen evolution reaction （OER） and oxygen reduction reaction （ORR） ***,FeNi3/NiFe2O4@NC exhibits outstanding OER performance,with only a264 mV overpotential at 10 mA·*** functiona theory （DFT） calculations reveal that the synergistic effect of the FeNi3/NiFe2O4@NC heterostructure can enhance conductivity,optimize the free energy of*to OH*during OER reaction,and promote catalytic *** work not only improves the removal rate of heavy metal ions but also obtains high-performance catalysts,while providing a new approach for the treatment and secondary utilization of heavy metal ion wastewater as well as the preparation of low-cost catalysts.

关键词： Bifunctional electrocatalyst Covalently modified MOF Ethylenediaminetetraacetic dianhydride Heavy metals

Gene signatures to therapeutics:Assessing the potential of ivermectin against t(4;14)multiple myeloma

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第1期15卷 115-129页

作者： Yang Song hao-jun zhang Xia Song Jie Geng Hong-Yi Li Li-Zhong zhang Bo Yang Xue-Chun Lu School of Basic Medicine Medical School of Chinese PLABeijing 100853China School of Basic Medicine Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology The Second Medical CentreChinese PLA General HospitalBeijing 100853China

BACKGROUND Multiple myeloma(MM)is a terminal differentiated B-cell tumor disease characterized by clonal proliferation of malignant plasma cells and excessive levels of monoclonal immunoglobulins in the bone *** translocation,(t)(4;14),results in high-risk MM with limited treatment ***,there is an urgent need for identification and validation of potential treatments for this MM *** data and sequencing information from public databases could offer opportunities for the discovery of new diagnostic or therapeutic *** To elucidate the molecular basis and search for potential effective drugs of t(4;14)MM subtype by employing a comprehensive *** The transcriptional signature of t(4;14)MM was sourced from the Gene Expression *** datasets,GSE16558 and GSE116294,which included 17 and 15 t(4;14)MM bone marrow samples,and five and four normal bone marrow samples,*** the differentially expressed genes were identified,the Cytohubba tool was used to screen for hub ***,the hub genes were analyzed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes *** the STRING database and Cytoscape,protein–protein interaction networks and core targets were *** small-molecule drugs were identified and validated using the Connectivity Map database and molecular docking analysis,*** In this study,a total of 258 differentially expressed genes with enriched functions in cancer pathways,namely cytokine receptor interactions,nuclear factor(NF)-κB signaling pathway,lipid metabolism,atherosclerosis,and Hippo signaling pathway,were *** hub genes(cd45,vcam1,ccl3,cd56,app,cd48,btk,ccr2,cybb,and cxcl12)were *** drugs,including ivermectin,deforolimus,and isoliquiritigenin,were predicted by the Connectivity Map database to have potential therapeutic effects on t(4;14)*** molecular docking,ivermectin showed strong binding affinity to all 10 ide

关键词： Multiple myeloma Functional enrichment analysis Molecular docking simulation Gene expression profiling Therapeutic target Ivermectin

Two-layer Lagrange-based relay network topology and trajectory design for solar system explorations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第6期67卷 342-358页

作者： jun CAO Jian JIAO hao LIU Rongxing LU Qinyu zhang Guangdong Provincial Key Laboratory of Aerospace Communication and Networking Technology Harbin Institute of Technology (Shenzhen) Faculty of Computer Science (FCS) University of New Brunswick

Exploration targeting outer planets and even the edge of the solar system is an emerging direction for the deep-space exploration in the next decades. To address this challenge, a novel two-layer Lagrangebased relay network topology is proposed in this study. Specifically, we utilize the Sun-Mars and Sun-Saturn Lagrange points(LPs) L4 and L5 to build a two-layer backbone relay network, which ensures continuous and high-efficiency communication capability for the exploration of the solar system. Furthermore, we utilize the planetary gravity assist and design the transfer trajectory of backbone relays with the help of planetary celestial body motion equations and Kepler's laws. Moreover, we conduct link budget analysis for multihop relay transmission under Gamma-Gamma distribution, shadowed Rician fading, and additive white Gaussian noise channels in several typical exploration scenarios and validate that the LP relays can effectively support future deep-space exploration missions.

关键词： deep-space communication Lagrangian points backbone relay network transfer trajectory relay selection

A CAD-BEM geometry transformation method for face-based primary geometric input based on closed contour recognition

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2024年第2期17卷 335-354页

作者： jun Xiao hao Zhou Shiji Yang Deyin zhang Borong Lin Department of Building Science School of ArchitectureTsinghua UniversityBeijing100084China Key Laboratory of Eco Planning&Green Building Ministry of EducationTsinghua UniversityBeijing100084China Institute for Urban Governance and Sustainable Development Tsinghua UniversityBeijing100084China

Performance analysis during the early design stage can significantly reduce building energy ***,it is difficult to transform computer-aided design(CAD)models into building energy models(BEM)to optimize building *** model structures for CAD and BEM are *** this study,geometry transformation methods was implemented in BES tools for the early design stage,including auto space generation(ASG)method based on closed contour recognition(CCR)and space boundary topology calculation *** program is developed based on modeling tools SketchUp to support the CAD format(like*.stl,*.dwg,*.ifc,etc.).It transforms face-based geometric information into a zone-based tree structure model that meets the geometric requirements of a single-zone BES combined with the other thermal parameter inputs of the *** addition,this study provided a space topology calculation method based on a single-zone BEM *** program was developed based on the SketchUp modeling tool to support additional CAD formats(such as*.stl,*.dwg,*.ifc),which can then be imported and transformed into*.*** to current methods mostly focused on BIM-BEM transformation,this method can ensure more modeling *** method was integrated into a performance analysis tool termed MOOSAS and compared with the current version of the transformation *** were tested on a dataset comprising 36 conceptual models without partitions and six real cases with detailed *** ensures a transformation rate of two times in any bad model condition and costs only 1/5 of the time required to calculate each room compared to the previous version.

关键词： geometry transformation building energy model computer aid design closed contour recognition

Preparation of CoO/SnO_(2)@NC/S composite as high-stability cathode material for lithium-sulfur batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2021年第10期28卷 1647-1655页

作者： Meng-ting Duan Meng-rong Wu Kai Xue Zheng-xu Bian Jing Shi Xing-mei Guo Fu Cao jun-hao zhang Qing-hong Kong Feng zhang School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of the Environment and Safety Engineering Jiangsu UniversityZhenjiang 212013China Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province Yancheng Institute of TechnologyYancheng 224051China

To improve the sulfur loading capacity of lithium-sulfur batteries(Li-S batteries)cathode and avoid the inevitable“shuttle effect”,hollow N doped carbon coated CoO/SnO_(2)(CoO/SnO_(2)@NC)composite has been designed and prepared by a hydrothermal-calcination *** specific surface area of CoO/SnO_(2)@NC composite is 85.464 m2·g^(-1),and the pore volume is 0.1189 cm3·g^(-1).The hollow core-shell structure as a carrier has a sulfur loading amount of 66.10%.The initial specific capacity of the assembled Li-S batteries is 395.7 mAh·g^(-1) at 0.2 C,which maintains 302.7 mAh·g^(-1) after 400 *** the rate increases to 2.5 C,the specific capacity still has 221.2 mAh·g^(-1).The excellent lithium storage performance is attributed to the core-shell structure with high specific surface area and *** structure effectively increases the sulfur loading,enhances the chemical adsorption of lithium polysulfides,and reduces direct contact between CoO/SnO_(2) and the electrolyte.

关键词： hydrothermal-calcination method CoO/SnO_(2)@NC composite lithium-sulfur battery cycling stability

Heterogeneous engineering of MnSe@NC@ReS_(2) core-shell nanowires for advanced sodium-/potassium-ion batteries

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第8期43卷 3713-3723页

作者： Sheng-jun Lu Jin-Yi Lin Cai-Hong Wang Yu-Fei zhang Yi zhang hao-Sen Fan College of Materials Science and Metallurgy Engineering Guizhou University Guiyang 550025China School of Energy Science and Engineering Nanjing Tech UniversityNanjing 211816China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China

Sodium-ion batteries(SIBs) and potassium-ion batteries(PIBs) have been attracting great attentions and widely been exploited due to the abundant sodium/potassium ***,the preparation of high-powered anode materials for SIBs/PIBs plays a decisive role for the commercial applications of SIBs/PIBs in the *** selenides are a class of potential anode materials for SIBs/PIBs because of their small band gap and high electrical *** this work,MnSe and ReS_(2) core-shell nanowires connecting by polydopamine derived carbon nanotube(MnSe@NC@ReS_(2)) have been successfully synthesized from growing ReS_(2) nanosheets array on the surface of MnSe@NC nano wires,which present excellent Na^(+)/K^(+) storage *** applied as SIBs anode,the specific capacity of 300 mAh·g^(-1) was maintwined after 400 cycles at the current density of 1.0 A·g^(-1).Besides,it could also keep 120 mAh·g^(-1) specific capacity after 900 cycles at 1.0 A·g^(-1) for the anode of *** heterogeneous engineering and one-dimensional-two-dimensional(1D-2D) hybrid strategies could provide an ideal strategy for the synthesis of new hetero-structured anode materials with outstanding battery performance for SIBs and PIBs.

关键词： Heterogeneous engineering Core-shell nanowires MnSe@NC@ReS_(2)nanowires Na^(+)batteries K^(+)batteries

High-performance lithium-sulfur battery based on porous N-rich g-C_(3)N_(4) nan-otubes via a self-template method

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2021年第10期28卷 1656-1665页

作者： Meng-rong Wu Ming-yue Gao Shu-ya zhang Ru Yang Yong-ming Chen Shang-qing Sun Jin-feng Xie Xing-mei Guo Fu Cao jun-hao zhang School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Zhenjiang Electric Power Supply Company State Grid Jiangsu Electric Power Co.Ltd.Zhenjiang 212000China

The commercial development of lithium-sulfur batteries(Li-S)is severely limited by the shuttle effect of lithium polysulfides(LPSs)and the non-conductivity of ***,porous g-C_(3)N_(4) nanotubes(PCNNTs)are synthesized via a self-template method and utilized as an efficient sulfur host *** one-dimensional PCNNTs have a high specific surface area(143.47 m^(2)·g^(-1))and an abundance of macro-/mesopores,which could achieve a high sulfur loading rate of 74.7wt%.A Li-S battery bearing the PCNNTs/S composite as a cathode displays a low capacity decay of 0.021% per cycle over 800 cycles at 0.5 C with an initial capacity of 704.8 mAh·g^(-1).PCNNTs with a tubular structure could alleviate the volume expansion caused by sulfur and lithium sulfide during charge/discharge *** N contents could greatly enhance the adsorption capacity of the carbon nitride for *** synergistic effects contribute to the excellent cycling stability and rate performance of the PCNNTs/S composite electrode.

关键词： self-template method porous g-C_(3)N_(4)nanotubes chemical adsorption synergistic effects lithium-sulfur batteries

Development review and the prospect of oil shale in-situ catalysis conversion technology

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1385-1395页

作者： Li Wang Chen-hao Gao Rui-Ying Xiong Xiao-jun zhang Ji-Xiang Guo The Unconventional Oil and Gas Institute China University of Petroleum-BeijingBeijing102200China

As an unconventional resource, oil shale possesses abundant reserves and significant potential for industrial applications. The rational and efficient development of oil shale resources holds immense importance in reducing national energy demand. In-situ catalytic technology, characterized by its high efficiency, low pollution, and minimal energy consumption, represents a key direction for future oil shale development. This paper provides a comprehensive review of research progress in in-situ oil shale mining technology, oil shale pyrolysis catalysts, the pyrolysis mechanism of kerogen, and the compatibility of different heating processes and catalysts. Furthermore, the paper proposes future research directions and prospects for oil shale in-situ catalytic technology, including reservoir modification, highefficiency catalyst synthesis, injection processes, and high-efficiency heating technology. These insights serve as valuable technical references for the advancement of oil shale in-situ catalytic technology.

关键词： Oil shale In-situ catalytic technology Pyrolysis catalyst Kerogen pyrolysis mechanism