检索结果-南通市图书馆

RiMOM-IM： A Novel Iterative Framework for Instance Matching

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2016年第1期31卷 185-197页

作者： Chao Shao Lin-Mei Hu Juan-Zi Li Zhi-Chun Wang Tonglee Chung jun-bo xia Department of Computer Science and Technology Tsinghua University Beijing 100084 China College of Information Science and Technology Beijing Normal University Beijing 100875 China

Instance matching, which aims at discovering the correspondences of instances between knowledge bases, is a fundamental issue for the ontological data sharing and integration in Semantic Web. Although considerable instance matching approaches have already been proposed, how to ensure both high accuracy and efficiency is still a big challenge when dealing with large-scale knowledge bases. This paper proposes an iterative framework, RiMOM-IM （RiMOM-Instance Matching）. The key idea behind this framework is to fully utilize the distinctive and available matching information to improve the efficiency and control the error propagation. We participated in the 2013 and 2014 competition of Ontology Alignment Evaluation Initiative （OAEI）, and our system was ranked the first. Furthermore, the experiments on previous OAEI datasets also show that our system performs the best.

关键词： instance matching large-scale knowledge base blocking similarity aggregation

Angiographic prevalence of myocardial bridging in a defined very large number of Chinese patients with chest pain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2008年第5期121卷 405-408页

作者： LI Jian-jun SHANG Zheng-lu YAO Min LI Jie YANG Yue-jin CHEN Ji-lin QIAO Shu-bin MA Wei-hua QIN Xue-wen LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI jun XU bo xia Ran GAO Run-lin Department of Cardiology Fuwai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China

Background Muscle fibers overlying the intramyocardial segment of an epicardial coronary artery are termed myocardial bridging （MB）. Variable prevalence of MB has been described at autopsy and angiographic series with small and large sample size studies. In addition, no similar study was reported in Chinese population. The aim of this study was to investigate the angiographic prevalence of MB in consecutive 37 106 Chinese patients with chest pain from our center. Methods We conducted an observational study to evaluate the consecutive cases with MB among patients undergone selective coronary angiography, and analyzed the angiograhic prevalence and clinical features of MB in this study of very large sample size. Results Among 37 105 patients with chest pain we found 1002 cases with 1011 MBs in a retrospective manner, and the overall prevalence was 2.70%. Although more than 99% （991/1002） of patients had single bridge, 8 cases were found to have more than two MBs （seven with two, and one with three）. Altogether 54.39% of cases （545/1002） had MB without atherosclerotic lesions, and 96.24% （973/1011） of bridging located in the left anterior descending coronary artery （LAD）, mainly in the middle of LAD （792/1011,78.33%）. According to Nobel classification, of the single bridge （n=-991）, 〈50% of obstruction was predominant （471/991,47.52%）. Totally 50%-69% accounted for 34.81% （345/991）, 〉70% of obstruction was 17.65% （175/991）. Conclusions These data showed that the prevalence of angiographically detectable MB in Chinese patients with chest pain was similar to those of the previous studies, with 2.7% prevalence in this very large sample size.

关键词： angiographic prevalence chest pain myocardial bridging

Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue Wei Wen-bo Cao Sai-jun Mo Zhi-Yan Sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-xia Yang Li-Ting Zhang xiao-jun Liu Xue-Bin Peng xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

脂肪酸移位酶FAT/CD36转运长链脂肪酸研究进展

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

动物医学进展 2017年第5期38卷 93-97页

作者：薄俊霞李敬达刘庆平大连大学生命科学与技术学院辽宁省糖脂代谢研究重点实验室辽宁大连116622

机体对长链脂肪酸(LCFAs)的摄取是细胞利用和调节脂肪酸代谢的重要环节,其中绝大多数LCFAs通过一系列膜转运蛋白介导的摄取作用进入细胞内进行代谢。脂肪酸移位酶(FAT/CD36)是一种分布在细胞膜上的二次跨膜糖蛋白,对长链脂肪酸的转运具... 详细信息

机体对长链脂肪酸(LCFAs)的摄取是细胞利用和调节脂肪酸代谢的重要环节,其中绝大多数LCFAs通过一系列膜转运蛋白介导的摄取作用进入细胞内进行代谢。脂肪酸移位酶(FAT/CD36)是一种分布在细胞膜上的二次跨膜糖蛋白,对长链脂肪酸的转运具有重要作用。论文对FAT/CD36的结构、转运长链脂肪酸的机制以及其表达调控进行综述,有助于更好的了解LCFAs作为重要营养物质的跨膜转运,以及代谢综合症时LCFAs经由FAT/CD36引发的发病机制。

关键词：长链脂肪酸脂肪酸营养脂肪酸移位酶跨膜转运代谢综合症

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 16-29页

作者： xia-Jie Quan Hao Liang Yong-Hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

脂肪酸移位酶FAT/CD36与长链脂肪酸的结合机制

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国动脉硬化杂志 2018年第1期26卷 25-28页

作者：薄俊霞李敬达刘庆平辽宁省糖脂代谢研究重点实验室大连大学生命科学与技术学院

目的探讨脂肪酸移位酶FAT/CD36与长链脂肪酸的结合机制。方法 ELISA分析重组蛋白FAT/CD36与不同种类长链脂肪酸结合强弱机制,分子模拟对接进一步验证其结合机制并分析其可能作用位点。结果ELISA证明重组蛋白FAT/CD36与不同种类长链... 详细信息

目的探讨脂肪酸移位酶FAT/CD36与长链脂肪酸的结合机制。方法 ELISA分析重组蛋白FAT/CD36与不同种类长链脂肪酸结合强弱机制,分子模拟对接进一步验证其结合机制并分析其可能作用位点。结果ELISA证明重组蛋白FAT/CD36与不同种类长链脂肪酸均显示特异性结合,结合值大小为油酸＞棕榈酸＞棕榈油酸＞肉豆蔻酸＞硬脂酸。分子模拟对接进一步验证FAT/CD36受体蛋白主要与其中的油酸、棕榈酸及棕榈油酸结合,且结合位点位于FAT/CD36受体蛋白胞外结构的Arg183-Lys-Gly-Lys-Arg-Asn-Leu-Ser-Tyr238区域组成的活性口袋。结论 FAT/CD36作为细胞长链脂肪酸转运的主要受体,其可能主要转运油酸、棕榈酸和棕榈油酸这三种脂肪酸。

关键词：脂肪酸移位酶长链脂肪酸分子模拟对接

Lower oxygen vacancy concentration in BiPO_(4)with unexpected higher photocatalytic activity

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第5期34卷 369-373页

作者： jun Xiong Haoxue Huang bo Lin Jiexiang xia jun Di School of Chemistry and Chemical Engineering Institute for Energy ResearchJiangsu UniversityZhenjiang 212013China School of Chemistry and Chemical Engineering National Special Superfine Powder Engineering Research CenterNanjing University of Science and TechnologyNanjing 210094China School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an 710049China

Defect engineering has been demonstrated to be an appealing strategy to boost the photocatalytic activity of ***,can higher defect concentration bring about higher photocatalytic activity?This is an open *** this work,BiPO_(4)photocatalysts with controllable oxygen vacancy concentrations were successfully *** photocatalytic activity of the obtained BiPO_(4)photocatalysts was determined by the removal of ciprofloxacin and 4-chlorophenol,as well as CO_(2)*** BiPO4materials with lower oxygen vacancy concentration could display unexpected higher photocatalytic *** the investigation of different factors which may affect the photocatalytic performance,such as crystal structure,morphology,specific surface area,defect,and energy band structure,it can be found that the energy band structure difference was responsible for the enhanced photocatalytic activity.

关键词： BiPO_(4) Photocatalytic Oxygen vacancy Ciprofloxacin Energy band structure

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

在线全文

学校读者我要写书评

暂无评论

Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-jun Zhang Wen-Wei Wang Jing-Shui Zhen bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model