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中西医治疗慢性萎缩性胃炎进展

实用中医内科杂志 2024年第7期38卷 13-15页

作者：刘方晓刘林白光焦政李晶赵佳琪辽宁中医药大学辽宁沈阳110847 辽宁中医药大学附属医院辽宁沈阳110032

慢性萎缩性胃炎(chronic atrophic gastritis,CAG)指胃黏膜腺体体积减小,量少,伴有或不伴有肠腺化生及(或)假幽门腺化生的慢性疾病,被认为是消化系统癌前疾病的一种。慢性萎缩性胃炎病程漫长,缠绵难愈,给患者生活带来极大不利影响。一... 详细信息

慢性萎缩性胃炎(chronic atrophic gastritis,CAG)指胃黏膜腺体体积减小,量少,伴有或不伴有肠腺化生及(或)假幽门腺化生的慢性疾病,被认为是消化系统癌前疾病的一种。慢性萎缩性胃炎病程漫长,缠绵难愈,给患者生活带来极大不利影响。一般采用根除幽门螺杆菌、促进胃动力等对症治疗方法,对慢性萎缩性胃炎进行西医治疗。中医药通过不同的药物组合,随证加减,在改善症状方面有优势。慢性萎缩性胃炎的中西医结合治疗,在改善症状的同时,对胃黏膜的萎缩和肠上皮化生起到阻断和逆转作用。文章从慢性萎缩性胃炎的病因、病机、辨证论治、中药西药并用、中成药治疗、针药并用、经验方治疗、内窥镜治疗等方面,对近年来我国慢性萎缩性胃炎的中医西医治疗进展进行了概述。

关键词：慢性萎缩性胃炎痞满病因病机辨证分型中西医结合治疗中成药胃癌

活细胞应激反应过程中线粒体和核仁微环境动力学的荧光寿命成像研究

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物理学报 2024年第7期73卷 354-367页

作者：杨志刚刘颖超张仕青罗瑞鉴赵需谦连加荣屈军乐深圳大学物理与光电工程学院光电子器件与系统教育部/广东省重点实验室深圳518060

核仁和线粒体在维持细胞平衡发挥重要作用,研究其生理过程有助于深入了解生物学功能.本文采用一种红色荧光的芘罗丹明荧光探针在不同条件下靶向标记细胞线粒体和核仁.通过激光共聚焦成像和荧光寿命成像技术分析HeLa细胞在光照和药物刺... 详细信息

核仁和线粒体在维持细胞平衡发挥重要作用,研究其生理过程有助于深入了解生物学功能.本文采用一种红色荧光的芘罗丹明荧光探针在不同条件下靶向标记细胞线粒体和核仁.通过激光共聚焦成像和荧光寿命成像技术分析HeLa细胞在光照和药物刺激下细胞凋亡的形态变化,并利用相图定量分析了线粒体与核仁的微环境变化,确定在稳态HeLa细胞中探针标记到的线粒体的平均荧光寿命约为3.65 ns,线粒体黏度约为66×10^(-3)Pa·s.在激光光照后,探针标记到HeLa细胞线粒体的荧光寿命降至3.61 ns,对应线粒体黏度增至约131×10^(-3)Pa·s;使用紫杉醇和秋水仙碱诱导细胞凋亡,观察到探针标记于HeLa细胞核仁的荧光寿命先增加后降低,反映了在HeLa细胞凋亡过程中核仁微环境的变化,证明HeLa细胞在非稳态情况下核仁和线粒体的功能变化,为线粒体和核仁功能障碍相关疾病研究提供了新的研究方法.

关键词：荧光寿命显微成像核仁微环境黏度

Extraction and characterization of bound extracellular polymeric substances from cultured pure cyanobacterium(Microcystis wesenbergii)

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Journal of Environmental Sciences 2014年第8期26卷 1725-1732页

作者： Lizhen liu Boqiang Qin Yunlin Zhang guangwei Zhu guang Gao Qi Huang Xin Yao State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography & LimnologyChinese Academy of Sciences University of Chinese Academy of Sciences School of Environment and Planning Liaocheng University

Preliminary characterization of bound extracellular polymeric substances（bEPS） of cyanobacteria is crucial to obtain a better understanding of the formation mechanism of cyanobacterial bloom. However,the characterization of bEPS can be affected by extraction methods. Five sets（including the control） of bEPS from Microcystis extracted by different methods were characterized using three-dimensional excitation and emission matrix（3DEEM） fluorescence spectroscopy combined chemical spectrophotometry; and the characterization results of bEPS samples were further compared. The agents used for extraction were NaOH,pure water and phosphate buffered saline（PBS） containing cationic exchange resins,and hot water. Extraction methods affected the fluorescence signals and intensities in the bEPS. Five fluorescence peaks were observed in the excitation and emission matrix fluorescence spectra of bEPS samples. Two peaks（peaks T1 and T2） present in all extractions were identified as protein-like fluorophores,two（peaks A and C） as humic-like fluorophores,and one（peak E） as a fulvic-like *** these substances,the humic-like and fulvic-like fluorescences were only seen in the bEPS extracted with hot water. Also,NaOH solution extraction could result in strong fluorescence intensities compared to the other extraction methods. It was suggested that NaOH at pH 10.0 was the most appropriate method to extract bEPS from Microcystis. In addition,dialysis could affect the yields and characteristics of extracted bEPS during the determination process. These results will help us to explore the issues of cyanobacterial blooms.

关键词： Bound extracellular polymeric substances(bEPS) Extraction Fluorescence intensities Microcystis Three-dimensional excitation and emission matrix(3DEEM)

ABI7500+BKV-DNA检测系统的性能评价

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医药论坛杂志 2024年第7期45卷 715-718页

作者：刘德军田向永河南省人民医院郑州大学河南省人民医院检验科郑州450003

目的评估ABI7500+BKV-DNA检测系统,对该系统进行性能验证,确认该检测系统是否符合要求。方法按中国合格评定国家认可委员会(CNAS)系列文件要求,对ABI7500+BKV-DNA检测系统的正确度、精密度、线性范围、最低检出限、特异性等性能参数进... 详细信息

目的评估ABI7500+BKV-DNA检测系统,对该系统进行性能验证,确认该检测系统是否符合要求。方法按中国合格评定国家认可委员会(CNAS)系列文件要求,对ABI7500+BKV-DNA检测系统的正确度、精密度、线性范围、最低检出限、特异性等性能参数进行验证。结果ABI7500+BKV-DNA检测系统的正确度符合要求,批内精密度(s批内)分别为3.11%、1.93%,批间精密度(s批间)分别为3.82%、2.20%,正确度符合要求。线性分析通过验证实验,最低检出限为2.0×10^(3)copies/mL。结论ABI7500+BKV-DNA检测系统的正确度、精密度、线性范围、最低检出限、特异性等性能参数均符合相关标准的要求,是临床检测BKV的首选方法。

关键词： BKV相关肾病 BK病毒 BKV感染正确度精密度线性 BKV-DNA

西方现代人格理想的追寻与构建——从哈姆雷特到浮士德

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山西大同大学学报（社会科学版） 2024年第1期38卷 108-111页

作者：刘志强鲍俊琴山西大同大学外国语学院山西大同037009 山西大同大学文学院山西大同037009

人的发现,人的个性发展与完善一直是西方文学关注的话题。从文艺复兴时期“人的发现”到18世纪启蒙时代主体性的人的觉醒和探索实践无不是伟大的文学家们对时代做出的回应和反思。莎士比亚笔下的哈姆雷特、歌德笔下的人物形象以及歌德... 详细信息

人的发现,人的个性发展与完善一直是西方文学关注的话题。从文艺复兴时期“人的发现”到18世纪启蒙时代主体性的人的觉醒和探索实践无不是伟大的文学家们对时代做出的回应和反思。莎士比亚笔下的哈姆雷特、歌德笔下的人物形象以及歌德本人一生的追求,展示了西方文学人性理想在精神发展脉络上的某些联系:从传统走向现代的西方人在自我认识的漫长历程中逐渐由审美的人性理想转向了更具扩张性的实践体验。浮士德的形象作为现代早期主体性人格理想的实践者,同时也引发了对现代性问题的警惕与反思。

关键词：人的发现主体意识的觉醒审美主体现代冒险主体

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《临证指南医案》自汗证治探析

亚太传统医药 2024年第1期20卷 208-211页

作者：姚军刘倩谢雪姣湖南中医药大学湖南长沙410208

自汗是特殊汗出的一种类型,该病易见而难治。基于清代名家叶天士之《临证指南医案》,深入阐析自汗之定义、病机、治法,总结叶天士杂症自汗证治特色及具体方药,并据此探讨特殊自汗证型,进一步丰富临床汗证诊疗经验。

关键词：《临证指南医案》叶天士自汗病机治法

Integrated System for Combined Optical Coherence Tomography-Raman Spectroscopy of Neocaridina denticulate sinensis

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Journal of Ocean University of China 2021年第1期20卷 94-100页

作者： liu Xiaoying ZHANG Xu MA jun SHI Xiaofeng Optics and Optoelectronics Laboratory Ocean University of ChinaQingdao 266100China

Optical coherence tomography(OCT)and Raman spectroscopy(RS)can be complementary biological tissue optical analysis *** study the internal structure and tissue compositions of biological samples,an OCT-RS system was built to carry out OCT section imaging and RS analysis in *** denticulate sinensis were collected regularly for morphological observation by OCT imaging and biochemical investigation based on the Raman *** internal structure of the *** sinensis was imaged by OCT,and the morphology of the tissues and the position in the body were distinguished according to the gray scale *** imaging depth along the vertical direction of Z-axis in *** sinensis is about 1.60 *** detection was selectively performed based on the OCT *** main Raman peaks of the rostrum,the cephalothorax,the abdominal segment,and the telson section are at 1006,1156,1447,1491 and 1515 cm-1,which are identified as proteins and amino *** presence of 1497 cm-1 at the cephalothorax is different from other parts,probably due to the presence of organs such as ovary,whose compositions are different from those of other *** combination of optical coherence tomography and Raman spectroscopy can provide information about morphological and biochemical features of tissues,and has potential applications in biomedical detection and imaging.

关键词： optical coherence tomography(OCT) Raman spectroscopy(RS) Neocaridina denticulate sinensis biological tissue

Coupling effect and characterization modeling of iron ore fines mixing and granulating at 0-1 mm

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Journal of Iron and Steel Research International 2019年第11期26卷 1154-1161页

作者： Dai-fei liu Xian-ju Shi Chao-jun Tang Hai-peng Cao jun Li School of Energy and Power Engineering Changsha University of Science and TechnologyChangsha 410114HunanChina Ironmaking Section Wuhan Branch of Baosteel Central Research Institute(R&D Center of Wuhan Iron&Steel Co.Ltd.)Wuhan 430000HubeiChina

Characteristic of iron ore is the essential factor of *** ores,namely specularite,magnetite concentrate and limonite,were selected as adhesion powder to investigate granulating behavior and evolution process of *** and modeling were performed to represent granulating behavior on the basis of selectivity,ballability and adhesion *** mass fraction of water and particles size of adhesion and nucleation were set at(11±1)%,0-1 mm and 3-5 mm,*** results show that selectivity and ballability promote the evolution of *** water absorption rate of specularite and the ballability of limonite are *** coupling effects exist in two ores mixing and present positive effect when the proportion of magnetite concentrate is greater than that of specularite or specularite and limonite *** three ores mixing,the coupling effect presents a complex superposition state.A characterization model of adhesion rate of mixing granulation was established by random forest *** output is adhesion rate,and its inputs include water absorption rate,balling index and mixing *** model parameters are 957 trees and four branches,and the training and prediction errors of the model are 2.3%and 3.7%,*** indicates that the random forest model can be used to represent coupling effects of mixing granulation.

关键词： Iron ore Granulating Coupling effect Modeling Random forest algorithm

基于HSV色彩空间的图像感兴趣区域提取方法研究

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软件工程 2024年第7期27卷 1-5页

作者：刘畅李军李晓明浙江理工大学机械工程学院浙江杭州310018 台州学院智能制造学院浙江台州318000

嵌入式设备中部署深度学习检测模型往往面临算力不足的问题,而感兴趣区域(ROI)提取可作为一种高效的性能优化手段。文章提出一种基于HSV(Hue,Saturation,Value)色彩空间模型的ROI提取的方法,将检测目标的像素信息转化到HSV色彩空间,在色... 详细信息

嵌入式设备中部署深度学习检测模型往往面临算力不足的问题,而感兴趣区域(ROI)提取可作为一种高效的性能优化手段。文章提出一种基于HSV(Hue,Saturation,Value)色彩空间模型的ROI提取的方法,将检测目标的像素信息转化到HSV色彩空间,在色相-饱和度(H-S)平面引入DBSCAN(Density-Based Spatial Clustering of Applications with Noise)聚类算法,精确定位目标的主色彩像素在H-S平面上的分布位置,同时过滤杂乱色彩,然后通过Quickhull(快壳)凸包算法,从散点数据中拟合出主色彩的精确分布范围。根据获取的主色彩范围对像素进行遍历,可以根据色彩信息有效地提取ROI。实验结果表明,经过该方法优化后的Faster R-CNN(Faster Regions with Convolutional Neural Networks)算法,较原模型减少了57.08%的平均推理耗时,同时精确率提升了0.9百分点。这对于嵌入式设备中进行实时目标检测具有重要的现实意义。

关键词： HSV色彩空间感兴趣区域目标检测色彩阈值

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