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Dynamically changing antineutrophil cytoplasmic antibodies in granulomatosis with polyangiitis:A case report

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World Journal of Clinical Cases 2024年第16期12卷 2881-2886页

作者： Yan Zhang Qiao-Ding dai Ji-An Wang Li-Ping Xu Qiang chen Yang-Zi Jin Department of Rheumatism and Immunology The First Affiliated Hospital of Zhejiang Chinese Medical University/Zhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006Zhejiang ProvinceChina Department of Orthopaedics The Affiliated Xiaoshan Hospital of Hangzhou Normal UniversityHangzhou 311202Zhejiang ProvinceChina Department of Otolaryngology The First Affiliated Hospital of Zhejiang Chinese Medical University/Zhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006Zhejiang ProvinceChina

BACKgROUND granulomatosis with polyangiitis(gPA)is one of the most prevalent forms of the antineutrophil cytoplasmic antibody(ANCA)-associated *** is characterized histologically by necrotizing granulomatous inflammation in addition to *** diagnosis of gPA depends on clinical presentation,serological evidence of a positive ANCA,and/or histological evidence of necrotizing vasculitis or granulomatous destructive parenchymal *** ANCA(c-ANCA)is positive in 65%-75% of gPA patients,accompanied by proteinase 3(PR3),the main target antigen of c-ANCA,another 5% of gPA patients had negative *** SUMMARY The patient,a 52-year-old male,presented with unexplained nasal congestion,tinnitus,and hearing *** a duration of 4 months experiencing these symptoms,the patient subsequently developed fever and *** imaging examination revealed the presence of bilateral auricular mastoiditis and partial paranasal sinusitis,and the ANCA results were *** anti-infective therapy proved to be ineffective,but the patient's symptoms and fever were quickly relieved after 1 wk of treatment with methylprednisolone 40 mg once a ***,after continuous use of methylprednisolone tablets for 3 months,the patient experienced a recurrence of fever accompanied by right-sided migraine,positive c-ANCA and PR3,and increased total protein in cerebrospinal *** and cyclophosphamide 0.8 g monthly,the patient experienced alleviation of fever and ***,the ANCA levels became negative and there has been no *** For gPA patients with negative ANCA,there is a potential for early missed *** integration of histopathological results and multidisciplinary communication plays a crucial role in facilitating ANCA-negative gPA.

关键词： Anti-neutrophil cytoplasmic antibodies granulomatosis with polyangiitis Antineutrophil cytoplasmic antibodyassociated vasculitis Immunosuppressive therapy Case report

弱精子症患者精子锌稳态蛋白、gPR39和ANO1 mRNA的表达变化及其临床意义

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中华男科学杂志 2024年第1期30卷 18-25页

作者：贺春戴芳芳刘俊生耿亚松周均霞胡一珍郑波王树松邢台不孕不育专科医院检验科河北邢台054004 河北省生殖健康科学技术研究院/河北省生殖医学重点实验室河北石家庄050071

目的:探究锌稳态相关蛋白、g蛋白偶联受体39(gPR39)及ANO1 mRNA在弱精子症精子中的表达变化,并分析其与精子运动能力的相关性。方法:选取2022年6月至2023年4月我中心收集的弱精子症患者精液标本(PR+NP15×10^(6)/ml)40例,正常精液标本(P... 详细信息

目的:探究锌稳态相关蛋白、g蛋白偶联受体39(gPR39)及ANO1 mRNA在弱精子症精子中的表达变化,并分析其与精子运动能力的相关性。方法:选取2022年6月至2023年4月我中心收集的弱精子症患者精液标本(PR+NP15×10^(6)/ml)40例,正常精液标本(PR+NP≥40%,PR≥32%,精子浓度>15×10^(6)/ml)42例。通过CASA检测精液常规参数及精子活力,测量两组精浆锌的含量,运用实时荧光定量PCR(RT-qPCR)对两组精子锌转运蛋白(ZIP13、ZIP8、ZNT10)、金属硫蛋白(MT1g、MT1、MTF)、gPR39和钙依赖性氯离子通道蛋白(ANO1)表达进行定量检测;运用激光共聚焦检测精子中的游离锌分布;运用免疫荧光染色观察精子中gPR39、MT1蛋白的表达;进一步采用Spearman秩相关分析其与精液参数的相关性。结果:与正常组相比,弱精子症组精浆锌的浓度无明显差异(P>0.05),弱精子症组精子游离锌水平明显降低(Pg、MTF、ZIP13、gPR39、ANO1 mRNA相对表达量低于正常组(P0.05);免疫荧光结果显示弱精子组gPR39蛋白表达较低(Pg、MTF、gPR39、ANO1 mRNA相对表达量与前向运动精子百分率和精子活动率呈正相关(Pg、MTF、ZIP13)、gPR39和ANO1 mRNA表达下调且其表达与精子运动能力呈正相关。

关键词：弱精子症锌敏感受体gPR39 ANO1 精子活力

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钼精选尾矿浮选回收铜

矿冶 2024年第2期33卷 210-216,224页

作者：车文芳杨剑波代旺邓荣东洛阳栾川钼业集团股份有限公司河南洛阳471000 福州大学紫金地质与矿业学院福州350000

某矿山钼精选尾矿含铜0.526%,铜主要以黄铜矿形式存在,具有综合回收利用价值。尾矿中其它矿物主要为石英、绿泥石和黄铁矿。尾矿粒度极细,且黄铁矿含量高,铜硫分离困难。采用单因素条件试验系统研究了浮选工艺参数条件和药剂制度对铜精... 详细信息

某矿山钼精选尾矿含铜0.526%,铜主要以黄铜矿形式存在,具有综合回收利用价值。尾矿中其它矿物主要为石英、绿泥石和黄铁矿。尾矿粒度极细,且黄铁矿含量高,铜硫分离困难。采用单因素条件试验系统研究了浮选工艺参数条件和药剂制度对铜精矿铜品位和铜回收率的影响,进一步优化工艺参数条件,并分别开展了开路和闭路浮选试验。结果表明,最佳浮选工艺参数条件和药剂用量分别为:矿浆浓度30%、水玻璃用量1000 g/t、石灰用量500 g/t、硫酸铜用量300 g/t、丁基黄药50 g/t、充气量0.2 m^(3)/h;采用一次粗选、三次精选、三次扫选(一粗三精三扫)的浮选工艺流程,最终可获得铜品位24.18%、铜回收率85.65%的铜精矿,综合浮选指标较佳,可实现钼精选尾矿中有价金属铜的高效回收。

关键词：钼精选尾矿钼浮选铜回收铜精矿

CDH1 promoter polymorphism(-347g→gA) is a possible prognostic factor in sporadic colorectal cancer

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World Journal of gastroenterology 2009年第42期15卷 5340-5345页

作者： Xiao-Ping Zou Wei-Jie dai jun Cao Department of gastroenterology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210008 Jiangsu Province China Department of Internal Medicine Clinical Medical Colleges of Drum Tower Nanjing Medical University Nanjing 210029 Jiangsu Province China

AIM:To investigate the role of the-347g→gA polymorphism in the progression of colorectal cancer(CRC) .METHODS:We designed a case-control study based on a population of CRC patients in China and normal healthy controls with no history of tumors or inherited *** chain reaction-restriction fragment length polymorphism(PCR-RFLP) analyses were used to genotype the variants,and immunohistochemical staining was performed to measure the expression of E-cadherin in different allele cases among the CRC patients and normal ***:The gA-allele(g/gA heterozygous and gA/gA homozygous) did not increase the risk of CRC compared with the g-allele(OR = 1.232,95% CI = 0.898-1.691) .However,the frequencies of the gAallele were higher in poorly differentiated(P = 0.002) and proximal(P = 0.019) CRC patients than in normal *** also observed that E-cadherin expression was lower in poorly differentiated CRC patients than in well differentiated CRC patients(P = 0.001) .Furthermore,E-cadherin expression was lower for the gA-allele than for the g-allele(g/g heterozygous) in CRC patients(P = 0.018) .In contrast,there was no significant difference in E-cadherin expression for the g-allele and gA-allele in normal controls(P = 0.292) .CONCLUSION:The-347g→gA promoter polymorphism in E-cadherin gene is associated with specific CRC features,and may be a prognostic factor rather than a susceptibility factor during the progression of CRC.

关键词： Allele Colorectal cancer E-cadherin Polymorphism Prognosis

分子印迹固相萃取-比率荧光法测定熟地黄中苯并[α]芘的含量

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实验室检测

实验室检测 2024年第6期2卷 47-52页

作者：文心懿戴寅范卉竹戴岭洪俊丽南京医科大学第一临床医学院南京医科大学药学院南京师范大学附属中学江宁分校

目的建立分子印迹固相萃取-比率荧光法,测定中药材熟地黄中苯并[α]芘（BaP）的含量。方法以表面树状功能化接枝的磁性硅胶纳米粒（Fe3O4@SiO2@PAMAM）为载体,BaP为模板分子,采用溶胶-凝胶法制备BaP分子印迹聚合物（BaP-MMIPs）。通... 详细信息

目的建立分子印迹固相萃取-比率荧光法,测定中药材熟地黄中苯并[α]芘（BaP）的含量。方法以表面树状功能化接枝的磁性硅胶纳米粒（Fe3O4@SiO2@PAMAM）为载体,BaP为模板分子,采用溶胶-凝胶法制备BaP分子印迹聚合物（BaP-MMIPs）。通过选择性识别吸附,比率荧光法检测,以浓度（C）为横坐标,荧光信号比值(I436/I604)为纵坐标,计算回归方程。结果成功合成具有特异识别性能的BaP-MMIPs,应用于熟地黄样品中BaP的高灵敏检测。BaP在0.14～3.0μg/mL范围内线性关系良好。检测限为80 ng/mL,定量限为112.5 ng/mL。回收率为89.5%～106.8%,RSD不大于3.6%。结论所建立分析方法结果准确,选择性高,灵敏度与重现性好,检测成本低,简便快速,可为中药BaP的限量控制提供参考。

关键词：熟地黄苯并[α]芘比率荧光分子印迹

g-C_(3)N_(4) encapsulated ZrO_(2) nanofibrous membrane decorated with CdS quantum dots: A hierarchically structured, self-supported electrocatalyst toward synergistic NH3 synthesis

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Nano Research 2021年第5期14卷 1479-1487页

作者： jun Song Jin dai Peng Zhang Yitao Liu Jianyong Yu Bin Ding Key Laboratory of Textile Science&Technology(Donghua University) Ministry of EducationInnovation Center for Textile Science and TechnologyDonghua UniversityShanghai200051China Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province Yancheng Institute of TechnologyYancheng224051China College of Textiles Donghua UniversityShanghai201620China State Center for International Cooperation on Designer Low-Carbon&Environmental Materials(CDLCEM) School of Materials Science and EngineeringZhengzhou UniversityZhengzhou450001China

The advancement of electrocatalytic N2 reduction reaction (NRR) toward ambient NH3 synthesis lies in the development of more affordable electrocatalysts than noble metals. Recently, various nanostructures of transition metal compounds have been proposed as effective electrocatalysts;however, they exist in the form of loose powders, which have to be immobilized on a matrix before serving as the electrode for electrolysis. The matrix, being it carbon paper, carbon cloth or metal foam, is electrocatalytically inactive, whose introduction inevitably raises the invalid weight while sacrificing the active sites of the electrode. Herein, we report on the fabrication of a flexible ZrO2 nanofibrous membrane as a novel, self-supported electrocatalyst. The heteroatom doping can not only endow the nanofibrous membrane with excellent flexibility, but also induce oxygen vacancies which are responsible for easier adsorption of N2 on the ZrO2 surface. To improve the electrocatalytic activity, a facile SILAR approach is employed to decorate it with CdS quantum dots (QDs), thereby tuning its Fermi level. To improve the conductivity, a g-C3N4 nanolayer is further deposited which is both conductive and active. The resulting hierarchically structured, self-supported electrocatalyst, consisting of g-C3N4 encapsulated ZrO2 nanofibrous membrane decorated with CdS QDs, integrates the merits of the three components, and exhibits a remarkable synergy toward NRR. Excellent NH3 yield of 6.32 × 10−10 mol·s−1cm−2 (−0.6 V vs. RHE) and Faradaic efficiency of 12.9% (−0.4 V vs. RHE) are attained in 0.1 M Na2SO4.

关键词： ZrO_(2)nanofibrous membrane CdS quantum dots g-C_(3)N_(4)nanolayer self-supported electrocatalyst NH_(3)synthesis

Pt-surface oxygen vacancies coupling accelerated photo-charge extraction and activated hydrogen evolution

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Nano Research 2023年第4期16卷 4736-4741页

作者： Fangxu dai Mingming Zhang Mingzhong Mi Zhenjiang Li jun Xing Lei Wang Key Laboratory of Eco-chemical Engineering Ministry of EducationCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China College of Environment and Safety Engineering Qingdao University of Science and TechnologyShandong Engineering Research Center for Marine Environment Corrosion and Safety ProtectionQingdao 266042China

Semiconductors-based heterogeneous photocatalytic water splitting has been extensively studied,but it still remains challenging to accelerate the separation of electron-hole pairs and facilitate the reaction *** we report a general strategy to fabricate highly efficient Pt/TiO_(2)photocatalyst by coupling the Pt co-catalysts and surface oxygen vacancies(VO)of TiO_(2).TiO_(2)was pre-modified with alkali or alkaline earth metals ion solutions,which produce a large number of surface hydroxyl on TiO_(2).Subsequently,the photodeposited Pt sub-nanoparticles substitute surface hydroxyl and induce surface VO on TiO_(2).The coupling of Pt and surface VO on TiO_(2)can accelerate the extraction of photo-charges through the interaction of Pt-VO-Ti bonds and reduce the hydrogen evolution barrier,thereby promoting the photocatalytic *** synthesized Pt-VO-TiO_(2)sample exhibits a photocatalytic hydrogen evolution activity as high as 1.5 L·g^(−1)·h^(−1),which is 2.2 times that of traditional Pt/TiO_(2).Our findings indepth understand the synergistic effect of co-catalysts and defects on photocatalysis and open up new possibilities for achieving robust photocatalytic water splitting.

关键词： oxygen vacancies co-catalyst surface hydroxyl photocatalytic hydrogen evolution reaction(HER)

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膜内麻雀优化ELM的软件缺陷预测算法

北京航空航天大学学报 2024年第2期50卷 643-654页

作者：唐宇代琪杨梦园陈丽芳华北理工大学理学院唐山063210 中国石油大学信息科学与工程学院北京102249 河北省数据科学与应用重点实验室唐山063210

原始麻雀搜索算法存在寻优精度低、迭代后期容易陷入局部极值的问题,结合高效寻优性能的改进麻雀搜索算法和具有并行计算能力的膜计算,提出一种膜内麻雀优化算法(IMSSA)。在10个CEC2017测试函数上的实验结果表明,IMSSA具有更高的寻优精... 详细信息

原始麻雀搜索算法存在寻优精度低、迭代后期容易陷入局部极值的问题,结合高效寻优性能的改进麻雀搜索算法和具有并行计算能力的膜计算,提出一种膜内麻雀优化算法(IMSSA)。在10个CEC2017测试函数上的实验结果表明,IMSSA具有更高的寻优精度。为进一步验证IMSSA的性能,使用IMSSA优化极限学习机(ELM)参数,提出一种膜内麻雀优化ELM(IMSSA-ELM)算法,并将其应用于软件缺陷预测领域。实验结果表明:在15个公开的软件缺陷数据集中,IMSSA-ELM算法预测性能在g-mean、MCC这2个评价指标下明显优于其他4种先进的对比算法,表明IMSSA-ELM算法具有更好的预测精度和稳定性,其实验结果在Friedman ranking和Holm’s post-hoc test非参数检验中具有明显的统计显著性。

关键词：改进麻雀搜索算法膜计算极限学习机优化算法软件缺陷预测

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5g陶瓷滤波器用喷涂银浆

华中科技大学学报（自然科学版） 2024年第3期52卷 78-83页

作者：黄帅谭划张海波彭戴武汉船用电力推进装置研究所湖北武汉430064 华中科技大学材料科学与工程学院材料成形与模具技术国家重点实验室湖北武汉430074 广东华中科技大学工业技术研究院广东东莞523808

从5g陶瓷滤波器用银浆的工艺特性出发,制备了分散性好、一致性高、烧结性能优异的球形亚微米银粉;制备了工艺匹配性好、拉力高的玻璃粉;制备了能湿润5g陶瓷滤波器精细化结构的有机载体.制造出5g陶瓷滤波器用喷涂银浆,其性能参数为:银含... 详细信息

从5g陶瓷滤波器用银浆的工艺特性出发,制备了分散性好、一致性高、烧结性能优异的球形亚微米银粉;制备了工艺匹配性好、拉力高的玻璃粉;制备了能湿润5g陶瓷滤波器精细化结构的有机载体.制造出5g陶瓷滤波器用喷涂银浆,其性能参数为:银含量为78%,黏度为7 Pa·s,方块电阻为4 mΩ,拉力为21 N/mm^(2).该银浆对5g陶瓷滤波器元器件的外表面、通孔、盲孔、凹槽等处均具有很好的金属化效果,银层没有出现缺银、龟裂、毛刺、流挂等问题.该5g陶瓷滤波器用喷涂银浆具有雾化性能好、湿润性高、不流挂、低方阻、高拉力的优点,在5g陶瓷滤波器领域具有广泛的应用前景.

关键词：陶瓷滤波器银粉玻璃粉有机载体喷涂银浆