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A Review of Point Feature Based Medical Image Registration

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Chinese Journal of Mechanical Engineering 2018年第4期31卷 21-36页

作者： Shao-Ya Guan Tian-Miao wang Cai Meng jun-chen wang School of Mechanical Engineering and Automation Beihang University Beijing Advanced Innovation Center for Biomedical Engineering Beihang University School of Astronautics Beihang University

Point features, as the basis of lines, surfaces, and bodies, are commonly used in medical image registration. To obtain an elegant spatial transformation of extracted feature points, many point set matching algorithms(PMs) have been developed to match two point sets by optimizing multifarious distance functions. There are ample reviews related to medical image registration and PMs which summarize their basic principles and main algorithms separately. However,to data, detailed summary of PMs used in medical image registration in different clinical environments has not been published. In this paper, we provide a comprehensive review of the existing key techniques of the PMs applied to medical image registration according to the basic principles and clinical applications. As the core technique of the PMs, geometric transformation models are elaborated in this paper, demonstrating the mechanism of point set registration. We also focus on the clinical applications of the PMs and propose a practical classification method according to their applications in different clinical surgeries. The aim of this paper is to provide a summary of pointfeaturebased methods used in medical image registration and to guide doctors or researchers interested in this field to choose appropriate techniques in their research.

关键词： Medical image registration Point set matching Optimization Assessment Application

Factors controlling N-nitrosodimethylamine （NDMA） formation from dissolved organic matter

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Frontiers of Environmental Science & Engineering 2013年第2期7卷 151-157页

作者： chengkunwang Xiaojian ZHANG Chao chen jun wang School of Environment Tsinghua University Beijing 100084 China

The formation of cancinogenic nitrosamines, esp. N-nitrosodimethylamine （NDMA） in water and wastewater treatment plants has drawn much attention in recent years. Dissolved organic matter from the transported Luan River water as water source of Tianjin was fractionated with different XAD resins and a series of ultra-filtration membranes with molecular weight （MW） cut-offs of 5k Da, 3k Da, and lk Da, respectively. The NDMA yields from the raw water and each fraction were measured to investigate their role in NDMA yield. Results indicated that the hydrophilic fraction had a higher NDMA yield than those of hydrophobic fraction and transphilic fraction. The fraction with MW below lk Da had a higher NDMA yield than that with larger MW. NDMA formation increased as the dissolved organic carbon （DOC） to dissolved organic nitrogen （DON） ratio decreased, which indicated that DON might serve as the real important precursor for NDMA. The correlation between NDMA yield and specific ultraviolet absorbance at 254nm （SUVA254） suggested that the latter might not represent the specific precursors for NDMA in the water. Besides the water quality, the influences of pH, disinfectant dosage, and disinfection contact time on the formation of NDMA were also examined. These results will help water treatment plants establish measures to control this harmful disinfection by-product.

关键词： N-nitrosodimethylamine (NDMA) disinfec-tion by-product dissolved organic nitrogen (DOC) hydro-philic molecular weight (MW) specific ultravioletabsorbance at 254 nm (SUVA254)

Effect of mutant p27^(kip1) gene on human cholangiocarcinoma cell line, QBC_(939)

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World Journal of Gastroenterology 2008年第34期14卷 5344-5348页

作者： Jian Luo Yong-jun chen Wei-Yu wang Sheng-Quan Zou Department of General Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM：To investigate the effects of exogenously mutated p27^kip1 （p27） on proliferation and apoptosis of human cholangiocarcinoma cell line, QBC939 in ***： Adenviral vectors were used to transfect mutated p27 cDNA into human QBC939 cell line. Expression of p27 was detected by RT-PCR. Western blot. Cell growth, morphological change, cell cycle, apoptosis and cloning formation were determined by MTT assay and flow ***： The expression of p27 protein and mRNA was increased signifi cantly in QBC939 cell line transfected with Ad-p27mt. The transfer of Ad-p27mt could signifi cantly inhibit the growth of QBC939 cells, decrease the cloning formation rate and induce apoptosis. p27 over expression caused cell cycle arrest at G0/G1 phase 72 h after infection with ***： p27 may cause cell cycle arrest at G0/G1 phase and subsequently lead to apoptosis. Recombinant adenovirus expressing mutant p27 may be potentially useful in gene therapy for cholangiocarcinoma.

关键词： Adenovirus Cholangiocarcinoma Gene therapy Cell cycle Apoptosis

Evaluation of Breeding Programs Combining Genomic Information in Chinese Holstein

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Agricultural Sciences in China 2011年第12期10卷 1949-1957页

作者： chen jun wang Ya-chun ZHANG Yi SUN Dong-xiao ZHANG Sheng-li ZHANG Yuan College of Animal Science and Technology/National Engineering Laboratory for Animal Breeding/Key Laboratory of Agricultural Animal Genetics and Breeding China Agricultural University Beijing 100193 P.R.China

Current study adopted gene flow theory and selection index method to compare the breeding efficiency of three breeding plans in the Chinese Holstein cattle using ZPLAN software. Simulated conventional progeny-testing program （PT） and young sire program （YS） were compared with breeding program using genomic selection （GS） taking parameters derived from Chinese Holstein breeding system. The results showed that, GS shortened generation interval by 1.5-2.2 years, and increased the genetic progress by 30-50%, comparing to PT and YS, respectively. Economic analysis showed that GS could obtain a higher breeding efficiency, being 119 and 97% higher than that of PT and YS, respectively; and GS was also powerful in improving functional traits with a low heritability. Main factors affecting breeding efficiency in GS were further discussed, including selection intensity, accuracy and the cost of SNP genotyping. Our finding provided references for future designing and implementing GS in Chinese dairy population.

关键词： Chinese Holstein genomic selection progeny-testing program young sire program breeding plan

NUMERICAL SIMULATION OF TIP-CLEARANCE FLOW IN CASCADE

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Journal of Hydrodynamics 2003年第1期15卷 62-66页

作者： chen Long, Yang chen jun, wang Guo qiangSchool of Naval Architecture and Ocean Engineering, Shanghai Jiaotong University, Shanghai 200030, China School of Naval Architecture and Ocean Engineering Shanghai Jiaotong University Shanghai 200030 China

The tip-clearance flow in a cascade was numerically simulated by solving theRANS equations of incompressible fluids. The computational model was based upon the artificialcompressibility formulation proposed by Chorin. The Baldwin-Lomax turbulence model was used to makethe governing equations closed. For the specific structure of tip-clearance flow, a multi-block gridstructure was adopted to facilitate numerical compulations. The comparison of numerical resultswith experimental data indicates that the present method is capable of simulating tip-clearanceflows with satisfactory accuracy.

关键词： cascade flow tip-clearance flow multi-block grid structure

Effect of aeration on fast gas pressure tests

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Mining Science and Technology 2009年第6期19卷 756-760页

作者： chen Yu-jia JIANG cheng-lin LI Xiao-wei TANG jun wang chen YANG Fei-long wang Fa-kai ZHANG Chao-jie DENG Shu-hua School of Safety Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Given the problem of the long time required for testing gas pressure, we propose a fast-test method in which we used a technique of fast borehole sealing and air replenishing. Based on the characteristics of gas emission from boreholes to be tested, we built a theoretical model for calculating parameters during the process of increasing natural pressure and aeration. Using this model, we investigated the effect of different aeration conditions on velocity of pressure tests. The result shows that: 1) aerating air into boreholes can speed up gas pressure tests and 2) the more similar the pressure of the aerated air to the original gas pressure, the smaller the gas volume absorbed by coal and the shorter the time needed in pressure test. A case study in the Lu’an mining area shows that the time needed for gas pressure test is only 4 h using our method of aeration and 29 h under conditions of increasing natural pressure, saving time by 86.2%. This case study also indicates that, by using the aeration method, only one hour is needed for gas pressure to reach a stable state, which breaks the record of the shortest time needed for gas pressure tests in China.

关键词： aeration gas pressure fast test aeration pressure adsorption quantity

Fluoxetine ameliorates symptoms of refractory chronic prostatitis/chronic pelvic pain syndrome

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Chinese Medical Journal 2011年第14期124卷 2158-2161页

作者： XIA Dan wang Ping chen jun wang Shuo JIANG Hai Department of Urology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003China

Background Category Ⅲ chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS） is a common syndrome of unclear etiology with significant impact on quality of life. Because the outcomes of multiple therapies for CP/CPPS have been far from approving, the possible psychological factors have been considered to play an important role in CP/*** on this, we investigated the role of antidepressant drug （fluoxetine） in men with refractory CP/*** In this study, 42 men diagnosed with refractory CP/CPPS without response to standard therapy （include multiple antibiotic courses and a-blockers） were referred for fluoxetine therapy. All patients received fluoxetine （20 mg/d） for three months and were clinically evaluated before （baseline）, and after 4, 8 and 12 weeks of therapy. The evaluation included a National Institutes of Health-chronic prostatitis symptom index （NIH-CPSI） and a Beck depression inventory （BDI） questionnaire. Moreover, the subjective global assessment （SGA） was assessed at the 4th, 8th and 12th week of *** Significant decreases were observed for total NIH-CPSI （28.55 to 9.29）, NIH-CPSI pain （14.69 to 5.19）,NIH-CPSI urinary （4.95 to 1.88 ）, NIH-CPSI quality of life （8.83 to 2.20）, and BDI （34.67 to 13.95） scores compared with baseline, all P values ＜0.05. Twenty-nine （69.05%） reported marked improvement on the subjective global assessment and 33 （78.57%） had a greater than 50% decrease in NIH-CPSI at the end of therapy （12th week）. At the same time, the Pearson correlation coefficient analysis demonstrated a positive correlation between BDI score and each CPSI score. No adverse events were reported in this *** Fluoxetine appears to be a safe and effective treatment in improving symptoms in, and the quality of life of, men with difficult CP/CPPS. Moreover, amelioration of difficult CP/CPPS-related symptoms could be related to a decrease in depressive symptoms.

关键词： chronic prostatitis chronic pelvic pain syndrome fluoxetine quality of life

Two-dimensional electrophoresis for comparative proteomic analysis of human bile

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Hepatobiliary & Pancreatic Diseases International 2007年第4期6卷 402-406页

作者： Bo chen,Jing-Qing Dong,Yong-jun chen,Jian-Ming wang,jun Tian,Chun-Ben wang and Sheng-Quan Zou Department of General Surgery,Tongji Hospital and Department of Proteomics Research Center,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China Department of General Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China.

BACKGROUND:Proteomic analysis of bile fluid holds promise as a method to identify biomarkers of bile tract diseases,especially for tumors. Two-dimensional electrophoresis(2-DE) is a popular and proven separation technique for proteome analysis,but using this strategy for bile fluid analysis is still not fully developed. This study was undertaken to(a) establish a reliable method for general clean-up to make bile fluid samples suitable for 2-DE;(b) obtain 2-D biliary maps with high reproducibility and resolution;and(c) identify protein patterns present in 2-D biliary maps for potential tumor biomarker discovery,with the intention of distinguishing malignant from benign causes of bile duct obstruction. METHODS:Bile fluid samples were obtained from two patients suffering from malignant and benign bile tract obstruction(one patient with cholangiocarcinoma as the experimental case,the other with cholelithiasis as control). A variety of sample preparation options,including delipidation,desalination and nucleic acid removal,were adopted to remove contaminants that affect 2-DE results. After that,each 350 μg purified sample was loaded onto nonlinear IPG strips(18 cm,pH 3-10 and pH 4-7) for first-dimension isoelectric focusing,and 12.5% SDS-PAGE electrophoresis for second dimension separation. Then 2-D maps were visualized after silver staining and analyzed with the Image Master 2-D software. RESULTS:A large number of protein spots were separated in 2-D maps from the experimental and control groups,with means of 250 and 216 spots on pH 3-10 IPG strips,and 182 and 176 spots on pH 4-7 strips,respectively. Approximately 16 and 23 spots were differentially expressed in matched pairs from the experimental and control cases using pH 3-10 and pH 4-7 strips. CONCLUSIONS:This study established a reliable sample preparation process suitable for 2-DE of bile fluid. By this method,2-D biliary maps with high reproducibility and resolution were obtained. The differentially displayed prote

关键词： proteome electrophoresis,gel,two-dimensional bile

Alkaline phosphatase activity and the phosphorus mineralization rate of Lake Taihu

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Science China Earth Sciences 2006年第z1期49卷 176-185页

作者： GAO Guang, ZHU Guangwei, QIN Boqiang, chen jun & wang Ke Nanjing Institute of Geography & Limnology, Chinese Academy of Sciences, Nanjing 210008, China Hohai University, Nanjing 210098, China Chinese Acad Sci Nanjing Inst Geog & Limnol Nanjing 210008 Peoples R China Hohai Univ Nanjing 210098 Peoples R China

The phosphorus fractions, the alkaline phosphatase activity (APA) and other water chemical parameters were concomitantly monitored from April 2003 to October 2004 in different ecotype sites of Lake Taihu. During the stages of algae growth, the phosphorus fractions and their relationships with APA in different ecotype sites were discussed and the phosphorus mineralization rate was calculated. In the water of Lake Taihu, most of the phosphorus (70.2%) could be attributed to the suspended particulate phosphorus, while the dissolved reactive phosphorus (DRP) seems to contribute less than 7%. About 58% of the total phosphorus, however, can be hydrolyzed as inorganic phosphate to compensate for phosphorus deficiency of algae and bacteria growth. During the different algae growth stages, the APA and its Kinetic parameters were varied significantly between different ecotype sites of Lake Taihu. This trend is also visible by comparing the phosphorus mineralization rate,and the most rapidly phosphorus turnover time is only several minutes. The fast recycle of phosphorus can, to some extent, be explained that the phosphorus source of algal blooms. The phytoplankton seems to compensate for phosphorus deficiency by using the alkaline phosphatase to hydrolyze phosphomonoesters.

关键词： Lake Taihu, alkaline phosphatase, kinetic parameters, phosphorus, mineralization rate.