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Synthesis of highly stable Ni nanoparticles via electrostatic self-assembly for enhanced hydrogen storage of MgH2

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Rare Metals 2024年第9期43卷 4356-4366页

作者： Qin-Ke Tang jiang-Chuan Liu Rui Shi Yun-Feng Zhu Ji-Guang Zhang Ya-Na Liu jun Wang Yao Zhang Xiao-Hui Hu Zhi-Bin Liu Li-Quan Li College of Materials Science and Engineering Jiangsu Collaborative Innovation Centre for Advanced Inorganic Function CompositesNanjing Tech University School of Materials Science and Engineering Southeast University

Magnesium-based hydrides have been widely recognized as an appropriate choice for solid-state hydrogen ***,its undesirable thermodynamics and sluggish hydrogenation/dehydrogenation kinetics are major bottlenecks for its ***,a highly stable and highly dispersed Ni-based catalyst （Ni/Al2O3/GN） was fabricated to promote the hydrogen storage performance of MgH2via the electrostatic effect of NiAl-LDH/GN precursor with a co-calcination reduction ***2-5wt % Ni/Al2O3/GN exhibits excellent hydrogen storage performance,releasing about 5.7 wt % hydrogen in 3500 s at 250℃,and can reach a saturation hydrogen absorption of about 6.15 wt% in 3000 s at 100℃.Furthermore,it also shows low dehydrogenation apparent activation energy of 89.1 and 118.2 kJ·***,the catalyst ensures the stability of both the physical phase and structure during ball milling and cycling *** role of each phase in Ni/Al2O3/GN on the hydrogen storage performance of MgH2was also discussed through experiments and theoretical calculation,and the synergistic catalytic mechanism of Ni/Al2O3/GN was clearly *** work provides a unique perspective for the preparation of highly stable and highly dispersible catalysts.

关键词： Catalytic mechanism Hydrogen storage performance Magnesium hydride Ni/Al2O3/GN

Discovery of a potential bladder cancer inhibitor CHNQD-01281 by regulating EGFR and promoting infiltration of cytotoxic T cells

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Marine Life Science & Technology 2024年第3期6卷 502-514页

作者： Jian-Yu Liu Yao-Yao jiang Peng-Jie Li Bo Yao Yi-Jing Song Ji-Xiu Gao Gulab Said Yang Gao jun-Yu Lai Chang-Lun Shao Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Chemistry Women University SwabiSwabi 23430Pakistan Laoshan Laboratory Qingdao 266237China Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China

As one of the common malignancies that threaten human life,bladder cancer occurs frequently with a high mortality rate in the world,due to its invasion,recurrence and drug *** products from marine microorganisms are becoming the hotspots in discovery of new candidate drug entities,especially in the area of *** A(BFA)is a natural Arf-GEFs inhibitor,but due to the low aqueous solubility,strong toxicity,and poor bioavailability,it is urgent to conduct structural optimization ***,a new BFA pyridine acrylate derivative CHNQD-01281 with improved solubility was prepared and found to exert moderate to strong antiproliferative activity on a variety of human cancer cell *** was noteworthy that CHNQD-01281 was most sensitive to two bladder cancer cell lines T24 and J82(IC50=0.079 and 0.081μmol/L)with high selectivity index(SI=14.68 and 14.32),suggesting a superior safety to *** vivo studies revealed that CHNQD-01281 remarkably suppressed tumor growth in a T24 nude mice xenograft model(TGI=52.63%)and prolonged the survival time(ILS=68.16%)in an MB49 allogeneic mouse model via inducing infiltration of cytotoxic T *** mechanism exploration indicated that CHNQD-01281 regulated both EGFR/PI3K/AKT and EGFR/ERK pathways and mediated the chemotactic effect of chemokines on immune effector ***,CHNQD-01281 may serve as a potential therapeutic agent for bladder cancer through multiple mechanisms.

关键词： Bladder cancer Marine natural products Brefeldin A EGFR/PI3K/AKT EGFR/ERK T-cell infiltration

Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder

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Neuroscience Bulletin 2024年第8期40卷 1104-1114页

作者： Man Chen Yun‑Hui Chu Wen‑Xiang Yu Yun‑Fan You Yue Tang Xiao‑Wei Pang hang Zhang Ke Shang Gang Deng Luo‑Qi Zhou Sheng Yang Wei Wang jun Xiao Dai‑Shi Tian Chuan Qin Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Neural Injury and Functional Reconstruction Huazhong University of Science and TechnologyWuhan 430030China Department of Neurology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China

Neuromyelitis optica spectrum disorder(NMOSD)is an autoimmune inflammatory demyelinating disease of the central nervous system(CNS)accompanied by blood-brain barrier(BBB)*** in microglial lipid metabolism is believed to be closely associated with the neuropathology of ***,there is limited evidence on the functional relevance of circulating lipids in CNS demyelination,cellular metabolism,and microglial ***,we found that serum low-density lipoprotein(LDL)was positively correlated with markers of neurological damage in NMOSD *** addition,we demonstrated in a mouse model of NMOSD that LDL penetrates the CNS through the leaky BBB,directly activating *** activation leads to excessive phagocytosis of myelin debris,inhibition of lipid metabolism,and increased glycolysis,ultimately exacerbating myelin *** also found that therapeutic interventions aimed at reducing circulating LDL effectively reversed the lipid metabolic dysfunction in microglia and mitigated the demyelinating injury in *** findings shed light on the molecular and cellular mechanisms underlying the positive correlation between serum LDL and neurological damage,highlighting the potential therapeutic target for lowering circulating lipids to alleviate the acute demyelinating injury in NMOSD.

关键词： Neuromyelitis optica spectrum disorder Low-density lipoprotein Microglia

Clinical characteristics of testicular torsion and factors influencing testicular salvage in children:A 12-year study in tertiary center

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World Journal of Clinical Cases 2024年第7期12卷 1251-1259页

作者： Xiang-Hui Gang Yuan-Yuan Duan Bin Zhang Zheng-Gan jiang Rong Zhang jun Chen Xiang-Yu Teng Duo-Bing Zhang Department of Urology Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of Ultrasound Diagnosis Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of Urology The Second Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina

BACKGROUND Testicular torsion is the most common acute scrotum worldwide and mainly occurs in children and *** have demonstrated that the duration of symptoms and torsion grade lead to different outcomes in children diagnosed with testicular *** To predict the possibility of testicular salvage(TS)in patients with testicular torsion in a tertiary *** We reviewed the charts of 75 pediatric patients with acute testicular torsion during a 12-year period from November 2011 to July 2023 at the Suzhou Hospital of Anhui Medical *** and multivariate logistic regression analyses were used to determine independent predictors of testicular *** data included clinical findings,physical examinations,laboratory data,color Doppler ultrasound findings,operating results,age,presenting institution status,and follow-up *** Our study included 75 *** was possible in 57.3%of all patients;testicular torsion occurred mostly in winter,and teenagers aged 11-15 years old accounted for 60%.Univariate logistic regression analyses revealed that younger age(P=0.09),body mass index(P=0.004),torsion angle(P=0.013),red blood cell count(P=0.03),neutrophil-to-lymphocyte ratio(P=0.009),and initial presenting institution(P<0.001)were associated with *** multivariate analysis,only the initial presenting institution predicted TS(P<0.05).CONCLUSION The initial presenting institution has a predictive value for predicting TS in patients with testicular *** with scrotal pain should be admitted to a tertiary hospital as soon as possible.

关键词： Testicular torsion Testicular salvage Pediatrics Predictors Case report

Modularized sulfur storage achieved by 100% space utilization host for high performance lithium-sulfur batteries

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Chinese Chemical Letters 2024年第4期35卷 237-243页

作者： jun jiang Tong Guo Wuxin Bai Mingliang Liu Shujun Liu Zhijie Qi Jingwen Sun Shugang Pan Aleksandr L.Vasiliev Zhiyuan Ma Xin Wang junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and TechnologyNanjing 210094China Changzhou Institute of Technology Changzhou 213032China Shubnikov Institute of Crystallography Russian Academy of SciencesLeninskii pr.59Moscow 119333Russia jiangsu Pylon Battery Co. Ltd.Yangzhou 211400China

Popularization of lithium-sulfur batteries(LSBs) is still hindered by shuttle effect and volume ***, a new modularized sulfur storage strategy is proposed to solve above problems and accomplished via employing 100% space utilization host material of cobalt loaded carbon nanoparticles derived from ZIF-67. The modular dispersed storage of sulfur not only greatly increases the proportion of active sulfur,but also inhibits the occurrence of volume expansion. Meanwhile, 100% space utilization host material can greatly improve the conductivity of the cathode, provide a larger electrolyte wetting interface and effectively suppress the shuttle effect. Moreover, loaded cobalt particles have high catalytic activity for electrochemical reaction and can effectively improve the redox kinetics. The cell with new cathode host material carbonized at 650 ℃(ZIF-67(650 ℃)) exhibits superior rate performance and can maintain a high specific capacity of 950 m Ah/g after 100 cycles at 0.2 C, showing a good cycle stability.

关键词： Modularized sulfur storage Space utilization Cathode host material ZIF-67 Lithium-sulfur batteries

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Implications of neutron skin measurements on Skyrme equations of state

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Chinese Physics C 2024年第6期48卷 155-161页

作者：管大为裴俊琛蒋崇基 State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

The recent measurements of neutron skins via parity violation in electron scattering have extracted an abnormally thick neutron skin for 208 Pb,which has significant consequences in nuclear equation of state(EoS)and neutron star *** this study,we perform optimizations of extended Skyrme forces in a consistent manner by including neutron skin thicknesses from PREX-Ⅱand CREX experiments and investigate nuclear EoSs and neutron stars in the GW170817 event By varying the fitting weights of neutron skins,several new Skyrme parameterizations are *** results show the competition in the fitting procedure to simultaneously describe neutron skins,other properties of finite nuclei,and neutron star *** prospects of resolving neutron skin issues are also discussed.

关键词： neutron skin equation of state neutron star Skyrme force

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Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis

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当代医学科学（英文） 2024年第4期44卷 809-819页

作者： Chen-guang YAO Zi-jia ZHAO Ting TAN jiang-ning YAN Zhong-wei CHEN jun-tao XIONG Han-luo LI Yan-hong WEI Kang-hong HU Sino-German Biomedical Center Hubei Provincial Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education & Hubei Province)Key Laboratory of Fermentation Engineering(Ministry of Education)National"111"Center for Cellular Regulation and Molecular PharmaceuticsHubei University of TechnologyWuhan 430068China Centerfor Evaluation of Hubei Medical Products Administration Wuhan 430068China

Objective:Lindqvist-type polyoxometalates(POMs)exhibit potential antitumor *** study aimed to examine the effects of Lindqvist-type POMs against breast cancer and the underlying ***:Using different cancer cell lines,the present study evaluated the antitumor activities of POM analogues that were modified at the body skeleton based on molybdenum-vanadium-centered negative oxygen ion polycondensations with different side *** colony formation assay,autophagy detection,mitochondrial observation,qRT-PCR,Western blotting,and animal model were used to evaluate the antitumor activities of POMs against breast cancer cells and the related ***:MO-4,a Lindqvist-type POM linking a proline at its side strain,was selected for subsequent experiments due to its low half maximal inhibitory concentration in the inhibition of proliferation of breast cancer *** was found that MO-4 induced the apoptosis of multiple types of breast cancer ***,MO-4 activated intracellular mitophagy by elevating mitochondrial reactive oxygen species(ROS)levels and resulting in *** vivo,breast tumor growth and distant metastasis were significantly reduced following MO-4 ***:Collectively,the results of the present study demonstrated that the novel Lindqvist-type POM MO-4 may exhibit potential in the treatment of breast cancer.

关键词： antitumor breast cancer mitochondria mitophagy polyoxometalate

Retinal sub-layer thicknesses, presence of lacunes, and their interaction with cognitive performance in recent single subcortical infarction

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中华医学杂志(英文版) 2024年第16期137卷 2014-2016页

作者： Cui Jingyu Kwapong William Robert Yan Yuying Cao Le Ye Chen Wang hang jiang Shuai Wu Bo Department of Neurology West China Hospital Sichuan University Chengdu Sichuan China

Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome

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World Journal of Cardiology 2024年第7期16卷 422-435页

作者： Si-Qi Li Dong-Yu Min jun-Wen jiang Xiao-Ying Li Xu-Na Yang Wen-Bo Gu Jia-Hui jiang Li-Hao Chen Han Nan Ze-Yu Chen Second Department of Cardiology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina

BACKGROUND Chronic heart failure is a complex clinical *** Chinese herbal compound preparation Jianpi Huatan Quyu recipe has been used to treat chronic heart failure;however,the underlying molecular mechanism is still not *** To identify the effective active ingredients of Jianpi Huatan Quyu recipe and explore its molecular mechanism in the treatment of chronic heart *** The effective active ingredients of eight herbs composing Jianpi Huatan Quyu recipe were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis *** target genes of chronic heart failure were searched in the Genecards *** target proteins of active ingredients were mapped to chronic heart failure target genes to obtain the common drugdisease targets,which were then used to construct a key chemical componenttarget network using Cytoscape 3.7.2 *** protein-protein interaction network was constructed using the String *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed through the Metascape ***,our previously published relevant articles were searched to verify the results obtained via network *** A total of 227 effective active ingredients for Jianpi Huatan Quyu recipe were identified,of which quercetin,kaempferol,7-methoxy-2-methyl isoflavone,formononetin,and isorhamnetin may be key active ingredients and involved in the therapeutic effects of TCM by acting on STAT3,MAPK3,AKT1,jun,MAPK1,TP53,TNF,HSP90AA1,p65,MAPK8,MAPK14,IL6,EGFR,EDN1,FOS,and other *** pathways identified by KEGG enrichment analysis include pathways in cancer,IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,calcium signaling pathway,cAMP signaling pathway,NF-kappaB signaling pathway,AMPK signaling pathway,*** studies on Jianpi Huatan Quyu recipe suggested that this Chinese compound preparation can regulate the TNF-α,IL-6,MAPK

关键词： Jianpi Huatan Quyu recipe Traditional Chinese medicine Chronic heart failure Data mining Network pharmacology Bioinformatics Spleen Qi deficiency syndrome