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Identification of Hub Genes and Key Pathways Associated with Peripheral T-cell Lymphoma

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Current Medical Science 2020年第5期40卷 885-899页

作者： Hai-xia GAO Meng-bo WANG Si-jing LI Jing NIU Jing XUE jun LI Xin-xia LI Department of Pathology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054China Xinjiang Medical University Urumqi 830011China Deparment of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases The First Affiliated HospitalShihezi University School of MedicineShihezi 832002China Department of Ultrasound The First Affiliated HospitalShihezi University School of MedicineShihezi 832002China

Peripheral T-cell lymphoma(PTCL)is a very aggressive and heterogeneous hematological malignancy and has no effective targeted *** molecular pathogenesis of PTCL remains *** this study,we chose the gene expression profile of GSE6338 from the Gene Expression Omnibus(GEO)database to identify hub genes and key pathways and explore possible molecular pathogenesis of PTCL by bioinformatic *** expressed gencs(DEGs)between PTCL and normal T cells were selected using GEO2R *** ontology(GO)analysis and Kyoto Encyclopedia of Gene and Genome(KEGG)pathway analysis were performed using Database for Annotation,Visualization and Integrated Discovery(DAVID).Moreover,the Search Tool for the Retrieval of Interacting Genes(STRING)and Molecular Complex Detection(MCODE)were utilized to construct protein-protein interaction(PPI)network and perform module analysis of these DEGs.A total of 518 DEGs were identifed,including 413 down-regulated and 105 up-regulated *** down-regulated genes were enriched in osteoclast differentiation,Chagas disease and mitogen-activated protein kinase(MAPK)signaling *** up-regulated genes were mainly associated with extracellular matrix(ECM)-receptor interaction,focal adhesion and pertussis.F our important modules were detected from the PPI network by using MCODE *** hub genes with a high degree of connectivity were *** study identifed DEGs,hub genes and pathways associated with PTCL by bioinformatic *** provide a basis for further study on the pathogenesis of PTCL.

关键词： peripheral Tcell lymphomas bioinformatic analysis protein-protein interaction hub genes pathwayg

An Adaptive Padding Correlation Filter With Group Feature Fusion for Robust Visual Tracking

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IEEE/CAA Journal of Automatica Sinica 2022年第10期9卷 1845-1860页

作者： Zihang Feng Liping Yan Yuanqing xia bo xiao Key Laboratory of Intelligent Control and Decision of Complex Systems the School of AutomationBeijing Institute of TechnologyBeijing 100081China IEEE the School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China

In recent visual tracking research,correlation filter(CF)based trackers become popular because of their high speed and considerable *** methods mainly work on the extension of features and the solution of the boundary effect to learn a better correlation ***,the related studies are *** exploring the potential of trackers in these two aspects,a novel adaptive padding correlation filter(APCF)with feature group fusion is proposed for robust visual tracking in this paper based on the popular context-aware tracking *** the tracker,three feature groups are fused by use of the weighted sum of the normalized response maps,to alleviate the risk of drift caused by the extreme change of single ***,to improve the adaptive ability of padding for the filter training of different object shapes,the best padding is selected from the preset pool according to tracking precision over the whole video,where tracking precision is predicted according to the prediction model trained by use of the sequence features of the first several *** sequence features include three traditional features and eight newly constructed *** experiments demonstrate that the proposed tracker is superior to most state-of-the-art correlation filter based trackers and has a stable improvement compared to the basic trackers.

关键词： Adaptive padding context information correlation filter(CF) feature group fusion robust visual tracking

Simultaneous measurement of velocity profile and liquid film thickness in horizontal gas–liquid slug flow by using ultrasonic Doppler method

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Chinese Journal of Chemical Engineering 2023年第6期58卷 323-340页

作者： Lusheng Zhai bo Xu Haiyan xia Ningde Jin School of Electrical and Information Engineering Tianjin UniversityTianjin 300072Chi

Horizontal gas-liquid two-phase flows widely exist in chemical engineering,oil/gas production and other important industrial *** flow pattern is the main form of horizontal gas-liquid flows and characterized by intermittent motion of film region and slug *** work aims to develop the ultrasonic Doppler method to realize the simultaneous measurement of the velocity profile and liquid film thickness of slug flow.A single-frequency single-channel transducer is adopted in the design of the field-programmable gate array based ultrasonic Doppler system.A multiple echo repetition technology is used to improve the temporal-spatial resolution for the velocity *** experiment of horizontal gas-liquid two-phase flow is implemented in an acrylic pipe with an inner diameter of 20 *** the aerated characteristics of the liquid slug,slug flow is divided into low-aerated slug flow,high-aerated slug flow and pseudo slug *** temporal-spatial velocity distributions of the three kinds of slug flows are reconstructed by using the ultrasonic velocity profile *** evolution characteristics of the average velocity profile in slug flows are investigated.A novel method is proposed to derive the liquid film thickness based on the instantaneous velocity *** liquid film thickness can be effectively measured by detecting the position and the size of the bubbles nearly below the elongated gas *** with the time of flight method,the film thickness measured by the Doppler system shows a higher accuracy as a bubble layer occurs in the film *** effect of the gas distribution on the film thickness is uncovered in three kinds of slug flows.

关键词： Gas–liquid flow Complex fluids Measurement Ultrasonic Doppler Velocity profile Liquid film thickness

Deflagration and detonation induced by shock wave focusing at different Mach numbers

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Chinese Journal of Aeronautics 2024年第2期37卷 249-258页

作者： Zezhong YANG jun CHENG bo ZHANG School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China

Shock wave focusing is an effective way to create a hot spot or a high-pressure and hightemperature region at a certain place,showing its unique usage in detonation initiation,which is beneficial for the development of detonation-based *** flame propagation behavior after the autoignition induced by shock wave focusing is crucial to the formation and self-sustaining of the detonation *** this study,wedge reflectors with two different angles(60°and 90°)and a planar reflector are employed,and the Mach number of incident shock waves ranging from 2.0 to 2.8 is utilized to trigger different flame propagation *** pressure transducers and the high-speed schlieren imaging system are both employed to investigate the shock-shock collision and ignition *** results reveal a total of four flame propagation modes:deflagration,DDT(Deflagration-to-Detonation Transition),unsteady detonation,and direct *** detonation wave formed in the DDT and unsteady detonation mode is only approximately 75%-85%of the Chapman-Jouguet(C-J)speed;meanwhile,the directly induced detonation wave speed is close to the C-J *** waves,which are strong evidence for the existence of detonation waves,are discovered in *** usage of wedge reflectors significantly reduces the initial pressure difference ratio needed for direct detonation *** also provide a practical method for differentiating between detonation and deflagration modes,which involves contrasting the speed of the reflected shock wave with the speed of the theoretically nonreactive reflected shock *** findings should serve as a reference for the detonation initiation technique in advanced detonation propulsion engines.

关键词： Deflagration Detonation Hydrogen Ignition Shock wave focusing

Effects of Contour Hedgerow Intercropping on Nutrient Losses from the Sloping Farmland in the Three Gorges Area,China

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Journal of Mountain Science 2012年第1期9卷 105-114页

作者： WANG Tao ZHU bo xia Lizhong Key Laboratory of Mountain Environment Evolvement and Regulation Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China Institute of Soil Science Chinese Academy of SciencesNanjing 210008China

Eutrophication is recognized as one of the major environmental problems in the Three Gorges *** hedgerows have been used as a major soil and water conservation measure in this ***,a two-year study was conducted to investigate the effects of contour hedgerow intercropping on nutrient loss from sloping farmland in this *** treatments were applied:(1) Maize + Soybean,(2) Maize,(3) Maize + Alfalfa,and(4) Maize + Hemerocallis citrina *** indicated that nutrient loss in the control treatment(Maize) was serious,especially the average loss flux of total nitrogen(2245.8 mg) and total phosphate(2434.2 mg) in a typical rainfall ***,the nutrient losses by runoff in the other three treatments with contour hedgerow intercropping showed significant *** with the control treatment,the total nitrogen loss in the Alfalfa and Hemerocallis citrina Baroni decreased by 80.9% and 85.0%,respectively,and the total phosphorus loss in the two treatments decreased by 91.2% and 92.5%,***,it is concluded that nutrient losses could be reduced by using contour hedgerows in the Three Gorges *** runoff volume and sediment loss was the main mechanisms of contour hedgerow intercropping to reduce nutrient loss.

关键词： Contour hedgerow Sloping farmland Nitrogen Phosphorus Three Gorges Reservoir China

Extended π-conjugated N-containing heteroaromatic hexacarboxylate organic anode for high performance rechargeable batteries

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Journal of Energy Chemistry 2020年第12期29卷 303-311页

作者： Shu-Biao xia Teng Liu Wen-Jin Huang Hong-bo Suo Fei-xiang Cheng Hong Guo Jian-jun Liu Center for Yunnan-Guizhou Plateau Chemical Functional Materials and Pollution Control Qujing Normal UniversityQujing 655011YunnanChina School of Pharmacy Liaocheng UniversityLiaocheng 252059ShandongChina School of Materials Science and Engineering Yunnan UniversityKunming 650091YunnanChina

Organic electrode materials are desirable for green and sustainable Li-ion batteries(LIBs) due to their light-weight, low cost, abundance and multi-electron transfer reactions during battery operation. However, the successful utilization of organic electrodes is hindered by their poor electrical conductivity and low cyclic stability. Herein, a facile synthesis of π-conjugated N-containing heteroaromatic hexacarboxylate(Li6-HAT) compound and its electrochemical performance as an anode material in LIBs is *** as-synthesized Li6-HAT electrode renders an ultrahigh initial capacity of 1126.3 m Ah g^(-1) at the current density of 100 m A g^(-1). Moreover, π-conjugated N-containing heteroaromatic center provide excellent reversibility of(de)lithiation process, resulting in excellent capacity retention. Furthermore, a combination of density functional theory(DFT) calculations, in-situ Fourier transform infrared(FTIR) and ex-situ X-ray photoelectron spectroscopy(XPS) characterization reveal that the π-conjugated nitrogen and carboxyl oxygen act as electrochemically active sites during the charge/discharge process. The current work provides novel insights into the charge storage mechanism of organic electrodes and opens up avenues for further development and utilization of organic electrodes in Li-ion batteries.

关键词： Li-ion batteries Hexacarboxylate π-conjugated compounds N-containing Organic anode

Single-base resolution analysis of DNA epigenome via high-throughput sequencing

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Science China(Life Sciences) 2016年第3期59卷 219-226页

作者： Jinying Peng bo xia Chengqi Yi State Key Laboratory of Protein and Plant Gene Research School of Life Sciences and Peking-Tsinghua Center for Life Sciences Peking University Synthetic and Functional Biomolecules Center College of Chemistry and Molecular Engineering Peking University

Epigenetic changes caused by DNA methylation and histone modifications play important roles in the regulation of various cellular processes and development. Recent discoveries of 5-methylcytosine(5m C) oxidation derivatives including 5-hydroxymethylcytosine(5hm C), 5-formylcytsine(5f C) and 5-carboxycytosine(5ca C) in mammalian genome further expand our understanding of the epigenetic regulation. Analysis of DNA modification patterns relies increasingly on sequencing-based profiling methods. A number of different approaches have been established to map the DNA epigenomes with single-base resolution, as represented by the bisulfite-based methods, such as classical bisulfite sequencing(BS-seq), TAB-seq(TET-assisted bisulfite sequencing), ox BS-seq(oxidative bisulfite sequencing) and etc. These methods have been used to generate base-resolution maps of 5m C and its oxidation derivatives in genomic samples. The focus of this review will be to discuss the chemical methodologies that have been developed to detect the cytosine derivatives in the genomic DNA.

关键词： epigenetics DNA methylation bisulfite sequencing (BS-Seq) TAB-seq oxBS-seq fC-CET

Charmless Hadronic Decays B→VV in the Topcolor－Assisted Technicolor Model

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Communications in Theoretical Physics 2003年第1X期40卷 77-84页

作者： xiaOZhen-jun GUOLi-bo DepartmentofPhysics NanjingNormalUniversityNanjing210097China

Based, on the effective Hamiltonian with the generalized factorization approach, we calculate the branching ratios and CP asymmetries of B→VV decays in the Topcolor-assisted Technicolor (TC2) model. Within the considered parameter space we find that: (a) for the pengunin-domdnated B→K^+φ and K^0φ decays, the new physics enhancements to the branching ratios are around 40%; (b) the measured branching branching ratios of B→K^+φ and K^φ decays prefer the range of 3bout half of the Belle's measurement; and (d) for most B→VV decays, the new physics corrections on their CP asymmetries are generally small or moderate in magnittude and insensitive to the variation of m* and Nc^eff.

关键词： B介子介子衰退分支比不对称 QCD 强相互作用

FORCES ON A NEAR-WALL CIRCULAR CYLINDER

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Journal of Hydrodynamics 2004年第6期16卷 658-664页

作者： ZHANJing-xia WANGJin-jun ZHANGPang-feng FluidMechanicsInstitute BeijingUniversityofAeronauticsandAstronauticsBeijing100083China

The pressure distribution around a near-wall smooth circular cylinder incross-flow was mainly investigated. The experiment was conducted at the sub-critical Reynolds numberranging from 2. 24 · 10~4 to 8. 94 · 10~4, at which the regular vortex separation exists on anisolated circular cylinder. The experimental results indicate that the forces on a circular cylindernear a plane wall are different from those on an isolated circular cylinder. Drag and liftcoefficients of a near-wall circular cylinder strongly depend on gap ratio. The increase of gapratio results in the increase of drag coefficient and the declination of lift coefficient, dragcoefficient ranges from 0. 5 to 1. 0, and lift coefficient from 0. 25 to 0 when gap ratio graduallyincreases from 0 to 1. 0, and then the forces tend to be nearly constant with the increase of gapratio. The attraction between a cylinder and a plane wall, i. e. , downward force, occurs when gapratio lies in certain range. The existence of cylinder changes the pressure gradient on the planewall, and the influence extends to the location where x/D 5. 0 .

关键词： gap ratio static pressure coefficient distribu-tiontlift coefficient dragcoefficient