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硝酸酯类药物不同途径给药后的药动学比较

中国新药与临床杂志 2004年第4期23卷 239-242页

作者：陈钧蒋新国江文明高小玲陆伟复旦大学药学院药剂学教研室上海200032

目的 :评价 5 单硝酸异山梨酯 (5 ISMN)片剂和注射剂及硝酸异山梨酯 (ISDN)注射剂在中国健康受试者中的药动学特征。方法 :18名男性健康受试者采用自身对照交叉给药的方式 ,单剂量口服5 ISMN片剂 2 0mg或静脉滴注 (静滴 ) 5 ISMN注... 详细信息

目的 :评价 5 单硝酸异山梨酯 (5 ISMN)片剂和注射剂及硝酸异山梨酯 (ISDN)注射剂在中国健康受试者中的药动学特征。方法 :18名男性健康受试者采用自身对照交叉给药的方式 ,单剂量口服5 ISMN片剂 2 0mg或静脉滴注 (静滴 ) 5 ISMN注射剂 (5mg·h- 1,维持 4h)或ISDN注射剂 (5mg·h- 1,维持 4h) ,采用气相色谱法测定血药浓度。结果 :18名受试者口服 5 ISMN片剂和静滴 5 ISMN注射剂后的药动学参数为 :Tmax 分别为 (0 .7±s 0 .6 ) ,(4 .1± 0 .7)h ;Cmax分别为 (389± 86 ) ,(2 83± 5 9) μg·L- 1;AUC0 ∞ 分别为 (32 6 6± 6 2 4 ) ,(3179± 76 9) μg·h·L- 1。静滴ISDN注射剂后IS DN ,2 单硝酸异山梨酯 (2 ISMN )和 5 ISMN的Cmax分别为 (18± 7) ,(5 9± 4 ) ,(2 0 9± 5 0 ) μg·L- 1;AUC0 t分别为 (85± 2 8) ,(380± 5 9) ,(1384± 4 2 7)μg·h·L- 1;T1/2 分别为 (1.0 0± 0 .2 0 ) ,(2 .6±0 .8) ,(6 .1± 0 .9)h。结论 :5 ISMN片剂与注射剂相比 ,两者的AUC等效 ,但片剂的达峰时间明显快于注射剂。ISDN注射剂给药后能较快达到稳态浓度 ,而且迅速代谢成活性代谢产物。

关键词：硝酸异山梨酯药动学色谱法气相投药口服输注静脉内单硝酸异山梨酯

渔船民参与式血吸虫病健康教育传播材料的研制与应用

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中国血吸虫病防治杂志 2016年第1期28卷 58-61页

作者：张晶李召军邱凌李东谌俊江谢华刘跃民胡飞袁敏林丹丹江西省寄生虫病防治研究所南昌330046

目的研制适用于湖沼型流行区渔船民的新型血防健康教育传播材料,并观察其应用效果。方法在鄱阳湖血吸虫病流行区余干县后山村随机选择292名成年村民开展血防知、信、行调查,并采用专题小组讨论法、个人访谈和专家咨询法,由项目研究人员... 详细信息

目的研制适用于湖沼型流行区渔船民的新型血防健康教育传播材料,并观察其应用效果。方法在鄱阳湖血吸虫病流行区余干县后山村随机选择292名成年村民开展血防知、信、行调查,并采用专题小组讨论法、个人访谈和专家咨询法,由项目研究人员与试点村渔船民志愿者共同研究,确定适于渔船民血防健康教育的核心信息和传播材料形式。结果设计制作了以渔船民为目标人群的参与式血吸虫病健康教育系列材料,包括两张实景张贴画、两块趣味拼图板、两个本土化血防小品、一首血防歌曲,并应用在血吸虫病流行区渔船民社区。现场应用效果显示,认为该系列健康教育传播材料具有科学性、可理解性、趣味性和适用性的预试验对象分别占98.97%、84.38%、78.35%、80.93%。结论参与式健康教育传播材料适合在渔船民中应用,该方式可供湖沼型血吸虫病流行区渔船民健康教育工作借鉴使用。

关键词：血吸虫病渔船民参与式健康教育传播材料湖沼地区

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试论社会主义和谐社会的基本价值诉求

宁夏党校学报 2007年第1期9卷 45-48页

作者：陈俊江李慧萍郑州大学公共管理学院河南平顶山450052

中国共产党十六届四中全会提出要构建一个各尽其能、各得其所的社会主义和谐社会,它是政治、经济、文化等各种人类活动因素综合作用的结果,是一个以人为本、多元一体、公平正义、稳定有序、人与自然和谐相处等基本价值诉求构成的统一体。

关键词：社会主义和谐社会以人为本基本价值

Nonlinear Out-of-Plane Mechanical Behaviours of Rectangular Woven Composite Flexible Skin Under Uniform Normal Pressure

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Acta Mechanica Solida Sinica 2023年第5期36卷 672-684页

作者： Di chen jun-jiang Xiong School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China School of Transportation Science and Engineering Beihang UniversityBeijing 102206China

This paper seeks to investigate nonlinear out-of-plane mechanical behaviours of woven composite flexible skin(WCFS)through experimental and theoretical ***,quasi-static experiments are carried out on rectangular WCFSs with different aspect ratios under uniform normal pressure to measure out-of-plane deformation and failure ***,a new three-parameter geometric model is presented to describe 3D geometry of pressurized WCFS,and thus,a nonlinear mechanical model is deduced for depicting the relationship between pressure and out-of-plane *** application of the aforementioned models for experimental results shows that the new models have adequately and logically depicted deformation geometry and nonlinear mechanical characteristics.

关键词： Woven compositeﬂexible skin Nonlinear performance Uniform normal pressure Geometric model Mechanical model Aspect ratio

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia Xiu-jun Zhan Charity Ngina Qing-Rui Zhang Xiao-Ge Li Qi-Bao jiang Shi Bai Miao-Miao jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

A concise synthesis of (±)-pregabalin via intramolecular C-H insertion of N-cumyl á-diazoacetamide

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合成化学 2004年第Z1期12卷 31-31页

作者： chen Zhen-liang LIU Wei-jun chen Zhi-yong jiang Yao-zhong HU Wen-hao Key laboratory for Asymmetric Synthesis and Chiratechnology Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China Key laboratory for Asymmetric Synthesis and Chiratechnology Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China Key laboratory for Asymmetric Synthesis and Chiratechnology Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China Key laboratory for Asymmetric Synthesis and Chiratechnology Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China Key laboratory for Asymmetric Synthesis and Chiratechnology Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China

Pregabalin 1 (3-aminomethyl-5-methyl hexanoic acid) is a potent anticonvulsant related to the inhibitory neurotransmitter a-aminobutyric acid (GABA).1 In preclinical trials of anticonvulsant activity, pregabalin is three to ten times more potent than gabapentin. Therefore,pregabalin can be used for the potential treatment of several central nervous system (CNS) disorders including epilepsy, neuropathic pain, anxiety and social phobia. Many synthetic routes have been developed to prepare pregabalin.2-3 However, there is a need to explore novel, practical and better synthetic approaches to pregabalin. Herein we report a concise synthesis of (±)-pregabalin from hydrolysis of corresponding (a)-lactam, which was obtained from the intramolecular C-H insertion of N-cumyl a-diazoacetamide 4.

关键词： Pregabalin, C-H insertion,(a)-lactam

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星载铯束管内铯炉的力学特性研究

真空科学与技术学报 2016年第10期36卷 1205-1209页

作者：杨军张涤新陈江王骥郑宁朱宏伟马寅光兰州空间技术物理研究所真空技术与物理重点实验室兰州730000

在ANSYS Workbench软件中建立了星载铯束管内铯炉的有限元模型。采用兰索斯法对模型作了模态分析,获得了铯炉的固有频率及振型。利用模态叠加法对模型作了铯炉的谐响应分析,研究了铯炉及其内部关键部件的结构变形与应力分布情况。数值... 详细信息

在ANSYS Workbench软件中建立了星载铯束管内铯炉的有限元模型。采用兰索斯法对模型作了模态分析,获得了铯炉的固有频率及振型。利用模态叠加法对模型作了铯炉的谐响应分析,研究了铯炉及其内部关键部件的结构变形与应力分布情况。数值结果表明:炉体主体结构和铯泡支撑体是铯炉力学特性的关键环节,会影响石墨、铯泡和准直器的工作性能。针对结构设计中存在的薄弱环节,提出了对铯炉主体结构和铯泡支撑体进行改进的有效措施。改进后铯炉的力学特性增强,对比铯束管内芯的基频,可避免铯炉不会发生共振。同时,由于抑制了振动对炉体内关键部件的影响,使得铯炉对铯流体的管理能力明显增强。

关键词：铯炉铯泡多孔材料力学特性有限元

Monitoring micro-structural evolution during aluminum sintering and understanding the sintering mechanism of aluminum nanoparticles:A molecular dynamics study

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Journal of Materials Science & Technology 2020年第22期54卷 92-100页

作者： jun jiang Pengwan chen Weifu Sun State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing401120China

In this work, molecular dynamics simulations have been performed to explore the structural evolution and underlying sintering mechanism of aluminum nanoparticles. The structural evolution during sintering was firstly monitored through radial distribution function and atomic migration, and the underlying sintering mechanism was further quantitatively characterized in terms of average displacement, mean squared distance(MSD), radius ratio(i.e., the ratio of the neck radius to the particle radius), shrinkage and radius of gyration, crystalline orientations, particle size, etc. Results show that the surface atoms of nanoparticles are more active than the internal atoms, favoring the mechanical rotation of nanoparticles during sintering. During the sintering process, average displacement, radius ratio and the shrinkage rate have undergone three stages with increasing the temperature:(1) a slow increase and subsequent abrupt hike after reaching the sintering temperature;(2) an almost plateau region over a wide span of temperature;(3) finally a sharp increase again after reaching the melting temperature. In contrast, MSD remains basically unchanged before melting, close to zero, followed by a sudden increase after melting temperature. Although the radius of gyration also experiences three stages, nonetheless it exhibits almost completely contrary trend. It has also been found that both sintering temperature and melting temperature demonstrate an almost linear increase with the increase of nanoparticle size ranging from4.0, 6.0, 8.0 to 10.0 nm in diameter. Finally, we also found that the particle direction has limited effect on neck growth during sintering.

关键词： Molecular dynamics simulation Aluminum nanoparticle Sintering Mechanical contact Microstructural evolution

Zinc-based fiber-shaped rechargeable batteries:Insights into structures,electrodes,and electrolytes

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Nano Research 2025年第1期18卷 278-293页

作者： Xuan Zhang Hongcheng Zhang Mengxiang chen Jingqi Lu Evgeny Zhuravlev Jing jiang Pin Liu Shengyang Dong Du Yuan Guoyin Zhu Lianbo Ma Yizhou Zhang Institute of Advanced Materials and Flexible Electronics(IAMFE) School of Chemistry and Materials ScienceNanjing University of Information Science and TechnologyNanjing 210044China School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China College of Materials Science and Engineering Changsha University of Science and TechnologyChangsha 410004China

The rapid evolution of flexible wearable electronics has spurred a growing demand for energy storage devices,characterized by low-cost manufacturing processes,high safety standards,exceptional electrochemical performance and robust mechanical *** novel flexible devices,fiber-shaped batteries(FSBs)have emerged as prominent solutions exceptionally suited to future applications,owing to their unique one-dimensional(1D)architecture,remarkable flexibility,potential for miniaturization,adaptability to deformation and compatibility with the conventional textile *** the forefront research on fiber-shaped batteries,zincbased FSBs(ZFSBs)have garnered significant attentions,featured by the promising electrochemical properties of metallic *** enthusiasm is driven by the impressive capacity of Zn(820 mAh·g^(-1))and its low redox potential(Zn/Zn^(2+):-0.76 V *** hydrogen electrode).This review aims to consolidate recent achievements in the structural design,fabrication processes and electrode materials of flexible ***,we highlight three representative structural configurations:parallel type,twisted type and coaxial *** also place special emphasis on electrode modifications and electrolyte ***,we delve into the promising development opportunities and anticipate future challenges associated with ZFSBs,emphasizing their potential roles in powering the next generation of wearable electronics.

关键词： zinc-based batteries fiber-shape parallel type twisted type coaxial type