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Nano Research 2023年第12期16卷 13182-13204页

作者： Lin-Jia Su Zi-Han Ji Mo-Xi Xu Jia-Qing Zhu Yi-Hai Chen jun-fei qiao Yi Wang Yao-Xin Lin CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology(NCNST)Beijing 100190China University of Chinese Academy of Sciences(UCAS) Beijing 100149China Department of Breast Surgery Harbin Medical University Cancer HospitalHarbin 150081China School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China Institute of Bioengineering and Institute of Materials Science&Engineering École Polytechnique Fédérale de Lausanne(EPFL)Lausanne1015Switzerland

RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or prevention of *** include antisense oligonucleotides(ASOs),small interfering RNAs(siRNAs),endogenous microRNAs(miRNAs),messenger RNAs(mRNAs),clustered regularly interspersed short palindromic repeats-associated protein 9(CRISPR/Cas9),single guide RNAs(sgRNAs),as well as RNA *** therapeutic agents exert their effects through various mechanisms such as gene inhibition,addition,replacement,and *** advancement of RNA biology and the field of RNA therapy has paved the way for the development and utilization of RNA-based nanomedicine in human *** remarkable example of RNA-based nanomedicine is the mRNA-based vaccines including mRNA-1273(Moderna)and BNT162b2(Pfizer/BioNTech)that have been successfully employed in response to the coronavirus disease 2019(COVID-19)*** review aims to highlight the advantages of RNA-based nanomedicines,provides an overview of significant developments in delivery systems,elucidates the molecular mechanisms of action underlying RNA-based nanomedicines,and discusses their clinical ***,the review will address the existing challenges and innovations in delivery platforms while exploring the future possibilities for these promising RNA-based nanomedicines.

关键词： RNA-based nanomedicine conjugate-based delivery system nanoparticle-based delivery system clinical trial

Structural engineering of high-entropy alloys for advanced electrocatalytic reactions

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Tungsten 2025年第1期7卷 1-31页

作者： qiao Xie Ying-Jie Yu Hai-jun Zhang Ya-Ping Deng Wen Lei The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Department of Chemical Engineering Waterloo Institute for Sustainable Energy Waterloo Institute for Nanotechnology University of Waterloo

High-entropy alloys(HEAs) have emerged as promising candidates to replace traditional precious metal catalysts,owing to their unique chemical and physical *** review commences by revisiting the fundamental concepts of HEAs,including their synthesis methods and structural control strategies in *** underscores the critical role of meticulously manipulating both macroscopic and microscopic structures of the HEAs to optimize their catalytic performance.A deep understanding of the structure-activity relationship in HEAs across various configurations is pivotal in developing more effective *** review methodically encapsulates the research progress of structural control strategies for HEAs in achieving efficient energy conversion,with the aim of gaining a better understanding of the relationship between structure and *** review concludes by summarizing the current achievements and challenges,and suggestions for potential future directions of HEAs in the fields of energy conversion and environmental purification.

关键词： Electrocatalytic Energy conversion High-entropy alloys Structural modulation

Stable copper boron–imidazolate cage as Cu-riched enzyme for highly efficient electrocatalytic CO2 reduction to ethylene

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Science China Chemistry 2025年

作者： jun-Qiang Chen qiao-Hong Li Qin-Long Hong Ping Shao Hai-Xia Zhang Jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Single-atom catalyst has garnered widespread attention to mimic mature enzymes due to its well-defined atomic structure and coordination environments. However, since the carbon–carbon（C–C） coupling reactions require synergistic catalysis of multiple sites, single-atom catalysts suffer from insufficient active sites and unclear reaction mechanisms. Controlling the reaction intermediates in a precisely targeted pocket through careful metal–organic cage design is therefore crucial. Here, we prepare a tetrahedral [Cu6L4]-type boron–imidazolate cage integrating highly active Cu sites and optimized cavity, which exhibits enzyme like specific catalytic performance in electrochemical CO2reduction reaction（CO2RR） to enhance the selectivity of *** analyses and computational calculations suggest that the single Cu site together with neighboring boron–imidazolate ligands provides suitably synergistic effects that enable the energetically favorable formation of an *COCHO intermediate, a key step determining selectivity. As a result, the [Cu6L4]-type cage of BIC-145 achieves a Faradaic efficiency of 28% for C2H4maintaining an average current density of -3.54 mA cm-2over a 5-hour electrolysis period. This work represents the first example for studying single-metal site catalysts with ultra-low coordination numbers through the rational design of metal–organic cages.

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan jun-Bo Yang Zhi-Li Zuo Han Guo Zi-fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

Underground location algorithm based on random forest and environmental factor compensation

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International Journal of Coal Science & Technology 2021年第5期8卷 1108-1117页

作者： Xin qiao fei Chang School of Electronic Engineering Chaohu UniversityChaohu 238000AnhuiChina Huishang Futures Co.LTD Hefei 230061AnhuiChina

Aiming at the poor location accuracy caused by the harsh and complex underground environment,long strip roadway,limited wireless transmission and sparse anchor nodes,an underground location algorithm based on random forest and compensation for environmental factors was ***,the underground wireless access point(AP)network model and tunnel environment were analyzed,and the fingerprint location algorithm was *** then the Received Signal Strength(RSS)was analyzed by Kalman Filter algorithm in the offline sampling and real-time positioning ***,the target speed constraint condition was introduced to reduce the error caused by environmental *** experimental results show that the proposed algorithm solves the problem of insufficient location accuracy and large fluctuation affected by environment when the anchor nodes are *** the same time,the average location accuracy reaches three meters,which can satisfy the application of underground rescue,activity track playback,disaster monitoring and *** has high application value in complex underground environment.

关键词： Underground Coal Mine Random Forest Kalman Filter Compensation Algorithm

Collective Entity Alignment for Knowledge Fusion of Power Grid Dispatching Knowledge Graphs

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IEEE/CAA Journal of Automatica Sinica 2022年第11期9卷 1990-2004页

作者： Linyao Yang Chen Lv Xiao Wang Ji qiao Weiping Ding jun Zhang fei-Yue Wang the State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190 the School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China the China Electric Power Research Institute Beijing 100192China IEEE the Qingdao Academy of Intelligent Industries Qingdao 256200China the School of Information Science and Technology Nantong UniversityNantong 226019China the School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China

Knowledge graphs(KGs)have been widely accepted as powerful tools for modeling the complex relationships between concepts and developing knowledge-based *** recent years,researchers in the field of power systems have explored KGs to develop intelligent dispatching systems for increasingly large power *** multiple power grid dispatching knowledge graphs(PDKGs)constructed by different agencies,the knowledge fusion of different PDKGs is useful for providing more accurate decision *** achieve this,entity alignment that aims at connecting different KGs by identifying equivalent entities is a critical *** entity alignment methods cannot integrate useful structural,attribute,and relational information while calculating entities’similarities and are prone to making many-to-one alignments,thus can hardly achieve the best *** address these issues,this paper proposes a collective entity alignment model that integrates three kinds of available information and makes collective counterpart *** model proposes a novel knowledge graph attention network(KGAT)to learn the embeddings of entities and relations explicitly and calculates entities’similarities by adaptively incorporating the structural,attribute,and relational ***,we formulate the counterpart assignment task as an integer programming(IP)problem to obtain one-to-one *** not only conduct experiments on a pair of PDKGs but also evaluate o ur model on three commonly used cross-lingual *** comparisons indicate that our model outperforms other methods and provides an effective tool for the knowledge fusion of PDKGs.

关键词： Entity alignment integer programming(IP) knowledge fusion knowledge graph embedding power dispatch

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Formation mechanism of surface oxide layer of grain-oriented silicon steel

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Journal of Iron and Steel Research International 2021年第3期28卷 327-334页

作者： Jia-long qiao fei-hu Guo Sheng-tao Qiu Xing-zhong Zhang Hai-jun Wang National Engineering Research Center of Continuous Casting Technology China Iron&Steel Research Institute GroupBeijing100081China School of Metallurgy and Resources Anhui University of TechnologyMa’anshan243002AnhuiChina

The surface oxide layer of grain-oriented electrical steels was investigated by scanning electron *** formation mechanism and the influence on the glass film of the surface oxide layer were analyzed by the calculation of thermodynamics and *** surface oxide layer with 2.3μm in thickness is mainly composed of SiO_(2),a small amount of FeO and Fe_(2)SiO_(4).During the formation of surface oxide layer,the restriction factor was the diffusion of O in the oxide *** the initial stage of the decarburization annealing,FeO would be formed on the surface ***_(2) and silicate particles rapidly nucleated,grew and formed a granular oxide layer in the *** the oxidation layer thickens,the nucleation of new particles decreases,and the growth of oxide particles would be dominant.A lamellar oxide layer was formed between the surface oxide layer and the steel matrix,and eventually formed a typical three-layer *** the high temperature annealing,MgO mainly reacted with SiO_(2) and Fe_(2)SiO_(4) in the surface oxide layer to form Mg2SiO_(4) and Fe_(2)SiO_(4) would respond first,thus forming the glass film with average thickness of 4.87μm.

关键词： Grain-oriented silicon steel Decarburizing annealing Surface oxide layer Formation mechanism Glass film

Effect of cerium addition on microstructure and mechanical properties of as-cast high grade knives steel

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Journal of Iron and Steel Research International 2022年第12期29卷 1986-1994页

作者： Xi-ya qiao Xiao Han Zhi-jun He Zhen Zhuang Xin Yang fei-xiong Mao School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051LiaoningChina Ningbo Key Laboratory of Marine Protection Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201ZhejiangChina

The carbides and mechanical properties of as-cast high grade knives steel with and without cerium(Ce)addition were *** as-cast microstructure of the steel,the size of carbide precipitation,carbide morphology,and mechanical properties were systematically studied through optical microscopy,scanning electron microscopy,and X-ray ***,through the Equilib module of the FactSage thermodynamics software,the changes in the precipitation type of the inclusions with Ce during the solidification of the steel were *** results indicate that the rare earth Ce is added into the steel to refine the as-cast microstructure of the *** types of inclusions in the steel are changed by the addition of *** precipitated carbide morphology changes from a complex rod shape to a relatively single lamellar *** rare earth inclusions formed in steel by a moderate addition of Ce can be severed as the core of heterogeneous nucleation of carbides,which reduce the size of carbide precipitation,promote the uniform distribution of carbide in the as-cast steel,and improve the mechanical properties of the as-cast high grade knives steel.

关键词： Carbide Microstructure Mechanical property Cerium High grade knives steel

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS