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Protective effect of Liangxue Huayu decoction on human retinal pigment epithelial cell(ARPE-19)injury induced by hypoxia through autophagy pathway

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Pharmacology Discovery 2024年第1期4卷 44-50页

作者： Han-Ran Zheng Yi-Tong Lin Sheng Chen Zi-Yang Chen jun-chang cao Zhao-Da Ye Yan-Hong Hu College of graduate Fujian University of Traditional Chinese MedicineFujian 350122China Department of Ophthalmology The Second People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFujian 350003China Comprehensive Outpatient Department Fujian Academy of Traditional Chinese Medicine SciencesFujian 350003China

Background:Exploring the protective mechanism of the Liangxue Huayu(LXHY)decoction on human retinal pigment epithelial(RPE)cells induced by hypoxia through the autophagy ***:The appropriate LXHY decoction concentration was determined by ***-19 cells were divided into the normal control group(A group),CoCl_(2)group(B group),3-Methyladenine(3-MA)group(treated with 3-MA(the inhibition of autophagy pathway))(C group),blank serum(BS)group(D group),LXHY drug-contained serum(DCS)group(E group),and Rapamycin(RAP)group[treated with LXHY drug-contained serum combined with rapamycin group(the activation of autophagy pathway)](F group).Counting the number of autophagosomes and autolysosomes in each group of cells under transmission electron *** infection of cells in each group by mRFP-GFP-LC3 fusion protein adenovirus,the strength of autophagic flux was *** mRNA expression levels of LC3 and Beclin-1 were detected by ***:CCK-8 assay results showed that LXHY DCS could inhibit the cell proliferation of ARPE-19 under hypoxia(all P<0.05).As the transmission electron microscopy assay result showed,compared with the normal control group,the number of autolysosomes was significantly increased in the CoCl_(2)group(P<0.05).Compared with CoCl_(2)group,the number of autolysosomes was significantly reduced the 3-Methyladenine group,blank serum group and LXHY drug-contained serum group(all P<0.001).As autophagic flux assay result showed,compared with the normal control group,the level of autophagosomes and autolysosomes were significantly risen in CoCl_(2)group(all P<0.001).Compared with the CoCl_(2)group,the level of autophagosomes and autolysosomes were significantly fell down in 3-Methyladenine group,blank serum group and LXHY drug-contained serum group(all P<0.05).The level of autolysosomes in the LXHY drug-contained serum group was lower than in the blank serum group(P<0.05).Compared with the LXHY drug-contained serum group,the levels o

关键词： Liangxue Huayu decoction age-related macular degeneration autophagy lysosome autophagosomes

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Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue Wei Wen-Bo cao Sai-jun Mo Zhi-Yan Sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

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Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 143-157页

作者： Xian-Rang cao Yin-Long Xu Jia-Wei Chai Kai Zheng jun-Jie Kong jun Liu Shun-Zhen Zheng Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Breast and Thyroid Surgery Shandong Provincial Maternal and Child Health Care HospitalJinan 250014Shandong ProvinceChina

BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various *** To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively *** between pretreatment RDW and clinicopathological characteristics and short-term outcomes were *** Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal *** pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,P<0.001)and severe POCs of grade IIIa or higher(hazard ratio=3.138,95%confidence interval:2.042-4.824,P<0.001)based on the Clavien-Dino classification *** analysis showed that high pretreatment RDW was an independent risk factor for Clavien-Dino classi-fication grade IIIb or higher POCs,a comprehensive complication index score≥26.2,severe postoperative pancreatic fistula,severe bile leakage and severe *** pretreatment RDW was positively associated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and was negatively associated with albumin and the prognostic nutritional *** Pretreatment RDW was a special parameter for patients who underwent *** was associated with malnutrition,severe inflammatory status and poorer short-term *** could be a surrogate marker for nutritional and inflammatory status in identifying patients who were at high risk of developing POCs after LPD.

关键词： Biomarker Laparoscopic pancreatoduodenectomy Postoperative complication Red blood cell distribution width Short-term outcomes

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压电换能器长度位移测量的一种新方法

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光电子．激光 2011年第2期22卷 166-169页

作者：来志曾晓东冯喆君曹长庆西安电子科技大学技术物理学院陕西西安710071

针对合成孔径激光雷达光源调腔用压电换能器(PZT)长度位移进行高精度测量的需要,提出一种基于干涉图像灰度最佳估计的双光束干涉测量方法。通过合理设计算法,理论上测量分辨率能够达到光源激光器波长的1/1 024;实验上对一管型PZT的长度... 详细信息

针对合成孔径激光雷达光源调腔用压电换能器(PZT)长度位移进行高精度测量的需要,提出一种基于干涉图像灰度最佳估计的双光束干涉测量方法。通过合理设计算法,理论上测量分辨率能够达到光源激光器波长的1/1 024;实验上对一管型PZT的长度位移进行了测量,精度达到10 nm量级。

关键词：合成孔径雷达压电换能器(PZT) 双光束干涉数字图像处理

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激光外差干涉中声光器件非互易特性研究

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光电子．激光 2011年第12期22卷 1765-1768页

作者：霍雷曾晓东冯喆珺曹长庆西安电子科技大学技术物理学院陕西西安710071

针对声光器件存在的非互易现象导致光强衰减影响衍射效率并降低激光外差干涉效率的问题,进行了一种基于声光驱动100MHz时声光器件非互易效应对激光外差干涉影响的研究。以光束衍射实验为主体,结合光阑、TeO2晶体对声光器件非互易值进行... 详细信息

针对声光器件存在的非互易现象导致光强衰减影响衍射效率并降低激光外差干涉效率的问题,进行了一种基于声光驱动100MHz时声光器件非互易效应对激光外差干涉影响的研究。以光束衍射实验为主体,结合光阑、TeO2晶体对声光器件非互易值进行测量,利用光功率计获得测量过程中的器件非互易数值,在不同驱动频率下分析衍射效率分布情况;并利用100MHz的声光调制器(AOM)进行激光外差干涉实验,判断声光器件非互易效应对外差中频信号的影响。实验表明,在AOM中心频率为100～105MHz情况下,利用非互易进行激光外差干涉实验,外差信号功率从+13dBm增加到+21dBm。结果表明,射频在100MHz时声光器件中存在非互易效应,利用非互易效应可有效提高激光外差干涉效率。

关键词：声光器件衍射效率非互易效应外差干涉

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葡萄膜炎并发白内障术中使用Chop钩象限性机械扩张瞳孔的效果

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国际眼科杂志 2022年第12期22卷 1943-1947页

作者：陈子扬曹俊昌叶照达陈胜胡艳红福建省中医药科学院综合门诊部福建福州350003 福建中医药大学附属第二人民医院眼科福建福州350003

目的:报道在葡萄膜炎并发白内障患者的白内障手术中使用一种特殊的Chop钩象限性机械扩张瞳孔的手术效果。方法:单手术、回顾性、非比较病例报道。纳入在白内障术中接受Chop钩象限性机械扩张瞳孔特殊技术治疗的葡萄膜炎并发白内障患者。... 详细信息

目的:报道在葡萄膜炎并发白内障患者的白内障手术中使用一种特殊的Chop钩象限性机械扩张瞳孔的手术效果。方法:单手术、回顾性、非比较病例报道。纳入在白内障术中接受Chop钩象限性机械扩张瞳孔特殊技术治疗的葡萄膜炎并发白内障患者。结果:共14例葡萄膜炎并发白内障患者16眼,男性5例,女性9例,平均年龄58.0±13.8(29~79)岁,在白内障手术中接受Chop钩象限性机械扩张瞳孔治疗。采用象限性机械瞳孔扩张后,扩张瞳孔直径为5.81±0.46(5.0~6.5)mm,并可保持至手术结束。术后,瞳孔居中,约为圆形,瞳孔直径为3.0~4.0mm。在某些情况下,在虹膜和瞳孔的边缘观察到小切迹,但患者没有出现眩光不适,直接和间接的光反射大致正常。散瞳孔治疗后,瞳孔变圆,与人工晶状体无粘连,术后最佳矫正视力(BCVA)明显优于术前(P21mmHg)、虹膜撕裂、虹膜异常、后粘连。结论:该象限机械瞳孔扩张技术对于葡萄膜炎并发白内障患者是一种简单有效的白内障手术方法,且并发症发生率低。

关键词：瞳孔扩张葡萄膜炎并发性白内障

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A novel image segmentation approach for wood plate surface defect classification through convex optimization

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Journal of Forestry Research 2018年第6期29卷 1789-1795页

作者： Zhanyuan chang jun cao Yizhuo Zhang College of Mechanical and Electrical Engineering Northeast Forestry University College of Information Mechanical and Electrical EngineeringShanghai Normal University

Detection of wood plate surface defects using image processing is a complicated problem in the forest industry as the image of the wood surface contains different kinds of defects. In order to obtain complete defect images, we used convex optimization(CO) with different weights as a pretreatment method for smoothing and the Otsu segmentation method to obtain the target defect area images. Structural similarity(SSIM) results between original image and defect image were calculated to evaluate the performance of segmentation with different convex optimization weights. The geometric and intensity features of defects were extracted before constructing a classification and regression tree(CART) classifier. The average accuracy of the classifier is 94.1% with four types of defects on Xylosma congestum wood plate surface: pinhole, crack,live knot and dead knot. Experimental results showed that CO can save the edge of target defects maximally, SSIM can select the appropriate weight for CO, and the CART classifier appears to have the advantages of good adaptability and high classification accuracy.

关键词： Convex optimization Threshold segmentation Structure similarity Decision tree Defect recognition

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Study on the Biological Activity of 3-Aroyl-5-substituted Thiophene Derivatives Based on the CoMFA Method

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Chinese Journal of Structural Chemistry 2020年第11期39卷 1978-1984页

作者： FENG Hui FENG chang-jun cao Jing-Pei Key Laboratory of Coal Processing and Efficient Utilization(Ministry of Education) Xuzhou 221116China School of Chemistry&Chemical Engineering Xuzhou University of TechnologyXuzhou 221018China

A three-dimensional quantitative structure-activity relationship(3 D-QSAR) study was conducted to analyze the A1 AR density(Bmax) of 56 3-aroyl-5-substituted thiophene derivatives(ASTDs) in human A1 Chinese hamster ovary(hA1 CHO) membranes by the comparative molecular field analysis(CoMFA) method. A training set of 45 compounds was used to establish the predictive model, which was verified by the test set of 17 compounds containing template molecule and 5 newly designed molecules. The cross-validation(R2 cv) and non-cross-validation(R2) coefficients of the training set were 0.655 and 0.959, respectively. The model was used to predict the activities of the compounds of the training and test sets, and the results indicated that the models had strong stability and good prediction ability. According to model analysis, the contribution of steric and electrostatic fields was 51.4% and 48.6%, respectively. Based on the 3 D contour maps, five excellent ASTDs agonists were designed, which need to be further verified by biomedical experiments.

关键词： 3-aroyl-5-substituted thiophene derivatives(ASTDs) A1AR density(Bmax) three-dimensional quantitative structure-activity relationship comparative molecular field analysis

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu junqiu Jia Rui Mao Xiang cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Metal-organic frameworks bonded with metal N-heterocyclic carbenes for efficient catalysis

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National Science Review 2022年第6期9卷 64-73页

作者： chang He jun Liang Yu-Huang Zou jun-Dong Yi Yuan-Biao Huang Rong cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Science and Technology Innovation Laboratory for Optoelectronic Information of China

Metal N-heterocyclic carbenes(M-NHCs) on the pore walls of a porous metal-organic framework(MOF)can be used as active sites for efficient organic catalysis. Traditional approaches that need strong alkaline reagents or insoluble Ag2O are not, however, suitable for the incorporation of NHCs on the backbones of MOFs because such reagents could destroy their frameworks or result in low reactivity. Accordingly,development of facile strategies toward functional MOFs with covalently bound M-NHCs for catalysis is needed. Herein, we describe the development of a general and facile approach to preparing MOFs with covalently linked active M-NHC(M = Pd, Ir) single-site catalysts by using a soluble Ag salt AgOC(CF3)3as the source and subsequent transmetalation. The well-defined M-NHC-MOF(M = Pd, Ir) catalysts obtained in this way have shown excellent catalytic activity and stability in Suzuki reactions and hydrogen transfer reactions. This provides a general and facile strategy for anchoring functional M-NHC single-site catalysts onto functionalized MOFs for different reactions.

关键词： metal-organic framework N-heterocyclic carbene MIL-101 Suzuki reaction transfer hydrogenation

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